Simultaneous measurement of sirolimus and everolimus in whole blood by HPLC with ultraviolet detection

Clinical Chemistry

Volumn 51, Issue 9, 2005, Pages 1721-1724

  Khoschsorur, GholamAli ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

EVEROLIMUS; RAPAMYCIN;

ARTICLE; BLOOD SAMPLING; GRAFT VERSUS HOST REACTION; IMMUNOSUPPRESSIVE TREATMENT; MEASUREMENT; ORGAN TRANSPLANTATION; RADIATION DETECTION; ULTRAVIOLET RADIATION;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; IMMUNOSUPPRESSIVE AGENTS; SIROLIMUS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 24144470033     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2005.051151     Document Type: Article

References (27)

1. Laplante A, Demeule M, Murphy GF, Beliveau R. Interaction of immunosuppressive agents rapamycin and its analogue SDZ-RAD with endothelial P-gp. Transplant Proc 2002;34:3393-5.
2. Sattler M, Guengerich FP, Yun CH, Christians U, Sewing KF. Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat. Drug Metab Dispos 1992;20:753-61.
3. Hallensieben K, Raida M, Habermehl G. Identification of new metabolite of macrolide immunosuppressant, like rapamycin and SDZ RAD, using high performance liquid chromatography and electrospray tandem mass spectrometry. J Am Soc Mass Spectrom 2000;11:516-25.
4. Christians U, Jacobsen W, Serkova N, Benet LZ, Vidal C, Sewing KF, et al. Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants. J Chromatogr B Biomed Sci 2000;748:41-53.
5. Lensmeyer GL, Poquette MA. Therapeutic monitoring of tacrolimus concentrations in blood: semi-automated extraction and liquid chromatography-electrospray ionization mass spectrometry. Ther Drug Monit 2001;23:239-49.
6. Deters M, Kaever V, Kirchner GI. Liquid chromatography/mass spectrometry for therapeutic drug monitoring of immunosuppressants. Anal Chim Acta 2003;492:133-45.
7. Shaw LM, Holt DW, Keown P, Venkataramanan R, Yatscoff RW. Current opinions on therapeutic drug monitoring of immunosuppressive drugs. Clin Ther 1999;21:1632-52.
8. Serkova N, Hausen B, Berry GJ, Jacobsen W, Benet LZ, Morris RE, et al. Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine. J Pharmacol Exp Ther 2000;294: 323-32.
9. Kovarik JM, Kahan BD, Kaplan B, Lorber M, Winkler M, Rouilly M, et al. Longitudinal assessment of everolimus in de novo renal transplant recipients over the first post-transplant year: pharmacokinetics, exposure-response relationships, and influence on cyclosporine. Clin Pharmacol Ther 2001;69:48-56.
10. Maleki S, Graves S, Becker S, Horwatt R, Hicks D, Stroshane RM, et al. Therapeutic monitoring of sirolimus in human whole-blood samples by high-performance liquid chromatography. Clin Ther 2000;22(Suppl B):B25-37.
11. Napoli KL, Kahan BD. Routine clinical monitoring of sirolimus (rapamycin) whole-blood concentrations by HPLC with ultraviolet detection. Clin Chem 1996;42:1943-8.
12. Holt DW, Lee T, Jones K, Johnston A. Validation of an assay for routine monitoring of sirolimus using HPLC with mass spectrometric detection. Clin Chem 2000;46:1179-83.
13. French DC, Saltzgueber M, Hicks DR, Cowper AL, Holt DW. HPLC assay with ultraviolet detection for therapeutic drug monitoring of sirolimus. Clin Chem 2001;47:1316-9.
14. Svensson JO, Brattstrom C, Sawe J. Determination of rapamycin in whole blood by HPLC. Ther Drug Monit 1997;19:112-6.
15. Baldelli S, Murgia S, Merlini S, Zenoni S, Perico N, Remuzzi G, et al. High-performance liquid chromatography with ultraviolet detection for therapeutic drug monitoring of everolimus. J Chromatogr B Analyt Technol Biomed Life Sci 2005;816:99-105.
16. Boudennaia TY, Napoli KL. Validation of a practical liquid chromatography with ultraviolet detection method for quantification of whole-blood everolimus in a clinical TDM laboratory. Ther Drug Monit 2005;27:171-7.
17. Taylor PJ, Salm P, Lynch SV, Pillans PI. Simultaneous quantification of tacrolimus and sirolimus, in human blood, by high-performance liquid chromatography-tandem mass spectrometry. Ther Drug Monit 2000;22:608-12.
18. Salm P, Taylor PJ, Pillans PI. The quantification of sirolimus by high-performance liquid chromatography-tandem mass spectrometry and microparticle enzyme immunoassay in renal transplant recipients. Clin Ther 2000;22(Suppl B):B71-85.
19. Kirchner GI, Vidal C, Jacobsen W, Franzke A, Hallensleben K, Christians U, et al. Simultaneous on-line extraction and analysis of sirolimus (rapamycin) and ciclosporin in blood by liquid chromatography-electrospray mass spectrometry. J Chromatogr B Biomed Sci Appl 1999;721:285-94.
20. Koal T, Deters M, Casetta B, Kaever. Simultaneous determination of four immunosuppressants by means of high speed and robust on-line solid phase extraction-high performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Biomed Sci 2004;805:215-22.
21. Ceglarek U, Lembcke J, Fiedler GM, Werner M, Witzigmann H, Hauss JP, et al. Rapid simultaneous quantification of immunosuppressants in transplant patients by turbulent flow chromatography combined with tandem mass spectrometry. Clin Chim Acta 2004;346:181-90.
22. Streit F, Armstrong VW, Oellerich M. Rapid liquid chromatography-tandem mass spectrometry routine method for simultaneous determination of sirolimus, everolimus, tacrolimus, and cyclosporin A. Clin Chem 2002;48: 955-8.
23. Annesley TM, Clayton L. Simple extraction protocol for analysis of immunosuppressant drugs in whole blood. Clin Chem 2004;50:1845-8.
24. Kahan BD, Napoli KL, Kelly PA, Podbielski J, Hussein I, Urbauer DL, et al. Therapeutic drug monitoring of sirolimus: correlations with efficacy and toxicity. Clin Transplant 2000;14:97-109.
25. Kovarik JM, Eisen H, Dorent R, Mancini D, Vigano M, Rouilly M, et al. Everolimus in de novo cardiac transplantation: pharmacokinetics, therapeutic range, and influence on cyclosporine exposure. J Heart Lung Transplant 2003;22:1117-25.
26. Annesley TM. Application of commercial calibration for the analysis of immunosuppressant drugs in whole blood. Clin Chem 2005;51:547-60.
27. Khoschsorur G, Erwa W, Fruewirth F, Meinitzer A, Hoebarth G, Halwachs-Baumann G. High-performance liquid Chromatographie method for the simultaneous determination of cyclosporine A and its four major metabolites in whole blood. Talanta 2005;65:638-43.