-
1
-
-
0015353260
-
Circadian rhythms in drinking behavior and locomotor activity of rats are eliminated by hypothalamic lesions
-
Stephan FK, Zucker I. Circadian rhythms in drinking behavior and locomotor activity of rats are eliminated by hypothalamic lesions. Proc Natl Acad Sci U S A 1972;69:1583-6.
-
(1972)
Proc Natl Acad Sci U S A
, vol.69
, pp. 1583-1586
-
-
Stephan, F.K.1
Zucker, I.2
-
2
-
-
0032486330
-
Role of the CLOCK protein in the mammalian circadian mechanism
-
Gekakis N, Staknis D, Nguyen HB, Davis FC, Wilsbacher LD, King DP, et al. Role of the CLOCK protein in the mammalian circadian mechanism. Science 1998;280:1564-9.
-
(1998)
Science
, vol.280
, pp. 1564-1569
-
-
Gekakis, N.1
Staknis, D.2
Nguyen, H.B.3
Davis, F.C.4
Wilsbacher, L.D.5
King, D.P.6
-
3
-
-
0037167866
-
Circadian rhythms: Finer clock control
-
Alvarez JD, Sehgal A. Circadian rhythms: finer clock control. Nature 2002;419:798-9.
-
(2002)
Nature
, vol.419
, pp. 798-799
-
-
Alvarez, J.D.1
Sehgal, A.2
-
4
-
-
0033597904
-
MCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop
-
Kume K, Zylka MJ, Sriram S, Shearman LP, Weaver DR, Jin X, et al. mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 1999;98:193-205.
-
(1999)
Cell
, vol.98
, pp. 193-205
-
-
Kume, K.1
Zylka, M.J.2
Sriram, S.3
Shearman, L.P.4
Weaver, D.R.5
Jin, X.6
-
5
-
-
4143142003
-
A functional genomics strategy reveals Rora as a component of the mammalian circadian clock
-
Sato TK, Panda S, Miraglia LJ, Reyes TM, Rudic RD, McNamara P, et al. A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron 2004;43:527-37.
-
(2004)
Neuron
, vol.43
, pp. 527-537
-
-
Sato, T.K.1
Panda, S.2
Miraglia, L.J.3
Reyes, T.M.4
Rudic, R.D.5
McNamara, P.6
-
6
-
-
0025630643
-
Expression of the liver-enriched transcriptional activator protein DBP follows a stringent circadian rhythm
-
Wuarin J, Schibler U. Expression of the liver-enriched transcriptional activator protein DBP follows a stringent circadian rhythm. Cell 1990;63:1257-66.
-
(1990)
Cell
, vol.63
, pp. 1257-1266
-
-
Wuarin, J.1
Schibler, U.2
-
7
-
-
33644625748
-
Feedback repression is required for mammalian circadian clock function
-
Sato TK, Yamada RG, Ukai H, Baggs JE, Miraglia LJ, Kobayashi TJ, et al. Feedback repression is required for mammalian circadian clock function. Nat Genet 2006;38:312-9.
-
(2006)
Nat Genet
, vol.38
, pp. 312-319
-
-
Sato, T.K.1
Yamada, R.G.2
Ukai, H.3
Baggs, J.E.4
Miraglia, L.J.5
Kobayashi, T.J.6
-
8
-
-
33748376677
-
Circadian clock coordinates cancer cell cycle progression, thymidylate synthase, and 5-fluorouracil therapeutic index
-
Wood PA, Du-Quiton J, You S, Hrushesky WJ. Circadian clock coordinates cancer cell cycle progression, thymidylate synthase, and 5-fluorouracil therapeutic index. Mol Cancer Ther 2006;5:2023-33.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2023-2033
-
-
Wood, P.A.1
Du-Quiton, J.2
You, S.3
Hrushesky, W.J.4
-
9
-
-
33645505715
-
Chronotherapeutics: The relevance of timing in cancer therapy
-
Levi F. Chronotherapeutics: the relevance of timing in cancer therapy. Cancer Causes Control 2006;17:611-21.
-
(2006)
Cancer Causes Control
, vol.17
, pp. 611-621
-
-
Levi, F.1
-
10
-
-
0142241211
-
Circadian timing in cancer treatment: The biological foundation for an integrative approach
-
Lis CG, Grutsch JF, Wood P, You M, Rich I, Hrushesky WJ. Circadian timing in cancer treatment: the biological foundation for an integrative approach. Integr Cancer Ther 2003;2:105-11.
-
(2003)
Integr Cancer Ther
, vol.2
, pp. 105-111
-
-
Lis, C.G.1
Grutsch, J.F.2
Wood, P.3
You, M.4
Rich, I.5
Hrushesky, W.J.6
-
11
-
-
0344011544
-
Changes in toxicity and effectiveness with timing of drug administration: Implications for drug safety
-
Ohdo S. Changes in toxicity and effectiveness with timing of drug administration: implications for drug safety. Drug Saf 2003;26:999-1010.
-
(2003)
Drug Saf
, vol.26
, pp. 999-1010
-
-
Ohdo, S.1
-
12
-
-
0033429554
-
Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
-
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR. Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J 1999;344:427-31.
-
(1999)
Biochem J
, vol.344
, pp. 427-431
-
-
Nave, B.T.1
Ouwens, M.2
Withers, D.J.3
Alessi, D.R.4
Shepherd, P.R.5
-
13
-
-
0033178702
-
Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells
-
Grewe M, Gansauge F, Schmid RM, Adler G, Seufferlein T. Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells. Cancer Res 1999;59:3581-7.
-
(1999)
Cancer Res
, vol.59
, pp. 3581-3587
-
-
Grewe, M.1
Gansauge, F.2
Schmid, R.M.3
Adler, G.4
Seufferlein, T.5
-
14
-
-
0029794614
-
Rapamycin inhibits constitutive p70s6k phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells
-
Seufferlein T, Rozengurt E. Rapamycin inhibits constitutive p70s6k phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells. Cancer Res 1996;56:3895-7.
-
(1996)
Cancer Res
, vol.56
, pp. 3895-3897
-
-
Seufferlein, T.1
Rozengurt, E.2
-
15
-
-
9144233506
-
Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells
-
Boulay A, Zumstein-Mecker S, Stephan C, Beuvink I, Zilbermann F, Haller R, et al. Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells. Cancer Res 2004;64:252-61.
-
(2004)
Cancer Res
, vol.64
, pp. 252-261
-
-
Boulay, A.1
Zumstein-Mecker, S.2
Stephan, C.3
Beuvink, I.4
Zilbermann, F.5
Haller, R.6
-
16
-
-
84886943015
-
Everolimus for the second-line treatment of advanced and/or metastatic renal cell cancer: A critique of the submission from Novartis
-
Pitt M, Crathorne L, Moxham T, Bond M, Hyde C. Everolimus for the second-line treatment of advanced and/or metastatic renal cell cancer: a critique of the submission from Novartis. Health Technol Assess 2010;14 Suppl 2:41-6.
-
(2010)
Health Technol Assess
, vol.14
, Issue.SUPPL. 2
, pp. 41-46
-
-
Pitt, M.1
Crathorne, L.2
Moxham, T.3
Bond, M.4
Hyde, C.5
-
17
-
-
33745150462
-
Ribosomal protein S6 phosphorylation: From protein synthesis to cell size
-
Ruvinsky I, Meyuhas O. Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem Sci 2006;31:342-8.
-
(2006)
Trends Biochem Sci
, vol.31
, pp. 342-348
-
-
Ruvinsky, I.1
Meyuhas, O.2
-
18
-
-
0028786952
-
Repression of capdependent translation by 4E-binding protein 1: Competition with p220 for binding to eukaryotic initiation factor-4E
-
Haghighat A, Mader S, Pause A, Sonenberg N. Repression of capdependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. EMBO J 1995;14:5701-9.
-
(1995)
EMBO J
, vol.14
, pp. 5701-5709
-
-
Haghighat, A.1
Mader, S.2
Pause, A.3
Sonenberg, N.4
-
19
-
-
0030716488
-
Regulation of eIF-4E BP1 phosphorylation by mTOR
-
Hara K, Yonezawa K, Kozlowski MT, Sugimoto T, Andrabi K, Weng QP, et al. Regulation of eIF-4E BP1 phosphorylation by mTOR. J Biol Chem 1997;272:26457-63.
-
(1997)
J Biol Chem
, vol.272
, pp. 26457-26463
-
-
Hara, K.1
Yonezawa, K.2
Kozlowski, M.T.3
Sugimoto, T.4
Andrabi, K.5
Weng, Q.P.6
-
20
-
-
79961165137
-
MTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
-
Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, et al. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell 2011;146:408-20.
-
(2011)
Cell
, vol.146
, pp. 408-420
-
-
Peterson, T.R.1
Sengupta, S.S.2
Harris, T.E.3
Carmack, A.E.4
Kang, S.A.5
Balderas, E.6
-
21
-
-
0037097863
-
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
-
Finger DC, Salama S, Tsou C, Harlow E, Blenis J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev 2002;16:1472-87.
-
(2002)
Genes Dev
, vol.16
, pp. 1472-1487
-
-
Finger, D.C.1
Salama, S.2
Tsou, C.3
Harlow, E.4
Blenis, J.5
-
22
-
-
4344595626
-
Regulation and role of autophagy in mammalian cells
-
Meijer AJ, Codogno P. Regulation and role of autophagy in mammalian cells. Int J Biochem Cell Biol 2004;36:2445-62.
-
(2004)
Int J Biochem Cell Biol
, vol.36
, pp. 2445-2462
-
-
Meijer, A.J.1
Codogno, P.2
-
23
-
-
77955163148
-
Circadian regulation of cell cycle: Molecular connections between aging and the circadian clock
-
Khapre RV, Samsa WE, Kondratov RV. Circadian regulation of cell cycle: molecular connections between aging and the circadian clock. Ann Med 2010;42:404-15.
-
(2010)
Ann Med
, vol.42
, pp. 404-415
-
-
Khapre, R.V.1
Samsa, W.E.2
Kondratov, R.V.3
-
24
-
-
77954684532
-
Tumor growth suppression in vivo by overexpression of the circadian component, PER2
-
Miyazaki K, Wakabayashi M, Hara Y, Ishida N. Tumor growth suppression in vivo by overexpression of the circadian component, PER2. Genes Cells 2010;15:351-8.
-
(2010)
Genes Cells
, vol.15
, pp. 351-358
-
-
Miyazaki, K.1
Wakabayashi, M.2
Hara, Y.3
Ishida, N.4
-
25
-
-
24144470033
-
Simultaneous measurement of sirolimus and everolimus in whole blood by HPLC with ultraviolet detection
-
Khoschsorur G. Simultaneous measurement of sirolimus and everolimus in whole blood by HPLC with ultraviolet detection. Clin Chem 2005;51:1721-4.
-
(2005)
Clin Chem
, vol.51
, pp. 1721-1724
-
-
Khoschsorur, G.1
-
26
-
-
51749095471
-
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression
-
Mao JH, Kim IJ, Wu D, Climent J, Kang HC, Del Rosario R, et al. FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science 2008;321:1499-502.
-
(2008)
Science
, vol.321
, pp. 1499-1502
-
-
Mao, J.H.1
Kim, I.J.2
Wu, D.3
Climent, J.4
Kang, H.C.5
Del Rosario, R.6
-
27
-
-
33750201262
-
Basis for dosing time-dependent change in the anti-tumor effect of imatinib in mice
-
Nakagawa H, Takiguchi T, Nakamura M, Furuyama A, Koyanagi S, Aramaki H, et al. Basis for dosing time-dependent change in the anti-tumor effect of imatinib in mice. Biochem Pharmacol 2006;72:1237-45.
-
(2006)
Biochem Pharmacol
, vol.72
, pp. 1237-1245
-
-
Nakagawa, H.1
Takiguchi, T.2
Nakamura, M.3
Furuyama, A.4
Koyanagi, S.5
Aramaki, H.6
-
28
-
-
33644832775
-
Circadian regulation of mouse topoisomerase I gene expression by glucocorticoid hormones
-
Kuramoto Y, Hata K, Koyanagi S, Ohdo S, Shimeno H, Soeda S. Circadian regulation of mouse topoisomerase I gene expression by glucocorticoid hormones. Biochem Pharmacol 2005;71:1155-61.
-
(2005)
Biochem Pharmacol
, vol.71
, pp. 1155-1161
-
-
Kuramoto, Y.1
Hata, K.2
Koyanagi, S.3
Ohdo, S.4
Shimeno, H.5
Soeda, S.6
-
29
-
-
0242610853
-
A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells
-
Koyanagi S, Kuramoto Y, Nakagawa H, Aramaki H, Ohdo S, Soeda S, et al. A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells. Cancer Res. 2003;63:7277-83.
-
(2003)
Cancer Res.
, vol.63
, pp. 7277-7283
-
-
Koyanagi, S.1
Kuramoto, Y.2
Nakagawa, H.3
Aramaki, H.4
Ohdo, S.5
Soeda, S.6
-
30
-
-
34248566788
-
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins
-
Busino L, Bassermann F, Maiolica A, Lee C, Nolan PM, Godinho SI, et al. SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science 2007;316:900-4.
-
(2007)
Science
, vol.316
, pp. 900-904
-
-
Busino, L.1
Bassermann, F.2
Maiolica, A.3
Lee, C.4
Nolan, P.M.5
Godinho, S.I.6
-
31
-
-
34249097203
-
Circadian mutant overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression
-
Siepka SM, Yoo SH, Park J, Song W, Kumar V, Hu Y, et al. Circadian mutant overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell 2007;129:1011-23.
-
(2007)
Cell
, vol.129
, pp. 1011-1023
-
-
Siepka, S.M.1
Yoo, S.H.2
Park, J.3
Song, W.4
Kumar, V.5
Hu, Y.6
-
32
-
-
0035812709
-
Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase
-
Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, et al. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 2001;294:173-7.
-
(2001)
Science
, vol.294
, pp. 173-177
-
-
Koepp, D.M.1
Schaefer, L.K.2
Ye, X.3
Keyomarsi, K.4
Chu, C.5
Harper, J.W.6
-
33
-
-
2942614705
-
Phosphorylation-dependent degradation of c-myc is mediated by the F-box protein Fbw7
-
Yada M, Hatakeyama S, Kamura T, Nishiyama M, Tsunematsu R, Imaki H, et al. Phosphorylation-dependent degradation of c-myc is mediated by the F-box protein Fbw7. EMBO J 2004;23:2116-25.
-
(2004)
EMBO J
, vol.23
, pp. 2116-2125
-
-
Yada, M.1
Hatakeyama, S.2
Kamura, T.3
Nishiyama, M.4
Tsunematsu, R.5
Imaki, H.6
|