Distinct effects of Zn2+, Cu2+, Fe3+, and Al3+ on amyloid-β stability, oligomerization, and aggregation: Amyloid-β destabilization promotes annular protofibril formation

Journal of Biological Chemistry

Volumn 286, Issue 11, 2011, Pages 9646-9656

  Chen, Wei Ting ^a,b   Liao, Yi Hung ^a,c   Yu, Hui Ming ^a   Cheng, Irene H ^b   Chen, Yun Ru ^a  

^a GENOMICS RESEARCH CENTER   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATION MECHANISM; ALZHEIMER DISEASE; BINDING AFFINITIES; BINDING KINETICS; CONFORMATIONAL CHANGE; DOT-BLOTTING; FIBRIL FORMATION; GUANIDINE HYDROCHLORIDE; HIGH CONCENTRATION; METAL ION BINDING; NUCLEATION PHASIS; NUCLEATION PROCESS; PHOTO-INDUCED; SENILE PLAQUES; STOPPED FLOW; THIOFLAVIN T;

ALUMINUM; AMINO ACIDS; BINDING ENERGY; FLUORESCENCE; GLYCOPROTEINS; METAL IONS; NEURODEGENERATIVE DISEASES; NUCLEATION; OLIGOMERIZATION; OLIGOMERS; TRANSMISSION ELECTRON MICROSCOPY;

ZINC;

ALUMINUM; AMYLOID BETA PROTEIN; COPPER ION; IRON; ZINC ION; AMYLOID; AMYLOID PRECURSOR PROTEIN; APP PROTEIN, HUMAN; COPPER; ZINC;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HYDROPHOBICITY; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN CROSS LINKING; PROTEIN DENATURATION; PROTEIN STABILITY; STOICHIOMETRY; TRANSMISSION ELECTRON MICROSCOPY; CHEMISTRY; HUMAN; PROTEIN MULTIMERIZATION; ULTRASTRUCTURE;

ALUMINUM; AMYLOID; AMYLOID BETA-PROTEIN PRECURSOR; COPPER; HUMANS; IRON; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; ZINC;

EID: 79953225854     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.177246     Document Type: Article

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