Exploring the physicochemical properties of oxime-reactivation therapeutics for cyclosarin, sarin, tabun, and VX inactivated acetylcholinesterase

Chemical Research in Toxicology

Volumn 27, Issue 1, 2014, Pages 99-110

  Esposito, Emilio Xavier ^a   Stouch, Terry R ^b   Wymore, Troy ^c   Madura, Jeffry D ^d  

^a ExeResearch LLC   (United States)

^b Science for Solutions   (United States)

^c OAK RIDGE NATIONAL LABORATORY   (United States)

^d DUQUESNE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 (4 CARBAMOYLPYRIDINIO) 4 (2 HYDROXYIMINOMETHYLPYRIDINIO) 2 BUTENE DIBROMIDE; 1 METHYLISONICOTINALDOXIME; ACETYLCHOLINESTERASE; CYCLOSARIN; K 074; METHOXIME; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; OBIDOXIME; OXIME; PRALIDOXIME; SARIN; TABUN; TO 020; TO 029; TO 033; TO 047; TO 052; TO 057; TO 058; TO 063; TO 092; TRIMEDOXIME; UNCLASSIFIED DRUG; CHOLINESTERASE INHIBITOR; ORGANOPHOSPHATE; ORGANOPHOSPHORUS COMPOUND; PHOSPHOROTHIOIC ACID DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; COMPARATIVE MOLECULAR SIMILARITY INDICES ANALYSIS; CONFORMATION; CONJUGATE; CONTROLLED STUDY; ENZYME REACTIVATION; GENETIC ALGORITHM; HYDROPHOBICITY; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PHARMACOPHORE; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DOSE RESPONSE; HUMAN; METABOLISM; REPRODUCIBILITY; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; ANIMALS; CHEMISTRY, PHYSICAL; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANOPHOSPHATES; ORGANOPHOSPHORUS COMPOUNDS; ORGANOTHIOPHOSPHORUS COMPOUNDS; OXIMES; RATS; REPRODUCIBILITY OF RESULTS; SARIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84892854004     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx400350b     Document Type: Article

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