One-year follow-up of platelet-rich plasma treatment in chronic achilles tendinopathy: A double-blind randomized placebo-controlled trial

American Journal of Sports Medicine

Volumn 39, Issue 8, 2011, Pages 1623-1629

  De Jonge, Suzan ^a,b   De Vos, Robert J ^b   Weir, Adam ^b   Van Schie, Hans T M ^a,c   Bierma Zeinstra, Sita M A ^a   Verhaar, Jan A N ^a   Weinans, Harrie ^a,d   Tol, Johannes L ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Hague Medical Center Antoniushove   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

Achilles tendon; Growth factors; Platelet rich plasma (PRP); Tendinopathy; Therapy

Indexed keywords

ACHILLES TENDON; ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ECHOGRAPHY; FOLLOW UP; HUMAN; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; TENDINITIS; THROMBOCYTE RICH PLASMA; TREATMENT OUTCOME;

ACHILLES TENDON; ADULT; AGED; DOUBLE-BLIND METHOD; FOLLOW-UP STUDIES; HUMANS; MIDDLE AGED; PLATELET-RICH PLASMA; TENDINOPATHY; TREATMENT OUTCOME;

EID: 80052526220     PISSN: 03635465     EISSN: 15523365     Source Type: Journal    
DOI: 10.1177/0363546511404877     Document Type: Article

References (48)

1. Alfredson H, Lorentzon R. Chronic tendon pain: no signs of chemical inflammation but high concentrations of the neurotransmitter glutamate. Implications for treatment? Curr Drug Targets. 2002;3(1):43-54. (Pubitemid 34296304)
2. Alfredson H, Ohberg L. Increased intratendinous vascularity in the early period after sclerosing injection treatment in Achilles tendinosis: a healing response? Knee Surg Sports Traumatol Arthrosc. 2006;14(4):399-401. (Pubitemid 43533010)
3. Alfredson H, Pietila T, Jonsson P, Lorentzon R. Heavy-load eccentric calf muscle training for the treatment of chronic Achilles tendinosis. Am J Sports Med. 1998;26(3):360-366. (Pubitemid 28248723)
4. Andres BM, Murrell GA. Treatment of tendinopathy: what works, what does not, and what is on the horizon. Clin Orthop Relat Res. 2008;466(7):1539-1554.
5. Anitua E, Sanchez M, Nurden AT, et al. Autologous fibrin matrices: a potential source of biological mediators that modulate tendon cell activities. J Biomed Mater Res A. 2006;77(2):285-293. (Pubitemid 47233530)
6. Astrom M, Rausing A. Chronic Achilles tendinopathy: a survey of surgical and histopathologic findings. Clin Orthop Relat Res. 1995;316:151-164.
7. Bleakney RR, White LM. Imaging of the Achilles tendon. Foot Ankle Clin. 2005;10(2):239-254. (Pubitemid 40732784)
8. Brown R, Orchard J, Kinchington M, Hooper A, Nalder G. Aprotinin in the management of Achilles tendinopathy: a randomised controlled trial. Br J Sports Med. 2006;40(3):275-279. (Pubitemid 43384753)
9. Castricini R, Longo UG, De Benedetto M, et al. Platelet-rich plasma augmentation for arthroscopic rotator cuff repair: a randomized controlled trial. Am J Sports Med. 2011;39:258-265.
10. Chan O, O'Dowd D, Padhiar N, et al. High volume image guided injections in chronic Achilles tendinopathy. Disabil Rehabil. 2008;30(20-22):1697-1708.
11. Creaney L. Platelet-rich plasma for treatment of Achilles tendinopathy. JAMA. 2010;303(17):1696; author reply 1697-1698.
12. de Jonge S, de Vos RJ, Van Schie HT, Verhaar JA, Weir A, Tol JL. One-year follow-up of a randomised controlled trial on added splinting to eccentric exercises in chronic midportion Achilles tendinopathy. Br J Sports Med. 2010;44(9):673-677.
13. de Mos M, van der Windt A, Jahr H, et al. Can platelet-rich plasma enhance tendon repair? A cell culture study. Am J Sports Med. 2008;36(6):1171-1178. (Pubitemid 351713047)
14. de Mos M, van El B, DeGroot J, et al. Achilles tendinosis: changes in biochemical composition and collagen turnover rate. Am J Sports Med. 2007;35(9):1549-1556. (Pubitemid 47301088)
15. de Vos RJ, van Veldhoven PL, Moen MH, Weir A, Tol JL, Maffulli N. Autologous growth factor injections in chronic tendinopathy: a systematic review. Br Med Bull. 2010;95:63-77.
16. de Vos RJ, Weir A, Tol JL, Verhaar JA, Weinans H, van Schie HT. No effects of PRP on ultrasonographic tendon structure and neovascularisation in chronic midportion Achilles tendinopathy. Br J Sports Med. 2011;45:387-392.
17. de Vos RJ, Weir A, van Schie HTM, et al. Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial. JAMA. 2010;303(2):144-149.
18. Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg. 2004;114(6):1502-1508. (Pubitemid 40361959)
19. Filardo G, Kon E, Della Villa S, Vincentelli F, Fornasari PM, Marcacci M. Use of platelet-rich plasma for the treatment of refractory jumper's knee. Int Orthop. 2010;34(6):909-915.
20. Fufa D, Shealy B, Jacobson M, Kevy S, Murray MM. Activation of platelet-rich plasma using soluble type I collagen. J Oral Maxillofac Surg. 2008;66(4):684-690. (Pubitemid 351381788)
21. Gaweda K, Tarczynska M, Krzyzanowski W. Treatment of Achilles tendinopathy with platelet-rich plasma. Int J Sports Med. 2010;31(8):577-583.
22. Khan KM, Cook JL, Bonar F, Harcourt P, Astrom M. Histopathology of common tendinopathies: update and implications for clinical management. Sports Med. 1999;27(6):393-408. (Pubitemid 29346822)
23. Knobloch K. The use of a neovascularization score to predict clinical severity in Achilles tendinopathy. Am J Sports Med. 2008;36(2):395; author reply 395-397.
24. Kon E, Filardo G, Delcogliano M, et al. Platelet-rich plasma: new clinical application: a pilot study for treatment of jumper's knee. Injury. 2009;40(6):598-603.
25. Longo UG, Ronga M, Maffulli N. Achilles tendinopathy. Sports Med Arthrosc. 2009;17(2):112-126.
26. Maffulli N, Khan KM, Puddu G. Overuse tendon conditions: time to change a confusing terminology. Arthroscopy. 1998;14(8):840-843. (Pubitemid 28531671)
27. Mishra A, Pavelko T. Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am J Sports Med. 2006;34(11): 1774-1778. (Pubitemid 44735517)
28. Movin T, Gad A, Reinholt FP, Rolf C. Tendon pathology in longstanding achillodynia: biopsy findings in 40 patients. Acta Orthop Scand. 1997;68(2):170-175. (Pubitemid 27202080)
29. Nin JR, Gasque GM, Azcarate AV, Beola JD, Gonzalez MH. Has platelet-rich plasma any role in anterior cruciate ligament allograft healing? Arthroscopy. 2009;25(11):1206-1213.
30. Ohberg L, Alfredson H. Effects on neovascularisation behind the good results with eccentric training in chronic mid-portion Achilles tendinosis? Knee Surg Sports Traumatol Arthrosc. 2004;12(5): 465-470. (Pubitemid 40883778)
31. Peerbooms JC, de Wolf GS, Colaris JW, Bruijn DJ, Verhaar JA. No positive effect of autologous platelet gel after total knee arthroplasty. Acta Orthop. 2009;80(5):557-562.
32. Peerbooms JC, Sluimer J, Bruijn DJ, Gosens T. Positive effect of an autologous platelet concentrate in lateral epicondylitis in a doubleblind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-year follow-up. Am J Sports Med. 2010;38(2):255-262.
33. Rabago D, Wilson J, Zgierska A. Platelet-rich plasma for treatment of Achilles tendinopathy. JAMA. 2010;303(17):1696-1697; author reply 1697-1698.
34. Rineer CA, Ruch DS. Elbow tendinopathy and tendon ruptures: epicondylitis, biceps and triceps ruptures. J Hand Surg Am. 2009;34(3):566-576.
35. Rompe JD, Nafe B, Furia JP, Maffulli N. Eccentric loading, shockwave treatment, or a wait-and-see policy for tendinopathy of the main body of tendo Achillis: a randomized controlled trial. Am J Sports Med. 2007;35(3):374-383. (Pubitemid 46280497)
36. Schepull T, Kvist J, Norrman H, Trinks M, Berlin G, Aspenberg P. Autologous platelets have no effect on the healing of human Achilles tendon ruptures: a randomized single-blind study. Am J Sports Med. 2011;39(1):38-47.
37. Scott A, Ashe MC. Common tendinopathies in the upper and lower extremities. Curr Sports Med Rep. 2006;5(5):233-241.
38. Sengkerij PM, de Vos RJ, Weir A, van Weelde BJ, Tol JL. Interobserver reliability of neovascularization score using power Doppler ultrasonography in midportion Achilles tendinopathy. Am J Sports Med. 2009;37(8):1627-1631.
39. Silva A, Sampaio R. Anatomic ACL reconstruction: does the plateletrich plasma accelerate tendon healing? Knee Surg Sports Traumatol Arthrosc. 2009;17(6):676-682.
40. Smidt N, van der Windt DA. Tennis elbow in primary care. BMJ. 2006;333(7575):927-928. (Pubitemid 44727787)
41. van Schie HT. Ultrasonographic Tissue Characterization of Equine Superficial Digital Flexor Tendons: Development and Applications of Computer-Aided Image Analysis [thesis]. Utrecht, the Netherlands; 2004.
42. van Schie HT, Bakker EM, Cherdchutham W, Jonker AM, van de Lest CH, van Weeren PR. Monitoring of the repair process of surgically created lesions in equine superficial digital flexor tendons by use of computerized ultrasonography. Am J Vet Res. 2009;70(1):37-48.
43. van Schie HT, de Vos RJ, de Jonge S, et al. Ultrasonographic tissue characterisation of human Achilles tendons: quantification of tendon structure through a novel non-invasive approach. Br J Sports Med. 2010;4416:1153-1159.
44. Ventura V, Terzaghi C, Borgo E, Verdoia C, Gallazzi M, Failoni S. Use of growth factors in ACL surgery: preliminary study. J Orthop Traumatol. 2005;6(2):76-79. (Pubitemid 41038497)
45. Virchenko O, Aspenberg P. How can one platelet injection after tendon injury lead to a stronger tendon after 4 weeks? Interplay between early regeneration and mechanical stimulation. Acta Orthop. 2006;77(5):806-812. (Pubitemid 44521924)
46. Wiegerinck JI, Reilingh ML, de Jonge MC, van Dijk CN, Kerkhoffs CM. Injection techniques of platelet-rich plasma into and around the Achilles tendon: a cadaveric study [published online ahead of print April 19, 2011] Am J Sports Med. doi:10.1177/0363546511401577.
47. Willberg L, Sunding K, Ohberg L, Forssblad M, Fahlstrom M, Alfredson H. Sclerosing injections to treat midportion Achilles tendinosis: a randomized controlled study evaluating two different concentrations of polidocanol. Knee Surg Sports Traumatol Arthrosc. 2008;16(9):859-864.
48. Yin Z, Chen X, Chen JL, Ouyang HW. Stem cells for tendon tissue engineering and regeneration. Expert Opin Biol Ther. 2010;10(5): 689-700.