Platelet concentrate vs. saline in a rat patellar tendon healing model

Knee Surgery, Sports Traumatology, Arthroscopy

Volumn 19, Issue 3, 2011, Pages 495-502

  Spang, Jeffrey T ^a   Tischer, Thomas ^b   Salzmann, Gian M ^b   Winkler, Tobias ^b   Burgkart, Rainer ^b   Wexel, Gabriele ^b   Imhoff, Andreas B ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Knee; Platelet; Platelet rich plasma; Tendon healing

Indexed keywords

EID: 79951557767     PISSN: 09422056     EISSN: 14337347     Source Type: Journal    
DOI: 10.1007/s00167-010-1291-1     Document Type: Article

References (33)

1. Anitua E (1999) Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants 14: 529-535.
2. Aspenberg P, Virchenko O (2004) Platelet concentrate injection improves achilles tendon repair in rats. Acta Orthop Scand 75: 93-99.
3. Berghoff WJ, Pietrzak WS, Rhodes RD (2006) Platelet-rich plasma application during closure following total knee arthroplasty. Orthopedics 29: 590-598.
4. Bielecki T, Gazdzik TS, Szczepanski T (2008) Benefit of percutaneous injection of autologous platelet-leukocyte-rich gel in patients with delayed union and nonunion. Eur Surg Res 40: 289-296.
5. Bogatov VB, Weinhold P, Dahners LE (2003) The influence of a cyclooxygenase-1 inhibitor on injured and uninjured ligaments in the rat. Am J Sports Med 31: 574-576.
6. Borzini P, Mazzucco L (2005) Tissue regeneration and in loco administration of platelet derivatives: clinical outcome, heterogeneous products, and heterogeneity of the effector mechanisms. Transfusion 45: 1759-1767.
7. Bosch G, van Schie HT, de Groot MW, Cadby JA, van de Lest CH, Barneveld A, van Weeren PR (2010) Effects of platelet-rich plasma on the quality of repair of mechanically induced core lesions in equine superficial digital flexor tendons: a placebo-controlled experimental study. J Orthop Res 28: 211-217.
8. de Mos M, van der Windt AE, Jahr H, van Schie HT, Weinans H, Verhaar JA, van Osch GJ (2008) Can platelet-rich plasma enhance tendon repair? A cell culture study. Am J Sports Med 36: 1171-1178.
9. DeFranco MJ, Bershadsky B, Ciccone J, Yum JK, Iannotti JP (2007) Functional outcome of arthroscopic rotator cuff repairs: a correlation of anatomic and clinical results. J Shoulder Elbow Surg 16: 759-765.
10. DelRossi AJ, Cernaianu AC, Vertrees RA, Wacker CJ, Fuller SJ, Cilley JH Jr, Baldino WA (1990) Platelet-rich plasma reduces postoperative blood loss after cardiopulmonary bypass. J Thorac Cardiovasc Surg 100: 281-286.
11. Everts PA, Devilee RJ, Brown Mahoney C, Eeftinck-Schattenkerk M, Box HA, Knape JT, van Zundert A (2006) Platelet gel and fibrin sealant reduce allogeneic blood transfusions in total knee arthroplasty. Acta Anaesthesiol Scand 50: 593-599.
12. Ferry ST, Dahners LE, Afshari HM, Weinhold PS (2007) The effects of common anti-inflammatory drugs on the healing rat patellar tendon. Am J Sports Med 35: 1326-1333.
13. Gardner MJ, Demetrakopoulos D, Klepchick PR, Mooar PA (2007) The efficacy of autologous platelet gel in pain control and blood loss in total knee arthroplasty. An analysis of the haemoglobin, narcotic requirement and range of motion. Int Orthop 31: 309-313.
14. Griffin XL, Smith CM, Costa ML (2008) The clinical use of platelet-rich plasma in the promotion of bone healing: a systematic review. Injury 40: 158-162.
15. Hakimi M, Jungbluth P, Sager M, Betsch M, Herten M, Becker J, Windolf J, Wild M (2010) Combined use of platelet-rich plasma and autologous bone grafts in the treatment of long bone defects in mini-pigs. Injury 41: 811-817.
16. Hanson CA, Weinhold PS, Afshari HM, Dahners LE (2005) The effect of analgesic agents on the healing rat medial collateral ligament. Am J Sports Med 33: 674-679.
17. Hartmann EK, Heintel T, Morrison RH, Weckbach A (2009) Influence of platelet-rich plasma on the anterior fusion in spinal injuries: a qualitative and quantitative analysis using computer tomography. Arch Orthop Trauma Surg 130: 909-914.
18. Hee HT, Majd ME, Holt RT, Myers L (2003) Do autologous growth factors enhance transforaminal lumbar interbody fusion? Eur Spine J 12: 400-407.
19. Kajikawa Y, Morihara T, Sakamoto H, Matsuda K, Oshima Y, Yoshida A, Nagae M, Arai Y, Kawata M, Kubo T (2008) Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing. J Cell Physiol 215: 837-845.
20. Kannus P, Jozsa L (1991) Histopathological changes preceding spontaneous rupture of a tendon. A controlled study of 891 patients. J Bone Joint Surg Am 73: 1507-1525.
21. Kovacevic D, Rodeo SA (2008) Biological augmentation of rotator cuff tendon repair. Clin Orthop Relat Res 466: 622-633.
22. Lyras DN, Kazakos K, Verettas D, Botaitis S, Agrogiannis G, Kokka A, Pitiakoudis M, Kotzakaris A (2009) The effect of platelet-rich plasma gel in the early phase of patellar tendon healing. Arch Orthop Trauma Surg 129: 1577-1582.
23. Margolis DJ, Kantor J, Santanna J, Strom BL, Berlin JA (2001) Effectiveness of platelet releasate for the treatment of diabetic neuropathic foot ulcers. Diabetes Care 24: 483-488.
24. Mishra A, Pavelko T (2006) Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am J Sports Med 34: 1774-1778.
25. Paavola M, Jarvinen TA (2005) Paratendinopathy. Foot Ankle Clin 10: 279-292.
26. Peerbooms JC, Sluimer J, Bruijn DJ, Gosens T (2010) Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-year follow-up. Am J Sports Med 38: 255-262.
27. Randelli PS, Arrigoni P, Cabitza P, Volpi P, Maffulli N (2008) Autologous platelet rich plasma for arthroscopic rotator cuff repair. A pilot study. Disabil Rehabil 30: 1584-1589.
28. Rodeo SA (2007) Biologic augmentation of rotator cuff tendon repair. J Shoulder Elbow Surg 16: S191-S197.
29. Sanchez M, Anitua E, Azofra J, Andia I, Padilla S, Mujika I (2007) Comparison of surgically repaired achilles tendon tears using platelet-rich fibrin matrices. Am J Sports Med 35: 245-251.
30. Scott A, Ashe MC (2006) Common tendinopathies in the upper and lower extremities. Curr Sports Med Rep 5: 233-241.
31. Virchenko O, Aspenberg P (2006) How can one platelet injection after tendon injury lead to a stronger tendon after 4 weeks? Interplay between early regeneration and mechanical stimulation. Acta Orthop 77: 806-812.
32. Virchenko O, Grenegard M, Aspenberg P (2006) Independent and additive stimulation of tendon repair by thrombin and platelets. Acta Orthop 77: 960-966.
33. Xu Y, Murrell GA (2008) The basic science of tendinopathy. Clin Orthop Relat Res 466: 1528-1538.