Synthesis, physical-chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4(1H)-ones: Iron chelators with the potential for treating Alzheimer's disease

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 3, 2011, Pages 1285-1297

  Gaeta, Alessandra ^a   Molina Holgado, Francisco ^b   Kong, Xiao L ^a   Salvage, Sarah ^a   Fakih, Sarah ^a   Francis, Paul T ^a   Williams, Robert J ^c   Hider, Robert C ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF ROEHAMPTON   (United Kingdom)

^c University of Bath   (United Kingdom)

Author keywords

Amyloid; Hydroxypyridin 4 ones; Neurodegeneration; Oxidative stress

Indexed keywords

2 ACETOXYMETHYL 3,4 DIBENZYLOXYPYRIDINE; 2 AMIDO 3 HYDROXYPYRIDIN 4(1H) ONE; 2 CARBOXY 3,4 DIBENZYLOXYPYRIDINE; 2 FORMYL 3,4 DIBENZYLOXYPYRIDINE; 2 HYDROXYMETHYL 3,4 DIBENZYLOXYPYRIDINE; 2 METHYL 3 BENZYLOXYPYRAN 4(1H) ONE; 2 METHYL 3 BENZYLOXYPYRIDIN 4(1H) ONE; 2 METHYL 3,4 DIBENZYLOXYPYRIDINE; 2 METHYL 3,4 DIBENZYLOXYPYRIDINE N OXIDE; CENTRAL NERVOUS SYSTEM AGENTS; IRON CHELATING AGENT; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CHELATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NERVE CELL; NEUROPROTECTION; NONHUMAN; RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CELL DEATH; CELLS, CULTURED; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IRON CHELATING AGENTS; MICE; MOLECULAR PROBES; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PYRONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79551488949     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.12.007     Document Type: Article

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