Peripheral blood mononuclear cells enhance the anabolic effects of platelet-rich plasma on anterior cruciate ligament fibroblasts

Journal of Orthopaedic Research

Volumn 31, Issue 1, 2013, Pages 29-34

  Yoshida, Ryu ^a   Murray, Martha M ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

anterior cruciate ligament; collagen; peripheral blood mononuclear cells; platelet rich plasma; tissue engineering

Indexed keywords

COLLAGEN; INTERLEUKIN 6; PROCOLLAGEN; PROCOLLAGEN TYPE 1; PROCOLLAGEN TYPE 3; TISSUE SCAFFOLD; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTERIOR CRUCIATE LIGAMENT; ARTICLE; BIOSYNTHESIS; CELL METABOLISM; CELL PROLIFERATION; CONTROLLED STUDY; FIBROBLAST; GENE EXPRESSION; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; THROMBOCYTE RICH PLASMA;

ANIMALS; ANTERIOR CRUCIATE LIGAMENT; CATTLE; CELLS, CULTURED; COCULTURE TECHNIQUES; COLLAGEN TYPE I; COLLAGEN TYPE III; CULTURE MEDIA, CONDITIONED; FIBROBLASTS; GENE EXPRESSION; INTERLEUKIN-6; KNEE INJURIES; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTES; MACROPHAGES; METABOLISM; MONOCYTES; PLATELET-RICH PLASMA; TISSUE ENGINEERING;

EID: 84870239534     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22183     Document Type: Article

References (36)

1. Junkin DM, Johnson DL, Fu FH, et al. 2009. Knee ligament injuries. In:, Kibler WB, editor. Orthopaedic knowledge update: sports medicine. Rosemont, IL: American Academy of Orthopaedic Surgeons. p 136.
2. Neuman P, Englund M, Kostogiannis I, et al. 2008. Prevalence of tibiofemoral osteoarthritis 15 years after nonoperative treatment of anterior cruciate ligament injury: a prospective cohort study. Am J Sports Med 36: 1717-1725.
3. Miller SL, Gladstone JN., 2002. Graft selection in anterior cruciate ligament reconstruction. Orthop Clin North Am 33: 675-683.
4. Liden M, Sernert N, Rostgard-Christensen L, et al. 2008. Osteoarthritic changes after anterior cruciate ligament reconstruction using bone-patellar tendon-bone or hamstring tendon autografts: a retrospective, 7-year radiographic and clinical follow-up study. Arthroscopy 24: 899-908.
5. Reinhardt KR, Hetsroni I, Marx RG., 2010. Graft selection for anterior cruciate ligament reconstruction: a level I systematic review comparing failure rates and functional outcomes. Orthop Clin North Am 41: 249-262.
6. Marx RE, Carlson ER, Eichstaedt RM, et al. 1998. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85: 638-646.
7. Werner S, Grose R., 2003. Regulation of wound healing by growth factors and cytokines. Physiol Rev 83: 835-870.
8. Harrison S, Vavken P, Kevy S, et al. 2011. Platelet activation by collagen provides sustained release of anabolic cytokines. Am J Sports Med 39: 729-734.
9. Vavken P, Sadoghi P, Murray MM., 2011. The effect of platelet concentrates on graft maturation and graft-bone interface healing in anterior cruciate ligament reconstruction in human patients: a systematic review of controlled trials. Arthroscopy 27: 1573-1583.
10. Harrold AJ., 1961. The defect of blood coagulation in joints. J Clin Path 14: 305-308.
11. Vavken P, Fleming BC, Mastrangelo AN, et al. 2012. Biomechanical outcomes after bioenhanced anterior cruciate ligament repair and anterior cruciate ligament reconstruction are equal in a porcine model. Arthroscopy 28: 672-680.
12. Joshi SM, Mastrangelo AN, Magarian EM, et al. 2009. Collagen-platelet composite enhances biomechanical and histologic healing of the porcine anterior cruciate ligament. Am J Sports Med 37: 2401-2410.
13. Kroon ME, van Schie ML, van der Vecht B, et al. 2002. Collagen type 1 retards tube formation by human microvascular endothelial cells in a fibrin matrix. Angiogenesis 5: 257-265.
14. Cheng M, Wang H, Yoshida R, et al. 2010. Platelets and plasma proteins are both required to stimulate collagen gene expression by anterior cruciate ligament cells in three-dimensional culture. Tissue Eng Part A 16A: 1479-1489.
15. Murray MM, Spindler KP, Abreu E, et al. 2007. Collagen-platelet rich plasma hydrogel enhances primary repair of the porcine anterior cruciate ligament. J Orthop Res 25: 81-91.
16. Murray MM, Spindler KP, Ballard P, et al. 2007. Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffold. J Orthop Res 25: 1007-1017.
17. Murray MM, Spindler KP, Devin C, et al. 2006. Use of a collagen-platelet rich plasma scaffold to stimulate healing of a central defect in the canine ACL. J Orthop Res 24: 820-830.
18. Spindler KP, Murray MM, Carey JL, et al. 2009. The use of platelets to affect functional healing of an anterior cruciate ligament (ACL) autograft in a caprine ACL reconstruction model. J Orthop Res 27: 631-638.
19. Fufa D, Shealy B, Jacobson M, et al. 2008. Activation of platelet-rich plasma using soluble type I collagen. J Oral Maxillofac Surg 66: 684-690.
20. Fleming BC, Spindler KP, Palmer MP, et al. 2009. Collagen-platelet composites improve the biomechanical properties of healing anterior cruciate ligament grafts in a porcine model. Am J Sports Med 37: 1554-1563.
21. Harrison SL, Vavken P, Murray MM., 2011. Erythrocytes inhibit ligament fibroblast proliferation in a collagen scaffold. J Orthop Res 29: 1361-1366.
22. Lopez-Vidriero E, Goulding KA, Simon DA, et al. 2010. The use of platelet-rich plasma in arthroscopy and sports medicine: optimizing the healing environment. Arthroscopy 26: 269-278.
23. McCarrel T, Fortier L., 2009. Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression. J Orthop Res 27: 1033-1042.
24. Anitua E, Sánchez M, Nurden AT, et al. 2006. New insights into and novel applications for platelet-rich fibrin therapies. Trends Biotechnol 24: 227-234.
25. Boswell SG, Cole BJ, Sundman EA, et al. 2012. Platelet-rich plasma: a milieu of bioactive factors. Arthroscopy 28: 429-439.
26. Chamberlain CS, Leiferman EM, Frisch KE, et al. 2011. The influence of macrophage depletion on ligament healing. Connect Tissue Res 52: 203-211.
27. Naldini A, Morena E, Fimiani M, et al. 2008. The effects of autologous platelet gel on inflammatory cytokine response in human peripheral blood mononuclear cells. Platelets 19: 268-274.
28. Waehre T, Damas JK, Yndestad A, et al. 2004. Effect of activated platelets on expression of cytokines in peripheral blood mononuclear cells-potential role of prostaglandin E2. Thromb Haemost 92: 1358-1367.
29. Andersen MB, Pingel J, Kjaer M, et al. 2011. Interleukin-6: a growth factor stimulating collagen synthesis in human tendon. J Appl Physiol 110: 1549-1554.
30. Duncan MR, Berman B., 1991. Stimulation of collagen and glycosaminoglycan production in cultured human adult dermal fibroblasts by recombinant human interleukin 6. J Invest Dermatol 97: 686-692.
31. Yoshida R, Vavken P, Murray MM., 2011. Decellularization of bovine anterior cruciate ligament tissues minimizes immunogenic reactions to alpha-gal epitopes by human peripheral blood mononuclear cells. Knee (Epub ahead of print).
32. Gosens T, Peerbooms JC, van Laar W, et al. 2011. Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up. Am J Sports Med 39: 1200-1208.
33. Nakao K, Yoneda K, Osaki T., 1995. Enhanced cytokine production and collagen synthesis of gingival fibroblasts from patients with denture fibromatosis. J Dent Res 74: 1072-1078.
34. Gonzalez-Amaro R, Alarcon-Segovia D, Alcocer-Varela J, et al. 1988. Mononuclear cell-fibroblast interactions in scleroderma. Clin Immunol Immunopathol 46: 412-420.
35. Murray MM, Palmer M, Abreu E, et al. 2009. Platelet-rich plasma alone is not sufficient to enhance suture repair of the ACL in skeletally immature animals: an in vivo study. J Orthop Res 27: 639-645.
36. Lin ZQ, Kondo T, Ishida Y, et al. 2003. Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice. J Leukoc Biol 73: 713-721.