Augmenting tendon and ligament repair with platelet-rich plasma (PRP)

Muscles, Ligaments and Tendons Journal

Volumn 3, Issue 3, 2013, Pages 139-149

  Yuan, Ting ^a,b   Zhang, Chang Qing ^b   Wang, James H C ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

Author keywords

Growth factors; PRP; Tendinopathy; Tendon and ligament injury

Indexed keywords

EID: 84892840016     PISSN: None     EISSN: 22404554     Source Type: Journal    
DOI: 10.11138/mltj/2013.3.3.139     Document Type: Review

References (147)

1. James R, Kesturu G, Balian G, Chhabra AB. Tendon: biology, biomechanics, repair, growth factors, and evolving treatment options. J Hand Surg Am 2008; 33:102-112.
2. Wang JH, Guo Q, Li B. Tendon biomechanics and mechanobiology-a minireview of basic concepts and recent advancements. J Hand Ther 2012; 25:133-140; quiz 141.
3. Khan U, Occleston NL, Khaw PT, McGrouther DA. Differences in proliferative rate and collagen lattice contraction between endotenon and synovial fibroblasts. J Hand Surg Am 1998; 23:266-273.
4. Evans RB. Managing the injured tendon: current concepts. J Hand Ther 2012; 25:173-189; quiz 190.
5. Longo UG, Lamberti A, Maffulli N, Denaro V. Tissue engineered biological augmentation for tendon healing: a systematic review. Br Med Bull 2011; 98:31-59.
6. Fenwick SA, Hazleman BL, Riley GP. The vasculature and its role in the damaged and healing tendon. Arthritis Res 2002; 4:252-260.
7. Finnoff JT, Fowler SP, Lai JK, Santrach PJ, Willis EA, et al. Treatment of chronic tendinopathy with ultrasound-guided needle tenotomy and platelet-rich plasma injection. PM R 2011; 3:900-911.
8. Brown J, Sivan M. Ultrasound-guided platelet-rich plasma injection for chronic patellar tendinopathy: a case report. PM R 2010; 2:969-972.
9. Kon E, Filardo G, Delcogliano M, Presti ML, Russo A, et al. Platelet-rich plasma: new clinical application: a pilot study for treatment of jumper's knee. Injury 2009; 40:598-603.
10. Owens RF, Jr., Ginnetti J, Conti SF, Latona C. Clinical and magnetic resonance imaging outcomes following platelet rich plasma injection for chronic midsubstance Achilles tendinopathy. Foot Ankle Int 2011; 32:1032-1039.
11. Gosens T, Peerbooms JC, van Laar W, den Oudsten BL. Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up. Am J Sports Med 2011; 39:1200-1208.
12. Scollon-Grieve KL, Malanga GA. Platelet-rich plasma injection for partial patellar tendon tear in a high school athlete: a case presentation. PM R 2011; 3:391-395.
13. Hechtman KS, Uribe JW, Botto-vanDemden A, Kiebzak GM. Platelet-rich plasma injection reduces pain in patients with recalcitrant epicondylitis. Orthopedics 2011; 34:92.
14. Yuan T, Guo SC, Han P, Zhang CQ, Zeng BF. Applications of leukocyte-and platelet-rich plasma (L-PRP) in trauma surgery. Curr Pharm Biotechnol 2012; 13:1173-1184.
15. Zhang J, Wang JH. Platelet-rich plasma releasate promotes differentiation of tendon stem cells into active tenocytes. Am J Sports Med 2010; 38:2477-2486.
16. Alsousou J, Ali A, Willett K, Harrison P. The role of plateletrich plasma in tissue regeneration. Platelets 2013; 24:173-182.
17. Anitua E, Andia I, Sanchez M, Azofra J, del Mar Zalduendo M, et al. Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture. J Orthop Res 2005; 23:281-286.
18. Chen L, Dong SW, Tao X, Liu JP, Tang KL, et al. Autologous platelet-rich clot releasate stimulates proliferation and inhibits differentiation of adult rat tendon stem cells towards nontenocyte lineages. J Int Med Res 2012; 40:1399-1409.
19. Taylor DW, Petrera M, Hendry M, Theodoropoulos JS. A systematic review of the use of platelet-rich plasma in sports medicine as a new treatment for tendon and ligament injuries. Clin J Sport Med 2011; 21:344-352.
20. Parafioriti A, Armiraglio E, Del Bianco S, Tibalt E, Oliva F, et al. Single injection of platelet-rich plasma in a rat Achilles tendon tear model. Muscles Ligaments Tendons J 2011; 1:41-47.
21. Yoshikawa Y, Abrahamsson SO. Dose-related cellular effects of platelet-derived growth factor-BB differ in various types of rabbit tendons in vitro. Acta Orthop Scand 2001; 72:287-292.
22. Rickert M, Jung M, Adiyaman M, Richter W, Simank HG. A growth and differentiation factor-5 (GDF-5)-coated suture stimulates tendon healing in an Achilles tendon model in rats. Growth Factors 2001; 19:115-126.
23. Molloy T, Wang Y, Murrell G. The roles of growth factors in tendon and ligament healing. Sports Med 2003; 33:381-394.
24. Kurtz CA, Loebig TG, Anderson DD, DeMeo PJ, Campbell PG. Insulin-like growth factor I accelerates functional recovery from Achilles tendon injury in a rat model. Am J Sports Med 1999; 27:363-369.
25. Chang J, Thunder R, Most D, Longaker MT, Lineaweaver WC. Studies in flexor tendon wound healing: neutralizing antibody to TGF-beta1 increases postoperative range of motion. Plast Reconstr Surg 2000; 105:148-155.
26. Xie X, Wang Y, Zhao C, Guo S, Liu S, et al. Comparative evaluation of MSCs from bone marrow and adipose tissue seeded in PRP-derived scaffold for cartilage regeneration. Biomaterials 2012; 33:7008-7018.
27. Marx RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg 2004; 62:489-496.
28. de Mos M, van der Windt AE, Jahr H, van Schie HTM, Weinans H, et al. Can platelet-rich plasma enhance tendon repair? A cell culture study. Am J Sports Med 2008; 36:1171-1178.
29. Kajikawa Y, Morihara T, Sakamoto H, Matsuda K, Oshima Y, et al. Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing. J Cell Physiol 2008; 215:837-845.
30. Kampa RJ, Connell DA. Treatment of tendinopathy: is there a role for autologous whole blood and platelet rich plasma injection? Int J Clin Pract 2010; 64:1813-1823.
31. Mishra A, Woodall J, Jr., Vieira A. Treatment of tendon and muscle using platelet-rich plasma. Clin Sports Med 2009; 28:113-125.
32. Sanchez M, Anitua E, Azofra J, Andia I, Padilla S, et al. Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices. Am J Sports Med 2007; 35:245-251.
33. Dohan Ehrenfest DM, Bielecki T, Jimbo R, Barbe G, Del Corso M, et al. Do the fibrin architecture and leukocyte content influence the growth factor release of platelet concentrates? An evidence-based answer comparing a pure platelet-rich plasma (P-PRP) gel and a leukocyte-and plateletrich fibrin (L-PRF). Curr Pharm Biotechnol 2012; 13:1145-1152.
34. Bielecki T, Dohan Ehrenfest DM, Everts PA, Wiczkowski A. The role of leukocytes from L-PRP/L-PRF in wound healing and immune defense: new perspectives. Curr Pharm Biotechnol 2012; 13:1153-1162.
35. Anitua E, Sanchez M. We cannot take oranges for apples in the field of platelet-rich plasma products. Scand J Med Sci Sports 2012; 22:147-148.
36. Jenis LG, Banco RJ, Kwon B. A prospective study of Autologous Growth Factors (AGF) in lumbar interbody fusion. Spine J 2006; 6:14-20.
37. Everts PA, van Zundert A, Schonberger JP, Devilee RJ, Knape JT. What do we use: platelet-rich plasma or plateletleukocyte gel? J Biomed Mater Res A 2008; 85:1135-1136.
38. Gardner MJ, Demetrakopoulos D, Klepchick PR, Mooar PA. The efficacy of autologous platelet gel in pain control and blood loss in total knee arthroplasty. An analysis of the haemoglobin, narcotic requirement and range of motion. Int Orthop 2007; 31:309-313.
39. Bielecki T, Gazdzik T, Arendt J, Szczepanski T, Król W, et al. Antibacterial effect of autologous platelet gel enriched with growth factors and other active substances an in vitro study. Journal of Bone & Joint Surgery, British Volume 2007; 89:417-420.
40. Spang JT, Tischer T, Salzmann GM, Winkler T, Burgkart R, et al. Platelet concentrate vs. saline in a rat patellar tendon healing model. Knee Surg Sports Traumatol Arthrosc 2011; 19:495-502.
41. Marx RE. Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant Dent 2001; 10:225-228.
42. Mazzocca AD, McCarthy MB, Chowaniec DM, Dugdale EM, Hansen D, et al. The positive effects of different platelet-rich plasma methods on human muscle, bone, and tendon cells. Am J Sports Med 2012; 40:1742-1749.
43. Graziani F, Ivanovski S, Cei S, Ducci F, Tonetti M, et al. The in vitro effect of different PRP concentrations on osteoblasts and fibroblasts. Clin Oral Implants Res 2006; 17:212-219.
44. Alsousou J, Thompson M, Hulley P, Noble A, Willett K. The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature. J Bone Joint Surg Br 2009; 91:987-996.
45. Galliera E, Corsi MM, Banfi G. Platelet rich plasma therapy: inflammatory molecules involved in tissue healing. J Biol Regul Homeost Agents 2012; 26:35S-42S.
46. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte-and platelet-rich fibrin (L-PRF). Trends Biotechnol 2009; 27:158-167.
47. Weibrich G, Kleis WK, Buch R, Hitzler WE, Hafner G. The Harvest Smart PRePTM system versus the Friadent-Schutze platelet-rich plasma kit. Clin Oral Implants Res 2003; 14:233-239.
48. Weibrich G, Kleis WK. Curasan PRP kit vs. PCCS PRP system. Collection efficiency and platelet counts of two different methods for the preparation of platelet-rich plasma. Clin Oral Implants Res 2002; 13:437-443.
49. Rapp M, Svoboda D, Wessel LM, Kaiser MM. Elastic Stable Intramedullary Nailing (ESIN), Orthoss(R) and Gravitational Platelet Separation--System (GPS(R): an effective method of treatment for pathologic fractures of bone cysts in children. BMC Musculoskelet Disord 2011; 12:45.
50. Everts PA, Hoffmann J, Weibrich G, Mahoney CB, Schonberger JP, et al. Differences in platelet growth factor release and leucocyte kinetics during autologous platelet gel formation. Transfus Med 2006; 16:363-368.
51. Yoshida R, Murray MM. Peripheral blood mononuclear cells enhance the anabolic effects of platelet-rich plasma on anterior cruciate ligament fibroblasts. J Orthop Res 2013; 31:29-34.
52. Andersen MB, Pingel J, Kjaer M, Langberg H. Interleukin-6: a growth factor stimulating collagen synthesis in human tendon. J Appl Physiol 2011; 110:1549-1554.
53. McCarrel TM, Minas T, Fortier LA. Optimization of leukocyte concentration in platelet-rich plasma for the treatment of tendinopathy. J Bone Joint Surg Am 2012; 94:e1431-1438.
54. Anitua E, Sanchez M, Orive G. The importance of understanding what is platelet-rich growth factor (PRGF) and what is not. J Shoulder Elbow Surg 2011; 20:e23-24; author reply e24.
55. van Hinsbergh VW, Collen A, Koolwijk P. Role of fibrin matrix in angiogenesis. Ann N Y Acad Sci 2001; 936:426-437.
56. Magarian EM, Vavken P, Murray MM. Human anterior cruciate ligament fibroblasts from immature patients have a stronger in vitro response to platelet concentrates than those from mature individuals. Knee 2011; 18:247-251.
57. Sciore P, Boykiw R, Hart DA. Semiquantitative reverse transcription-polymerase chain reaction analysis of mRNA for growth factors and growth factor receptors from normal and healing rabbit medial collateral ligament tissue. J Orthop Res 1998; 16:429-437.
58. Deroanne CF, Hajitou A, Calberg-Bacq CM, Nusgens BV, Lapiere CM. Angiogenesis by fibroblast growth factor 4 is mediated through an autocrine up-regulation of vascular endothelial growth factor expression. Cancer Res 1997; 57:5590-5597.
59. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, et al. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998; 85:638-646.
60. Lynch SE, Colvin RB, Antoniades HN. Growth factors in wound healing. Single and synergistic effects on partial thickness porcine skin wounds. J Clin Invest 1989; 84:640-646.
61. Pierce GF, Mustoe TA, Lingelbach J, Masakowski VR, Griffin GL, et al. Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms. J Cell Biol 1989; 109:429-440.
62. Letson AK, Dahners LE. The effect of combinations of growth factors on ligament healing. Clin Orthop Relat Res 1994:207-212.
63. Bennett NT, Schultz GS. Growth factors and wound healing: biochemical properties of growth factors and their receptors. Am J Surg 1993; 165:728-737.
64. Jackson JR, Minton JA, Ho ML, Wei N, Winkler JD. Expression of vascular endothelial growth factor in synovial fibroblasts is induced by hypoxia and interleukin 1beta. J Rheumatol 1997; 24:1253-1259.
65. Petersen W, Unterhauser F, Pufe T, Zantop T, Sudkamp NP, et al. The angiogenic peptide vascular endothelial growth factor (VEGF) is expressed during the remodeling of free tendon grafts in sheep. Arch Orthop Trauma Surg 2003; 123:168-174.
66. Wei XL, Lin L, Hou Y, Fu X, Zhang JY, et al. Construction of recombinant adenovirus co-expression vector carrying the human transforming growth factor-beta1 and vascular endothelial growth factor genes and its effect on anterior cruciate ligament fibroblasts. Chin Med J (Engl) 2008; 121:1426-1432.
67. Zhang F, Liu H, Stile F, Lei MP, Pang Y, et al. Effect of vascular endothelial growth factor on rat Achilles tendon healing. Plast Reconstr Surg 2003; 112:1613-1619.
68. Tohyama H, Yoshikawa T, Ju YJ, Yasuda K. Revascularization in the tendon graft following anterior cruciate ligament reconstruction of the knee: its mechanisms and regulation. Chang Gung Med J 2009; 32:133-139.
69. Yoshikawa T, Tohyama H, Katsura T, Kondo E, Kotani Y, et al. Effects of local administration of vascular endothelial growth factor on mechanical characteristics of the semitendinosus tendon graft after anterior cruciate ligament reconstruction in sheep. Am J Sports Med 2006; 34:1918-1925.
70. DesRosiers EA, Yahia L, Rivard CH. Proliferative and matrix synthesis response of canine anterior cruciate ligament fibroblasts submitted to combined growth factors. J Orthop Res 1996; 14:200-208.
71. Gillery P, Leperre A, Maquart FX, Borel JP. Insulin-like growth factor-I (IGF-I) stimulates protein synthesis and collagen gene expression in monolayer and lattice cultures of fibroblasts. J Cell Physiol 1992; 152:389-396.
72. Hansen M, Boesen A, Holm L, Flyvbjerg A, Langberg H, et al. Local administration of insulin-like growth factor-I (IGF-I) stimulates tendon collagen synthesis in humans. Scand J Med Sci Sports 2012:doi: 10.1111/j.1600-0838.2011.01431.x.
73. Lyras DN, Kazakos K, Verettas D, Chronopoulos E, Folaranmi S, et al. Effect of combined administration of transforming growth factor-b1 and insulin-like growth factor I on the mechanical properties of a patellar tendon defect model in rabbits. Acta Orthop Belg 2010; 76:380-386.
74. Throm AM, Liu WC, Lock CH, Billiar KL. Development of a cell-derived matrix: effects of epidermal growth factor in chemically defined culture. J Biomed Mater Res A 2010; 92:533-541.
75. Marui T, Niyibizi C, Georgescu HI, Cao M, Kavalkovich KW, et al. Effect of growth factors on matrix synthesis by ligament fibroblasts. J Orthop Res 1997; 15:18-23.
76. Hagerty P, Lee A, Calve S, Lee CA, Vidal M, et al. The effect of growth factors on both collagen synthesis and tensile strength of engineered human ligaments. Biomaterials 2012; 33:6355-6361.
77. Wasterlain AS, Braun HJ, Harris AH, Kim HJ, Dragoo JL. The systemic effects of platelet-rich plasma injection. Am J Sports Med 2013; 41:186-193.
78. Chan BP, Chan KM, Maffulli N, Webb S, Lee KK. Effect of basic fibroblast growth factor. An in vitro study of tendon healing. Clin Orthop Relat Res 1997:239-247.
79. Folkman J, Klagsbrun M. Angiogenic factors. Science 1987; 235:442-447.
80. Mansukhani A, Dell'Era P, Moscatelli D, Kornbluth S, Hanafusa H, et al. Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin. Proc Natl Acad Sci U S A 1992; 89:3305-3309.
81. Zhang J, Middleton KK, Fu FH, Im HJ, JH W. HGF Mediates the Anti-inflammatory Effects of PRP on Injured Tendons. PlosOne 2013; 8:e67303.
82. Creaney L, Hamilton B. Growth factor delivery methods in the management of sports injuries: the state of play. Br J Sports Med 2008; 42:314-320.
83. Van Belle E, Witzenbichler B, Chen D, Silver M, Chang L, et al. Potentiated angiogenic effect of scatter factor/hepatocyte growth factor via induction of vascular endothelial growth factor: the case for paracrine amplification of angiogenesis. Circulation 1998; 97:381-390.
84. Ueshima K, Kitaoka K, Nakase J, Xu Q, Matsumoto K, et al. Promotion of rabbit ligament healing by local delivery of hepatocyte growth factor. J Orthop Sci 2011; 16:451-457.
85. Nakase J, Kitaoka K, Matsumoto K, Tomita K. Facilitated tendon-bone healing by local delivery of recombinant hepatocyte growth factor in rabbits. Arthroscopy 2010; 26:84-90.
86. Ono I, Yamashita T, Hida T, Jin HY, Ito Y, et al. Local administration of hepatocyte growth factor gene enhances the regeneration of dermis in acute incisional wounds. J Surg Res 2004; 120:47-55.
87. Franco D, Franco T, Schettino AM, Filho JM, Vendramin FS. Protocol for Obtaining Platelet-Rich Plasma (PRP), Platelet-Poor Plasma (PPP), and Thrombin for Autologous Use. Aesthetic Plast Surg 2012; 36:1254-1259.
88. Landesberg R, Moses M, Karpatkin M. Risks of using platelet rich plasma gel. J Oral Maxillofac Surg 1998; 56:1116-1117.
89. Virchenko O, Grenegard M, Aspenberg P. Independent and additive stimulation of tendon repair by thrombin and platelets. Acta Orthop 2006; 77:960-966.
90. Coughlin SR. Sol Sherry lecture in thrombosis: how thrombin 'talks' to cells: molecular mechanisms and roles in vivo. Arterioscler Thromb Vasc Biol 1998; 18:514-518.
91. Moojen DJ, Everts PA, Schure RM, Overdevest EP, van Zundert A, et al. Antimicrobial activity of platelet-leukocyte gel against Staphylococcus aureus. J Orthop Res 2008; 26:404-410.
92. Jia WT, Zhang CQ, Wang JQ, Feng Y, Ai ZS. The prophylactic effects of platelet-leucocyte gel in osteomyelitis: an experimental study in a rabbit model. J Bone Joint Surg Br 2010; 92:304-310.
93. Li H, Hamza T, Tidwell JE, Clovis N, Li B. Unique Antimicrobial Effects of Platelet-Rich Plasma and Its Efficacy as a Prophylaxis to Prevent Implant-Associated Spinal Infection. Adv Healthc Mater 2013:doi: 10.1002/adhm.201200465.
94. Drago L, Bortolin M, Vassena C, Taschieri S, Del Fabbro M. Antimicrobial activity of pure platelet-rich plasma against microorganisms isolated from oral cavity. BMC Microbiol 2013; 13:47.
95. Berthet J, Damien P, Hamzeh-Cognasse H, Arthaud CA, Eyraud MA, et al. Human platelets can discriminate between various bacterial LPS isoforms via TLR4 signaling and differential cytokine secretion. Clinical Immunology 2012; 145:189-200.
96. Aspenberg P, Virchenko O. Platelet concentrate injection improves Achilles tendon repair in rats. Acta Orthop Scand 2004; 75:93-99.
97. Lyras D, Kazakos K, Verettas D, Polychronidis A, Simopoulos C, et al. Immunohistochemical study of angiogenesis after local administration of platelet-rich plasma in a patellar tendon defect. Int Orthop 2010; 34:143-148.
98. Lyras DN, Kazakos K, Verettas D, Botaitis S, Agrogiannis G, et al. The effect of platelet-rich plasma gel in the early phase of patellar tendon healing. Arch Orthop Trauma Surg 2009; 129:1577-1582.
99. Murray MM, Spindler KP, Ballard P, Welch TP, Zurakowski D, et al. Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffold. J Orthop Res 2007; 25:1007-1017.
100. Anitua E, Sanchez M, Nurden AT, Zalduendo M, de la Fuente M, et al. Autologous fibrin matrices: a potential source of biological mediators that modulate tendon cell activities. J Biomed Mater Res A 2006; 77:285-293.
101. McCarrel T, Fortier L. Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression. J Orthop Res 2009; 27:1033-1042.
102. Kaux JF, Drion PV, Colige A, Pascon F, Libertiaux V, et al. Effects of platelet-rich plasma (PRP) on the healing of Achilles tendons of rats. Wound Repair Regen 2012; 20:748-756.
103. Bi Y, Ehirchiou D, Kilts TM, Inkson CA, Embree MC, et al. Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche. Nat Med 2007; 13:1219-1227.
104. Rui YF, Lui PP, Li G, Fu SC, Lee YW, et al. Isolation and Characterization of Multipotent Rat Tendon-Derived Stem Cells. Tissue Eng Part A 2010; 16:1549-1558.
105. Bertrand-Duchesne MP, Grenier D, Gagnon G. Epidermal growth factor released from platelet-rich plasma promotes endothelial cell proliferation in vitro. J Periodontal Res 2010; 45:87-93.
106. Matsui M, Tabata Y. Enhanced angiogenesis by multiple release of platelet-rich plasma contents and basic fibroblast growth factor from gelatin hydrogels. Acta Biomater 2012; 8:1792-1801.
107. Davidson CJ, Ganion LR, Gehlsen GM, Verhoestra B, Roepke JE, et al. Rat tendon morphologic and functional changes resulting from soft tissue mobilization. Med Sci Sports Exerc 1997; 29:313-319.
108. Caplan AI. Bone development and repair. Bioessays 1987; 6:171-175.
109. Ventura A, Terzaghi C, Borgo E, Verdoia C, Gallazzi M, et al. Use of growth factors in ACL surgery: preliminary study. Journal of Orthopaedics and Traumatology 2005; 6:76-79.
110. Paoloni J, De Vos RJ, Hamilton B, Murrell GA, Orchard J. Platelet-rich plasma treatment for ligament and tendon injuries. Clin J Sport Med 2011; 21:37-45.
111. Kannus P, Jozsa L, Natri A, Jarvinen M. Effects of training, immobilization and remobilization on tendons. Scand J Med Sci Sports 1997; 7:67-71.
112. Pajala A, Kangas J, Ohtonen P, Leppilahti J. Rerupture and deep infection following treatment of total Achilles tendon rupture. J Bone Joint Surg Am 2002; 84-A:2016-2021.
113. Schepull T, Kvist J, Norrman H, Trinks M, Berlin G, et al. Autologous platelets have no effect on the healing of human achilles tendon ruptures: a randomized single-blind study. Am J Sports Med 2011; 39:38-47.
114. Virchenko O, Aspenberg P. How can one platelet injection after tendon injury lead to a stronger tendon after 4 weeks? Interplay between early regeneration and mechanical stimulation. Acta Orthop 2006; 77:806-812.
115. Thanasas C, Papadimitriou G, Charalambidis C, Paraskevopoulos I, Papanikolaou A. Platelet-rich plasma versus autologous whole blood for the treatment of chronic lateral elbow epicondylitis: a randomized controlled clinical trial. Am J Sports Med 2011; 39:2130-2134.
116. Gaweda K, Tarczynska M, Krzyzanowski W. Treatment of Achilles tendinopathy with platelet-rich plasma. Int J Sports Med 2010; 31:577-583.
117. Monto RR. Platelet rich plasma treatment for chronic Achilles tendinosis. Foot Ankle Int 2012; 33:379-385.
118. de Jonge S, de Vos RJ, Weir A, van Schie HT, Bierma-Zeinstra SM, et al. One-year follow-up of platelet-rich plasma treatment in chronic Achilles tendinopathy: a double-blind randomized placebo-controlled trial. Am J Sports Med 2011; 39:1623-1629.
119. de Vos RJ, Weir A, van Schie HT, Bierma-Zeinstra SM, Verhaar JA, et al. Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial. JAMA 2010; 303:144-149.
120. Mishra A, Pavelko T. Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. The American journal of sports medicine 2006; 34:1774-1778.
121. Peerbooms JC, Sluimer J, Bruijn DJ, Gosens T. Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-year follow-up. Am J Sports Med 2010; 38:255-262.
122. Rabago D BT, Zgierska AE, Zeisig E, Ryan M, et al. A systematic review of four injection therapies for lateral epicondylosis: prolotherapy, polidocanol, whole blood and platelet-rich plasma. Br J Sports Med 2009; 43:471-481.
123. Creaney L. Platelet-rich plasma for treatment of Achilles tendinopathy. JAMA 2010; 303:1696; author reply 1697-1698.
124. Filardo G, Kon E, Della Villa S, Vincentelli F, Fornasari PM, et al. Use of platelet-rich plasma for the treatment of refractory jumper's knee. Int Orthop 2010; 34:909-915.
125. Mautner K, Colberg RE, Malanga G, Borg-Stein JP, Harmon KG, et al. Outcomes after ultrasound-guided platelet-rich plasma injections for chronic tendinopathy: a multicenter, retrospective review. PM R 2013; 5:169-175.
126. Harmon K, Drezner J, Rao A. Platelet rich plasma for chronic tendinopathy. Br J Sports Med 2013; 47:x-e2.
127. Ferreroa G, Fabbroa E, Orlandia D, Martinia C, Lacellib F, et al. Ultrasound-guided injection of platelet-rich plasma in chronic Achilles and patellar tendinopathy. J Ultrasound 2012; 15:260-266.
128. Vogrin M, Rupreht M, Dinevski D, Haspl M, Kuhta M, et al. Effects of a platelet gel on early graft revascularization after anterior cruciate ligament reconstruction: a prospective, randomized, double-blind, clinical trial. Eur Surg Res 2010; 45:77-85.
129. Vogrin M, Rupreht M, Crnjac A, Dinevski D, Krajnc Z, et al. The effect of platelet-derived growth factors on knee stability after anterior cruciate ligament reconstruction: a prospective randomized clinical study. Wien Klin Wochenschr 2010; 122 Suppl 2:91-95.
130. Silva A, Sampaio R. Anatomic ACL reconstruction: does the platelet-rich plasma accelerate tendon healing? Knee Surg Sports Traumatol Arthrosc 2009; 17:676-682.
131. Nin JR, Gasque GM, Azcarate AV, Beola JD, Gonzalez MH. Has platelet-rich plasma any role in anterior cruciate ligament allograft healing? Arthroscopy 2009; 25:1206-1213.
132. Harrold AJ. The defect of blood coagulation in joints. J Clin Pathol 1961; 14:305-308.
133. Engebretsen L, Steffen K, Alsousou J, Anitua E, Bachl N, et al. IOC consensus paper on the use of platelet-rich plasma in sports medicine. Br J Sports Med 2010; 44:1072-1081.
134. Del Buono A, Papalia R, Denaro V, Maccauro G, Maffulli N. Platelet rich plasma and tendinopathy: state of the art. Int J Immunopathol Pharmacol 2011; 24:79-83.
135. Jiang D, Wang JH. Tendinopathy and its treatment with platelet-rich plasma (PRP). Histol Histopathol 2013; Epub date June 16.
136. Nakama LH, King KB, Abrahamsson S, Rempel DM. Evidence of tendon microtears due to cyclical loading in an in vivo tendinopathy model. J Orthop Res 2005; 23:1199-1205.
137. Kannus P, Jozsa L. Histopathological changes preceding spontaneous rupture of a tendon. A controlled study of 891 patients. J Bone Joint Surg Am 1991; 73:1507-1525.
138. Pietramaggiori G, Scherer SS, Cervi D, Klement G, Orgill DP. Tumors stimulate platelet delivery of angiogenic factors in vivo: an unexpected benefit. Am J Pathol 2008; 173:1609-1616.
139. Italiano JE Jr, Richardson JL, Patel-Hett S, Battinelli E, Zaslavsky A, et al. Angiogenesis is regulated by a novel mechanism: pro-and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood 2008; 111:1227-1233.
140. Cervi D, Yip TT, Bhattacharya N, Podust VN, Peterson J, et al. Platelet-associated PF-4 as a biomarker of early tumor growth. Blood 2008; 111:1201-1207.
141. Shah M, Foreman DM, Ferguson MW. Neutralising antibody to TGF-beta 1,2 reduces cutaneous scarring in adult rodents. J Cell Sci 1994; 107 (Pt 5):1137-1157.
142. Nagineni CN, Amiel D, Green MH, Berchuck M, Akeson WH. Characterization of the intrinsic properties of the anterior cruciate and medial collateral ligament cells: an in vitro cell culture study. J Orthop Res 1992; 10:465-475.
143. Hannafin JA, Attia ET, Warren RF, Bhargava MM. Characterization of chemotactic migration and growth kinetics of canine knee ligament fibroblasts. J Orthop Res 1999; 17:398-404.
144. Eliasson P, Andersson T, Aspenberg P. Rat Achilles tendon healing: mechanical loading and gene expression. J Appl Physiol 2009; 107:399-407.
145. Maffulli N, King JB. Effects of physical activity on some components of the skeletal system. Sports Med 1992; 13:393-407.
146. Zeichen J, van Griensven M, Bosch U. The proliferative response of isolated human tendon fibroblasts to cyclic biaxial mechanical strain. Am J Sports Med 2000; 28:888-892.
147. Voleti PB, Buckley MR, Soslowsky LJ. Tendon healing: repair and regeneration. Annu Rev Biomed Eng 2012; 14:47-71.