Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury

American Journal of Respiratory Cell and Molecular Biology

Volumn 39, Issue 1, 2008, Pages 53-60

  Kaynar, A Murat ^a   Houghton, A McGarry ^a   Lum, Esther H ^b   Pitt, Bruce R ^c   Shapiro, Steven D ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Emigration; Endothelial injury; Neutrophil elastase; Ventilator induced lung injury

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; LEUKOCYTE ELASTASE; MATRIGEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; BLOOD CELL COUNT; CELL INTERACTION; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; LUNG BLOOD VESSEL; LUNG COMPLIANCE; LUNG INJURY; LUNG LAVAGE; LUNG WEIGHT; MOUSE; NONHUMAN; POSITIVE END EXPIRATORY PRESSURE; VENTILATOR;

ANIMALS; CHEMOTAXIS, LEUKOCYTE; ENDOTHELIUM, VASCULAR; LEUKOCYTE ELASTASE; LUNG; LUNG DISEASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; ORGAN SIZE; PULMONARY VEINS; RESPIRATORY DISTRESS SYNDROME, ADULT; TIDAL VOLUME; VENTILATORS, MECHANICAL;

MUS;

EID: 45849151057     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2007-0315OC     Document Type: Article

References (41)

1. Tremblay L, Valenza F, Ribeiro SP, Li J, Slutsky AS. Injurious ventilatory strategies increase cytokines and c-fos m-rna expression in an isolated rat lung model. J Clin Invest 1997;99:944-952.
2. Chapman KE, Sinclair SE, Zhuang D, Hassid A, Desai LP, Waters CM. Cyclic mechanical strain increases reactive oxygen species production in pulmonary epithelial cells. Am J Physiol 2005;289:L834-L841.
3. Belperio JA, Keane MP, Burdick MD, Londhe V, Xue YY, Li K, Phillips RJ, Strieter RM. Critical role for cxcr2 and cxcr2 ligands during the pathogenesis of ventilator-induced lung injury. J Clin Invest 2002;110:1703-1716.
4. Imai Y, Parodo J, Kajikawa O, de Perrot M, Fischer S, Edwards V, Cutz E, Liu M, Keshavjee S, Martin TR, et al. Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA 2003;289:2104-2112.
5. Gattinoni L, Presenti A, Torresin A, Baglioni S, Rivolta M, Rossi F, Scarani F, Marcolin R, Cappelletti G. Adult respiratory distress syndrome profiles by computed tomography. J Thorac Imaging 1986;1: 25-30.
6. The acute respiratory distress syndrome network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000;342:1301-1308.
7. Markos J, Doerschuk CM, English D, Wiggs BR, Hogg JC. Effect of positive end-expiratory pressure on leukocyte transit in rabbit lungs. J Appl Physiol 1993;74:2627-2633.
8. Inano H, English D, Doerschuk CM. Effect of zymosan-activated plasma on the deformability of rabbit polymorphonuclear leukocytes. J Appl Physiol 1992;73:1370-1376.
9. Wang Q, Pfeiffer GR II, Stevens T, Doerschuk CM. Lung microvascular and arterial endothelial cells differ in their responses to intercellular adhesion molecule-1 ligation. Am J Respir Crit Care Med 2002;166: 872-877.
10. Doerschuk CM, Winn RK, Coxson HO, Harlan JM. Cd18-dependent and -independent mechanisms of neutrophil emigration in the pulmonary and systemic microcirculation of rabbits. J Immunol 1990;144: 2327-2333.
11. Kumasaka T, Doyle NA, Quinlan WM, Graham L, Doerschuk CM. Role of cd 11/cd 18 in neutrophil emigration during acute and recurrent pseudomonas aeruginosa-induced pneumonia in rabbits. Am J Pathol 1996;148:1297-1305.
12. Willeke T, Scharffetter-Kochanek K, Gaehtgens P, Walzog B. A role for beta2 integrin (cd11/cd18)-mediated tyrosine signaling in extravasation of human polymorphonuclear neutrophils. Biorheology 2001;38: 89-100.
13. Lee CT, Fein AM, Lippmann M, Holtzman H, Kimbel P, Weinbaum G. Elastolytic activity in pulmonary lavage fluid from patients with adult respiratory-distress syndrome. N Engl J Med 1981;304:192-196.
14. Huber AR, Weiss SJ. Disruption of the subendothelial basement membrane during neutrophil diapedesis in an in vitro construct of a blood vessel wall. J Clin Invest 1989;83:1122-1136.
15. Belaaouaj A, McCarthy R, Baumann M, Gao Z, Ley TJ, Abraham SN, Shapiro SD. Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nat Med 1998;4:615-618.
16. Hirche TO, Atkinson JJ, Bahr S, Belaaouaj A. Deficiency in neutrophil elastase does not impair neutrophil recruitment to inflamed sites. Am J Respir Cell Mol Biol 2004;30:576-584.
17. Mizgerd JP, Kubo H, Kutkoski GJ, Bhagwan SD, Scharffetter-Kochanek K, Beaudet AL, Doerschuk CM. Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for cd11/cd18 revealed by cd18-deficient mice. J Exp Med 1997;186:1357-1364.
18. Horwitz M, Benson KF, Person RE, Aprikyan AG, Dale DC. Mutations in ela2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis. Nat Genet 1999;23:433-436.
19. Guice KS, Oldham KT, Caty MG, Johnson KJ, Ward PA. Neutrophil-dependent, oxygen-radical mediated lung injury associated with acute pancreatitis. Ann Surg 1989;210:740-747.
20. Till GO, Johnson KJ, Kunkel R, Ward PA. Intravascular activation of complement and acute lung injury: dependency on neutrophils and toxic oxygen metabolites. J Clin Invest 1982;69:1126-1135.
21. Tumen J, Meyrick B, Berry L Jr, Brigham KL. Antiproteinases protect cultured lung endothelial cells from endotoxin injury. J Appl Physiol 1988;65:835-843.
22. Bode W, Meyer E Jr, Powers JC. Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors. Biochemistry 1989;28: 1951-1963.
23. Owen CA, Campbell MA, Sannes PL, Boukedes SS, Campbell EJ. Cell surface-bound elastase and cathepsin g on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases. J Cell Biol 1995;131:775-789.
24. Mainardi CL, Dixit SN, Kang AH. Degradation of type iv (basement membrane) collagen by a proteinase isolated from human polymorphonuclear leukocyte granules. J Biol Chem 1980;255:5435-5441.
25. DiMartino SJ, Shah AB, Trujillo G, Kew RR. Elastase controls the binding of the vitamin d-binding protein (gc-globulin) to neutrophils: a potential role in the regulation of c5a co-chemotactic activity. J Immunol 2001;166:2688-2694.
26. McDonald JA, Kelley DG. Degradation of fibronectin by human leukocyte elastase: release of biologically active fragments. J Biol Chem 1980; 255:8848-8858.
27. Shapiro SD. Neutrophil elastase: path clearer, pathogen killer, or just pathologic? Am J Respir Cell Mol Biol 2002;26:266-268.
28. Tkalcevic J, Novelli M, Phylactides M, Iredale JP, Segal AW, Roes J. Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin g. Immunity 2000;12: 201-210.
29. Belaaouaj A, Kim KS, Shapiro SD. Degradation of outer membrane protein a in Escherichia coli killing by neutrophil elastase. Science 2000;289:1185-1188.
30. Shapiro SD, Goldstein NM, Houghton AM, Kobayashi DK, Kelley D, Belaaouaj A. Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Am J Pathol 2003;163:2329-2335.
31. Chua F, Dunsmore SE, Clingen PH, Mutsaers SE, Shapiro SD, Segal AW, Roes J, Laurent GJ. Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis. Am J Pathol 2007;170: 65-74.
32. Woo SW, Hedley-Whyte J. Macrophage accumulation and pulmonary edema due to thoracotomy and lung over inflation. J Appl Physiol 1972;33:14-21.
33. Parsons PE, Sugahara K, Cott GR, Mason RJ, Henson PM. The effect of neutrophil migration and prolonged neutrophil contact on epithelial permeability. Am J Pathol 1987;129:302-312.
34. Woodman RC, Reinhardt PH, Kanwar S, Johnston FL, Kubes P. Effects of human neutrophil elastase (hne) on neutrophil function in vitro and in inflamed microvessels. Blood 1993;82:2188-2195.
35. Delacourt C, Herigault S, Delclaux C, Poncin A, Levame M, Harf A, Saudubray F, Lafuma C. Protection against acute lung injury by intravenous or intratracheal pretreatment with epi-hne-4, a new potent neutrophil elastase inhibitor. Am J Respir Cell Mol Biol 2002;26:290-297.
36. Delclaux C, Delacourt C, D'Ortho MP, Boyer V, Lafuma C, Harf A. Role of gelatinase b and elastase in human polymorphonuclear neutrophil migration across basement membrane. Am J Respir Cell Mol Biol 1996;14:288-295.
37. Honore S, Attalah HL, Azoulay E, Soussy CJ, Saudubray F, Harf A, Brochard L, Delclaux C. Beneficial effect of an inhibitor of leukocyte elastase (epi-hne-4) in presence of repeated lung injuries. Shock 2004; 22:131-136.
38. Wang S, Dangerfield JP, Young RE, Nourshargh S. Pecam-1, alpha6 integrins and neutrophil elastase cooperate in mediating neutrophil transmigration. J Cell Sci 2005;118:2067-2076.
39. Cai TQ, Wright SD. Human leukocyte elastase is an endogenous ligand for the integrin cr3 (cd11b/cd18, mac-1, alpha m beta 2) and modulates polymorphonuclear leukocyte adhesion. J Exp Med 1996; 184:1213-1223.
40. Champagne B, Tremblay P, Cantin A, St Pierre Y. Proteolytic cleavage of icam-1 by human neutrophil elastase. J Immunol 1998;161:6398-6405.
41. Zeiher BG, Artigas A, Vincent JL, Dmitrienko A, Jackson K, Thompson BT, Bernard G. Neutrophil elastase inhibition in acute lung injury: results of the strive study. Crit Care Med 2004;32:1695-1702.