Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 15, 2008, Pages 7358-7370

  Reddy, M Vijaya Bhaskar ^a   Su, Chung Ren ^a   Chiou, Wen Fei ^b   Liu, Yi Nan ^c   Chen, Rosemary Yin Hwa ^c   Bastow, Kenneth F ^c   Lee, Kuo Hsiung ^c   Wu, Tian Shung ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Cytotoxicity; Mannich bases of heterocyclic chalcones

Indexed keywords

1 [2 HYDROXY 4 (3 METHYLBUT 2 ENYLOXY) 3 (MORPHOLINOMETHYL)PHENYL] 3 (3 METHYLTHIOPHEN 2 YL)PROP 2 EN 1 ONE; 1 [2 HYDROXY 4 ISOPROPOXY 3 (MORPHOLINOMETHYL)PHENYL] 3 (THIOPHEN 2 YL)PROP 2 EN 1 ONE; 1 [2 HYDROXY 4 ISOPROPOXY 5 (MORPHOLINOMETHYL)PHENYL] 3 (THIOPHEN 2 YL)PROP 2 EN 1 ONE; 1 [2 HYDROXY 4 METHOXY 3 (MORPHOLINOMETHYL)PHENYL] 3 (PYRIDIN 2 YL)PROP 2 EN 1 ONE; 1 [2 HYDROXY 4 METHOXY 3 (MORPHOLINOMETHYL)PHENYL] 3 (THIOPHEN 2 YL)PROP 2 EN 1 ONE; 1 [2 HYDROXY 4 METHOXY 5 (MORPHOLINOMETHYL)PHENYL] 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 [2 HYDROXY 4 METHOXY 5 (MORPHOLINOMETHYL)PHENYL] 3 (PYRIDIN 3 YL)PROP 2 EN 1 ONE; 1 [2 HYDROXY 4 METHOXY 5 (MORPHOLINOMETHYL)PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [2,4 DIHYDROXY 3 (MORPHOLINOMETHYL)PHENYL] 3 (PYRIDIN 2 YL)PROP 2 EN 1 ONE; 1 [4 ETHOXY 2 HYDROXY 5 (MORPHOLINOMETHYL)PHENYL] 3 (3 METHYLTHIOPHEN 2 YL)PROP 2 EN 1 ONE; 1 [4 ETHOXY 2 HYDROXY 5 (MORPHOLINOMETHYL)PHENYL] 3 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE; 1 [4 ETHOXY 2 HYDROXY 5 (MORPHOLINOMETHYL)PHENYL] 3 (FURAN 2 YL)PROP 2 EN 1 ONE; 1 [4 ETHOXY 2 HYDROXY 5 (MORPHOLINOMETHYL)PHENYL] 3 (PYRIDIN 2 YL)PROP 2 EN 1 ONE; 1 [4 ETHOXY 2 HYDROXY 5 (MORPHOLINOMETHYL)PHENYL] 3 (PYRIDIN 3 YL)PROP 2 EN 1 ONE; 1 [4 ETHOXY 2 HYDROXY 5 (MORPHOLINOMETHYL)PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 HYDROXY 3 (MORPHOLINOMETHYL)PHENYL] 3 (3 METHYLTHIOPHEN 2 YL)PROP 2 EN 1 ONE; 1 [4 HYDROXY 3 (MORPHOLINOMETHYL)PHENYL] 3 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE; 1 [4 HYDROXY 3 (MORPHOLINOMETHYL)PHENYL] 3 (PYRIDIN 2 YL)PROP 2 EN 1 ONE; 1 [4 HYDROXY 3 (MORPHOLINOMETHYL)PHENYL] 3 (PYRIDIN 3 YL)PROP 2 EN 1 ONE; 1 [4 HYDROXY 3 (MORPHOLINOMETHYL)PHENYL] 3 (PYRIDIN 4 YL)PROP 2 EN 1 ONE; 1 [4 HYDROXY 3 (MORPHOLINOMETHYL)PHENYL] 3 (THIOPHEN 2 YL)PROP 2 EN 1 ONE; 1 [4 HYDROXY 3 (MORPHOLINOMETHYL)PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 HYDROXY 3,5 BIS(MORPHOLINOMETHYL)PHENYL] 3 (PYRIDIN 2 YL)PROP 2 EN 1 ONE; 3 (FURAN 2 YL) 1 [2 HYDROXY 4 METHOXY 3 (MORPHOLINOMETHYL)PHENYL]PROP 2 EN 1 ONE; 3 (FURAN 2 YL) 1 [4 HYDROXY 3 (MORPHOLINOMETHYL)PHENYL]PROP 2 EN 1 ONE; CHALCONE DERIVATIVE; CYTOTOXIC AGENT; HETEROCYCLIC COMPOUND; MANNICH BASE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL STRAIN MCF 7; CLAISEN CONDENSATION; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MULTIDRUG RESISTANCE; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHALCONES; DRUG DESIGN; HUMANS; MANNICH BASES; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 48449103931     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.06.018     Document Type: Article

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