The epidemiology of food allergy in Europe: A systematic review and meta-analysis

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 69, Issue 1, 2014, Pages 62-75

  Nwaru, B I ^a   Hickstein, L ^b   Panesar, S S ^c   Muraro, A ^d   Werfel, T ^e   Cardona, V ^f   Dubois, A E J ^g   Halken, S ^h   Hoffmann Sommergruber, K ⁱ   Poulsen, L K ^j   Roberts, G ^k,l,m   Van Ree, R ⁿ   Vlieg Boerstra, B J ^o   Sheikh, A ^c,p  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF PADOVA   (Italy)

^e HANNOVER MEDICAL SCHOOL   (Germany)

^f HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^g UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^h ODENSE UNIVERSITY HOSPITAL   (Denmark)

ⁱ MEDICAL UNIVERSITY OF VIENNA   (Austria)

^j Mental Health Services CPH   (Denmark)

^k ST MARY S HOSPITAL   (United Kingdom)

^l UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^m UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

ⁿ UNIVERSITY OF AMSTERDAM   (Netherlands)

^o ACADEMIC MEDICAL CENTER   (Netherlands)

^p BRIGHAM AND WOMEN S HOSPITAL   (United States)

more..

Author keywords

epidemiology; Europe; food allergy; risk factors; systematic review

Indexed keywords

IMMUNOGLOBULIN E;

ALLERGIC DISEASE; ATOPY; CONTACT SENSITIZATION; DEMOGRAPHY; DISEASE COURSE; EUROPE; FAMILY HISTORY; FOOD ALLERGY; HUMAN; INCIDENCE; MEDICAL HISTORY; PREVALENCE; PRICK TEST; PRIORITY JOURNAL; PROGNOSIS; PROVOCATION TEST; REVIEW; RISK FACTOR; SYSTEMATIC REVIEW;

EPIDEMIOLOGY; EUROPE; FOOD ALLERGY; RISK FACTORS; SYSTEMATIC REVIEW;

EUROPE; FOOD HYPERSENSITIVITY; HUMANS; PREVALENCE; PROGNOSIS; REGISTRIES; RISK FACTORS;

EID: 84892780291     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/all.12305     Document Type: Review

References (95)

1. Deckers IA, McLean S, Linssen S, Mommers M, van Schayck CP, Sheikh A,. Investigating international time trends in the incidence and prevalence of atopic eczema 1990-2010: a systematic review of epidemiological studies. PLoS ONE 2012; 7: e39803.
2. Anandan C, Gupta R, Simpson R, Fischbacher C, Sheikh A,. Epidemiology and disease burden from allergic disease in Scotland: analyses of national databases. J R Soc Med 2009; 102: 431-442.
3. Anandan C, Nurmatov U, van Schayck OC, Sheikh A,. Is the prevalence of asthma declining? Systematic review of epidemiological studies Allergy 2010; 65: 152-167.
4. Gupta R, Sheikh A, Strachan DP, Anderson HR,. Burden of allergic disease in the UK: secondary analyses of national databases. Clin Exp Allergy 2004a; 34: 520-526.
5. Schoenwetter WF, Dupclay L Jr, Appajosyula S, Botteman MF, Pashos CL,. Economic impact and quality of life burden of allergic rhinitis. Curr Med Res Opin 2004; 20: 305-317.
6. Allen JK, Koplin JJ,. The epidemiology of IgE-mediated FA and anaphylaxis. Immunol Allergy Clin N Am 2012; 32: 35-50.
7. Sampson HA,. FA: accurately identifying clinical reactivity. Allergy 2005; 60 (Suppl. 79): 19-24.
8. Prescott S, Allen KJ,. FA: riding the second wave of the allergy epidemic. Pediatr Allergy Immunol 2011; 22: 155-160.
9. Lack G,. Update on risk factors for FA. J Allergy Clin Immunol 2012; 129: 1187-1197.
10. Sicherer SH,. Epidemiology of FA. J Allergy Clin Immunol 2011; 127: 594-602.
11. Johansson SG, Hourihane JO, Bousquet J, Bruijnzeel-Koomen C, Dreborg S, Haahtela T, et al. EAACI (the European Academy of Allergology and Clinical Immunology) nomenclature task force. A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy 2001; 56: 813-824.
12. Masilamani M, Commins S, Shreffler W,. Determinants of FA. Immunol Allergy Clin N Am 2012; 32: 11-33.
13. Burks AW, Tang M, Sicherer S, Muraro A, Eigenmann PA, Ebisawa M, et al. ICON: food allergy. J Allergy Clin Immunol 2012; 129: 906-920.
14. Nwaru BI, Panesar SS, Hickstein L, Rader T, Werfel T, Muraro A, et al. The epidemiology of food allergy in Europe: protocol for a systematic review. Clin Transl Allergy 2013; 3: 13.
15. Newcombe RG,. Two-sided confidence intervals for the single proportion: comparison of seven methods. Stat Med 1998; 17: 857-872.
16. Chafen JJS, Newberry SJ, Riedl MA, Bravata DM, Maglione M, Suttorp MJ, et al. Diagnosing and managing common food allergies: a systematic review. JAMA 2010; 303: 1848-1856.
17. Bant A, Kruszewski J,. Increased sensitization prevalence to common inhalant and food allergens in young adult Polish males. Ann Agric Environ Med 2008; 15: 21-27.
18. Burney P, Summers C, Chinn S, Hooper R, Van Ree R, Lidholm J,. Prevalence and distribution of sensitization to foods in the European Community Respiratory Health Survey: a EuroPrevall analysis. Allergy 2010; 65: 1182-1188.
19. Woods RK, Abramson M, Bailey M, Walters EH,. International prevalences of reported food allergies and intolerances. Comparisons arising from the European community respiratory health survey (ECRHS) 1991-1994. Eur J Clin Nutr 2001; 55: 298-304.
20. Caffarelli C, Coscia A, Ridolo E, Povesi Dascola C, Gelmett C, Raggi V, et al. Parents' estimate of FA prevalence and management in Italian school-aged children. Pediatr Int 2011; 53: 505-510.
21. Colver AF, Nevantaus H, Macdougall CF, Cant AJ,. Severe food-allergic reactions in children across the UK and Ireland, 1998-2000. Acta Paediatr 2005; 94: 689-695.
22. Du Toit G, Katz Y, Sasieni P, Mesher D, Maleki SJ, Fisher HR, et al. Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy. J Allergy Clin Immunol 2008; 122: 984-991.
23. Dubakiene R, Rudzeviciene O, Butiene I, Sezaite I, Petronyte M, Vaicekauskaite D, et al. Studies on early allergic sensitization in the Lithuanian birth cohort. Sci World J 2012; 909524.
24. Eggesbø M, Botten G, Stigum H, Nafstad P, Magnus P,. Is delivery by cesarean section a risk factor for FA? J Allergy Clin Immunol 2003; 112: 420-426.
25. Eggesbø M, Botten G, Halvorsen R, Magnus P,. The prevalence of allergy to egg: a population-based study in young children. Allergy 2001a; 56: 403-411.
26. Eggesbø M, Botten G, Halvorsen R, Magnus P,. The prevalence of CMA/CMPI in young children: The validity of parentally perceived reactions in a population-based study. Allergy 2001b; 56: 393-402.
27. Eller E, Kjaer HF, Host A, Andersen KE, Bindslev-Jensen C,. FA and food sensitization in early childhood: Results from the DARC cohort. Allergy 2009; 64: 1023-1029.
28. Kjaer HF, Eller E, Host A, Andersen KE, Bindslev-Jensen C,. The prevalence of allergic diseases in an unselected group of 6-year-old children. The DARC birth cohort study. Pediatr Allergy Immunol 2008; 19: 737-745.
29. Johnke H, Norberg LA, Vach W, Host A, Andersen KE,. Patterns of sensitization in infants and its relation to atopic dermatitis. Pediatr Allergy Immunol 2006; 17: 591-600.
30. Falcao H, Lunet N, Lopes C, Barros H,. Food hypersensitivity in Portuguese adults. Eur J Clin Nutr 2004; 58: 1621-1625.
31. Flokstra-de Blok BMJ, Doriene van Ginkel C, Roerdink EM, Kroeze MAJM, Stel AA, van der Meulen GN, et al. Extremely low prevalence of epinephrine autoinjectors in high-risk food-allergic adolescents in Dutch high schools. Pediatr Allergy Immunol 2011; 22: 374-377.
32. Fox AT, Sasieni P, du Toit G, Syed H, Lack G,. Household peanut consumption as a risk factor for the development of peanut allergy. J Allergy Clin Immunol 2009; 123: 417-423.
33. Frongia O, Bellomo AR, Di Giorgio G, Fiumalbi C, Frizza J, Maresca C, et al. Food allergies and intolerance in infants and children. [Italian] Intolleranze e allergie alimentari nella prima infanzia. Medico e Bambino 2005; 24: 533-538.
34. Gelincik A, Buyukozturk S, Gul H, Isik E, Issever H, Ozseker F, et al. Confirmed prevalence of FA and non-allergic food hypersensitivity in a Mediterranean population. Clin Exp Allergy 2008; 38: 1333-1341.
35. Grundy J, Matthews S, Bateman B, Dean T, Arshad SH,. Rising prevalence of allergy to peanut in children: data from 2 sequential cohorts. J Allergy Clin Immunol 2002; 110: 784-789.
36. Gupta R, Sheikh A, Strachan DP, Anderson HR,. Time trends in allergic disorders in the UK. Thorax 2007; 62: 91-96.
37. Gupta R, Sheikh A, Strachan DP, Anderson HR,. Burden of allergic disease in the UK: secondary analyses of national databases. Clin Exp Allergy 2004b; 34: 520-526.
38. Gupta R, Sheikh A, Strachan DP, Anderson HR,. Increasing hospital admissions for systemic allergic disorders in England: analysis of national admissions data. BMJ 2003; 327: 1142-1143.
39. Host A, Halken S, Jacobsen HP, Christensen AE, Herskind AM, Plesner K,. Clinical course of cow's milk protein allergy/intolerance and atopic diseases in childhood. Pediatr Allergy Immunol 2002; 13: 23-28.
40. Hourihane JO, Aiken R, Briggs R, Gudgeon LA, Grimshaw KEC, DunnGalvin A, et al. The impact of government advice to pregnant mothers regarding peanut avoidance on the prevalence of peanut allergy in United Kingdom children at school entry. J Allergy Clin Immunol 2007; 119: 1197-1202.
41. Isolauri E, Huurre A, Salminen S, Impivaara O,. The allergy epidemic extends beyond the past few decades. Clin Exp Allergy 2004; 34: 1007-1010.
42. Johansson SGO, Nopp A, Florvaag E, Lundahl J, Soderstrom T, Guttormsen AB, et al. High prevalence of IgE antibodies among blood donors in Sweden and Norway. Allergy 2005; 60: 1312-1315.
43. Julge K, Vasar M, Bjorksten B,. Development of allergy and IgE antibodies during the first five years of life in Estonian children. Clin Exp Allergy 2001; 31: 1854-1861.
44. Vasar M, Julge K, Bjorksten B,. Development of atopic sensitization and allergic diseases in early childhood. Acta Paediatri 2000; 89: 523-527.
45. Kanny G, Moneret-Vautrin DA, Flabbee J, Beaudouin E, Morisset M, Thevenin F,. Population study of FA in France. J Allergy Clin Immunol 2001; 108: 133-140.
46. Kotz D, Simpson CR, Sheikh A,. Incidence, prevalence, and trends of general practitioner-recorded diagnosis of peanut allergy in England, 2001 to 2005. J Allergy Clin Immunol 2011; 127: 623-630. [Correction added on 7 January 2014, after first online publication: page range corrected.]
47. Krause TG, Koch A, Poulsen LK, Kristensen B, Olsen OR, Melbye M,. Atopic sensitization among children in an Arctic environment. Clin Exp Allergy 2002; 32: 367-372.
48. Kristinsdottir H, Clausen M, Ragnarsdottir HS, Halldorsdottir IH, McBride D, Beyer K, et al. [Prevalence of FA in Icelandic infants during first year of life]. [Icelandic] Algengi faeduofnaemis hja islenskum bornum a fyrsta ari. Laeknabladid 2011; 97: 11-18.
49. Kucukosmanoglu E, Yazi D, Yesil O, Akkoc T, Gezer M, Bakirci N, et al. Prevalence of egg sensitization in Turkish infants based on skin prick test. Allergol Immunopathol 2008; 36: 141-144.
50. Kurukulaaratchy RJ, Matthews S, Arshad SH,. Defining childhood atopic phenotypes to investigate the association of atopic sensitization with allergic disease. Allergy 2005; 60: 1280-1286.
51. Arshad SH, Tariq SM, Matthews S, Hakim E,. Sensitization to common allergens and its association with allergic disorders at age 4 years: a whole population birth cohort study. Pediatrics 2001; 108: e33.
52. Tariq SM, Matthews SM, Hakim EA, Arshad SH,. Egg allergy in infancy predicts respiratory allergic disease by 4 years of age. Pediatr Allergy Immunol 2000; 11: 162-167.
53. Kvenshagen B, Halvorsen R, Jacobsen M,. Is there an increased frequency of FA in children delivered by caesarean section compared to those delivered vaginally? Acta Paediatr 2009; 98: 324-327.
54. Majkowska-Wojciechowska B, Wardzynska A, Luczynska M, Kowalski MK, Makowska J, Kowalski ML,. Food hypersensitivity in the population of school children in Lodz-Results of the "EuroPrevall" surveys. Alergia Astma Immunologia 2009; 14: 35-44.
55. Marklund B, Ahlstedt S, Nordström G,. Health-related quality of life among adolescents with allergy-like conditions: with emphasis on food hypersensitivity. Health Qual Life Outcomes 2004; 2: 65.
56. Matricardi PM, Bockelbrink A, Beyer K, Keil T, Niggemann B, Gruber C, et al. Primary versus secondary immunoglobulin e sensitization to soy and wheat in the Multi-Centre Allergy Study cohort. Clin Exp Allergy 2008; 38: 493-500.
57. Mossakowska M, Pawlinska-Chmara R, Broczek KM,. Asthma, allergy, and respiratory symptoms in centenarians living in Poland. J Physiol Pharmacol 2008; 59 (Suppl. 6): 483-489.
58. Nicolaou N, Poorafshar M, Murray C, Simpson A, Winell H, Kerry G, et al. Allergy or tolerance in children sensitized to peanut: prevalence and differentiation using component-resolved diagnostics. J Allergy Clin Immunol 2010; 125: 191-197.
59. Niggemann B, Schmitz R, Schlaud M,. The high prevalence of peanut sensitization in childhood is due to cross-reactivity to pollen. Allergy 2011; 66: 980-981.
60. Orhan F, Karakas T, Cakir M, Aksoy A, Baki A, Gedik Y,. Prevalence of immunoglobulin E-mediated FA in 6-9-year-old urban schoolchildren in the eastern Black Sea region of Turkey. Clin Exp Allergy 2009; 39: 1027-1035.
61. Ostblom E, Lilja G, Ahlstedt S, van Hage M, Wickman M,. Patterns of quantitative food-specific IgE-antibodies and reported food hypersensitivity in 4-year-old children. Allergy 2008a; 63: 418-424.
62. Ostblom E, Lilja G, Pershagen G, Van Hage M, Wickman M,. Phenotypes of food hypersensitivity and development of allergic diseases during the first 8 years of life. Clin Exp Allergy 2008b; 38: 1325-1332.
63. Ostblom E, Wickman M, van Hage M, Lilja G,. Reported symptoms of food hypersensitivity and sensitization to common foods in 4-year-old children. Acta Paediatr 2008c; 97: 85-90.
64. Almqvist C, Pershagen G, Wickman M,. Low socioeconomic status as a risk factor for asthma, rhinitis and sensitization at 4 years in a birth cohort. Clin Exp Allergy 2005; 35: 612-618.
65. Osterballe M, Mortz CG, Hansen TK, Andersen KE, Bindslev-Jensen C,. The prevalence of food hypersensitivity in young adults. Pediatr Allergy Immunol 2009; 20: 686-692.
66. Osterballe M, Hansen TK, Mortz CG, Host A, Bindslev-Jensen C,. The prevalence of food hypersensitivity in an unselected population of children and adults. Pediatr Allergy Immunol 2005; 16: 567-573.
67. Penard-Morand C, Raherison C, Kopferschmitt C, Caillaud D, Lavaud F, Charpin D, et al. Prevalence of FA and its relationship to asthma and allergic rhinitis in schoolchildren. Allergy 2005; 60: 1165-1171.
68. Pereira B, Venter C, Grundy J, Clayton CB, Arshad SH, Dean T,. Prevalence of sensitization to food allergens, reported adverse reaction to foods, food avoidance, and food hypersensitivity among teenagers. J Allergy Clin Immunol 2005; 116: 884-892.
69. Pyrhönen K, Hiltunen L, Kaila M, Nayha S, Laara E,. Heredity of food allergies in an unselected child population: an epidemiological survey from Finland. Pediatr Allergy Immunol 2011; 22: e124-e132.
70. Pyrhönen K, Nayha S, Kaila M, Hiltunen L, Laara E,. Occurrence of parent-reported food hypersensitivities and food allergies among children aged 1-4 yr. Pediatr Allergy Immunol 2009; 20: 328-338.
71. Pyziak K, Kamer B,. Natural history of IgE-dependent FA diagnosed in children during the first three years of life. Adv Med Sci 2011; 56: 48-55.
72. Rance F, Grandmottet X, Grandjean H,. Prevalence and main characteristics of schoolchildren diagnosed with food allergies in France. Clin Exp Allergy 2005; 35: 167-172.
73. Roberts G, Peckitt C, Northstone K, Strachan D, Lack G, Henderson J, et al. Relationship between aeroallergen and food allergen sensitization in childhood. Clin Exp Allergy 2005; 35: 933-940.
74. Lack G, Fox D, Northstone K, Golding J,. Factors associated with the development of peanut allergy in childhood. N Engl J Med 2003; 348: 977-985.
75. Rona RJ, Keil T, Summers C, Gislason D, Zuidmeer L, Sodergren E, et al. The prevalence of FA: A meta-analysis. J Allergy Clin Immunol 2007; 120: 638-646.
76. Ronchetti R, Jesenak M, Trubacova D, Pohanka V, Villa MP,. Epidemiology of atopy patch tests with food and inhalant allergens in an unselected population of children. Pediatr Allergy Immunol 2008; 19: 599-604.
77. Sandin A, Annus T, Bjorksten B, Nilsson L, Riikjarv MA, van Hage-Hamsten M, et al. Prevalence of self-reported FA and IgE antibodies to food allergens in Swedish and Estonian schoolchildren. Eur J Clin Nutr 2005; 59: 399-403.
78. Soost S, Leynaert B, Almqvist C, Edenharter G, Zuberbier T, Worm M,. Risk factors of adverse reactions to food in German adults. Clin Exp Allergy 2009; 39: 1036-1044.
79. Roehr CC, Edenharter G, Reimann S, Ehlers I, Worm M, Zuberbier T, et al. FA and non-allergic food hypersensitivity in children and adolescents. Clin Exp Allergy 2004; 34: 1534-1541.
80. Zuberbier T, Edenharter G, Worm M, Ehlers I, Reimann S, Hantke T, et al. Prevalence of adverse reactions to food in Germany-A population study. Allergy 2004; 59: 338-345.
81. Schnabel E, Sausenthaler S, Schaaf B, Schafer T, Lehmann I, Behrendt H, et al. Prospective association between food sensitization and FA: results of the LISA birth cohort study. Clin Exp Allergy 2010; 40: 450-457.
82. Schafer T, Bohler E, Ruhdorfer S, Weigl L, Wessner D, Heinrich J, et al. Epidemiology of FA/food intolerance in adults: associations with other manifestations of atopy. Allergy 2001; 56: 1172-1179.
83. Steinke M, Fiocchi A, Kirchlechner V, Ballmer-Weber B, Brockow K, Hischenhuber C, et al. Perceived FA in children in 10 European nations: a randomised telephone survey. Int Arch Allergy Immunol 2007; 143: 290-295.
84. Venter C, Hasan Arshad S, Grundy J, Pereira B, Bernie Clayton C, Voigt K, et al. Time trends in the prevalence of peanut allergy: three cohorts of children from the same geographical location in the UK. Allergy 2010; 65: 103-108.
85. Venter C, Pereira B, Voigt K, Grundy J, Clayton CB, Higgins B, et al. Prevalence and cumulative incidence of food hypersensitivity in the first 3 years of life. Allergy 2008; 63: 354-359.
86. Dean T, Venter C, Pereira B, Arshad SH, Grundy J, Clayton CB, et al. Patterns of sensitization to food and aeroallergens in the first 3 years of life. J Allergy Clin Immunol 2007; 120: 1166-1171.
87. Venter C, Pereira B, Grundy J, Clayton CB, Roberts G, Higgins B, et al. Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life. J Allergy Clin Immunol 2006a; 117: 1118-1124.
88. Venter C, Pereira B, Grundy J, Clayton CB, Arshad SH, Dean T,. Prevalence of sensitization reported and objectively assessed food hypersensitivity amongst six-year-old children: a population-based study. Pediatr Allergy Immunol 2006b; 17: 356-363.
89. Von Hertzen L, Makela MJ, Petays T, Jousilahti P, Kosunen TU, Laatikainen T, et al. Growing disparities in atopy between the Finns and the Russians: a comparison of 2 generations. J Allergy Clin Immunol 2006; 117: 151-157.
90. Zuidmeer L, Goldhahn K, Rona RJ, Gislason D, Madsen C, Summers C, et al. The prevalence of plant food allergies: A systematic review. J Allergy Clin Immunol 2008; 121: 1210-1218. [Correction added on 7 January 2014, after first online publication: page range corrected.]
91. Martens M, Schnoor HJ, Malling H-J, Poulsen LK,. The clinical relevance of in vivo/in vitro tests for cereal and peanut sensitization in grass pollen allergic patients. Clin Transl Allergy 2011; 1: 15.
92. Wang J, Calatroni A, Visness CM, Sampson HA,. Correlation of specific IgE to shrimp with cockroach and dust mite exposure and sensitization in an inner-city population. J Allergy Clin Immunol 2011; 128: 834-837.
93. Sidenius KE, Hallas TE, Poulsen LK, Mosbech H,. Allergen cross-reactivity between house-dust mites and other invertebrates. Allergy 2001; 56: 723-733.
94. The EAACI Food Allergy and Anaphylaxis Public Declaration: http://www.anaphylaxisireland.ie/wp-content/uploads/2013/04/ FoodAllergyAnaphylaxisPublic DeclarationCombined-1.pdf (Accessed 27 May 2013).
95. Papadopoulos NG, Agache I, Bavbek S, Bilo BM, Braido F, Cardona V, et al. Research needs in allergy: an EAACI position paper, in collaboration with EFA. Clin Transl Allergy 2012; 2: 21.