Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN

Molecular Biology of the Cell

Volumn 22, Issue 4, 2011, Pages 437-447

  Tang, Ming ^a   Iijima, Miho ^a   Kamimura, Yoichiro ^a   Chen, Lingfeng ^a   Long, Yu ^a   Devreotes, Peter ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; P21 ACTIVATED KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B;

ARTICLE; CANCER INHIBITION; CYTOKINESIS; DICTYOSTELIUM; ENZYME PHOSPHORYLATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

CELL CYCLE PROTEINS; CELL POLARITY; CHEMOTAXIS; CYCLIC AMP; CYTOSKELETON; DICTYOSTELIUM; GENE DELETION; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

DICTYOSTELIUM; GUIBOURTIA DEMEUSEI;

EID: 79951828073     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E10-06-0522     Document Type: Article

References (43)

1. Bosgraaf L, Keizer-Gunnink I, Van Haastert PJ (2008). PI3-kinase signaling contributes to orientation in shallow gradients and enhances speed in steep chemoattractant gradients. J Cell Sci 121, 3589-3597.
2. Chalhoub N, Baker SJ (2009). PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol 4, 127-150.
3. Chalhoub N, Zhu G, Zhu X, Baker SJ (2009). Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains. Genes Dev 23, 1619-1624.
4. Charest PG, Firtel RA (2006). Feedback signaling controls leading-edge formation during chemotaxis. Curr Opin Genet Dev 16, 339-347. (Pubitemid 43994452)
5. Chen L, Iijima M, Tang M, Landree MA, Huang YE, Xiong Y, Iglesias PA, Devreotes PN (2007). PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Dev Cell 12, 603-614. (Pubitemid 46523645)
6. Chung CY, Firtel RA (1999). PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis. J Cell Biol 147, 559-576.
7. Chung CY, Potikyan G, Firtel RA (2001). Control of cell polarity and chemo taxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol Cell 7, 937-947. (Pubitemid 32525741)
8. Comer FI, Lippincott CK, Masbad JJ, Parent CA (2005). The PI3K-mediated activation of CRAC independently regulates adenylyl cyclase activation and chemotaxis. Curr Biol 15, 134-139.
9. Cote JF, Motoyama AB, Bush JA, Vuori K (2005). A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling. Nat Cell Biol 7, 797-807.
10. Engelhardt B (2008). Immune cell entry into the central nervous system: involvement of adhesion molecules and chemokines. J Neurol Sci 274, 23-26.
11. Fine B et al. (2009). Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science 325, 1261-1265.
12. Funamoto S, Milan K, Meili R, Firtel RA (2001). Role of phosphatidylinositol 3′ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in dictyostelium. J Cell Biol 153, 795-810.
13. Hill KM, Kalifa S, Das JR, Bhatti T, Gay M, Williams D, Taliferro-Smith L, De Marzo AM (2010). The role of PI 3-kinase p110beta in AKT signally, cell survival, and proliferation in human prostate cancer cells. Prostate 70, 755-764.
14. Hoeller O, Kay RR (2007). Chemotaxis in the absence of PIP3 gradients. Curr Biol 17, 813-817. (Pubitemid 46635122)
15. Huang YE, Iijima M, Parent CA, Funamoto S, Firtel RA, Devreotes P (2003). Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells. Mol Biol Cell 14, 1913-1922.
16. Iijima M, Devreotes P (2002). Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109, 599-610. (Pubitemid 34628723)
17. Inoue T, Meyer T (2008). Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration. PLoS One 3, e3068.
18. Janetopoulos C, Borleis J, Vazquez F, Iijima M, Devreotes P (2005). Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis. Dev Cell 8, 467-477. (Pubitemid 40450737)
19. Janetopoulos C, Devreotes P (2006). Phosphoinositide signaling plays a key role in cytokinesis. J Cell Biol 174, 485-490. (Pubitemid 44231860)
20. Jones GE (2000). Cellular signaling in macrophage migration and chemotaxis. J Leukoc Biol 68, 593-602.
21. Kamimura Y, Devreotes PN (2010). Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5- trisphosphate- dependent and -independent protein kinase B activation and chemotaxis. J Biol Chem 285, 7938-7946.
22. Kamimura Y, Xiong Y, Iglesias PA, Hoeller O, Bolourani P, Devreotes PN (2008). PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr Biol 18, 1034-1043.
23. Larsen M, Hoffman MP, Sakai T, Neibaur JC, Mitchell JM, Yamada KM (2003). Role of PI 3-kinase and PIP3 in submandibular gland branching morphogenesis. Dev Biol 255, 178-191. (Pubitemid 36287149)
24. Liao XH, Buggey J, Kimmel AR (2010). Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2. J Cell Sci 123, 983-992.
25. Liu Q, Sasaki T, Kozieradzki I, Wakeham A, Itie A, Dumont DJ, Penninger JM (1999). SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival. Genes Dev 13, 786-791. (Pubitemid 29169837)
26. Martin-Belmonte F, Gassama A, Datta A, Yu W, Rescher U, Gerke V, Mostov K (2007). PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. Cell 128, 383-397. (Pubitemid 46123512)
27. Martin-Belmonte F, Mostov K (2008). Regulation of cell polarity during epithelial morphogenesis. Curr Opin Cell Biol 20, 227-234.
28. Moore MA (2001). The role of chemoattraction in cancer metastases. Bioessays 23, 674-676.
29. Mortimer D, Fothergill T, Pujic Z, Richards LJ, Goodhill GJ (2008). Growth cone chemotaxis. Trends Neurosci 31, 90-98.
30. Muller-Taubenberger A, Bretschneider T, Faix J, Konzok A, Simmeth E, Weber I (2002). Differential localization of the Dictyostelium kinase DPAKa during cytokinesis and cell migration. J Muscle Res Cell Motil 23, 751-763. (Pubitemid 36995055)
31. Nishikimi A et al. (2009). Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Sciences 324, 384-387.
32. Rivard N (2009). Phosphatidylinositol 3-kinase: a key regulator in adherens junction formation and function. Front Biosci 14, 510-522.
33. Sarraj B, Massberg S, Li Y, Kasorn A, Subramanian K, Loison F, Silberstein LE, von Andrian U, Luo HR (2009). Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation. J Immunol 182, 7190-7200.
34. Savarin-Vuaillat C, Ransohoff RM (2007). Chemokines and chemokine receptors in neurological disease: raise, retain, or reduce? Neurotherapeutics 4, 590-601.
35. Simon SI, Sarantos MR, Green CE, Schaff UY (2009). Leucocyte recruitment under fluid shear: mechanical and molecular regulation within the inflammatory synapse. Clin Exp Pharmacol Physiol 36, 217-224.
36. Simpson L, Parsons R (2001). PTEN: life as a tumor suppressor. Exp Cell Res 264, 29-41. (Pubitemid 32989079)
37. Swaney KF, Huang CH, Devreotes PN (2010). Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity. Annu Rev Biophys 39, 265-289.
38. Van Haastert PJ, Devreotes PN (2004). Chemotaxis: signalling the way forward. Nat Rev Mol Cell Biol 5, 626-634. (Pubitemid 39025063)
39. van Haastert PJ, Keizer-Gunnink I, Kortholt A (2007). Essential role of PI3- kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis. J Cell Biol 177, 809-816. (Pubitemid 46873087)
40. Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, Bourne HR (2002). A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol 4, 509-513.
41. Williams DA, Zheng Y, Cancelas JA (2008). Rho GTPases and regulation of hemato poietic stem cell localization. Methods Enzymol 439, 365-393.
42. Yoo SK, Deng Q, Cavnar PJ, Wu YI, Hahn KM, Huttenlocher A (2010). Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish. Dev Cell 18, 226-236.
43. Zhou K, Pandol S, Bokoch G, Traynor-Kaplan AE (1998). Disruption of Dictyostelium PI3K genes reduces [32P]phosphatidylinositol 3,4 bisphosphate and [32P]phosphatidylinositol trisphosphate levels, alters F-actin distribution and impairs pinocytosis. J Cell Sci 111, 283-294. (Pubitemid 28064152)