Research needs in allergy: An EAACI position paper, in collaboration with EFA

Clinical and Translational Allergy

Volumn 2, Issue 1, 2012, Pages

  Papadopoulos, Nikolaos G ^a   Agache, Ioana ^b   Bavbek, Sevim ^c   Bilo, Beatrice M ^d   Braido, Fulvio ^e   Cardona, Victoria ^f   Custovic, Adnan ^g   DeMonchy, Jan ^h   Demoly, Pascal ⁱ   Eigenmann, Philippe ^j   Gayraud, Jacques ^k   Grattan, Clive ^l   Heffler, Enrico ^m   Hellings, Peter W ⁿ   Jutel, Marek ^o   Knol, Edward ^p   Lötvall, Jan ^q   Muraro, Antonella ^r   Poulsen, Lars K ^s   Roberts, Graham ^t   Schmid Grendelmeier, Peter ^u   Skevaki, Chrysanthi ^a   Triggiani, Massimo ^v   VanRee, Ronald ^w   Werfel, Thomas ^x   Flood, Breda ^y   Palkonen, Susanna ^y   Savli, Roberta ^y   Allegri, Pia ^z   Annesi Maesano, Isabella ^aa   Annunziato, Francesco ^ab   Antolin Amerigo, Dario ^ac   Apfelbacher, Christian ^ad,dg   Blanca, Miguel ^ae   Bogacka, Ewa ^o   Bonadonna, Patrizia ^af   Bonini, Matteo ^ag   Boyman, Onur ^u   Brockow, Knut ^ah   Burney, Peter ^ai   Buters, Jeroen ^aj   Butiene, Indre ^ak   Calderon, Moises ^al   Cardell, Lars Olaf ^am   Caubet, Jean Christoph ^an   Celenk, Sevcan ^ao   Cichocka Jarosz, Ewa ^ap   Cingi, Cemal ^aq   Couto, Mariana ^ar   DeJong, Nicolette ^as   Del Giacco, Stefano ^at   Douladiris, Nikolaos ^a   Fassio, Filippo ^au   Fauquert, Jean Luc ^av   Fernandez, Javier ^aw   Rivas, Montserrat Fernandez ^ax   Ferrer, Marta ^ay   Flohr, Carsten ^az   Gardner, James ^ba   Genuneit, Jon ^bb   Gevaert, Philippe ^bc   Groblewska, Anna ^bd   Hamelmann, Eckard ^be   Hoffmann, Hans Jürgen ^bf   Hoffmann Sommergruber, Karin ^bg   Hovhannisyan, Lilit ^bh   Hox, Valérie ⁿ   Jahnsen, Frode L ^bi   Kalayci, Ömer ^bj   Kalpaklioglu, Ayse Füsun ^bk   Kleine Tebbe, Jörg ^bk   Konstantinou, George ^bl   Kurowski, Marcin ^bm   Lau, Susanne ^bn   Lauener, Roger ^bo   Lauerma, Antti ^bp   Logan, Kirsty ^bq   Magnan, Antoine ^br   Makowska, Joanna ^bs   Makrinioti, Heidi ^ai   Mangina, Paraskevi ^a   Manole, Felicia ^bt   Mari, Adriano ^bu   Mazon, Angel ^bv   Mills, Clare ^g   Mingomataj, Ervin Ç ^bw   Niggemann, Bodo ^bx   Nilsson, Gunnar ^by   Ollert, Markus ^ah   O'Mahony, Liam ^u   O'Neil, Serena ^q   Pala, Gianni ^bz   Papi, Alberto ^ca   Passalacqua, Gianni ^cb   Perkin, Michael ^br   Pfaar, Oliver ^cc   Pitsios, Constantinos ^cd   Quirce, Santiago ^ce   Raap, Ulrike ^x   Raulf Heimsoth, Monika ^cf   Rhyner, Claudio ^ca   Robson Ansley, Paula ^cg   Alves, Rodrigo Rodrigues ^ch   Roje, Zeljka ^ci   Rondon, Carmen ^cj   Rudzeviciene, Odilija ^ak   Ruëff, Franziska ^ck   Rukhadze, Maia ^cl   Rumi, Gabriele ^cm   Sackesen, Cansin ^bj   Santos, Alexandra F ^cn,co   Santucci, Annalisa ^cp   Scharf, Christian ^cq   Schmidt Weber, Carsten ^cr   Schnyder, Benno ^cs   Schwarze, Jürgen ^ct   Senna, Gianenrico ^cu   Sergejeva, Svetlana ^cv   Seys, Sven ^cw   Siracusa, Andrea ^cx   Skypala, Isabel ^al   Sokolowska, Milena ^cy   Spertini, Francois ^cz   Spiewak, Radoslaw ^da   Sprikkelman, Aline ^db   Sturm, Gunter ^dc   Swoboda, Ines ^bg   Terreehorst, Ingrid ^w   Toskala, Elina ^dd   Traidl Hoffmann, Claudia ^ah   Venter, Carina ^de   Vlieg Boerstra, Berber ⁿ   Whitacker, Paul ^df   Worm, Margitta ^bn   Xepapadaki, Paraskevi ^a   Akdis, Cezmi A ^u   more..

^a UNIVERSITY OF ATHENS   (Greece)

^b TRANSILVANIA UNIVERSITY OF BRASOV   (Romania)

^c ANKARA UNIVERSITY   (Turkey)

^d OSPEDALI RIUNITI   (Italy)

^e UNIVERSITY OF GENOA   (Italy)

^f HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^g UNIVERSITY OF MANCHESTER   (United Kingdom)

^h UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

ⁱ MONTPELLIER UNIVERSITY HOSPITAL   (France)

^j Children's Hospital of Geneva   (Switzerland)

^k Polyclinique de LOrmeau   (France)

^l NORFOLK AND NORWICH UNIVERSITY HOSPITAL   (United Kingdom)

^m UNIVERSITY OF TURIN   (Italy)

ⁿ UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^o WROCLAW MEDICAL UNIVERSITY   (Poland)

^p UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^q Krefting Research Centre   (Sweden)

^r UNIVERSITY OF PADOVA   (Italy)

^s GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^t UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^u UNIVERSITY OF ZURICH   (Switzerland)

^v UNIVERSITY OF SALERNO   (Italy)

^w ACADEMIC MEDICAL CENTER   (Netherlands)

^x HANNOVER MEDICAL SCHOOL   (Germany)

^y EFA European Federation of Allergy and Airways Diseases Patients' Associations   (Belgium)

^z Rapallo Hospital   (Italy)

^aa SORBONNE UNIVERSITÉ   (France)

^ab UNIVERSITY OF FLORENCE   (Italy)

^ac HOSPITAL UNIVERSITARIO PRÍNCIPE DE ASTURIAS   (Spain)

^ad UNIVERSITY OF REGENSBURG   (Germany)

^ae Hospital Carlos Maya   (Italy)

^af UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^ag SAPIENZA UNIVERSITY OF ROME   (Italy)

^ah TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^ai IMPERIAL COLLEGE LONDON   (United Kingdom)

^aj INSTITUTE OF EPIDEMIOLOGY   (Germany)

^ak VILNIUS UNIVERSITY   (Lithuania)

^al ROYAL BROMPTON HOSPITAL   (United Kingdom)

^am KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^an GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^ao ULUDAG UNIVERSITY   (Turkey)

^ap JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^aq ESKISEHIR OSMANGAZI UNIVERSITY   (Turkey)

^ar Centro Hospitalar Universitário de São João   (Portugal)

^as ERASMUS MEDICAL CENTER   (Netherlands)

^at UNIVERSITY OF CAGLIARI   (Italy)

^au CAREGGI UNIVERSITY HOSPITAL   (Italy)

^av UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

^aw MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^ax HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^ay UNIVERSITY OF NAVARRA   (Spain)

^az ST THOMAS HOSPITAL   (United Kingdom)

^ba ROYAL FREE HOSPITAL   (United Kingdom)

^bb UNIVERSITY OF ULM   (Germany)

^bc GHENT UNIVERSITY HOSPITAL   (Belgium)

^bd POLISH MOTHER S MEMORIAL HOSPITAL RESEARCH INSTITUTE   (Poland)

^be ST JOSEF HOSPITAL   (Germany)

^bf AARHUS UNIVERSITY HOSPITAL   (Denmark)

^bg MEDICAL UNIVERSITY OF VIENNA   (Austria)

^bh INSTITUTE OF MOLECULAR BIOLOGY   (Armenia)

^bi OSLO UNIVERSITY HOSPITAL   (Norway)

^bj HACETTEPE UNIVERSITY   (Turkey)

^bk Allergie und Asthma Zentrum Westend Berlin   (Germany)

^bl 424 General Army Hospital   (Greece)

^bm MEDICAL UNIVERSITY OF LODZ   (Poland)

^bn CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^bo Hochgebirgsklinik   (Switzerland)

^bp HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^bq KING'S COLLEGE LONDON   (United Kingdom)

^br L INSTITUT DU THORAX   (France)

^bs L'Institut du Thorax ^*  (Poland)

^bt UNIVERSITY OF ORADEA   (Romania)

^bu LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^bv HOSPITAL UNIVERSITARIO LA FE   (Spain)

^bw Mother Theresa School of Medicine   (Albania)

^bx DRK KLINIKEN BERLIN WESTEND   (Germany)

^by KAROLINSKA INSTITUTE   (Sweden)

^bz IRCCS   (Italy)

^ca UNIVERSITY OF FERRARA   (Italy)

^cb DIMI Padiglione Maragliano   (Italy)

^cc UNIVERSITY OF HEIDELBERG   (Germany)

^cd HAROKOPIO UNIVERSITY   (Greece)

^ce HOSPITAL UNIVERSITARIO LA PAZ IDIPAZ   (Spain)

^cf RUHR UNIVERSITY BOCHUM   (Germany)

^cg NORTHUMBRIA UNIVERSITY   (United Kingdom)

^ch HOSPITAL DO DIVINO ESPÍRITO SANTO   (Portugal)

^ci UNIVERSITY HOSPITAL SPLIT   (Croatia)

^cj HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^ck UNIVERSITY OF MUNICH   (Germany)

^cl Center of Allergy and Immunology   (Georgia)

^cm University Hospital Split ^*  (Italy)

^cn KING'S COLLEGE LONDON   (United Kingdom)

^co CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^cp Rimini Infermi Hospital   (Italy)

^cq Medical University of Greifswald   (Germany)

^cr TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^cs UNIVERSITY OF BERN   (Switzerland)

^ct UNIVERSITY OF EDINBURGH   (United Kingdom)

^cu Azienda Ospedaliero Universitaria   (Italy)

^cv UNIVERSITY OF TARTU   (Estonia)

^cw UNIVERSITY OF LEUVEN   (Belgium)

^cx UNIVERSITY OF PERUGIA   (Italy)

^cy NATIONAL INSTITUTES OF HEALTH   (United States)

^cz LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^da JAGIELLONIAN UNIVERSITY   (Poland)

^db EMMA CHILDREN S HOSPITAL   (Netherlands)

^dc MEDICAL UNIVERSITY OF GRAZ   (Austria)

^dd TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^de David Hide Asthma and Allergy Research Centre   (United Kingdom)

^df Department of Otolaryngology   (United Kingdom)

^dg BRIGHTON AND SUSSEX MEDICAL SCHOOL   (United Kingdom)

more..

Author keywords

Allergic diseases; Allergy; Europe; Policy; Research funding; Research needs

Indexed keywords

CYTOKINE;

AIR POLLUTION; AIRBORNE PARTICLE; ALLERGY; ASTHMA; BIOTECHNOLOGY; CHILDHOOD; CHRONIC DISEASE; CLINICAL PRACTICE; DIETARY INTAKE; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG HYPERSENSITIVITY; ENVIRONMENTAL FACTOR; EPIDEMIOLOGICAL DATA; EYE ALLERGY; FOOD ALLERGY; HEALTH CARE ORGANIZATION; HEALTH SERVICE; HELPER CELL; HUMAN; IMMUNE RESPONSE; IMMUNOLOGY; IMMUNOTHERAPY; INFECTION; INSECT STING; INTERNATIONAL COOPERATION; MOLECULAR BIOLOGY; NONHUMAN; NUTRITION; OCCUPATIONAL ALLERGY; PATHOPHYSIOLOGY; PATIENT REPORTED OUTCOME; PHENOTYPE; PRIORITY JOURNAL; REVIEW; RHINITIS; SKIN ALLERGY; SPORT; TREATMENT OUTCOME;

EID: 84988375083     PISSN: None     EISSN: 20457022     Source Type: Journal    
DOI: 10.1186/2045-7022-2-21     Document Type: Review

References (141)

1. World Health Organization FSn307. http://www.who.int/mediacentre/factsheets/fs307/en/index.html.
2. Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, Weiland SK, Williams H: Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 2006, 368(9537):733-743.
3. European Federation of Allergy and Airway diseases, Patients Associations, (EFA): Fighting for breath. http://wwwefanetorg/activities/documents/Fighting-For-Breath1pdf.
4. Jarvis D, Burney P: ABC of allergies. The epidemiology of allergic disease. BMJ 1998, 316(7131):607-610.
5. European Community Respiratory Health Survey: Variations in the prevalence of respiratory symptoms, selfreported asthma attacks and the use of asthma medication in the European Community respiratory health survey (ECRHS). Eur Respir J 1996, 9:687-695.
6. E V: EFA Book on Respiratory Allergies - Raise Awareness, Relieve the Burden. http://wwwefanetorg/documents/EFABookonRespiratoryAllergiesFINALpdf] 2011.
7. Wertz DA, Pollack M, Rodgers K, Bohn RL, Sacco P, Sullivan SD: Impact of asthma control on sleep, attendance at work, normal activities, and disease burden. Ann Allergy Asthma Immunol 2010, 105(2):118-123.
8. European Respiratory Society, [ERS]: European Lung Book. The First Comprehensive Survey on Respiratory Health in Europe.
9. Foundation EL: Economic Impact of Lung Diseases. 2011.
10. Verboom P, Hakkaart-Van L, Sturkenboom M, De Zeeuw R, Menke H, Rutten F: The cost of atopic dermatitis in the Netherlands: an international comparison. Br J Dermatol 2002, 147(4):716-724.
11. Mancini AJ, Kaulback K, Chamlin SL: The socioeconomic impact of atopic dermatitis in the United States: a systematic review. Pediatr Dermatol 2008, 25(1):1-6.
12. Council of the European Union: Council conclusions on prevention, early diagnosis and treatment of chronic respiratory diseases in children. http://wwwconsiliumeuropaeu/uedocs/cms-Data/docs/pressdata/en/lsa/126522pdf.
13. Kauppi P, Linna M, Martikainen J, Makela MJ, Haahtela T: Follow-up of the Finnish Asthma Programme 2000-2010: reduction of hospital burden needs risk group rethinking. Thorax 2012, [Epub ahead of print] PMID 22504963.
14. Beasley RKU, von Mutius E, Pearce N, International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee: Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet 1998, 351:1225-1232.
15. Sunyer J, Anto JM, Tobias A, Burney P: Generational increase of self-reported first attack of asthma in fifteen industrialized countries. European Community Respiratory Health Study (ECRHS). Eur Respir J 1999, 14(4):885-891.
16. Bousquet J, Kauffmann F, Demoly P, Leynaert B, Bousquet PJ, Demenais F, Lenzen G, Burney PG, Zuberbier T, Van Cauwenberge P: [GA2LEN (Global Allergy and Asthma European Network)]. Rev Mal Respir 2009, 26(6):577-586.
17. Burney P, Summers C, Chinn S, Hooper R, van Ree R, Lidholm J: Prevalence and distribution of sensitization to foods in the European Community Respiratory Health Survey: a EuroPrevall analysis. Allergy 2010, 65(9):1182-1188.
18. von Mutius E, Vercelli D: Farm living: effects on childhood asthma and allergy. Nat Rev Immunol 2010, 10(12):861-868.
19. Brown SJ, Asai Y, Cordell HJ, Campbell LE, Zhao Y, Liao H, Northstone K, Henderson J, Alizadehfar R, Ben-Shoshan M, et al: Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy. J Allergy Clin Immunol 2011, 127(3):661-667.
20. Akdis CA, Akdis M, Trautmann A, Blaser K: Immune regulation in atopic dermatitis. Curr Opin Immunol 2000, 12:641-646.
21. Larche M, Akdis CA, Valenta R: Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol 2006, 6(10):761-771.
22. Gilles S, Fekete A, Zhang X, Beck I, Blume C, Ring J, Schmidt-Weber C, Behrendt H, Schmitt-Kopplin P, Traidl-Hoffmann C: Pollen metabolome analysis reveals adenosine as a major regulator of dendritic cell-primed T(H) cell responses. J Allergy Clin Immunol 2011, 127(2):454-461.
23. Basinski TM, Holzmann D, Eiwegger T, Zimmermann M, Klunker S, Meyer N, Schmid-Grendelmeier P, Jutel M, Akdis CA: Dual nature of T cell-epithelium interaction in chronic rhinosinusitis. J Allergy Clin Immunol 2009, 124(1):74-80. e71-78.
24. Akdis CA: Allergy and hypersensitivity: mechanisms of allergic disease. Curr Opin Immunol 2006, 18(6):718-726.
25. Hammad H, Chieppa M, Perros F, Willart MA, Germain RN, Lambrecht BN: House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nat Med 2009, 15(4):410-416.
26. Mjosberg JM, Trifari S, Crellin NK, Peters CP, van Drunen CM, Piet B, Fokkens WJ, Cupedo T, Spits H: Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161. Nat Immunol 2011, 12(11):1055-1062.
27. Strid J, Sobolev O, Zafirova B, Polic B, Hayday A: The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy. Science 2011, 334(6060):1293-1297.
28. Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI: Human nutrition, the gut microbiome and the immune system. Nature 2011, 474(7351):327-336.
29. Ashe A, Sapetschnig A, Weick EM, Mitchell J, Bagijn MP, Cording AC, Doebley AL, Goldstein LD, Lehrbach NJ, Le Pen J, et al: PiRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans. Cell 2012, 150(1):88-99.
30. Eyerich S, Eyerich K, Pennino D, Carbone T, Nasorri F, Pallotta S, Cianfarani F, Odorisio T, Traidl-Hoffmann C, Behrendt H, et al: Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest 2009, 119(12):3573-3585.
31. Burgler S, Ouaked N, Bassin C, Basinski TM, Mantel PY, Siegmund K, Meyer N, Akdis CA, Schmidt-Weber CB: Differentiation and functional analysis of human T(H)17 cells. J Allergy Clin Immunol 2009, 123(3):588-595.
32. Stassen M, Schmitt E, Bopp T: From interleukin-9 to T helper 9 cells. Ann N Y Acad Sci 2012, 1247:56-68.
33. Wisniewski JA, Borish L: Novel cytokines and cytokine-producing T cells in allergic disorders. Allergy Asthma Proc 2011, 32(2):83-94.
34. Akdis CA: Therapies for allergic inflammation: refining strategies to induce tolerance. Nat Med 2012, 18(5):736-749.
35. Pelaia G, Renda T, Romeo P, Busceti MT, Maselli R: Omalizumab in the treatment of severe asthma: efficacy and current problems. Ther Adv Respir Dis 2008, 2(6):409-421.
36. Wenzel SE: Eosinophils in asthma-closing the loop or opening the door? N Engl J Med 2009, 360.
37. Eberlein B, Krischan L, Darsow U, Ollert M, Ring J: Double positivity to bee and wasp venom: Improved diagnostic procedure by recombinant allergen-based IgE testing and basophil activation test including data about cross-reactive carbohydrate determinants. J Allergy Clin Immunol 2012, 14:14.
38. Harwanegg C, Hiller R: Protein microarrays in diagnosing IgE-mediated diseases: spotting allergy at the molecular level. Expert Rev Mol Diagn 2004, 4(4):539-548.
39. Scala E, Alessandri C, Bernardi ML, Ferrara R, Palazzo P, Pomponi D, Quaratino D, Rasi C, Zaffiro A, Zennaro D, et al: Cross-sectional survey on immunoglobulin E reactivity in 23, 077 subjects using an allergenic molecule-based microarray detection system. Clin Exp Allergy 2010, 40(6):911-921.
40. Hoffmann HJ, Bogebjerg M, Nielsen LP, Dahl R: Lysis with Saponin improves detection of the response through CD203c and CD63 in the basophil activation test after crosslinking of the high affinity IgE receptor FcepsilonRI. Clin Mol Allergy 2005, 3:10.
41. Ebo DG, Bridts CH, Hagendorens MM, Mertens CH, De Clerck LS, Stevens WJ: Flowassisted diagnostic management of anaphylaxis from rocuronium bromide. Allergy 2006, 61(8):935-939.
42. El-Ghaiesh S, Monshi MM, Whitaker P, Jenkins R, Meng X, Farrell J, Elsheikh A, Peckham D, French N, Pirmohamed M, et al: Characterization of the antigen specificity of T-cell clones from piperacillin-hypersensitive patients with cystic fibrosis. J Pharmacol Exp Ther 2012, 341(3):597-610.
43. Patrick DL, Burke LB, Powers JH, Scott JA, Rock EP, Dawisha S, O'Neill R, Kennedy DL: Patient-reported outcomes to support medical product labeling claims: FDA perspective. Value Health 2007, 10(Suppl 2):S125-137.
44. Baiardini I, Bousquet PJ, Brzoza Z, Canonica GW, Compalati E, Fiocchi A, Fokkens W, van Wijk RG, La Grutta S, Lombardi C, et al: Recommendations for assessing patientreported outcomes and health-related quality of life in clinical trials on allergy: a GA(2)LEN taskforce position paper. Allergy 2010, 65(3):290-295.
45. European Medicines Agency, Committee for medicinal products for human use, (CHMP): Reflection paper on the regulatory guidance for the use of health-related quality of life (HROL) measures in the evaluation of medicinal products. European Medicines Agency website 2005, (cited 2007 April) 2005.
46. US Department of Health and Human Services FDA Center for Drug Evaluation and Research: Guidance for Industry: patient reported outcome measures: use in medical product development to support labelling claims: draft guidance. Health Qual Life Outcomes 2006, 4:79.
47. Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Schunemann HJ: GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008, 336:924-926.
48. Leynaert B, Soussan D: Monitoring the quality-of-life in allergic disorders. Curr Opin Allergy Clin Immunol 2003, 3(3):177-183.
49. Baiardini I, Braido F, Brandi S, Tarantini F, Bonini S, Bousquet PJ, Zuberbier T, Demoly P, Canonica GW: The impact of GINA suggested drugs for the treatment of asthma on Health-Related Quality of Life: a GA(2)LEN review. Allergy 2008, 63(8):1015-1030.
50. Baiardini I, Braido F, Tarantini F, Porcu A, Bonini S, Bousquet PJ, Zuberbier T, Demoly P, Canonica GW: ARIA-suggested drugs for allergic rhinitis: what impact on quality of life? A GA2LEN review. Allergy 2008, 63(6):660-669.
51. van derVelde JL, Flokstra-de Blok BM, Vlieg-Boerstra BJ, Oude Elberink JN, Schouten JP, Dunngalvin A, Hourihane JO, Duiverman EJ, Dubois AE: Test-retest reliability of the Food Allergy Quality of Life Questionnaires (FAQLQ) for children, adolescents and adults. Qual Life Res: Inst J Qual Life Aspects Treatment, Care Rehabil 2009, 18(2):245-251.
52. World Health Organization: Fact Sheet no307. 2011. http://www.who.int/mediacentre/factsheets/fs307/en/index.html.
53. Holgate S, Bisgaard H, Bjermer L, Haahtela T, Haughney J, Horne R, McIvor A, Palkonen S, Price DB, Thomas M, et al: The Brussels Declaration: the need for change in asthma management. Eur Respir J 2008, 32(6):1433-1442.
54. Lane S, Molina J, Plusa T: An international observational prospective study to determine the cost of asthma exacerbations (COAX). Respir Med 2006, 100(3):434-450.
55. Sears MR, Greene JM, Willan AR, Wiecek EM, Taylor DR, Flannery EM, Cowan JO, Herbison GP, Silva PA, Poulton R: A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med 2003, 349(15):1414-1422.
56. Lotvall J, Akdis CA, Bacharier LB, Bjermer L, Casale TB, Custovic A, Lemanske RF Jr, Wardlaw AJ, Wenzel SE, Greenberger PA: Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol 2011, 127(2):355-360.
57. Agache I, Akdis C, Jutel M, Virchow JC: Untangling asthma phenotypes and endotypes. Allergy 2012, 67(7):835-846.
58. Auffray C, Charron D, Hood L: Predictive, preventive, personalized and participatory medicine: back to the future. Genome Med 2010, 2(8):57.
59. Greiner AN, Hellings PW, Rotiroti G, Scadding GK: Allergic rhinitis. Lancet 2011, 378(9809):2112-2122.
60. Maurer M, Zuberbier T: Undertreatment of rhinitis symptoms in Europe: findings from a cross-sectional questionnaire survey. Allergy 2007, 62(9):1057-1063.
61. Bousquet J, Bachert C, Canonica GW, Mullol J, Van Cauwenberge P, Jensen CB, Fokkens WJ, Ring J, Keith P, Gopalan G, et al: Efficacy of desloratadine in persistent allergic rhinitis - a GA(2)LEN study. Int Arch Allergy Immunol 2010, 153(4):395-402.
62. Watelet JB, Van Zele T, Gjomarkaj M, Canonica GW, Dahlen SE, Fokkens W, Lund VJ, Scadding GK, Mullol J, Papadopoulos N, et al: Tissue remodelling in upper airways: where is the link with lower airway remodelling? Allergy 2006, 61(11):1249-1258.
63. Scadding G, Hellings P, Alobid I, Bachert C, Fokkens W, van Wijk RG, Gevaert P, Guilemany J, Kalogjera L, Lund V, et al: Diagnostic tools in Rhinology EAACI position paper. Clin Transl Allergy 2011, 1(1):2.
64. Hellings PW, Dobbels F, Denhaerynck K, Piessens M, Ceuppens JL, De Geest S: Explorative study on patients' perceived knowledge level, expectations, preferences and fear for side effects for treatment for allergic rhinitis. Clin Transl Allergy 2012, 2(1):9.
65. Kong HH OJ, Deming C, Conlan S, Grice EA, Beatson MA, Nomicos E, Polley EC, Komarow HD, NISC Comparative Sequence Program, Murray PR, Turner ML, Segre JA: Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res 2012, Epub ahead of print.
66. Fox ATSP, du Toit G, Syed H, Lack G: Household peanut consumption as a risk factor for the development of peanut allergy. J Allergy Clin Immunol 2009, 123(2):417-423.
67. Schultz Larsen F, Diepgen T, Svensson A: The occurrence of atopic dermatitis in north Europe: an international questionnaire study. J Am Acad Dermatol 1996, 34(5 Pt 1):760-764.
68. Williams H, Robertson C, Stewart A, Ait-Khaled N, Anabwani G, Anderson R, Asher I, Beasley R, Bjorksten B, Burr M, et al: Worldwide variations in the prevalence of symptoms of atopic eczema in the international study of asthma and allergies in childhood. J Allergy Clin Immunol 1999, 103(1 Pt 1):125-138.
69. Kawasaki HNK, Kubo A, Hata T, Shimizu A, Mizuno H, Yamada T, Amagai M: Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrinnull mice. J Allergy Clin Immunol 2012, .
70. Soyka MB, Wawrzyniak P, Eiwegger T, Holzmann D, Treis A, Wanke K, Kast JI, Akdis CA: Defective epithelial barrier in chronic rhinosinusitis: The regulation of tight junctions by IFN-gamma and IL-4. J Allergy Clin Immunol 2012.
71. Rantanen T: The cause of the Chinese sofa/chair dermatitis epidemic is likely to be contact allergy to dimethylfumarate, a novel potent contact sensitizer. Br J Dermatol 2008, 159(1):218-221.
72. Spiewak R: Food-provoked eczema: a hypothesis on the possible role of systemic contact allergy to haptens present in both cosmetics and foods. Estetol Med Kosmetol 2011, 1(1):35-40.
73. Faurschou AMT, Johansen JD, Thyssen JP: Metal allergen of the 21st Century - a review on exposure, epidemiology and clinical manifestations of palladium allergy95. Contact Dermatitis 2011, 644:185-195.
74. Hellgren L: The prevalence of urticaria in the total population. Acta Allergol 1972, 27(3):236-240.
75. Saini SRK, Hsieh HJ, Wong DA, Conner E, Kaplan A, Spector S, Maurer M: A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine-refractory chronic idiopathic urticaria. J Allergy Clin Immunol 2011, 128(3):567-573.
76. Peden D, Reed CE: Environmental and occupational allergies. J Allergy Clin Immunol 2010, 125(2 Suppl 2):S150-160.
77. Cecchi L, D'Amato G, Ayres JG, Galan C, Forastiere F, Forsberg B, Gerritsen J, Nunes C, Behrendt H, Akdis C, et al: Projections of the effects of climate change on allergic asthma: the contribution of aerobiology. Allergy 2010, 65(9):1073-1081.
78. Buters JT, Kasche A, Weichenmeier I, Schober W, Klaus S, Traidl-Hoffmann C, Menzel A, Huss-Marp J, Kramer U, Behrendt H: Year-to-year variation in release of Bet v 1 allergen from birch pollen: evidence for geographical differences between West and South Germany. Int Arch Allergy Immunol 2008, 145(2):122-130.
79. Laatikainen T, von Hertzen L, Koskinen JP, Makela MJ, Jousilahti P, Kosunen TU, Vlasoff T, Ahlstrom M, Vartiainen E, Haahtela T: Allergy gap between Finnish and Russian Karelia on increase. Allergy 2011, 66(7):886-892.
80. Flohr C, Quinnell RJ, Britton J: Do helminth parasites protect against atopy and allergic disease? Clin Exp Allergy 2009, 39(1):20-32.
81. Erb KJ: Can helminths or helminth-derived products be used in humans to prevent or treat allergic diseases? Trends Immunol 2009, 30(2):75-82.
82. Bisgaard H, Li N, Bonnelykke K, Chawes BL, Skov T, Paludan-Muller G, Stokholm J, Smith B, Krogfelt KA: Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age. J Allergy Clin Immunol 2011, 128(3):646-652.
83. Papadopoulos NG, Christodoulou I, Rohde G, Agache I, Almqvist C, Bruno A, Bonini S, Bont L, Bossios A, Bousquet J, et al: Viruses and bacteria in acute asthma exacerbations- a GA(2) LEN-DARE systematic review. Allergy 2011, 66(4):458-468.
84. Skevaki CL, Psarras S, Volonaki E, Pratsinis H, Spyridaki IS, Gaga M, Georgiou V, Vittorakis S, Telcian AG, Maggina P, et al: Rhinovirus-induced basic fibroblast growth factor release mediates airway remodeling features. Clinical and translational allergy 2012, 2(1):14.
85. Jackson DJ, Gangnon RE, Evans MD, Roberg KA, Anderson EL, Pappas TE, Printz MC, Lee WM, Shult PA, Reisdorf E, et al: Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med 2008, 178(7):667-672.
86. Papadopoulos NG, Xepapadaki P, Mallia P, Brusselle G, Watelet JB, Xatzipsalti M, Foteinos G, Van Drunen CM, Fokkens WJ, D'Ambrosio C, et al: Mechanisms of virusinduced asthma exacerbations: State-of-the-art. A GA2LEN and InterAirways document. Allergy: European J Allergy Clin Immunol 2007, 62(5):457-470.
87. Contoli M, Message SD, Laza-Stanca V, Edwards MR, Wark PA, Bartlett NW, Kebadze T, Mallia P, Stanciu LA, Parker HL, et al: Role of deficient type III interferon-lambda production in asthma exacerbations. Nat Med 2006, 12(9):1023-1026.
88. Miller EK, Edwards KM, Weinberg GA, Iwane MK, Griffin MR, Hall CB, Zhu Y, Szilagyi PG, Morin LL, Heil LH, et al: A novel group of rhinoviruses is associated with asthma hospitalizations. J Allergy Clin Immunol 2009, 123(1):98-104.
89. Sun K, Metzger DW: Inhibition of pulmonary antibacterial defense by interferongamma during recovery from influenza infection. Nat Med 2008, 14(5):558-564.
90. Oude Elberink J: Venom immunotherapy (VIT): clinical efficacy and improvement in quality of life. Drugs Today 2008, 44:43-45.
91. Bilo BM, Bonifazi F: Advances in hymenoptera venom immunotherapy. Curr Opin Allergy Clin Immunol 2007, 7(6):567-573.
92. Niedoszytko M, Bruinenberg M, de Monchy J, Weersma RK, Wijmenga C, Jassem E, Elberink JN: Changes in gene expression caused by insect venom immunotherapy responsible for the long-term protection of insect venom-allergic patients. Ann Allergy Asthma Immunol 2011, 106(6):502-510.
93. Borer-Reinhold M, Haeberli G, Bitzenhofer M, Jandus P, Hausmann O, Fricker M, Helbling A, Muller U: An increase in serum tryptase even below 11.4 ng/mL may indicate a mast cell-mediated hypersensitivity reaction: a prospective study in Hymenoptera venom allergic patients. Clin Exp Allergy 2011, 41(12):1777-1783.
94. Rueff F, Przybilla B, Bilo MB, Muller U, Scheipl F, Aberer W, Birnbaum J, Bodzenta-Lukaszyk A, Bonifazi F, Bucher C, et al: Predictors of side effects during the buildup phase of venom immunotherapy for Hymenoptera venom allergy: the importance of baseline serum tryptase. J Allergy Clin Immunol 2010, 126(1):105-111.
95. Bilo MB, Cinti B, Brianzoni MF, Braschi MC, Bonifazi M, Antonicelli L: Honeybee venom immunotherapy: a comparative study using purified and nonpurified aqueous extracts in patients with normal Basal serum tryptase concentrations. J Allergy 2012, 869243:12. Epub 2012 Jan 12.
96. Scurlock AM, Vickery BP, Hourihane JO, Burks AW: Pediatric food allergy and mucosal tolerance. Mucosal Immunol 2010, 3(4):345-354.
97. Fernandez-Rivas M, Bolhaar S, Gonzalez-Mancebo E, Asero R, van Leeuwen A, Bohle B, Ma Y, Ebner C, Rigby N, Sancho AI, et al: Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foods. J Allergy Clin Immunol 2006, 118(2):481-488.
98. Zuidmeer-Jongejan L, Fernandez-Rivas M, Poulsen LK, Neubauer A, Asturias J, Blom L, Boye J, Bindslev-Jensen C, Clausen M, Ferrara R, et al: FAST: Towards safe and effective subcutaneous immunotherapy of persistent life-threatening food allergies. Clinical and translational allergy 2012, 2(1):5.
99. Mills EN, Mackie AR, Burney P, Beyer K, Frewer L, Madsen C, Botjes E, Crevel RW, van Ree R: The prevalence, cost and basis of food allergy across Europe. Allergy 2007, 62(7):717-722.
100. Vassallo MF, Camargo CA Jr: Potential mechanisms for the hypothesized link between sunshine, vitamin D, and food allergy in children. J Allergy Clin Immunol 2010, 126(2):217-222.
101. Noimark L, Cox HE: Nutritional problems related to food allergy in childhood. Pediatr Allergy Immunol 2008, 19(2):188-195.
102. Excellence NIfHaC: NICE Clinical Guideline 116. Food Allergy in Children and Young People. Diagnosis and assessment of food allergy in children and young people in primary care and community settings.: ; 2011. http://guidance.nice.org.uk/CG116.
103. Gomes ECM, Praca F, Gomes L, Marino E, Demoly P: Self-reported drug allergy in a general adult Portuguese population. Clin Exp Allergy 2004, 34:1597-1601.
104. Demoly PPW, Pirmohamed M, Romano A: Important questions in Allergy: 1-drug allergy/hypersensitivity. Allergy Asthma Clin Immunol 2008, 63(5):616-619.
105. Brockow KRA, Blanca M, Ring J, Pichler W, Demoly P: General considerations for skin test procedures in the diagnosis of drug hyper-sensitivity. Allergy 2002, 57:45-51.
106. Adkinson NF ED Jr, Gruchalla R, Haggerty H, Kawabata T, Sandler JD, Updyke L, Shear NH, Wierda D: Health and environmental sciences institute task force: Task force report: future research needs for the prevention and management of immune-mediated drug hypersensitivity reactions. J Allergy Clin Immunol 2002, 1098(3):S461-467.
107. Gleeson M: Immune function in sport and exercise. J Appl Physiol 2007, 103(2):693-699.
108. Lakier Smith L: Overtraining, excessive exercise, and altered immunity: is this a T helper-1 versus T helper-2 lymphocyte response? Sports Med 2003, 33(5):347-364.
109. Fitch KD: An overview of asthma and airway hyper-responsiveness in Olympic athletes. Br J Sports Med 2012, 46(6):413-416.
110. Bonini M, Lapucci G, Petrelli G, Todaro A, Pamich T, Rasi G, Bonini S: Predictive value of allergy and pulmonary function tests for the diagnosis of asthma in elite athletes. Allergy 2007, 62(10):1166-1170.
111. Schwartz LB, Delgado L, Craig T, Bonini S, Carlsen KH, Casale TB, Del Giacco S, Drobnic F, van Wijk RG, Ferrer M, et al: Exercise-induced hypersensitivity syndromes in recreational and competitive athletes: a PRACTALL consensus report (what the general practitioner should know about sports and allergy). Allergy 2008, 63(8):953-961.
112. Jaakkola MS, Jaakkola JJ: Assessment of public health impact of work-related asthma. BMC Med Res Methodol 2012, 12:22.
113. Henneberger PK, Mirabelli MC, Kogevinas M, Anto JM, Plana E, Dahlman-Hoglund A, Jarvis DL, Kromhout H, Lillienberg L, Norback D, et al: The occupational contribution to severe exacerbation of asthma. Eur Respir J 2010, 36(4):743-750.
114. Kogevinas M, Zock JP, Jarvis D, Kromhout H, Lillienberg L, Plana E, Radon K, Toren K, Alliksoo A, Benke G, et al: Exposure to substances in the workplace and new-onset asthma: an international prospective population-based study (ECRHS-II). Lancet 2007, 370(9584):336-341.
115. Vandenplas O, Lantin AC, D'Alpaos V, Larbanois A, Hoet P, Vandeweerdt M, Thimpont J, Speybroeck N: Time trends in occupational asthma in Belgium. Respir Med 2011, 105(9):1364-1372.
116. Paris C, Ngatchou-Wandji J, Luc A, McNamee R, Bensefa-Colas L, Larabi L, Telle-Lamberton M, Herin F, Bergeret A, Bonneterre V, et al: Work-related asthma in France: recent trends for the period 2001-2009. Occup Environ Med 2012, 69(6):391-397.
117. Moscato G, Pala G, Barnig C, De Blay F, Del Giacco SR, Folletti I, Heffler E, Maestrelli P, Pauli G, Perfetti L, et al: EAACI consensus statement for investigation of work-related asthma in non-specialized centres. Allergy 2012, 67(4):491-501.
118. Moscato G, Vandenplas O, Van Wijk RG, Malo JL, Perfetti L, Quirce S, Walusiak J, Castano R, Pala G, Gautrin D, et al: EAACI position paper on occupational rhinitis. Respir Res 2009, 3(10):16.
119. Moscato G, Pala G, Boillat MA, Folletti I, Gerth van Wijk R, Olgiati-Des Gouttes D, Perfetti L, Quirce S, Siracusa A, Walusiak-Skorupa J, et al: EAACI position paper: prevention of work-related respiratory allergies among pre-apprentices or apprentices and young workers. Allergy 2011, 66(9):1164-1173.
120. Cowl CT: Occupational asthma: review of assessment, treatment, and compensation. Chest 2011, 139(3):674-681.
121. Tarlo SM, Liss GM: Prevention of occupational asthma. Curr Allergy Asthma Rep 2010, 10(4):278-286.
122. Baur X, Sigsgaard T: The new guidelines for management of work-related asthma. Eur Respir J 2012, 39(3):518-519.
123. de Groene GJ, Pal TM, Beach J, Tarlo SM, Spreeuwers D, Frings-Dresen MH, Mattioli S, Verbeek JH: Workplace interventions for treatment of occupational asthma. Cochrane Database Syst Rev 2011, 11(5).
124. Vandenplas O, Dressel H, Wilken D, Jamart J, Heederik D, Maestrelli P, Sigsgaard T, Henneberger P, Baur X: Management of occupational asthma: cessation or reduction of exposure? A systematic review of available evidence. Eur Respir J 2011, 38(4):804-811.
125. Lack G: Epidemiologic risks for food allergy. J Allergy Clin Immunol 2008, 121(6):1331-1336.
126. Martinez FD: New insights into the natural history of asthma: primary prevention on the horizon. J Allergy Clin Immunol 2011, 128(5):939-945.
127. DunnGalvin A, Daly D, Cullinane C, Stenke E, Keeton D, Erlewyn-Lajeunesse M, Roberts GC, Lucas J, Hourihane JO: Highly accurate prediction of food challenge outcome using routinely available clinical data. J Allergy Clin Immunol 2011, 127(3):633-639.
128. Papadopoulos NG, Arakawa H, Carlsen KH, Custovic A, Gern J, Lemanske R, Le Souef P, Makela M, Roberts G, Wong G, et al: International consensus on (ICON) pediatric asthma. Allergy 2012, 67(8):976-997.
129. Bozzetto S, Carraro S, Giordano G, Boner A, Baraldi E: Asthma, allergy and respiratory infections: the vitamin D hypothesis. Allergy 2012, 67(1):10-17.
130. Roberts G, Patel N, Levi-Schaffer F, Habibi P, Lack G: Food allergy as a risk factor for life-threatening asthma in childhood: a case-controlled study. J Allergy Clin Immunol 2003, 112(1):168-174.
131. Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ: An integrative systems biology approach to understanding pulmonary diseases. Chest 2010, 137(6):1410-1416.
132. Niggemann B, Jacobsen L, Dreborg S, Ferdousi HA, Halken S, Host A, Koivikko A, Koller D, Norberg LA, Urbanek R, et al: Five-year follow-up on the PAT study: specific immunotherapy and long-term prevention of asthma in children. Allergy 2006, 61(7):855-859.
133. Edgecombe K, Latter S, Peters S, Roberts G: Health experiences of adolescents with uncontrolled severe asthma. Arch Dis Child 2010, 95(12):985-991.
134. Monks H, Gowland MH, MacKenzie H, Erlewyn-Lajeunesse M, King R, Lucas JS, Roberts G: How do teenagers manage their food allergies? Clin Exp Allergy 2010, 40(10):1533-1540.
135. EAACI: A European Declaration of Immunotherapy. Designing the future of allergen specific immunotherapy. Clinical and translational allergy 2012, 2:20.
136. Bilo BM, Bonifazi F: Hymenoptera venom immunotherapy. Immunotherapy 2011, 3(2):229-246.
137. Warrington R: Immunotherapy in asthma. Immunotherapy 2010, 2(5):711-725.
138. Calderon M, Cardona V, Demoly P: One hundred years of allergen immunotherapy European Academy of Allergy and Clinical Immunology celebration: review of unanswered questions. Allergy 2012, 67(4):462-476.
139. Jutel M, Akdis CA: Immunological mechanisms of allergen-specific immunotherapy. Allergy 2011, 66(6):725-732.
140. Fujita H, Soyka MB, Akdis M, Akdis CA: Mechanisms of allergen-specific immunotherapy. Clin Transl Allergy 2012, 2(1):2.
141. Palomares O, Rückert B, Jartti T, Kücüksezer UC, Puhakka T, Gomez E, Fahrner HB, Speiser A, Jung A, Kwok WW, et al: Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance. J Allergy Clin Immunol 2012, 129:510-520.