Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal- striatal brain systems during arithmetic and temporal transformations in working memory

Journal of Neuroscience

Volumn 27, Issue 49, 2007, Pages 13393-13401

  Tan, Hao Yang ^a   Chen, Qiang ^a   Goldberg, Terry E ^b   Mattay, Venkata S ^a   Meyer Lindenberg, Andreas ^a   Weinberger, Daniel R ^a   Callicott, Joseph H ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b ZUCKER HILLSIDE HOSPITAL   (United States)

Author keywords

Cerebral cortex; Dopamine; Executive cognition; fMRI; Genetics

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE; METHIONINE; VALINE;

ADULT; ARITHMETIC; ARTICLE; BRAIN FUNCTION; COGNITION; CONTROLLED STUDY; DOPAMINERGIC ACTIVITY; DOPAMINERGIC NERVE CELL; FEMALE; HUMAN; HUMAN EXPERIMENT; INFORMATION PROCESSING; MALE; NEUROMODULATION; NORMAL HUMAN; PARIETAL LOBE; PREFRONTAL CORTEX; PRIORITY JOURNAL; STRIATE CORTEX; WORKING MEMORY;

ADOLESCENT; ADULT; AMINO ACID SUBSTITUTION; CATECHOL O-METHYLTRANSFERASE; CORPUS STRIATUM; DOPAMINE; FEMALE; HUMANS; MALE; MATHEMATICS; MEMORY, SHORT-TERM; METHIONINE; PARIETAL LOBE; PREFRONTAL CORTEX; REACTION TIME; VALINE;

EID: 37149054393     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4041-07.2007     Document Type: Article

References (52)

1. Akil M, Kolachana BS, Rothmond DA, Hyde TM, Weinberger DR, Kleinman JE (2003) Catechol-O-Methyltransferase genotype and dopamine regulation in the human brain. J Neurosci 23:2008-2013.
2. Alexander GE, DeLong MR, Strick PL (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Rev of Neuroscience 9:357-381.
3. Bertolino A, Caforio G, Blasi G, De Candia M, Latorre V, Petruzzella V, Altamura M, Nappi G, Papa S, Callicott JH, Mattay VS, Bellomo A, Scarabino T, Weinberger DR, Nardini M (2004) Interaction of COMT Val108/158 Met genotype and Olanzapine treatment on prefrontal cortical cunction in patients with schizophrenia. Am J Psychiatry 161:1798-1805.
4. Bertolino A, Blasi G, Latorre V, Rubino V, Rampino A, Sinibaldi L, Caforio G, Petruzzella V, Pizzuti A, Scarabino T, Nardini M, Weinberger DR, Dallapiccola B (2006) Additive effects of genetic variation in dopamine regulating genes on working memory cortical activity in human brain. J Neurosci 26:3918-3922.
5. Callicott JH, Mattay VS, Bertolino A, Callicott JH, Mattay VS, Bertolino A, Finn K, Coppola R, Frank JA, Goldberg TE, Weinberger DR (1999) Physiological characteristics of capacity constraints in working memory as revealed by functional MRI. Cereb Cortex 9:20-26.
6. Chen J, Lipska BK, Halim N, Ma QD, Matsumoto M, Melhem S, Kolachana BS, Hyde TM, Herman MM, Apud J, Egan MF, Kleinman JE, Weinberger DR (2004) Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet 75:807-821.
7. Deco G, Rolls ET (2005) Attention, short-term memory, and action selection: a unifying theroy. Prog Neurobiol 76:236-256.
8. Dehaene S, Piazza M, Pinel P, Cohen L (2003) Three parietal circuits for number processing. Cogn Neuropsychol 20:487-506.
9. D'Esposito M, Postle BR, Ballard D, Lease J (1999) Maintenance versus manipulation of information held in working memory: an event-related fMRI study. Brain Cogn 41:66-86.
10. Durstewitz D, Seamans JK, Sejnowski TJ (2000) Neurocomputational models of working memory. Nat Neurosci [Suppl] 3:1184-1191.
11. Egan MF, Goldberg TE, Gscheidle T, Weirich M, Rawlings R, Hyde TM, Bigelow L, Weinberger DR (2001a) Relative risk for cognitive impairments in siblings of patients with schizophrenia. Biol Psychiatry 50:98-107.
12. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR (2001b) Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 98:6917-6922.
13. Friston KJ, Buechel C, Fink GR, Morris J, Rolls E, Dolan RJ (1997) Psychophysiological and modulatory interactions in neuroimaging. NeuroImage 6:218.
14. Fuster JM (1997) The prefrontal cortex: anatomy, physiology, and neuropsychology of the frontal lobe. Philadelphia: Lippincott-Raven.
15. Genovese CR, Lazar NA, Nichols T (2002) Thresholding of statistical maps in functional imaging using the false discovery rate. NeuroImage 15:870-878.
16. Gogos JA, Morgan M, Luine V, Ogawa S, Pfaff D, Karayiourgou M (1998) Catechol-o-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci USA 95:9991-9996.
17. Goldman-Rakic PS (1995) Cellular basis of working memory. Neuron 14:477.
18. Goldman-Rakic PS (1996) Regional and cellular fractionation of working memory. Proc Natl Acad Sci USA 93:13473-13480.
19. Goldman-Rakic PS, Lidow MS, Gallager DW (1990) Overlap of dopaminergic, adrenergic, and serotoninergic receptors and complementarity of their subtypes in primate prefrontal cortex. J Neurosci 10:2125-2138.
20. Gothelf D, Eliez S, Thompson T, Gothelf D, Eliez S, Thompson T, Hinard C, Penniman L, Feinstein C, Kwon H, Jin S, Jo B, Antonarakis SE, Morris MA, Reiss AL (2005) COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome. Nat Neurosci 8:1500-1502.
21. Grace AA (2000) Gating of information flow within the limbic system and the pathophysiology of schizophrenia. Brain Res Brain Res Rev 31:330-341.
22. Gruber AJ, Dayan P, Gutkin BS, Solla SA (2006) Dopamine modulation in the basal ganglia locks the gate to working memory. J Comput Neurosci 20:153-166.
23. Hubbard EM, Piazza M, Pinel P, Dehaene S (2005) Interactions between number and space in parietal cortex. Nat Rev Neurosci 6:435-448.
24. Karoum F, Chrapusta SJ, Egan MJ (1994) 3-methoxytyramine is the major metabolite of released dopamine in the rat frontal cortex: reassessment of the effects of antipsychotics on the dynamics of dopamine release and metabolism in the frontal cortex, nucleus accumbens and striatum by a simple two-pool model. J Neurochem 63:972-979.
25. Koechlin E, Ody C, Kouneiher FT (2003) The architecture of cognitive control in the human prefrontal cortex. Science 302:1181-1185.
26. Liddle P, Kiehl K, Smith A (2001) Event-related fMRI study of response inhibition. Hum Brain Mapp 12:100-109.
27. Mattay VS, Goldberg TE, Fera F, Hariri AR, Tessitore A, Egan MF, Kolachana B, Callicott JH, Weinberger DR (2003) Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proc Natl Acad Sci USA 100:6186-6191.
28. Meyer-Lindenberg A, Kohn PD, Kolachana B, Kippenhan S, McInerney-Leo A, Nussbaum R, Weinberger DR, Berman KF (2005) Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype. Nat Neurosci 8:594-596.
29. Meyer-Lindenberg AS, Nichols T, Callicott JH, Ding J, Kolachana B, Buckholtz J, Mattay VS, Egan M, Weinberger DR (2006) Impact of complex genetic variation in COMT on human brain function. Mol Psychiatry 11:867-877.
30. Miller EK, Cohen JD (2001) An integrative theory of prefrontal cortex function. Ann Rev Neurosci 24:167-202.
31. Mink JW (1996) The basal ganglia: focused selection and inhibition of competing motor programs. Prog Neurobiol 50:381-425.
32. O'Reilly RC (2006) Biologically based computational models of high-level cognition. Science 314:91-94.
33. O'Reilly RC, Frank MJ (2006) Making working memory work: a computational model of learning in the prefrontal cortex and basal ganglia. Neural Comput 18:283-328.
34. Oldfield R (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9:97-113.
35. Sakai K, Passingham RE (2002) Prefrontal interactions reflect future task operations. Nat Neurosci 6:75-81.
36. Sakai K, Rowe JB, Passingham RE (2002) Active maintenance in prefrontal area 46 creates distractor-resistant memory. Nat Neurosci 5:479-484.
37. Sawaguchi T, Goldman-Rakic PS (1991) D1 dopamine receptors in prefrontal cortex: involvement in working memory. Science 251:947-950.
38. Seamans JK, Yang CR (2004) The principal features and mechanisms of dopamine modulation in the prefrontal cortex. Prog Neurobiol 74:1-57.
39. Seamans JK, Gorelova N, Durstewitz D, Yang CR (2001) Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons. J Neurosci 21:3628.
40. Spencer KM, Nestor PG, Perlmutter R, Niznikiewicz MA, Klump MC, Frumin M, Shenton ME, McCarley RW (2004) Neural synchrony indexes disordered perception and cognition in schizophrenia. Proc Natl Acad Sci USA 101:17288-17293.
41. Tan HY, Choo WC, Fones CSL, Chee MWL (2005) fMRI study of maintenance and manipulation processes within working memory in first-episode schizophrenia. Am J Psychiatry 162:1849-1858.
42. Tan HY, Sust S, Buckholtz JW, Mattay VS, Meyer-Lindenberg A, Egan MF, Weinberger DR, Callicott JH (2006) Dysfunctional prefrontal regional specialization and compensation in schizophrenia. Am J Psychiatry 163:1969-1977.
43. Tan HY, Chen Q, Sust S, Buckholtz JW, Meyers JD, Egan MF, Mattay VS, Meyer-Lindenberg A, Weinberger DR, Callicott JH (2007) Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes in working memory brain function. Proc Natl Acad Sci USA 104:12536-12541.
44. Tanaka SC, Doya K, Okada G, Ueda K, Okamoto Y, Yamawaki S (2004) Prediction of immediate and future rewards differentially recruits cortico-basal ganglia loops. Nat Neurosci 7:887-893.
45. Tunbridge EM, Harrison PJ, Weinberger DR (2006) Catechol-o- Methyltransferase, cognition, and psychosis: Val158Met and beyond. Biol Psychiatry 60:141-151.
46. Vijayraghavan S, Wang M, Birnbaum SG, Williams GV, Arnsten AFT (2007) Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Nat Neurosci 10:376-384.
47. Wager TD, Nichols TE (2003) Optimization of experimental design in fMRI: a general framework using a genetic algorithm. NeuroImage 18:293-309.
48. Weinberger DR (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Arc Gen Psychiatry 44:660-669.
49. Williams GV, Goldman-Rakic PS (1995) Modulation of memory fields by dopamine D1 receptors in prefrontal cortex. Nature 376:572-575.
50. Winterer G, Weinberger DR (2004) Genes, dopamine and cortical signal-to-noise ratio in schizophrenia. Trends Neurosci 27:683-690.
51. Winterer G, Egan MF, Kolachana BS, Goldberg TE, Coppola R, Weinberger DR (2006) Prefrontal electrophysiologic "noise" and catechol-O- methyltransferase genotype in schizophrenia. Biol Psychiatry 60:578-584.
52. Worsley KJ, Marrett S, Neelin P, Vandal AC, Friston KJ, Evans AC (1996) A unified statistical approach for determining significant signals in images of cerebral activation. Hum Brain Mapp 4:58-73.