-
3
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman, J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med., 285: 1182-1186, 1971.
-
(1971)
N. Engl. J. Med.
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
4
-
-
0025953395
-
Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: Concentration in tumor blood vessels
-
Dvorak, H. F., Sioussat, T. M., Brown, L. F., Berse, B., Nagy, J. A., Sotrel, A., Manseau, E. J., Van de Water, L., and Senger, D. R. Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels. J. Exp. Med., 174: 1275-1278, 1991.
-
(1991)
J. Exp. Med.
, vol.174
, pp. 1275-1278
-
-
Dvorak, H.F.1
Sioussat, T.M.2
Brown, L.F.3
Berse, B.4
Nagy, J.A.5
Sotrel, A.6
Manseau, E.J.7
Van De Water, L.8
Senger, D.R.9
-
5
-
-
0028824336
-
Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor 121
-
Asano, M., Yukita, A., Matsumoto, T., Kondo, S., and Suzuki, H. Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor 121. Cancer Res., 55: 5296-5301, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 5296-5301
-
-
Asano, M.1
Yukita, A.2
Matsumoto, T.3
Kondo, S.4
Suzuki, H.5
-
6
-
-
0026572345
-
The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
-
de Vries, C., Escobedo, J. A., Ueno, H., Houck, K., Ferrara, N., and Williams, L. T. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science (Wash. DC). 255: 989-991, 1992.
-
(1992)
Science (Wash. DC)
, vol.255
, pp. 989-991
-
-
De Vries, C.1
Escobedo, J.A.2
Ueno, H.3
Houck, K.4
Ferrara, N.5
Williams, L.T.6
-
7
-
-
0026702970
-
Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
-
Terman, B. I., Dougher-Vermazen, M., Carrion, M. E., Dimitrov, D., Armellino, D. C., Gospodarowicz, D., and Bohlen, P. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem. Biophys. Res. Commun., 187: 1579-1586, 1992.
-
(1992)
Biochem. Biophys. Res. Commun.
, vol.187
, pp. 1579-1586
-
-
Terman, B.I.1
Dougher-Vermazen, M.2
Carrion, M.E.3
Dimitrov, D.4
Armellino, D.C.5
Gospodarowicz, D.6
Bohlen, P.7
-
8
-
-
0029039195
-
Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
-
Levy, A. P., Levy, N. S., Wegner, S., and Goldberg, M. A. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J. Biol. Chem., 270: 13333-13340, 1995.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 13333-13340
-
-
Levy, A.P.1
Levy, N.S.2
Wegner, S.3
Goldberg, M.A.4
-
9
-
-
0036579996
-
The combination of angiogenic therapy with other modalities
-
O'Reilly, M. S. The combination of angiogenic therapy with other modalities. Cancer J., volume 8(Suppl. 1): S89-S99, 2002.
-
(2002)
Cancer J.
, vol.8
, Issue.SUPPL. 1
-
-
O'Reilly, M.S.1
-
10
-
-
0030868867
-
Chronopharmacological study of interferon-α in mice
-
Koyanagi, S., Ohdo, S., Yukawa, E., and Higuchi, S. Chronopharmacological study of interferon-α in mice. J. Pharmacol. Exp. Ther., 283: 259-264, 1997.
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.283
, pp. 259-264
-
-
Koyanagi, S.1
Ohdo, S.2
Yukawa, E.3
Higuchi, S.4
-
11
-
-
0037309359
-
Optimizing the dosing schedule of TNP-470 [O-(chloroacetyl-carbamoyl)fumagillol] enhances its antitumor and antiangiogenic efficacies
-
Koyanagi, S., Nakagawa, H., Kuramoto, Y., Ohdo, S., Soeda, S., and Shimeno, H. Optimizing the dosing schedule of TNP-470 [O-(chloroacetyl-carbamoyl)fumagillol] enhances its antitumor and antiangiogenic efficacies. J. Pharmacol. Exp. Ther., 304: 669-674, 2003.
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.304
, pp. 669-674
-
-
Koyanagi, S.1
Nakagawa, H.2
Kuramoto, Y.3
Ohdo, S.4
Soeda, S.5
Shimeno, H.6
-
12
-
-
0035106940
-
Changing the dosing schedule minimizes the disruptive effects of interferon on clock function
-
Ohdo, S., Koyanagi, S., Suyama, H., Higuchi, S., and Aramaki, H. Changing the dosing schedule minimizes the disruptive effects of interferon on clock function. Nat. Med., 7: 356-360, 2001.
-
(2001)
Nat. Med.
, vol.7
, pp. 356-360
-
-
Ohdo, S.1
Koyanagi, S.2
Suyama, H.3
Higuchi, S.4
Aramaki, H.5
-
13
-
-
0015504847
-
Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat
-
Moore, R. Y., and Eichler, V. B. Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat. Brain Res., 42: 201-206, 1972.
-
(1972)
Brain Res.
, vol.42
, pp. 201-206
-
-
Moore, R.Y.1
Eichler, V.B.2
-
14
-
-
0032486330
-
Role of the CLOCK protein in the mammalian circadian mechanism
-
Gekakis, N., Staknis, D., Nguyen, H. B., Davis, F. C., Wilsbacher, L. D., King, D. P., Takahashi, J. S., and Weitz, C. J. Role of the CLOCK protein in the mammalian circadian mechanism. Science (Wash. DC), 280: 1564-1569, 1998.
-
(1998)
Science (Wash. DC)
, vol.280
, pp. 1564-1569
-
-
Gekakis, N.1
Staknis, D.2
Nguyen, H.B.3
Davis, F.C.4
Wilsbacher, L.D.5
King, D.P.6
Takahashi, J.S.7
Weitz, C.J.8
-
15
-
-
0033597904
-
mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop
-
Kume, K., Zylka, M. J., Sriram, S., Shearman, L. P., Weaver, D. R., Jin, X., Maywood, E. S., Hastings, M. H., and Reppert, S. M. mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell, 98: 193-205, 1999.
-
(1999)
Cell
, vol.98
, pp. 193-205
-
-
Kume, K.1
Zylka, M.J.2
Sriram, S.3
Shearman, L.P.4
Weaver, D.R.5
Jin, X.6
Maywood, E.S.7
Hastings, M.H.8
Reppert, S.M.9
-
16
-
-
8944248812
-
FIk-1 as a target for tumor growth inhibition
-
Strawn, L. M., McMahon, G., App, H., Schreck, R., Kuchler, W. R., Longhi, M. P., Hui, T. H., Tang, C., Levitzki, A., Gazit, A., Chen, I., Keri, G., Orfi, L., Risau, W., Flamme, I., Ullrich, A., Hirth, K. P., and Shawver, L. K. FIk-1 as a target for tumor growth inhibition. Cancer Res., 56: 3540-3545, 1996.
-
(1996)
Cancer Res.
, vol.56
, pp. 3540-3545
-
-
Strawn, L.M.1
McMahon, G.2
App, H.3
Schreck, R.4
Kuchler, W.R.5
Longhi, M.P.6
Hui, T.H.7
Tang, C.8
Levitzki, A.9
Gazit, A.10
Chen, I.11
Keri, G.12
Orfi, L.13
Risau, W.14
Flamme, I.15
Ullrich, A.16
Hirth, K.P.17
Shawver, L.K.18
-
17
-
-
0025204095
-
Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumor growth
-
Ingber, D., Fujita, T., Kishimoto, S., Sudo, K., Kanamaru, T., Brem, H., and Folkman, J. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumor growth. Nature (Lond.), 348: 555-557, 1990.
-
(1990)
Nature (Lond.)
, vol.348
, pp. 555-557
-
-
Ingber, D.1
Fujita, T.2
Kishimoto, S.3
Sudo, K.4
Kanamaru, T.5
Brem, H.6
Folkman, J.7
-
18
-
-
0032834472
-
Inhibition of tumor growth by marimastat in a human xenograft model of gastric cancer: Relationship with levels of circulating CEA
-
Watson, S. A., Morris, T. M., Collins, H. M., Bawden, L. J., Hawkins, K., and Bone, E. A. Inhibition of tumor growth by marimastat in a human xenograft model of gastric cancer: relationship with levels of circulating CEA. Br. J. Cancer, 81: 19-23, 1999.
-
(1999)
Br. J. Cancer
, vol.81
, pp. 19-23
-
-
Watson, S.A.1
Morris, T.M.2
Collins, H.M.3
Bawden, L.J.4
Hawkins, K.5
Bone, E.A.6
-
19
-
-
0037067652
-
Phenotypic rescue of a peripheral clock genetic defect via SCN hierarchical dominance
-
Pando, M. P., Morse, D., Cermakian, N., and Sassone-Corsi, P. Phenotypic rescue of a peripheral clock genetic defect via SCN hierarchical dominance. Cell, 110: 107-117, 2002.
-
(2002)
Cell
, vol.110
, pp. 107-117
-
-
Pando, M.P.1
Morse, D.2
Cermakian, N.3
Sassone-Corsi, P.4
-
20
-
-
0035966317
-
Posttranslational mechanisms regulate the mammalian circadian clock
-
Lee, C., Etchegaray, J. P., Cagampang, F. R., Loudon, A. S., and Reppert, S. M. Posttranslational mechanisms regulate the mammalian circadian clock. Cell, 107: 855-867, 2001.
-
(2001)
Cell
, vol.107
, pp. 855-867
-
-
Lee, C.1
Etchegaray, J.P.2
Cagampang, F.R.3
Loudon, A.S.4
Reppert, S.M.5
-
21
-
-
0037178787
-
The orphan nuclear receptor REV-ERBα controls circadian transcription within the positive limb of the mammalian circadian oscillator
-
Preitner, N., Damiola, F., Molina, L. L., Zakany, J., Duboule, D., Albrecht, U., and Schibler, U. The orphan nuclear receptor REV-ERBα controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell, 110: 251-260, 2002.
-
(2002)
Cell
, vol.110
, pp. 251-260
-
-
Preitner, N.1
Damiola, F.2
Molina, L.L.3
Zakany, J.4
Duboule, D.5
Albrecht, U.6
Schibler, U.7
-
22
-
-
0032102386
-
Three period homologs in mammals: Differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain
-
Zylka, M. J., Shearman, L. P., Weaver, D. R., and Reppert, S. M. Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain. Neuron. 20: 1103-1110, 1998.
-
(1998)
Neuron.
, vol.20
, pp. 1103-1110
-
-
Zylka, M.J.1
Shearman, L.P.2
Weaver, D.R.3
Reppert, S.M.4
-
23
-
-
0031039243
-
The biology of vascular endothelial growth factor
-
Ferrara, N., and Davis-Smith, T. The biology of vascular endothelial growth factor. Endocr. Rev., 18: 4-25, 1997.
-
(1997)
Endocr. Rev.
, vol.18
, pp. 4-25
-
-
Ferrara, N.1
Davis-Smith, T.2
-
24
-
-
0032510778
-
The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors
-
Hogenesch, J. B., Gu, Y. Z., Jain, S., and Bradfield, C. A. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc. Natl. Acad. Sci. USA, 95: 5474-5479, 1998.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 5474-5479
-
-
Hogenesch, J.B.1
Gu, Y.Z.2
Jain, S.3
Bradfield, C.A.4
-
25
-
-
0034220768
-
The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors
-
Hogenesch, J. B., Gu, Y. Z., Moran, S. M., Shimomura, K., Radcliffe, L. A., Takahashi, J. S., and Bradfield, C. A. The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors. J. Neurosci., 20: RC83, 2000.
-
(2000)
J. Neurosci.
, vol.20
-
-
Hogenesch, J.B.1
Gu, Y.Z.2
Moran, S.M.3
Shimomura, K.4
Radcliffe, L.A.5
Takahashi, J.S.6
Bradfield, C.A.7
-
26
-
-
0035910429
-
Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide
-
Kimura, H., Weisz, A., Ogura, T., Hitomi, Y., Kurashima, Y., Hashimoto, K., D'Acquisto, F., Makuuchi, M., and Esumi, H. Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide. J. Biol. Chem., 276: 2292-2298, 2000.
-
(2000)
J. Biol. Chem.
, vol.276
, pp. 2292-2298
-
-
Kimura, H.1
Weisz, A.2
Ogura, T.3
Hitomi, Y.4
Kurashima, Y.5
Hashimoto, K.6
D'Acquisto, F.7
Makuuchi, M.8
Esumi, H.9
-
27
-
-
0024818355
-
Vascular endothelial growth factor is a secreted angiogenic mitogen
-
Leung, D. W., Cachianes, G., Kuang, W. J., Goeddel, D. V., and Ferrara, N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science (Wash. DC), 246: 1306-1309, 1989.
-
(1989)
Science (Wash. DC)
, vol.246
, pp. 1306-1309
-
-
Leung, D.W.1
Cachianes, G.2
Kuang, W.J.3
Goeddel, D.V.4
Ferrara, N.5
-
28
-
-
0032547763
-
Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells: Role of fit-1
-
Wang, H., and Keiser, J. A. Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells: role of fit-1. Circ. Res., 83: 832-840, 1998.
-
(1998)
Circ. Res.
, vol.83
, pp. 832-840
-
-
Wang, H.1
Keiser, J.A.2
-
30
-
-
0026625037
-
Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor
-
Reyes, H., Reisz-Porszasz, S., and Hankinson, O. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science (Wash. DC), 256: 1193-1195, 1992.
-
(1992)
Science (Wash. DC)
, vol.256
, pp. 1193-1195
-
-
Reyes, H.1
Reisz-Porszasz, S.2
Hankinson, O.3
-
31
-
-
0033536228
-
The mPer2 gene encodes a functional component of the mammalian circadian clock
-
Zheng, B., Larkin, D. W., Albrecht, U., Sun, Z. S., Sage, M., Eichele, G., Lee, C. C., and Bradley, A. The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature (Lond.), 400: 169-173, 1999.
-
(1999)
Nature (Lond.)
, vol.400
, pp. 169-173
-
-
Zheng, B.1
Larkin, D.W.2
Albrecht, U.3
Sun, Z.S.4
Sage, M.5
Eichele, G.6
Lee, C.C.7
Bradley, A.8
-
32
-
-
0035203884
-
Hypoxia affects expression of circadian genes PER1 and CLOCK in mouse brain
-
Chilov, D., Hofer, T., Bauer, C., Wenger, R. H., and Gassmann, M. Hypoxia affects expression of circadian genes PER1 and CLOCK in mouse brain. FASEB J., 15: 2613-2622, 2001.
-
(2001)
FASEB J.
, vol.15
, pp. 2613-2622
-
-
Chilov, D.1
Hofer, T.2
Bauer, C.3
Wenger, R.H.4
Gassmann, M.5
-
33
-
-
0031472474
-
Two period homologs: Circadian expression and photic regulation in the suprachiasmatic nuclei
-
Shearman, L. P., Zylka, M. J., Weaver, D. R., Kolakowski, L. F., Jr., and Reppert, S. M. Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron, 19: 1261-1269, 1997.
-
(1997)
Neuron
, vol.19
, pp. 1261-1269
-
-
Shearman, L.P.1
Zylka, M.J.2
Weaver, D.R.3
Kolakowski Jr., L.F.4
Reppert, S.M.5
-
34
-
-
0037426839
-
Rhythmic histone acetylation underlies transcription in the mammalian circadian clock
-
Etchegaray, J. P., Lee, C., Wade, P. A., and Reppert, S. M. Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Nature (Lond.). 421: 177-182, 2003.
-
(2003)
Nature (Lond.)
, vol.421
, pp. 177-182
-
-
Etchegaray, J.P.1
Lee, C.2
Wade, P.A.3
Reppert, S.M.4
-
35
-
-
0032538797
-
Signal transduction of hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1a
-
Kallio, J. P., Okamoto, K., O'Brien, S., Carrero, P., Makino, Y., Tanaka, H., and Poellinger, L. Signal transduction of hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1a. EMBO J., 17: 6573-6586, 1998.
-
(1998)
EMBO J.
, vol.17
, pp. 6573-6586
-
-
Kallio, J.P.1
Okamoto, K.2
O'Brien, S.3
Carrero, P.4
Makino, Y.5
Tanaka, H.6
Poellinger, L.7
-
36
-
-
0030932849
-
Tumor-associated angiogenesis: Mechanisms, clinical implications, and therapeutic strategies
-
Pluda, J. M. Tumor-associated angiogenesis: mechanisms, clinical implications, and therapeutic strategies. Semin. Oncol., 24: 203-218, 1997.
-
(1997)
Semin. Oncol.
, vol.24
, pp. 203-218
-
-
Pluda, J.M.1
-
37
-
-
0036971959
-
Diurnal fluctuation of edema synchronized with plasma VEGF concentration in a patient with POEMS syndrome
-
Endo, I., Mitsui, T., Nishino, M., Oshima, Y., and Matsumoto, T. Diurnal fluctuation of edema synchronized with plasma VEGF concentration in a patient with POEMS syndrome. Intern. Med., 41: 1196-1198, 2002.
-
(2002)
Intern. Med.
, vol.41
, pp. 1196-1198
-
-
Endo, I.1
Mitsui, T.2
Nishino, M.3
Oshima, Y.4
Matsumoto, T.5
|