In silico and in vitro studies to elucidate the role of Cu2+ and galanthamine as the limiting step in the amyloid beta (1-42) fibrillation process

Protein Science

Volumn 22, Issue 10, 2013, Pages 1320-1335

  Hernández Rodríguez, Maricarmen ^a   Correa Basurto, José ^a   Benitez Cardoza, Claudia G ^a   Resendiz Albor, Aldo Arturo ^a   Rosales Hernández, Martha C ^a  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

Alzheimer's disease; Amyloid beta peptide (Ab); Copper; Molecular dynamics simulations; Oligomerization

Indexed keywords

AMINO ACID; AMYLOID BETA PROTEIN[1-42]; COPPER ION; GALANTAMINE; MONOMER; OLIGOMER; THIOFLAVINE;

ALPHA HELIX; ARTICLE; BETA SHEET; CIRCULAR DICHROISM; COMPUTER MODEL; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FIBER; FLUORESCENCE SPECTROSCOPY; HYDROGEN BOND; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN SYNTHESIS; SIMULATION;

ALZHEIMER'S DISEASE; AMYLOID BETA PEPTIDE (AΒ); COPPER; MOLECULAR DYNAMICS SIMULATIONS; OLIGOMERIZATION;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMINO ACIDS; AMYLOID; AMYLOID BETA-PEPTIDES; CIRCULAR DICHROISM; COPPER; GALANTAMINE; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; SPECTROMETRY, FLUORESCENCE;

EID: 84892926256     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2319     Document Type: Article

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