Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates

Biochemical Pharmacology

Volumn 73, Issue 11, 2007, Pages 1807-1817

  Worek, Franz ^a   Aurbek, Nadine ^a   Koller, Marianne ^a   Becker, Christian ^a   Eyer, Peter ^b   Thiermann, Horst ^a  

^a BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Acetylcholinesterase; Aging; Organophosphates; Oximes; Reactivation; Structure activity relationship

Indexed keywords

1,1' METHYLENEBIS(4 HYDROXYIMINOMETHYLPYRIDINIUM) DICHLORIDE; ACETYLCHOLINESTERASE; ALKYL GROUP; OBIDOXIME; ORGANOPHOSPHATE; PHOSPHONIC ACID DERIVATIVE; PHOSPHORAMIDIC ACID DERIVATIVE; PRALIDOXIME; TABUN; TRIMEDOXIME;

ARTICLE; CHOLINESTERASE INHIBITION; CONCENTRATION (PARAMETERS); DEALKYLATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME KINETICS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TIME;

ACETYLCHOLINESTERASE; AGING; AMIDES; CHOLINESTERASE REACTIVATORS; HUMANS; KINETICS; OBIDOXIME CHLORIDE; OXIMES; PHOSPHORIC ACID ESTERS; PHOSPHORIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34247165881     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.02.008     Document Type: Article

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