Neuroimaging and plasticity in schizophrenia

Restorative Neurology and Neuroscience

Volumn 32, Issue 1, 2014, Pages 119-127

  Meyer Lindenberg, Andreas ^a   Tost, Heike ^a  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

Author keywords

functional magnetic resonance imaging; graph theory; neurodevelopment; plasticity; rapid transcranial magnetic stimulation; Schizophrenia

Indexed keywords

ARTICLE; BRAIN REGION; GENETIC RISK; GENETIC VARIABILITY; GRAY MATTER; HIPPOCAMPUS; HUMAN; NERVE CELL DIFFERENTIATION; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NERVE DEGENERATION; NEUROIMAGING; PHENOTYPE; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA; TRANSCRANIAL MAGNETIC STIMULATION;

FUNCTIONAL MAGNETIC RESONANCE IMAGING; GRAPH THEORY; NEURODEVELOPMENT; PLASTICITY; RAPID TRANSCRANIAL MAGNETIC STIMULATION; SCHIZOPHRENIA;

BRAIN; HUMANS; NEUROIMAGING; NEURONAL PLASTICITY; SCHIZOPHRENIA;

EID: 84892862632     PISSN: 09226028     EISSN: 18783627     Source Type: Journal    
DOI: 10.3233/RNN-139014     Document Type: Article

References (89)

1. Achard, S., & Bullmore, E. (2007). Efficiency and cost of economical brain functional networks. PLoS Comput Biol, 3(2), e17
2. Bassett, D.S., Bullmore, E., Verchinski, B.A., Mattay, V.S., Weinberger, D.R., & Meyer-Lindenberg, A. (2008). Hierarchical organization of human cortical networks in health and schizophrenia. J Neurosci, 28(37), 9239-9248
3. Bassett, D.S., Greenfield, D.L., Meyer-Lindenberg, A.,Weinberger, D.R., Moore, S.W., & Bullmore, E.T. (2010). Efficient physical embedding of topologically complex information processing networks in brains and computer circuits. PLoS Comput Biol, 6(4), e1000748
4. Bassett, D.S., Meyer-Lindenberg, A., Achard, S., Duke, T., & Bullmore, E. (2006). Adaptive reconfiguration of fractal smallworld human brain functional networks. Proc Natl Acad Sci U S A, 103(51), 19518-19523
5. Bassett, D.S.,Wymbs, N.F., Porter, M.A., Mucha, P.J., Carlson, J.M., & Grafton, S.T. (2011). Dynamic reconfiguration of human brain networks during learning. Proc Natl Acad Sci U S A, 108(18), 7641-7646
6. Benes, F.M., McSparren, J., Bird, E.D., SanGiovanni, J.P., & Vincent, S.L. (1991). Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients. Arch Gen Psychiatry, 48(11), 996-1001
7. Bennett, M.R. (2011). Schizophrenia: Susceptibility genes, dendritic-spine pathology and gray matter loss. Prog Neurobiol, 95(3), 275-300
8. Bertolino, A., Rubino, V., Sambataro, F., Blasi, G., Latorre, V., Fazio, L., Caforio, G., Petruzzella, V., Kolachana, B., Hariri, A., Meyer-Lindenberg, A., Nardini, M., Weinberger, D.R., & Scarabino, T. (2006). Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype. Biol Psychiatry, 60(11), 1250-1258
9. Bilek, E., Schafer, A., Ochs, E., Esslinger, C., Zangl, M., Plichta, M.M., Braun, U., Kirsch, P., Schulze, T.G., Rietschel, M., Meyer-Lindenberg, A., & Tost, H. (2013). Application of High-Frequency Repetitive Transcranial Magnetic Stimulation to the DLPFC Alters Human Prefrontal-Hippocampal Functional Interaction. J Neurosci, 33(16), 7050-7056
10. Bollob'as, B. (1985). Random graphs. London: Academic Press
11. Bullmore, E.T., & Bassett, D.S. (2011). Brain graphs: Graphical models of the human brain connectome. Annu Rev Clin Psychol, 7, 113-140
12. Callicott, J.H., Egan, M.F., Mattay, V.S., Bertolino, A., Bone, A.D., Verchinksi, B., & Weinberger, D.R. (2003a). Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. Am J Psychiatry, 160(4), 709-719
13. Callicott, J.H., Mattay, V.S., Verchinski, B.A., Marenco, S., Egan, M.F., & Weinberger, D.R. (2003b). Complexity of prefrontal cortical dysfunction in schizophrenia: More than up or down. Am J Psychiatry, 160(12), 2209-2215
14. Castren, E., & Rantamaki, T. (2010). The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity. Dev Neurobiol, 70(5), 289-297
15. Clarke, M.C., Harley, M., & Cannon, M. (2006). The role of obstetric events in schizophrenia. Schizophr Bull, 32(1), 3-8
16. Durbin, R., & Mitchison, G. (1990). A dimension reduction framework for understanding cortical maps. Nature, 343(6259), 644-647
17. Ellison-Wright, I., Glahn, D.C., Laird, A.R., Thelen, S.M., & Bullmore, E. (2008). The anatomy of first-episode and chronic schizophrenia: An anatomical likelihood estimation metaanalysis. Am J Psychiatry, 165(8), 1015-1023
18. Esslinger, C., Walter, H., Kirsch, P., Erk, S., Schnell, K., Arnold, C., Haddad, L., Mier, D., Opitz von Boberfeld, C., Raab, K., Witt, S.H., Rietschel, M., Cichon, S., & Meyer-Lindenberg, A. (2009). Neural mechanisms of a genome-wide supported psychosis variant. Science, 324(5927), 605
19. Fornito, A., Zalesky, A., Bassett, D.S., Meunier, D., Ellison-Wright, I., Yucel, M., Wood, S.J., Shaw, K., O'Connor, J., Nertney, D., Mowry, B.J., Pantelis, C., & Bullmore, E.T. (2011). Genetic influences on cost-efficient organization of human cortical functional networks. J Neurosci, 31(9), 3261-3270
20. Frantseva, M.V., Fitzgerald, P.B., Chen, R., Moller, B., Daigle, M., & Daskalakis, Z.J. (2008). Evidence for impaired long-Term potentiation in schizophrenia and its relationship to motor skill learning. Cereb Cortex, 18(5), 990-996
21. Friston, K.J. (1996). Theoretical neurobiology and schizophrenia. Br Med Bull, 52(3), 644-655
22. Garey, L.J., Ong, W.Y., Patel, T.S., Kanani, M., Davis, A., Mortimer, A.M., Barnes, T.R., & Hirsch, S.R. (1998). Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia. J Neurol Neurosurg Psychiatry, 65(4), 446-453
23. Giorgio, A., Watkins, K.E., Chadwick, M., James, S., Winmill, L., Douaud, G., De Stefano, N., Matthews, P.M., Smith, S.M., Johansen-Berg, H., & James, A.C. (2010). Longitudinal changes in grey and white matter during adolescence. Neuroimage, 49(1), 94-103
24. Glantz, L.A., & Lewis, D.A. (2000). Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Arch Gen Psychiatry, 57(1), 65-73
25. Glausier, J.R., & Lewis, D.A. (2012). Dendritic spine pathology in schizophrenia. Neuroscience
26. Harrison, P.J., & Weinberger, D.R. (2005). Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence. Mol Psychiatry, 10(1), 40-68. image 45
27. He, Y., Chen, Z.J., & Evans, A.C. (2007). Small-world anatomical networks in the human brain revealed by cortical thickness from MRI. Cereb Cortex, 17(10), 2407-2419
28. Hoftman, G.D., & Lewis, D.A. (2011). Postnatal developmental trajectories of neural circuits in the primate prefrontal cortex: Identifying sensitive periods for vulnerability to schizophrenia. Schizophr Bull, 37(3), 493-503
29. Huerta, P.T., & Volpe, B.T. (2009). Transcranial magnetic stimulation, synaptic plasticity and network oscillations. J Neuroeng Rehabil, 6, 7
30. Hulshoff Pol, H.E., & Kahn, R.S. (2008). What happens after the first episode? A review of progressive brain changes in chronically ill patients with schizophrenia. Schizophr Bull, 34(2), 354-366
31. Huttenlocher, P.R. (1990). Morphometric study of human cerebral cortex development. Neuropsychologia, 28(6), 517-527
32. Hwang, J.H., Kim, S.H., Park, C.S., Bang, S.A. & Kim, S.E. Acute high-frequency rTMS of the left dorsolateral prefrontal cortex and attentional control in healthy young men. Brain Res, 1329, 152-158
33. Jakob, H., & Beckmann, H. (1986). Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J Neural Transm, 65(3-4), 303-326
34. Kapczinski, F., Frey, B.N., Kauer-Sant'Anna, M., & Grassi-Oliveira, R. (2008). Brain-derived neurotrophic factor and neuroplasticity in bipolar disorder. Expert Rev Neurother, 8(7), 1101-1113
35. Kraepelin, E., Barclay, R.M., & Robertson, G.M. (1919). Dementia præcox and paraphrenia, Edinburgh: E. & S. Livingstone
36. Lee, L., Siebner, H., & Bestmann, S. (2006). Rapid modulation of distributed brain activity by transcranial magnetic stimulation of human motor cortex. Behav Neurol, 17(3-4), 135-148
37. Lewis, D.A. (2009). Neuroplasticity of excitatory and inhibitory cortical circuits in schizophrenia. Dialogues Clin Neurosci, 11(3), 269-280
38. Liu, Y., Liang, M., Zhou, Y., He, Y., Hao, Y., Song, M., Yu, C., Liu, H., Liu, Z., & Jiang, T. (2008). Disrupted small-world networks in schizophrenia. Brain, 131(Pt 4), 945-961
39. Lucassen, P.J., Meerlo, P., Naylor, A.S., van Dam, A.M., Dayer, A.G., Fuchs, E., Oomen, C.A., & Czeh, B. Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action. Eur Neuropsychopharmacol, 20(1), 1-17
40. Ma, S., Calhoun, V.D., Eichele, T., Du, W., & Adali, T. (2012). Modulations of functional connectivity in the healthy and schizophrenia groups during task and rest. Neuroimage, 62(3), 1694-1704
41. Markram, H., Lubke, J., Frotscher, M., & Sakmann, B. (1997). Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs. Science, 275(5297), 213-215
42. Martin, S.J., & Morris, R.G. (2002). New life in an old idea: The synaptic plasticity and memory hypothesis revisited. Hippocampus, 12(5), 609-636
43. Mathalon, D.H., & Ford, J.M. (2012). Neurobiology of schizophrenia: Search for the elusive correlation with symptoms. Front Hum Neurosci, 6, 136
44. Meyer-Lindenberg, A. (2010). From maps to mechanisms through neuroimaging of schizophrenia. Nature, 468(7321), 194-202
45. Meyer-Lindenberg, A. (2011). Neuroimaging and the question of neurodegeneration in schizophrenia. Prog Neurobiol, 95(4), 514-516
46. Meyer-Lindenberg, A., Olsen, R.K., Kohn, P.D., Brown, T., Egan, M.F., Weinberger, D.R., & Berman, K.F. (2005). Regionally specific disturbance of dorsolateral prefrontal-hippocampal functional connectivity in schizophrenia. Arch Gen Psychiatry, 62(4), 379-386
47. Meyer-Lindenberg, A., Straub, R.E., Lipska, B.K.,Verchinski, B.A., Goldberg, T., Callicott, J.H., Egan, M.F., Huffaker, S.S., Mattay, V.S., Kolachana, B., Kleinman, J.E., & Weinberger, D.R. (2007). Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition. J Clin Invest, 117(3), 672-682
48. Micheloyannis, S., Pachou, E., Stam, C.J., Breakspear, M., Bitsios, P., Vourkas, M., Erimaki, S., & Zervakis, M. (2006). Small-world networks and disturbed functional connectivity in schizophrenia. Schizophr Res, 87(1-3), 60-66
49. Morel, B.A. (1890). Trait'a des maladies mentales. Paris: Masson
50. Murray, R. (2003). The epidemiology of schizophrenia, Cambridge University Press, Cambridge. U.K.; New York
51. Murray, R.M., & Lewis, S.W (1987). Is schizophrenia a neurodevelopmental disorder? Br Med J (Clin Res Ed), 295(6600), 681-682
52. Pascual-Leone, A., Tormos, J.M., Keenan, J., Tarazona, F., Canete, C., & Catala, M.D. (1998). Study and modulation of human cortical excitability with transcranial magnetic stimulation. J Clin Neurophysiol, 15(4), 333-343
53. Peinemann, A., Reimer, B., Loer, C., Quartarone, A., Munchau, A., Conrad, B., & Siebner, H.R. (2004). Long-lasting increase in corticospinal excitability after 1800 pulses of subthreshold 5Hz repetitive TMS to the primary motor cortex. Clin Neurophysiol, 115(7), 1519-1526
54. Piper, M., Beneyto, M., Burne, T.H., Eyles, D.W., Lewis, D.A., & McGrath, J.J. (2012). The neurodevelopmental hypothesis of schizophrenia: Convergent clues from epidemiology and neuropathology. Psychiatr Clin North Am, 35(3), 571-584
55. Powell, S.B. (2010). Models of neurodevelopmental abnormalities in schizophrenia. Curr Top Behav Neurosci, 4, 435-481
56. Rasetti, R., Sambataro, F., Chen, Q., Callicott, J.H., Mattay, V.S., & Weinberger, D.R. (2011). Altered cortical network dynamics:A potential intermediate phenotype for schizophrenia and association with ZNF804A. Arch Gen Psychiatry, 68(12), 1207-1217
57. Rounis, E., Lee, L., Siebner, H.R., Rowe, J.B., Friston, K.J., Rothwell, J.C., & Frackowiak, R.S. (2005). Frequency specific changes in regional cerebral blood flow and motor system connectivity following rTMS to the primary motor cortex. Neuroimage, 26(1), 164-176
58. Rounis, E., Stephan, K.E., Lee, L., Siebner, H.R., Pesenti, A., Friston, K.J., Rothwell, J.C., & Frackowiak, R.S. (2006). Acute changes in frontoparietal activity after repetitive transcranial magnetic stimulation over the dorsolateral prefrontal cortex in a cued reaction time task. J Neurosci, 26(38), 9629-9638
59. Rubinov, M., Knock, S.A., Stam, C.J., Micheloyannis, S., Harris, A.W., Williams, L.M., & Breakspear, M. (2009). Small-world properties of nonlinear brain activity in schizophrenia. Hum Brain Mapp, 30(2), 403-416
60. Siebner, H., Peller, M., Bartenstein, P., Willoch, F., Rossmeier, C., Schwaiger, M., & Conrad, B. (2001). Activation of frontal premotor areas during suprathreshold transcranial magnetic stimulation of the left primary sensorimotor cortex: A glucose metabolic PET study. Hum Brain Mapp, 12(3), 157-167
61. Siebner, H.R., & Rothwell, J. (2003). Transcranial magnetic stimulation: New insights into representational cortical plasticity. Exp Brain Res, 148(1), 1-16
62. Sigurdsson, T., Stark, K.L., Karayiorgou, M., Gogos, J.A., & Gordon, J.A. (2010). Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia. Nature, 464(7289), 763-767
63. Sirota, A., Montgomery, S., Fujisawa, S., Isomura, Y., Zugaro, M., & Buzsaki, G. (2008). Entrainment of neocortical neurons and gamma oscillations by the hippocampal theta rhythm. Neuron, 60(4), 683-697
64. Sporns, O., Tononi, G., & Kotter, R. (2005). The human connectome: Astructural description of the human brain. PLoS Comput Biol, 1(4), e42
65. Stephan, K.E., Baldeweg, T., & Friston, K.J. (2006). Synaptic plasticity and dysconnection in schizophrenia. Biol Psychiatry, 59(10), 929-939
66. Suchanek, R., Owczarek, A., Paul-Samojedny, M., Kowalczyk, M., Kucia, K., & Kowalski, J. (2013). BDNF val66met polymorphism is associated with age at onset and intensity of symptoms of paranoid schizophrenia in a Polish population. J Neuropsychiatry Clin Neurosci, 25(1), 88-94
67. Sullivan, P.F., Daly, M.J., & O'Donovan, M. (2012). Genetic architectures of psychiatric disorders: The emerging picture and its implications. Nat Rev Genet, 13(8), 537-551
68. Sullivan, P.F.,Kendler, K.S., & Neale, M.C. (2003). Schizophrenia as a complex trait: Evidence from a meta-Analysis of twin studies. Arch Gen Psychiatry, 60(12), 1187-1192
69. Takeuchi, H., Sekiguchi, A., Taki, Y., Yokoyama, S., Yomogida, Y., Komuro, N., Yamanouchi, T., Suzuki, S., & Kawashima, R. (2010). Training of working memory impacts structural connectivity. J Neurosci, 30(9), 3297-3303
70. Tamminga, C.A., Southcott, S., Sacco, C., Wagner, A.D., & Ghose, S. (2012). Glutamate dysfunction in hippocampus: Relevance of dentate gyrus and CA3 signaling. Schizophr Bull, 38(5), 927-935
71. Tan, H.Y., Callicott, J.H., & Weinberger, D.R. (2007a). Dysfunctional and compensatory prefrontal cortical systems, genes and the pathogenesis of schizophrenia. Cereb Cortex, 17(Suppl 1), i171-i181
72. Tan, H.Y., Chen, Q., Goldberg, T.E., Mattay, V.S., Meyer-Lindenberg, A., Weinberger, D.R., & Callicott, J.H. (2007b). Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memory. J Neurosci, 27(49), 13393-13401
73. Tan, H.Y., Chen, Q., Sust, S., Buckholtz, J.W., Meyers, J.D., Egan, M.F., Mattay, V.S., Meyer-Lindenberg, A., Weinberger, D.R., & Callicott, J.H. (2007c). Epistasis between catechol-Omethyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function. Proc Natl Acad Sci U S A, 104(30), 12536-12541
74. Tan, H.Y., Nicodemus, K.K., Chen, Q., Li, Z., Brooke, J.K., Honea, R., Kolachana, B.S., Straub, R.E., Meyer-Lindenberg, A., Sei, Y., Mattay, V.S., Callicott, J.H., & Weinberger, D.R. (2008). Genetic variation in AKT1 is linked to dopamine-Associated prefrontal cortical structure and function in humans. J Clin Invest, 118(6), 2200-2208
75. Tan, H.Y., Sust, S., Buckholtz, J.W., Mattay, V.S., Meyer-Lindenberg, A., Egan, M.F., Weinberger, D.R., & Callicott, J.H. (2006). Dysfunctional prefrontal regional specialization and compensation in schizophrenia. Am J Psychiatry, 163(11), 1969-1977
76. Thomason, M.E., Yoo, D.J., Glover, G.H., & Gotlib, I.H. (2009). BDNF genotype modulates resting functional connectivity in children. Front Hum Neurosci, 3, 55
77. Uhlhaas, P.J., Roux, F., Singer, W., Haenschel, C., Sireteanu, R., & Rodriguez, E. (2009). The development of neural synchrony reflects late maturation and restructuring of functional networks in humans. Proc Natl Acad Sci U S A, 106(24), 9866-9871
78. van Os, J., Kenis, G., & Rutten, B.P. (2010). The environment and schizophrenia. Nature, 468(7321), 203-212
79. Vanderhasselt, M.A., De Raedt, R., Leyman, L., & Baeken, C. (2009). Acute effects of repetitive transcranial magnetic stimulation on attentional control are related to antidepressant outcomes. J Psychiatry Neurosci, 34(2), 119-126
80. Wang, H., Wang, X., & Scheich, H. (1996). LTD and LTP induced by transcranial magnetic stimulation in auditory cortex. Neuroreport, 7(2), 521-525
81. Watts, D.J., & Strogatz, S.H. (1998). Collective dynamics of 'smallworld' networks. Nature, 393(6684), 440-442
82. Weickert, T.W., Terrazas, A., Bigelow, L.B., Malley, J.D., Hyde, T., Egan, M.F., Weinberger, D.R., & Goldberg, T.E. (2002). Habit and skill learning in schizophrenia: Evidence of normal striatal processing with abnormal cortical input. Learning & memory (Cold Spring Harbor, N.Y, 9(6), 430-442
83. Weinberger, D.R. (1987). Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry, 44(7), 660-669
84. Weinberger, D.R., Berman, K.F., & Zec, R.F. (1986). Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Arch Gen Psychiatry, 43(2), 114-124
85. Wobrock, T., Hasan, A., & Falkai, P. (2012). Innovative treatment approaches in schizophrenia enhancing neuroplasticity: Aerobic exercise, erythropoetin and repetitive transcranial magnetic stimulation. Curr Pharm Biotechnol, 13(8), 1595-1605
86. Wright, I.C., Rabe-Hesketh, S., Woodruff, P.W., David, A.S., Murray, R.M., & Bullmore, E.T. (2000). Meta-Analysis of regional brain volumes in schizophrenia. Am J Psychiatry, 157(1), 16-25
87. Yu, Q., Sui, J., Rachakonda, S., He, H., Gruner, W., Pearlson, G., Kiehl, K.A., & Calhoun, V.D. (2011a). Altered topological properties of functional network connectivity in schizophrenia during resting state: A small-world brain network study. PloS one, 6(9), e25423
88. Yu, Q., Sui, J., Rachakonda, S., He, H., Pearlson, G., & Calhoun, V.D. (2011b). Altered small-world brain networks in temporal lobe in patients with schizophrenia performing an auditory oddball task. Front Syst Neurosci, 5, 7
89. Zhang, J.P., Lencz, T., Geisler, S., DeRosse, P., Bromet, E.J., & Malhotra, A.K. (2013). Genetic variation in BDNF is associated with antipsychotic treatment resistance in patients with schizophrenia. Schizophr Res, 146(1-3), 285-288