New melatonin (MT1/MT2) ligands: Design and synthesis of (8,9-dihydro-7H-furo[3,2-f]chromen-1-yl) derivatives

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 3, 2014, Pages 986-996

  Landagaray, Elodie ^a   Ettaoussi, Mohamed ^a   Leclerc, Véronique ^a   Traoré, Balla ^a   Perez, Valérie ^b   Nosjean, Olivier ^b   Boutin, Jean A ^b   Caignard, Daniel Henri ^b   Delagrange, Philippe ^b   Berthelot, Pascal ^a   Yous, Saïd ^a  

^a UNIV LILLE   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

Benzofuran derivatives; Melatonin; MT1; MT2 selectivity

Indexed keywords

8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL DERIVATIVE; BENZOFURAN DERIVATIVE; MELATONIN; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; MELATONIN DERIVATIVE; N [2 (2 ALLYL 8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL)ETHYL]ACETAMIDE; N [2 (2 BENZOYL 8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL)ETHYL]ACETAMIDE; N [2 (2 PHENYL 8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL)ETHYL]ACETAMIDE; N [2 (2 VINYL 8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL)ETHYL]ACETAMIDE; N [2 (8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL)ETHYL] 2 IODOACETAMIDE; N [2 (8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL)ETHYL] N METHYLACETAMIDE; N [2 (8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL)ETHYL] N' BUTYLTHIOUREA; N [2 (8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL)ETHYL] N' BUTYLUREA; N [2 (8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL)ETHYL] N' CYLOPROPYLTHIOUREA; N [2 (8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL)ETHYL] N' PROPYLTHIOUREA; N [2 (8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL)ETHYL] N' PROPYLUREA; N [2 (8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL)ETHYL]ACETAMIDE; N [2 (8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL)ETHYL]BUT 2 ENAMIDE; N [2 (8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL)ETHYL]BUT 3 ENAMIDE; N [2 (8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL)ETHYL]PROP 2 ENAMIDE; N [2 [2 (2 METHOXYBENZOYL) 8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL]ETHYL]ACETAMIDE; N [2 [2 (3 FORMYLPHENYL) 8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL]ETHYL]ACETAMIDE; N [2 [2 (3 HYDROXYPHENYL) 8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL]ETHYL]ACETAMIDE; N [2 [2 (3 METHOXYBENZOYL) 8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL]ETHYL]ACETAMIDE; N [2 [2 (3 METHOXYPHENYL) 8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL]ETHYL]ACETAMIDE; N [2 [2 (4 METHOXYBENZOYL) 8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL]ETHYL]ACETAMIDE; N [2 [2 [3 (HYDROXYMETHYL)PHENYL] 8,9 DIHYDRO 7H FURO[3,2 F]CHROMEN 1 YL]ETHYL]ACETAMIDE; S 21767; UNCLASSIFIED DRUG; UNINDEXED DRUG; AMIDE; DRUG DERIVATIVE; LIGAND;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BEHAVIOR DISORDER; BINDING AFFINITY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; HUMAN; HUMAN CELL; JET LAG; MOUSE; NEOPHOBIA; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY; ANIMAL; BENZOFURAN DERIVATIVES; CHEMISTRY; CHINESE HAMSTER OVARY; CHO; CHO CELL LINE; CRICETULUS; DRUG EFFECT; DRUG POTENTIATION; GUANOSINE-5′[Γ-(35)S]-TRIPHOSPHATE; HEK; HEK293 CELL LINE; HUMAN EMBRYONIC KIDNEY; METABOLISM; MLT; MT(1); MT(2)-SELECTIVITY; SYNTHESIS; [(35)S]-GTPΓS;

BENZOFURAN DERIVATIVES; CHINESE HAMSTER OVARY; CHO; GUANOSINE-5′[Γ-(35)S]-TRIPHOSPHATE; HEK; HUMAN EMBRYONIC KIDNEY; MELATONIN; MLT; MT(1); MT(2)-SELECTIVITY; [(35)S]-GTPΓS;

AMIDES; ANIMALS; BENZOFURANS; CHEMISTRY TECHNIQUES, SYNTHETIC; CHO CELLS; CRICETULUS; HEK293 CELLS; HUMANS; LIGANDS; MELATONIN; RECEPTOR, MELATONIN, MT1; RECEPTOR, MELATONIN, MT2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84892741546     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.12.054     Document Type: Article

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