BDNF genotype modulates resting functional connectivity in children

Frontiers in Human Neuroscience

Volumn 3, Issue NOV, 2009, Pages

  Thomason, Moriah E ^a   Yoo, Daniel J ^a   Glover, Gary H ^b   Gotlib, Ian H ^a  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adolescents; BDNF; Children; fMRI; Functional connectivity; Gene; Resting state

Indexed keywords

EID: 84872202022     PISSN: 16625161     EISSN: None     Source Type: Journal    
DOI: 10.3389/neuro.09.055.2009     Document Type: Article

References (62)

1. Bath, K. G., and Lee, F. S. (2006). Variant BDNF (Val66Met) impact on brain structure and function. Cogn. Affect. Behav. Neurosci. 6, 79-85.
2. Birn, R. M., Smith, M. A., Jones, T. B., and Bandettini, P. A. (2008). The respiration response function: the temporal dynamics of fMRI signal fluctuations related to changes in respiration. Neuroimage 40, 644-654.
3. Broyd, S. J., Demanuele, C., Debener, S., Helps, S. K., James, C. J., and Sonuga-Barke, E. J. (2009). Default-mode brain dysfunction in mental disorders: a systematic review. Neurosci. Biobehav. Rev. 33, 279-296.
4. Bueller, J. A., Aftab, M., Sen, S., Gomez-Hassan, D., Burmeister, M., and Zubieta, J. K. (2006). BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects. Biol. Psychiatry 59, 812-815.
5. Burgund, E. D., Kang, H. C., Kelly, J. E., Buckner, R. L., Snyder, A. Z., Petersen, S. E., and Schlaggar, B. L. (2002). The feasibility of a common stereotactic space for children and adults in fMRI studies of development. Neuroimage 17, 184-200.
6. Casey, B. J., Glatt, C. E., Tottenham, N., Soliman, F., Bath, K., Amso, D., Altemus, M., Pattwell, S., Jones, R., Levita, L., McEwen, B., Magarinos, A. M., Gunnar, M., Thomas, K. M., Mezey, J., Clark, A. G., Hempstead, B. L., and Lee, F. S. (2009). Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development. Neuroscience 164, 108-120.
7. Chang, C., Cunningham, J. P., and Glover, G. H. (2009). Influence of heart rate on the BOLD signal: the cardiac response function. Neuroimage 44, 857-869.
8. Chao, M. V. (2003). Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat. Rev. Neurosci. 4, 299-309.
9. Chen, Z. Y., Patel, P. D., Sant, G., Meng, C. X., Teng, K. K., Hempstead, B. L., and Lee, F. S. (2004). Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wildtype BDNF in neurosecretory cells and cortical neurons. J. Neurosci. 24, 4401-4411.
10. Chepenik, L. G., Fredericks, C., Papademetris, X., Spencer, L., Lacadie, C., Wang, F., Pittman, B., Duncan, J. S., Staib, L. H., Duman, R. S., Gelernter, J., and Blumberg, H. P. (2009). Effects of the brain-derived neurotrophic growth factor val66met variation on hippocampus morphology in bipolar disorder. Neuropsychopharmacology 34, 944-951.
11. Conner, J. M., Lauterborn, J. C., Yan, Q., Gall, C. M., and Varon, S. (1997). Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport. J. Neurosci. 17, 2295-2313.
12. Cox, R. (1996). AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput. Biomed. Res. 29, 162-173.
13. Critchley, H. D., Wiens, S., Rotshtein, P., Ohman, A., and Dolan, R. J. (2004). Neural systems supporting interoceptive awareness. Nat. Neurosci. 7, 189-195.
14. Dempster, E., Toulopoulou, T., McDonald, C., Bramon, E., Walshe, M., Filbey, F., Wickham, H., Sham, P. C., Murray, R. M., and Collier, D. A. (2005). Association between BDNF val66 met genotype and episodic memory. Am. J. Med. Genet. B Neuropsychiatr. Genet. 134B, 73-75.
15. Desai, N. S., Rutherford, L. C., and Turrigiano, G. G. (1999). BDNF regulates the intrinsic excitability of cortical neurons. Learn. Mem. 6, 284-291.
16. Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., Lu, B., and Weinberger, D. R. (2003). The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257-269.
17. Etkin, A., Egner, T., Peraza, D. M., Kandel, E. R., and Hirsch, J. (2006). Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala. Neuron 51, 871-882.
18. Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., and Raichle, M. E. (2005). The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc. Natl. Acad. Sci. U.S.A. 102, 9673-9678.
19. Fox, M. D., Zhang, D., Snyder, A. Z., and Raichle, M. E. (2009). The global signal and observed anticorrelated resting state brain networks. J. Neurophysiol. 101, 3270-3283.
20. Fransson, P. (2005). Spontaneous lowfrequency BOLD signal fluctuations: an fMRI investigation of the restingstate default mode of brain function hypothesis. Hum. Brain Mapp. 26, 15-29.
21. Friston, K. J., Frith, C. D., Liddle, P. F., and Frackowiak, R. S. (1993). Functional connectivity: the principal-component analysis of large (PET) data sets. J. Cereb. Blood Flow Metab. 13, 5-14.
22. Frodl, T., Schule, C., Schmitt, G., Born, C., Baghai, T., Zill, P., Bottlender, R., Rupprecht, R., Bondy, B., Reiser, M., Moller, H. J., and Meisenzahl, E. M. (2007). Association of the brainderived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression. Arch. Gen. Psychiatry 64, 410-416.
23. Gabrieli, J. D., and Preston, A. R. (2003). Visualizing genetic influences on human brain functions. Cell 112, 144-145.
24. Geller, B., Williams, M., Zimerman, B., and Frazier, J. (1996). WASH-UKSADS (Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia). St. Louis, MO, Washington University.
25. Geller, B., Zimerman, B., Williams, M., Bolhofner, K., Craney, J. L., DelBello, M. P., and Soutullo, C. (2001). Reliability of the Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASHU-KSADS) mania and rapid cycling sections. J. Am. Acad. Child Adolesc. Psychiatry 40, 450-455.
26. Glover, G., and Law, C. (2001). Spiral-in/ out BOLD fMRI for increased SNR and reduced suceptibility artifacts. Magn. Reson. Med. 46, 515-522.
27. Gratacos, M., Gonzalez, J. R., Mercader, J. M., de Cid, R., Urretavizcaya, M., and Estivill, X. (2007). Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia. Biol. Psychiatry 61, 911-922.
28. Greicius, M. (2008). Resting-state functional connectivity in neuropsychiatric disorders. Curr. Opin. Neurol. 21, 424-430.
29. Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., Reiss, A. L., and Schatzberg, A. F. (2007). Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus. Biol. Psychiatry 62, 429-437
30. Greicius, M. D., Srivastava, G., Reiss, A. L., and Menon, V. (2004). Defaultmode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc. Natl. Acad. Sci. U.S.A. 101, 4637-4642.
31. Greicius, M. D., Supekar, K., Menon, V., and Dougherty, R. F. (2009). Restingstate functional connectivity reflects structural connectivity in the default mode network. Cereb. Cortex 19, 72-78.
32. Habas, C., Kamdar, N., Nguyen, D., Prater, K., Beckmann, C. F., Menon, V., and Greicius, M. D. (2009). Distinct cerebellar contributions to intrinsic connectivity networks. J. Neurosci. 29, 8586-8594.
33. Hagmann, P., Cammoun, L., Gigandet, X., Meuli, R., Honey, C. J., Wedeen, V. J., and Sporns, O. (2008). Mapping the structural core of human cerebral cortex. PLoS Biol. 6, e159. doi: 10.1371/ journal.pbio.0060159.
34. Hariri, A. R., Goldberg, T. E., Mattay, V. S., Kolachana, B. S., Callicott, J. H., Egan, M. F., and Weinberger, D. R. (2003). Brain-derived neurotrophic factor val-66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J. Neurosci. 23, 6690-6694.
35. Ho, B. C., Milev, P., O'Leary, D. S., Librant, A., Andreasen, N. C., and Wassink, T. H. (2006). Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers. Arch. Gen. Psychiatry 63, 731-740.
36. Horwitz, B. (2003). The elusive concept of brain connectivity. Neuroimage 19, 466-470.
37. Huang, E. J., and Reichardt, L. F. (2001). Neurotrophins: roles in neuronal development and function. Annu. Rev. Neurosci. 24, 677-736.
38. Kelly, A. M., Di Martino, A., Uddin, L. Q., Shehzad, Z., Gee, D. G., Reiss, P. T., Margulies, D. S., Castellanos, F. X., and Milham, M. P. (2009). Development of anterior cingulate functional connectivity from late childhood to early adulthood. Cereb. Cortex 19, 640-657.
39. Kim, D., Adalsteinsson, E., Glover, G., and Spielman, D. (2002). Regularized higher-order in vivo shimming. Magn. Reson. Med. 48, 715-722.
40. Koch, M. A., Norris, D. G., and Hund-Georgiadis, M. (2002). An investigation of functional and anatomical connectivity using magnetic resonance imaging. Neuroimage 16, 241-250.
41. Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., and Bonhoeffer, T. (1995). Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc. Natl. Acad. Sci. U.S.A. 92, 8856-8860.
42. Krasnow, B., Tamm, L., Greicius, M. D., Yang, T. T., Glover, G. H., Reiss, A. L., and Menon, V. (2003). Comparison of fMRI activation at 3 and 1.5 T during perceptual, cognitive, and affective processing. Neuroimage 18, 813-826.
43. Lewin, G. R., and Barde, Y. A. (1996). Physiology of the neurotrophins. Annu. Rev. Neurosci. 19, 289-317.
44. Lu, B., and Gottschalk, W. (2000). Modulation of hippocampal synaptic transmission and plasticity by neurotrophins. Prog. Brain Res. 128, 231-241.
45. McAllister, A. K., Katz, L. C., and Lo, D. C. (1999). Neurotrophins and synaptic plasticity. Annu. Rev. Neurosci. 22, 295-318.
46. Meindl, T., Teipel, S., Elmouden, R., Mueller, S., Koch, W., Dietrich, O., Coates, U., Reiser, M., and Glaser, C. (2009). Test-retest reproducibility of the default-mode network in healthy individuals. Hum. Brain Mapp.
47. Murphy, K., Birn, R. M., Handwerker, D. A., Jones, T. B., and Bandettini, P. A. (2009). The impact of global signal regression on resting state correlations: are anti-correlated networks introduced? Neuroimage 44, 893-905.
48. Patterson, S. L., Abel, T., Deuel, T. A., Martin, K. C., Rose, J. C., and Kandel, E. R. (1996). Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron 16, 1137-1145.
49. Pezawas, L., Verchinski, B. A., Mattay, V. S., Callicott, J. H., Kolachana, B. S., Straub, R. E., Egan, M. F., Meyer-Lindenberg, A., and Weinberger, D. R. (2004). The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. J. Neurosci. 24, 10099-10102.
50. Pollatos, O., Gramann, K., and Schandry, R. (2007). Neural systems connecting interoceptive awareness and feelings. Hum. Brain Mapp. 28, 9-18.
51. Preston, A. R., Thomason, M. E., Ochsner, K. N., Cooper, J. C., and Glover, G. H. (2004). Comparison of spiral-in/out and spiral-out BOLD fMRI at 1.5 and 3 T. Neuroimage 21, 291-301.
52. Pruessner, J. C., Li, L. M., Serles, W., Pruessner, M., Collins, D. L., Kabani, N., Lupien, S., and Evans, A. C. (2000). Volumetry of hippocampus and amygdala with high-resolution MRI and three-dimensional analysis software: minimizing the discrepancies between laboratories. Cereb. Cortex 10, 433-442.
53. Quigley, M., Cordes, D., Turski, P., Moritz, C., Haughton, V., Seth, R., and Meyerand, M. E. (2003). Role of the corpus callosum in functional connectivity. AJNR Am. J. Neuroradiol. 24, 208-212.
54. Ranganath, C., Heller, A., Cohen, M. X., Brozinsky, C. J., and Rissman, J. (2005). Functional connectivity with the hippocampus during successful memory formation. Hippocampus 15, 997-1005.
55. Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., and Greicius, M. D. (2007). Dissociable intrinsic connectivity networks for salience processing and executive control. J. Neurosci. 27, 2349-2356.
56. Stoop, R., and Poo, M. M. (1996). Synaptic modulation by neurotrophic factors: differential and synergistic effects of brain-derived neurotrophic factor and ciliary neurotrophic factor. J. Neurosci. 16, 3256-3264.
57. Szeszko, P. R., Lipsky, R., Mentschel, C., Robinson, D., Gunduz-Bruce, H., Sevy, S., Ashtari, M., Napolitano, B., Bilder, R. M., Kane, J. M., Goldman, D., and Malhotra, A. K. (2005). Brainderived neurotrophic factor val66met polymorphism and volume of the hippocampal formation. Mol. Psychiatry 10, 631-636.
58. Taylor, K. S., Seminowicz, D. A., and Davis, K. D. (2008). Two systems of resting state connectivity between the insula and cingulate cortex. Hum. Brain Mapp.
59. Thomason, M. E., Chang, C. E., Glover, G. H., Gabrieli, J. D., Greicius, M. D., and Gotlib, I. H. (2008). Defaultmode function and task-induced deactivation have overlapping brain substrates in children. Neuroimage 41, 1493-1503.
60. Vincent, J. L., Snyder, A. Z., Fox, M. D., Shannon, B. J., Andrews, J. R., Raichle, M. E., and Buckner, R. L. (2006). Coherent spontaneous activity identifies a hippocampal-parietal memory network. J. Neurophysiol. 96, 3517-3531.
61. Weissenbacher, A., Kasess, C., Gerstl, F., Lanzenberger, R., Moser, E., and Windischberger, C. (2009). Correlations and anticorrelations in resting-state functional connectivity MRI: a quantitative comparison of preprocessing strategies. Neuroimage 47, 1408-1416.
62. Yushkevich, P. A., Piven, J., Hazlett, H. C., Smith, R. G., Ho, S., Gee, J. C., and Gerig, G. (2006). User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability. Neuroimage 31, 1116-1128.