메뉴 건너뛰기




Volumn 65, Issue 3, 2009, Pages 390-398

In vitro selection of Plasmodium falciparum drug-resistant parasite lines

Author keywords

'Accelerated resistance to multidrug'; Clones; Mutation rate; Per parasite resistant frequency; Resistance indexes

Indexed keywords

ANTIPROTOZOAL AGENT; ATOVAQUONE; AZITHROMYCIN; BMS 3888891; BMS 388891; CHLOROQUINE; CYCLOGUANIL; FLUOROOROTIC ACID; HALOFANTRINE; MEFLOQUINE; PYRIMETHAMINE; QUININE; SULFADOXINE; UNCLASSIFIED DRUG;

EID: 77950309299     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkp449     Document Type: Review
Times cited : (47)

References (71)
  • 1
    • 42349104331 scopus 로고    scopus 로고
    • Qinghaosu (artemisinin): the price of success
    • White NJ. Qinghaosu (artemisinin): the price of success. Science 2008; 320: 330-4.
    • (2008) Science , vol.320 , pp. 330-334
    • White, N.J.1
  • 2
    • 2142659388 scopus 로고    scopus 로고
    • Antimalarial drug resistance
    • White NJ. Antimalarial drug resistance. J Clin Invest 2004; 113: 1084-92.
    • (2004) J Clin Invest , vol.113 , pp. 1084-1092
    • White, N.J.1
  • 4
    • 31944444061 scopus 로고    scopus 로고
    • Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10
    • Afonso A, Hunt P, Cheesman S et al. Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10. Antimicrob Agents Chemother 2006; 50: 480-9.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 480-489
    • Afonso, A.1    Hunt, P.2    Cheesman, S.3
  • 5
    • 0035021982 scopus 로고    scopus 로고
    • Of mice and malaria mutants: unravelling the genetics of drug resistance using rodent malaria models
    • Carlton JM, Hayton K, Cravo PV et al. Of mice and malaria mutants: unravelling the genetics of drug resistance using rodent malaria models. Trends Parasitol 2001; 17: 236-42.
    • (2001) Trends Parasitol , vol.17 , pp. 236-242
    • Carlton, J.M.1    Hayton, K.2    Cravo, P.V.3
  • 6
    • 34250662528 scopus 로고    scopus 로고
    • Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites
    • Hunt P, Afonso A, Creasey A et al. Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites. Mol Microbiol 2007; 65: 27-40.
    • (2007) Mol Microbiol , vol.65 , pp. 27-40
    • Hunt, P.1    Afonso, A.2    Creasey, A.3
  • 7
    • 0345096564 scopus 로고    scopus 로고
    • Chloroquine resistance in Plasmodium chabaudi: are chloroquine-resistance transporter (crt) and multi-drug resistance (mdr1) orthologues involved?
    • Hunt P, Cravo PV, Donleavy P et al. Chloroquine resistance in Plasmodium chabaudi: are chloroquine-resistance transporter (crt) and multi-drug resistance (mdr1) orthologues involved? Mol Biochem Parasitol 2004; 133: 27-35.
    • (2004) Mol Biochem Parasitol , vol.133 , pp. 27-35
    • Hunt, P.1    Cravo, P.V.2    Donleavy, P.3
  • 8
    • 2942525695 scopus 로고    scopus 로고
    • Gene synteny and chloroquine resistance in Plasmodium chabaudi
    • Hunt P, Martinelli A, Fawcett R et al. Gene synteny and chloroquine resistance in Plasmodium chabaudi. Mol Biochem Parasitol 2004; 136: 157-64.
    • (2004) Mol Biochem Parasitol , vol.136 , pp. 157-164
    • Hunt, P.1    Martinelli, A.2    Fawcett, R.3
  • 9
    • 0017311840 scopus 로고
    • Human malaria parasites in continuous culture
    • Trager W, Jensen JB. Human malaria parasites in continuous culture. Science 1976; 193: 673-5.
    • (1976) Science , vol.193 , pp. 673-675
    • Trager, W.1    Jensen, J.B.2
  • 10
    • 0018185109 scopus 로고
    • Chloroquine resistance produced in vitro in an African strain of human malaria
    • Nguyen-Dinh P, Trager W. Chloroquine resistance produced in vitro in an African strain of human malaria. Science 1978; 200: 1397-8.
    • (1978) Science , vol.200 , pp. 1397-1398
    • Nguyen-Dinh, P.1    Trager, W.2
  • 11
    • 33846105531 scopus 로고    scopus 로고
    • Artemether/lumefantrine in the treatment of uncomplicated falciparum malaria
    • Kokwaro G, Mwai L, Nzila A. Artemether/lumefantrine in the treatment of uncomplicated falciparum malaria. Expert Opin Pharmacother 2007; 8: 75-94.
    • (2007) Expert Opin Pharmacother , vol.8 , pp. 75-94
    • Kokwaro, G.1    Mwai, L.2    Nzila, A.3
  • 12
    • 34447617873 scopus 로고    scopus 로고
    • Efficacy and safety of dihydroartemisinin-piperaquine
    • Myint HY, Ashley EA, Day NP et al. Efficacy and safety of dihydroartemisinin-piperaquine. Trans R Soc Trop Med Hyg 2007; 101: 858-66.
    • (2007) Trans R Soc Trop Med Hyg , vol.101 , pp. 858-866
    • Myint, H.Y.1    Ashley, E.A.2    Day, N.P.3
  • 13
    • 51749098784 scopus 로고    scopus 로고
    • Fixed-dose pyronaridine-artesunate combination for treatment of uncomplicated falciparum malaria in pediatric patients in Gabon
    • Ramharter M, Kurth F, Schreier AC et al. Fixed-dose pyronaridine-artesunate combination for treatment of uncomplicated falciparum malaria in pediatric patients in Gabon. J Infect Dis 2008; 198: 911-9.
    • (2008) J Infect Dis , vol.198 , pp. 911-919
    • Ramharter, M.1    Kurth, F.2    Schreier, A.C.3
  • 14
    • 34247561355 scopus 로고    scopus 로고
    • Artesunate, artemether or quinine in severe Plasmodium falciparum malaria?
    • Checkley AM, Whitty CJ. Artesunate, artemether or quinine in severe Plasmodium falciparum malaria? Expert Rev Anti Infect Ther 2007; 5: 199-204.
    • (2007) Expert Rev Anti Infect Ther , vol.5 , pp. 199-204
    • Checkley, A.M.1    Whitty, C.J.2
  • 15
    • 23944443703 scopus 로고    scopus 로고
    • Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial
    • Dondorp A, Nosten F, Stepniewska K et al. Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial. Lancet 2005; 366: 717-25.
    • (2005) Lancet , vol.366 , pp. 717-725
    • Dondorp, A.1    Nosten, F.2    Stepniewska, K.3
  • 17
    • 68049123592 scopus 로고    scopus 로고
    • Artemisinin resistance in Plasmodium falciparum malaria
    • Dondorp AM, Nosten F, Yi P et al. Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med 2009; 361: 455-67.
    • (2009) N Engl J Med , vol.361 , pp. 455-467
    • Dondorp, A.M.1    Nosten, F.2    Yi, P.3
  • 18
    • 28244477359 scopus 로고    scopus 로고
    • Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6
    • Jambou R, Legrand E, Niang M et al. Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6. Lancet 2005; 366: 1960-3.
    • (2005) Lancet , vol.366 , pp. 1960-1963
    • Jambou, R.1    Legrand, E.2    Niang, M.3
  • 19
    • 63149132005 scopus 로고    scopus 로고
    • Resistance to antimalarial compounds: methods and applications
    • Witkowski B, Berry A, Benoit-Vical F. Resistance to antimalarial compounds: methods and applications. Drug Resist Updat 2009; 12: 42-50.
    • (2009) Drug Resist Updat , vol.12 , pp. 42-50
    • Witkowski, B.1    Berry, A.2    Benoit-Vical, F.3
  • 20
    • 0036790841 scopus 로고    scopus 로고
    • The assessment of antimalarial drug efficacy
    • White NJ. The assessment of antimalarial drug efficacy. Trends Parasitol 2002; 18: 458-64.
    • (2002) Trends Parasitol , vol.18 , pp. 458-464
    • White, N.J.1
  • 21
    • 0024273546 scopus 로고
    • Plasmodium falciparum: induction of resistance to mefloquine in cloned strains by continuous drug exposure in vitro
    • Oduola AM, Milhous WK, Weatherly NF et al. Plasmodium falciparum: induction of resistance to mefloquine in cloned strains by continuous drug exposure in vitro. Exp Parasitol 1988; 67: 354-60.
    • (1988) Exp Parasitol , vol.67 , pp. 354-360
    • Oduola, A.M.1    Milhous, W.K.2    Weatherly, N.F.3
  • 22
    • 0024356582 scopus 로고
    • Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum
    • Wilson CM, Serrano AE, Wasley A et al. Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum. Science 1989; 244: 1184-6.
    • (1989) Science , vol.244 , pp. 1184-1186
    • Wilson, C.M.1    Serrano, A.E.2    Wasley, A.3
  • 23
    • 2442655302 scopus 로고    scopus 로고
    • Molecular epidemiology of malaria in Cameroon. XX. Experimental studies on various factors of in vitro drug sensitivity assays using fresh isolates of Plasmodium falciparum
    • Basco LK. Molecular epidemiology of malaria in Cameroon. XX. Experimental studies on various factors of in vitro drug sensitivity assays using fresh isolates of Plasmodium falciparum. Am J Trop Med Hyg 2004; 70: 474-80.
    • (2004) Am J Trop Med Hyg , vol.70 , pp. 474-480
    • Basco, L.K.1
  • 24
    • 34247532965 scopus 로고    scopus 로고
    • Influence of oxygen on asexual blood cycle and susceptibility of Plasmodium falciparum to chloroquine: requirement of a standardized in vitro assay
    • Briolant S, Parola P, Fusai T et al. Influence of oxygen on asexual blood cycle and susceptibility of Plasmodium falciparum to chloroquine: requirement of a standardized in vitro assay. Malar J 2007; 6: 44.
    • (2007) Malar J , vol.6 , pp. 44
    • Briolant, S.1    Parola, P.2    Fusai, T.3
  • 25
    • 65649106581 scopus 로고    scopus 로고
    • Plasmodium falciparum pfmdr1 amplification, mefloquine resistance, and parasite fitness
    • Preechapornkul P, Imwong M, Chotivanich K et al. Plasmodium falciparum pfmdr1 amplification, mefloquine resistance, and parasite fitness. Antimicrob Agents Chemother 2009; 53: 1509-15.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 1509-1515
    • Preechapornkul, P.1    Imwong, M.2    Chotivanich, K.3
  • 26
    • 0027474443 scopus 로고
    • Derivation of highly mefloquine-resistant lines from Plasmodium falciparum in vitro
    • Peel SA, Merritt SC, Handy J et al. Derivation of highly mefloquine-resistant lines from Plasmodium falciparum in vitro. Am J Trop Med Hyg 1993; 48: 385-97.
    • (1993) Am J Trop Med Hyg , vol.48 , pp. 385-397
    • Peel, S.A.1    Merritt, S.C.2    Handy, J.3
  • 27
    • 0019470781 scopus 로고
    • Decrease in susceptibility of Plasmodium falciparum to mefloquine in continuous culture
    • Brockelman CR, Monkolkeha S, Tanariya P. Decrease in susceptibility of Plasmodium falciparum to mefloquine in continuous culture. Bull World Health Organ 1981; 59: 249-52.
    • (1981) Bull World Health Organ , vol.59 , pp. 249-252
    • Brockelman, C.R.1    Monkolkeha, S.2    Tanariya, P.3
  • 28
    • 0021269959 scopus 로고
    • Plasmodium falciparum: mefloquine resistance produced in vitro
    • Lambros C, Notsch JD. Plasmodium falciparum: mefloquine resistance produced in vitro. Bull World Health Organ 1984; 62: 433-8.
    • (1984) Bull World Health Organ , vol.62 , pp. 433-438
    • Lambros, C.1    Notsch, J.D.2
  • 29
    • 0028014644 scopus 로고
    • Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine
    • Cowman AF, Galatis D, Thompson JK. Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine. Proc Natl Acad Sci USA 1994; 91: 1143-7.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 1143-1147
    • Cowman, A.F.1    Galatis, D.2    Thompson, J.K.3
  • 30
    • 19344377032 scopus 로고    scopus 로고
    • Contribution of the pfmdr1 gene to antimalarial drug-resistance
    • Duraisingh MT, Cowman AF. Contribution of the pfmdr1 gene to antimalarial drug-resistance. Acta Trop 2005; 94: 181-90.
    • (2005) Acta Trop , vol.94 , pp. 181-190
    • Duraisingh, M.T.1    Cowman, A.F.2
  • 31
    • 0032804039 scopus 로고    scopus 로고
    • The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand
    • Price RN, Cassar C, Brockman A et al. The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand. Antimicrob Agents Chemother 1999; 43: 2943-9.
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 2943-2949
    • Price, R.N.1    Cassar, C.2    Brockman, A.3
  • 32
    • 2142769136 scopus 로고    scopus 로고
    • Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
    • Price RN, Uhlemann AC, Brockman A et al. Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number. Lancet 2004; 364: 438-47.
    • (2004) Lancet , vol.364 , pp. 438-447
    • Price, R.N.1    Uhlemann, A.C.2    Brockman, A.3
  • 33
    • 33845663264 scopus 로고    scopus 로고
    • Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand
    • Uhlemann AC, McGready R, Ashley EA et al. Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand. J Infect Dis 2007; 195: 134-41.
    • (2007) J Infect Dis , vol.195 , pp. 134-141
    • Uhlemann, A.C.1    McGready, R.2    Ashley, E.A.3
  • 34
    • 0026645269 scopus 로고
    • Selection for high-level chloroquine resistance results in deamplification of the pfmdr1 gene and increased sensitivity to mefloquine in Plasmodium falciparum
    • Barnes DA, Foote SJ, Galatis D et al. Selection for high-level chloroquine resistance results in deamplification of the pfmdr1 gene and increased sensitivity to mefloquine in Plasmodium falciparum. EMBO J 1992; 11: 3067-75.
    • (1992) EMBO J , vol.11 , pp. 3067-3075
    • Barnes, D.A.1    Foote, S.J.2    Galatis, D.3
  • 35
    • 34250644012 scopus 로고    scopus 로고
    • Is PfCRT a channel or a carrier? Two competing models explaining chloroquine resistance in Plasmodium falciparum
    • Sanchez CP, Stein WD, Lanzer M. Is PfCRT a channel or a carrier? Two competing models explaining chloroquine resistance in Plasmodium falciparum. Trends Parasitol 2007; 23: 332-9.
    • (2007) Trends Parasitol , vol.23 , pp. 332-339
    • Sanchez, C.P.1    Stein, W.D.2    Lanzer, M.3
  • 36
    • 33749989605 scopus 로고    scopus 로고
    • Transporters involved in resistance to antimalarial drugs
    • Valderramos SG, Fidock DA. Transporters involved in resistance to antimalarial drugs. Trends Pharmacol Sci 2006; 27: 594-601.
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 594-601
    • Valderramos, S.G.1    Fidock, D.A.2
  • 37
    • 34548635564 scopus 로고    scopus 로고
    • Advances in understanding the genetic basis of antimalarial drug resistance
    • Ekland EH, Fidock DA. Advances in understanding the genetic basis of antimalarial drug resistance. Curr Opin Microbiol 2007; 10: 363-70.
    • (2007) Curr Opin Microbiol , vol.10 , pp. 363-370
    • Ekland, E.H.1    Fidock, D.A.2
  • 38
    • 18244396971 scopus 로고    scopus 로고
    • Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum
    • Cooper RA, Ferdig MT, Su XZ et al. Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum. Mol Pharmacol 2002; 61: 35-42.
    • (2002) Mol Pharmacol , vol.61 , pp. 35-42
    • Cooper, R.A.1    Ferdig, M.T.2    Su, X.Z.3
  • 39
    • 0030217936 scopus 로고    scopus 로고
    • Plasmodium falciparum: chloroquine selection of a cloned line and DNA rearrangements
    • Lim AS, Cowman AF. Plasmodium falciparum: chloroquine selection of a cloned line and DNA rearrangements. Exp Parasitol 1996; 83: 283-94.
    • (1996) Exp Parasitol , vol.83 , pp. 283-294
    • Lim, A.S.1    Cowman, A.F.2
  • 40
    • 0022921684 scopus 로고
    • Plasmodium falciparum: induction, selection, and characterization of pyrimethamine-resistant mutants
    • Banyal HS, Inselburg J. Plasmodium falciparum: induction, selection, and characterization of pyrimethamine-resistant mutants. Exp Parasitol 1986; 62: 61-70.
    • (1986) Exp Parasitol , vol.62 , pp. 61-70
    • Banyal, H.S.1    Inselburg, J.2
  • 41
    • 0023549501 scopus 로고
    • Pyrimethamine resistant Plasmodium falciparum: overproduction of dihydrofolate reductase by a gene duplication
    • Inselburg J, Bzik DJ, Horii T. Pyrimethamine resistant Plasmodium falciparum: overproduction of dihydrofolate reductase by a gene duplication. Mol Biochem Parasitol 1987; 26: 121-34.
    • (1987) Mol Biochem Parasitol , vol.26 , pp. 121-134
    • Inselburg, J.1    Bzik, D.J.2    Horii, T.3
  • 42
    • 0025338631 scopus 로고
    • Mutant dihydrofolate reductase-thymidylate synthase genes in pyrimethamine-resistant Plasmodium falciparum with polymorphic chromosome duplications
    • Tanaka M, Gu HM, Bzik DJ et al. Mutant dihydrofolate reductase-thymidylate synthase genes in pyrimethamine-resistant Plasmodium falciparum with polymorphic chromosome duplications. Mol Biochem Parasitol 1990; 42: 83-91.
    • (1990) Mol Biochem Parasitol , vol.42 , pp. 83-91
    • Tanaka, M.1    Gu, H.M.2    Bzik, D.J.3
  • 43
    • 14144253009 scopus 로고    scopus 로고
    • Mechanisms of resistance of malaria parasites to antifolates
    • Gregson A, Plowe CV. Mechanisms of resistance of malaria parasites to antifolates. Pharmacol Rev 2005; 57: 117-45.
    • (2005) Pharmacol Rev , vol.57 , pp. 117-145
    • Gregson, A.1    Plowe, C.V.2
  • 44
    • 33748755472 scopus 로고    scopus 로고
    • The past, present and future of antifolates in the treatment of Plasmodium falciparum infection
    • Nzila A. The past, present and future of antifolates in the treatment of Plasmodium falciparum infection. J Antimicrob Chemother 2006; 57: 1043-54.
    • (2006) J Antimicrob Chemother , vol.57 , pp. 1043-1054
    • Nzila, A.1
  • 45
    • 34247211044 scopus 로고    scopus 로고
    • Antifolates can have a role in the treatment of Plasmodium vivax
    • Hawkins VN, Joshi H, Rungsihirunrat K et al. Antifolates can have a role in the treatment of Plasmodium vivax. Trends Parasitol 2007; 23: 213-22.
    • (2007) Trends Parasitol , vol.23 , pp. 213-222
    • Hawkins, V.N.1    Joshi, H.2    Rungsihirunrat, K.3
  • 46
    • 0033931237 scopus 로고    scopus 로고
    • Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site
    • Korsinczky M, Chen N, Kotecka B et al. Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site. Antimicrob Agents Chemother 2000; 44: 2100-8.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 2100-2108
    • Korsinczky, M.1    Chen, N.2    Kotecka, B.3
  • 47
    • 33746742419 scopus 로고    scopus 로고
    • Prevalence of Plasmodium falciparum cytochrome b gene mutations in isolates imported from Africa, and implications for atovaquone resistance
    • Berry A, Senescau A, Lelievre J et al. Prevalence of Plasmodium falciparum cytochrome b gene mutations in isolates imported from Africa, and implications for atovaquone resistance. Trans R Soc Trop Med Hyg 2006; 100: 986-8.
    • (2006) Trans R Soc Trop Med Hyg , vol.100 , pp. 986-988
    • Berry, A.1    Senescau, A.2    Lelievre, J.3
  • 48
    • 33750024079 scopus 로고    scopus 로고
    • Clinical atovaquone-proguanil resistance of Plasmodium falciparum associated with cytochrome b codon 268 mutations
    • Musset L, Bouchaud O, Matheron S et al. Clinical atovaquone-proguanil resistance of Plasmodium falciparum associated with cytochrome b codon 268 mutations. Microbes Infect 2006; 8: 2599-604.
    • (2006) Microbes Infect , vol.8 , pp. 2599-2604
    • Musset, L.1    Bouchaud, O.2    Matheron, S.3
  • 49
    • 33746322417 scopus 로고    scopus 로고
    • Detection of atovaquone-proguanil resistance conferring mutations in Plasmodium falciparum cytochrome b gene in Luanda,Angola
    • Pimentel S, Nogueira F, Benchimol C et al. Detection of atovaquone-proguanil resistance conferring mutations in Plasmodium falciparum cytochrome b gene in Luanda, Angola. Malar J 2006; 5: 30.
    • (2006) Malar J , vol.5 , pp. 30
    • Pimentel, S.1    Nogueira, F.2    Benchimol, C.3
  • 50
    • 23344435930 scopus 로고    scopus 로고
    • Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis
    • Buckner FS, Eastman RT, Yokoyama K et al. Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis. Curr Opin Investig Drugs 2005; 6: 791-7.
    • (2005) Curr Opin Investig Drugs , vol.6 , pp. 791-797
    • Buckner, F.S.1    Eastman, R.T.2    Yokoyama, K.3
  • 51
    • 20244388655 scopus 로고    scopus 로고
    • Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum
    • Eastman RT, White J, Hucke O et al. Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum. J Biol Chem 2005; 280: 13554-9.
    • (2005) J Biol Chem , vol.280 , pp. 13554-13559
    • Eastman, R.T.1    White, J.2    Hucke, O.3
  • 52
    • 38149038655 scopus 로고    scopus 로고
    • 2-Oxo-tetrahydro-1,8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials
    • Olepu S, Suryadevara PK, Rivas K et al. 2-Oxo-tetrahydro-1,8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials. Bioorg Med Chem Lett 2008; 18: 494-7.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 494-497
    • Olepu, S.1    Suryadevara, P.K.2    Rivas, K.3
  • 53
    • 33846597493 scopus 로고    scopus 로고
    • In vitro antimalarial activity of azithromycin, artesunate, and quinine in combination and correlation with clinical outcome
    • Noedl H, Krudsood S, Leowattana W et al. In vitro antimalarial activity of azithromycin, artesunate, and quinine in combination and correlation with clinical outcome. Antimicrob Agents Chemother 2007; 51: 651-6.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 651-656
    • Noedl, H.1    Krudsood, S.2    Leowattana, W.3
  • 54
    • 43149110788 scopus 로고    scopus 로고
    • A randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women
    • Kalilani L, Mofolo I, Chaponda M et al. A randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women. PLoS ONE 2007; 2: e1166.
    • (2007) PLoS ONE , vol.2
    • Kalilani, L.1    Mofolo, I.2    Chaponda, M.3
  • 55
    • 33750682726 scopus 로고    scopus 로고
    • Azithromycin combination therapy with artesunate or quinine for the treatment of uncomplicated Plasmodium falciparum malaria in adults: a randomized, phase 2 clinical trial in Thailand
    • Noedl H, Krudsood S, Chalermratana K et al. Azithromycin combination therapy with artesunate or quinine for the treatment of uncomplicated Plasmodium falciparum malaria in adults: a randomized, phase 2 clinical trial in Thailand. Clin Infect Dis 2006; 43: 1264-71.
    • (2006) Clin Infect Dis , vol.43 , pp. 1264-1271
    • Noedl, H.1    Krudsood, S.2    Chalermratana, K.3
  • 56
    • 33646000851 scopus 로고    scopus 로고
    • Effective treatment of uncomplicated Plasmodium falciparum malaria with azithromycin-quinine combinations: a randomized, dose-ranging study
    • Miller RS, Wongsrichanalai C, Buathong N et al. Effective treatment of uncomplicated Plasmodium falciparum malaria with azithromycin-quinine combinations: a randomized, dose-ranging study. Am J Trop Med Hyg 2006; 74: 401-6.
    • (2006) Am J Trop Med Hyg , vol.74 , pp. 401-406
    • Miller, R.S.1    Wongsrichanalai, C.2    Buathong, N.3
  • 57
    • 29844439697 scopus 로고    scopus 로고
    • A double-blind, randomized study of azithromycin compared to chloroquine for the treatment of Plasmodium vivax malaria in India
    • Dunne MW, Singh N, Shukla M et al. A double-blind, randomized study of azithromycin compared to chloroquine for the treatment of Plasmodium vivax malaria in India. Am J Trop Med Hyg 2005; 73: 1108-11.
    • (2005) Am J Trop Med Hyg , vol.73 , pp. 1108-1111
    • Dunne, M.W.1    Singh, N.2    Shukla, M.3
  • 58
    • 20844449544 scopus 로고    scopus 로고
    • A multicenter study of azithromycin, alone and in combination with chloroquine, for the treatment of acute uncomplicated Plasmodium falciparum malaria in India
    • Dunne MW, Singh N, Shukla M et al. A multicenter study of azithromycin, alone and in combination with chloroquine, for the treatment of acute uncomplicated Plasmodium falciparum malaria in India. J Infect Dis 2005; 191: 1582-8.
    • (2005) J Infect Dis , vol.191 , pp. 1582-1588
    • Dunne, M.W.1    Singh, N.2    Shukla, M.3
  • 59
    • 34047255258 scopus 로고    scopus 로고
    • In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin
    • Sidhu AB, Sun Q, Nkrumah LJ et al. In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin. J Biol Chem 2007; 282: 2494-504.
    • (2007) J Biol Chem , vol.282 , pp. 2494-2504
    • Sidhu, A.B.1    Sun, Q.2    Nkrumah, L.J.3
  • 60
    • 0017144224 scopus 로고
    • The chemotherapy of rodent malaria, XXVI. The potential value of WR 122,455 (a 9-phenanthrenemethanol) against drug-resistant malaria parasites
    • Peters W, Porter M. The chemotherapy of rodent malaria, XXVI. The potential value of WR 122,455 (a 9-phenanthrenemethanol) against drug-resistant malaria parasites. Ann Trop Med Parasitol 1976; 70: 271-81.
    • (1976) Ann Trop Med Parasitol , vol.70 , pp. 271-281
    • Peters, W.1    Porter, M.2
  • 61
    • 0014583425 scopus 로고
    • Plasmodium vinckei: production of chloroquine-resistant strain
    • Powers KG, Jacobs RL, Good WC et al. Plasmodium vinckei: production of chloroquine-resistant strain. Exp Parasitol 1969; 26: 193-202.
    • (1969) Exp Parasitol , vol.26 , pp. 193-202
    • Powers, K.G.1    Jacobs, R.L.2    Good, W.C.3
  • 62
    • 0017309731 scopus 로고
    • Genetics of chloroquine resistance in malaria parasites
    • Rosario VE. Genetics of chloroquine resistance in malaria parasites. Nature 1976; 261: 585-6.
    • (1976) Nature , vol.261 , pp. 585-586
    • Rosario, V.E.1
  • 63
    • 0030829371 scopus 로고    scopus 로고
    • Variations in frequencies of drug resistance in Plasmodium falciparum
    • Rathod PK, McErlean T, Lee PC. Variations in frequencies of drug resistance in Plasmodium falciparum. Proc Natl Acad Sci USA 1997; 94: 9389-93.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 9389-9393
    • Rathod, P.K.1    McErlean, T.2    Lee, P.C.3
  • 64
    • 2142657830 scopus 로고    scopus 로고
    • Defective DNA repair as a potential mechanism for the rapid development of drug resistance in Plasmodium falciparum
    • Trotta RF, Brown ML, Terrell JC et al. Defective DNA repair as a potential mechanism for the rapid development of drug resistance in Plasmodium falciparum. Biochemistry 2004; 43: 4885-91.
    • (2004) Biochemistry , vol.43 , pp. 4885-4891
    • Trotta, R.F.1    Brown, M.L.2    Terrell, J.C.3
  • 65
    • 0000841123 scopus 로고
    • Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria
    • Peterson DS, Walliker D, Wellems TE. Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Proc Natl Acad Sci USA 1988; 85: 9114-8.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 9114-9118
    • Peterson, D.S.1    Walliker, D.2    Wellems, T.E.3
  • 66
    • 0009745853 scopus 로고
    • Studies on Plasmodium berghei Vincke and Lips, 1948. XXIX. The size of parasite population and its relation to the selection of a strain resistant to sulphadiazine
    • Ramakrishnan SP, Prakash S, Chowdhury DS et al. Studies on Plasmodium berghei Vincke and Lips, 1948. XXIX. The size of parasite population and its relation to the selection of a strain resistant to sulphadiazine. Indian J Malariol 1961; 15: 95-106.
    • (1961) Indian J Malariol , vol.15 , pp. 95-106
    • Ramakrishnan, S.P.1    Prakash, S.2    Chowdhury, D.S.3
  • 67
    • 0014243865 scopus 로고
    • The effect of parasite populations on the curative action of pyrimethamine
    • Martin DC, Arnold JD. The effect of parasite populations on the curative action of pyrimethamine. Trans R Soc Trop Med Hyg 1968; 62: 379-84.
    • (1968) Trans R Soc Trop Med Hyg , vol.62 , pp. 379-384
    • Martin, D.C.1    Arnold, J.D.2
  • 68
    • 0037423830 scopus 로고    scopus 로고
    • The de novo selection of drug-resistant malaria parasites
    • White NJ, Pongtavornpinyo W. The de novo selection of drug-resistant malaria parasites. Proc Biol Sci 2003; 270: 545-54.
    • (2003) Proc Biol Sci , vol.270 , pp. 545-554
    • White, N.J.1    Pongtavornpinyo, W.2
  • 69
    • 33646352709 scopus 로고    scopus 로고
    • Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure
    • Daher W, Biot C, Fandeur T et al. Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure. Malar J 2006; 5: 11.
    • (2006) Malar J , vol.5 , pp. 11
    • Daher, W.1    Biot, C.2    Fandeur, T.3
  • 70
    • 33847624986 scopus 로고    scopus 로고
    • Proteome analysis of new antimalarial endoperoxide against Plasmodium falciparum
    • Aly NS, Hiramoto A, Sanai H et al. Proteome analysis of new antimalarial endoperoxide against Plasmodium falciparum. Parasitol Res 2007; 100: 1119-24.
    • (2007) Parasitol Res , vol.100 , pp. 1119-1124
    • Aly, N.S.1    Hiramoto, A.2    Sanai, H.3
  • 71
    • 62249160684 scopus 로고    scopus 로고
    • Probing the multifactorial basis of Plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE
    • Nkrumah LJ, Riegelhaupt PM, Moura P et al. Probing the multifactorial basis of Plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE. Mol Biochem Parasitol 2009; 165: 122-31.
    • (2009) Mol Biochem Parasitol , vol.165 , pp. 122-131
    • Nkrumah, L.J.1    Riegelhaupt, P.M.2    Moura, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.