BDNF val66met polymorphism is associated with age at onset and intensity of symptoms of paranoid schizophrenia in a Polish population

Journal of Neuropsychiatry and Clinical Neurosciences

Volumn 25, Issue 1, 2013, Pages 88-94

  Suchanek, Renata ^a   Owczarek, Aleksander ^a   Paul Samojedny, Monika ^a   Kowalczyk, Małgorzata ^a   Kucia, Krzysztof ^a   Kowalski, Jan ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ADULT; ALLELE; ARTICLE; AUTHOR; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HALLUCINATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NEGATIVE SYNDROME; ONSET AGE; PARANOID SCHIZOPHRENIA; POSITIVE AND NEGATIVE SYNDROME SCALE; POSITIVE SYNDROME; PRIORITY JOURNAL; SUICIDAL BEHAVIOR;

ADULT; AGE OF ONSET; ANALYSIS OF VARIANCE; BRAIN-DERIVED NEUROTROPHIC FACTOR; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; METHIONINE; MIDDLE AGED; POLAND; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA, PARANOID; SEX FACTORS; VALINE;

EID: 84883292503     PISSN: 08950172     EISSN: 15457222     Source Type: Journal    
DOI: 10.1176/appi.neuropsych.11100234     Document Type: Article

References (32)

1. Craddock N, O'Donovan MC, Owen MJ: The genetics of schizophrenia and bipolar disorder: dissecting psychosis. J Med Genet 2005; 42:193-204
2. Chao MV, Rajagopal R, Lee FS: Neurotrophin signalling in health and disease. Clin Sci (Lond) 2006; 110:167-173
3. Hashimoto T, Bergen SE, Nguye QL, et al: Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. J Neurosci 2005; 25:372-383
4. Chen C, Wang J, Wang B, et al: Decreased levels of serum brain-derived neurotrophic factor in drug-naïve first-episode schizophrenia: relationship to clinical phenotypes. Psychopharmacology (Berl) 2009; 207:375-380
5. Egan MF, Kojima M, Callicott JH, et al: The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003; 112:257-269
6. Chen ZY, Patel PD, Sant G, et al: Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci 2004; 24:4401-4411
7. Skibinska M, Hauser J, Czerski PM, et al: Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder. World J Biol Psychiatry 2004; 5:215-220
8. Neves-Pereira M, Cheung JK, Pasdar A, et al: BDNF gene is a risk factor for schizophrenia in a Scottish population. Mol Psychiatry 2005; 10:208-212
9. Xu MQ, St Clair D, Ott J, et al: Brain-derived neurotrophic factor gene C-270T and Val66Met functional polymorphisms and risk of schizophrenia: a moderate-scale population-based study and meta-analysis. Schizophr Res 2007; 91:6-13
10. First MB, Spitzer RL, Gibbon M, et al: Structured Clinical Interview for DSM-IV Axis I Disorders, Clinicial Version (SCID-CV). Washington, DC, American Psychiatric Press, 1997
11. Tochigi M, Otowa T, Suga M, et al: No evidence for an association between the BDNF Val66Met polymorphism and schizophrenia or personality traits. Schizophr Res 2006; 87:45-47
12. Naoe Y, Shinkai T, Hori H, et al: No association between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and schizophrenia in Asian populations: evidence from a case-control study and meta-analysis. Neurosci Lett 2007; 415:108-112
13. Golimbet VE, Korovaǐtseva GI, Abramova LI, et al: [Association between the Val66Met polymorphism of brain-derived neurotrophic factor gene and schizophrenia in Russians]. Mol Biol (Moscow) 2008; 42:599-603
14. Jönsson EG, Edman-Ahlbom B, Sillén A, et al: Brain-derived neurotrophic factor gene (BDNF) variants and schizophrenia: an association study. Prog Neuropsychopharmacol Biol Psychiatry 2006; 30:924-933
15. Schumacher J, Jamra RA, Becker T, et al: Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Biol Psychiatry 2005; 58:307-314
16. Gratacòs M, González JR, Mercader JM, et al: Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia. Biol Psychiatry 2007; 61:911-922
17. Guillin O, Demily C, Thibaut F: Brain-derived neurotrophic factor in schizophrenia and its relation with dopamine. Int Rev Neurobiol 2007; 78:377-395
18. Pillai A: Brain-derived neurotropic factor/TrkB signaling in the pathogenesis and novel pharmacotherapy of schizophrenia. Neurosignals 2008; 16:183-193
19. Luellen BA, Bianco LE, Schneider LM, et al: Reduced brainderived neurotrophic factor is associated with a loss of serotonergic innervation in the hippocampus of aging mice. Genes Brain Behav 2007; 6:482-490
20. Coyle JT: Glutamate and schizophrenia: beyond the dopamine hypothesis. Cell Mol Neurobiol 2006; 26:365-384
21. Tost H, Alam T, Meyer-Lindenberg A: Dopamine and psychosis: theory, pathomechanisms and intermediate phenotypes. Neurosci Biobehav Rev 2010; 34:689-700
22. Chang HA, Lu RB, Shy MJ, et al: Brain-derived neurotrophic factor Val66Met polymorphism: association with psychopathological symptoms of schizophrenia? J Neuropsychiatry Clin Neurosci 2009; 21:30-37
23. Spalletta G, Morris DW, Angelucci F, et al: BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia. Eur Psychiatry 2010; 25:311-313
24. Rosa A, Cuesta MJ, Fatjó-Vilas M, et al: The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with risk for psychosis: evidence from a familybased association study. Am J Med Genet B Neuropsychiatr Genet 2006; 141B:135-138
25. Numata S, Ueno SI, Iga JI, et al: Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms. Neurosci Lett 2006; 401:1-5
26. Szeszko PR, Lipsky R, Mentschel C, et al: Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formation. Mol Psychiatry 2005; 10:631-636
27. Ho BC, Andreasen NC, Dawson JD, et al: Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia. Am J Psychiatry 2007; 164:1890-1899
28. Huang TL, Lee CT: Associations between serum brainderived neurotrophic factor levels and clinical phenotypes in schizophrenia patients. J Psychiatr Res 2006; 40: 664-668
29. Dwivedi Y: Brain-derived neurotrophic factor and suicide pathogenesis. Ann Med 2010; 42:87-96
30. Keller S, Sarchiapone M, Zarrilli F, et al: Increased BDNF promoter methylation in the Wernicke area of suicide subjects. Arch Gen Psychiatry 2010; 67:258-267
31. Pregelj P, Nedic G, Paska AV, et al: The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide. J Affect Disord 2011; 128:287-290
32. Sarchiapone M, Carli V, Roy A, et al: Association of polymorphism (Val66Met) of brain-derived neurotrophic factor with suicide attempts in depressed patients. Neuropsychobiology 2008; 57:139-145