Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: Toward combination chemotherapy of malaria through a single chemical entity

Journal of Medicinal Chemistry

Volumn 53, Issue 22, 2010, Pages 8202-8206

  Gibbons, Peter ^a   Verissimo, Edite ^b   Araujo, Nuna C ^b   Barton, Victoria ^a   Nixon, Gemma L ^c   Amewu, Richard K ^a   Chadwick, James ^a   Stocks, Paul A ^c   Biagini, Giancarlo A ^c   Srivastava, Abhishek ^c   Rosenthal, Philip J ^d   Gut, Jiri ^d   Guedes, Rita C ^e   Moreira, Rui ^e   Sharma, Raman ^a,c   Berry, Neil ^a   Cristiano, M Lurdes S ^b   Shone, Alison E ^c   Ward, Stephen A ^c   O'Neill, Paul M ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF ALGARVE   (Portugal)

^c LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 TRIOXOLANE; ANTIMALARIAL AGENT; ARTEMISIN; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; ENDOPEROXIDE; FALCIPAIN 2; FALCIPAIN 3; IRON; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DECOMPOSITION; DRUG STRUCTURE; ENZYME INHIBITION; HYDROGEN BOND; IC 50; MALARIA; NONHUMAN; PHARMACOPHORE; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ANTIMALARIALS; CHALCONES; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ERYTHROCYTES; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PEROXIDES; PLASMODIUM FALCIPARUM; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649526279     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1009567     Document Type: Article

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