Bioactive proteinase 3 on the cell surface of human neutrophils: Quantification, catalytic activity, and susceptibility to inhibition

Journal of Immunology

Volumn 165, Issue 6, 2000, Pages 3366-3374

  Campbell, E J ^a   Campbell, M A ^a   Owen, C A ^a  

^a UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT; CYTOKINE; FIBRONECTIN; MYELOBLASTIN; PROTEINASE INHIBITOR;

ARTICLE; CATALYSIS; CELL SURFACE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IONIC STRENGTH; ISOELECTRIC POINT; NEUTROPHIL; PRIORITY JOURNAL;

EID: 0034665315     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.6.3366     Document Type: Article

References (32)

1. The cell biology of leukocyte-mediated proteolysis
2. Presence of proteinase 3 in secretory vesicles: Evidence of a novel, highly mobilizable intracellular pool distinct from azurophil granules
3. Proteinase 3, the target antigen of anticytoplasmic antibodies circulating in Wegener's granulomatosis: Immunolocalization in normal and pathologic tissues
4. Specificity of anti-neutrophil cytoplasmic autoantibodies for proteinase 3
5. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro
6. Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase
7. Interleukin-8 processing by neutrophil elastase, cathepsin G and proteinase-3
8. Converting enzyme-independent release of tumor necrosis factor a and IL-1β from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3
9. Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo
10. Transforming growth factor-β (TGF-β) expression and interaction with proteinase 3 (PR3) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis
11. Bimodal distribution of proteinase 3 (PR3) surface expression reflects a constitutive heterogeneity in the polymorphonuclear neutrophil pool
12. Inducible binding of cathepsin G to the cell surface of neutrophils: A mechanism for mediating extracellular proteolytic activity of cathepsin G
13. Cell-surface-bound elastase and cathepsin G on human neutrophils: A novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases
14. Cytokines regulate membrane-bound leukocyte elastase on neutrophils: A novel mechanism for effector activity
15. Angiotensin II generation at the cell surface of activated neutrophils: Novel cathepsin G-mediated catalytic activity that is resistant to inhibition
16. Isolation of mononuclear cells and granulocytes from human blood: Isolation of mononuclear cells by one centrifugation and of granulocytes by combining centrifugation and sedimentation at 1 g
17. Elastase and cathepsin G of human monocytes: Quantification of cellular content, release in response to stimuli, and heterogeneity in elastase-mediated proteolytic activity
18. Substrate and inhibitor studies on proteinase 3
19. Ultrastructural quantitation of peroxidase-and elastase-containing granules in human neutrophils
20. Nonisotropic enzyme-inhibitor interactions: A novel non-oxidative mechanism for quantum proteolysis by human neutrophils
21. 107) of elastase and cathepsin G activities: Consequence for neutrophil-platelet cooperation
22. Interaction of secretory leukocyte protease inhibitor with proteinase-3
23. Comparison of properties of membrane bound versus soluble forms of human leukocyte elastase and cathepsin G
24. Proteinase 3, a potent secretagogue in airways, is present in cystic fibrosis sputum
25. 1-Antitrypsin: Molecular pathology, leukocytes, and tissue damage
26. Secretion of mucus proteinase inhibitor and elafin by Clara cell and type II pneumocyte cell lines
27. Proteinase 3: A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters
28. Human leukocyte elastase and cathepsin G: Structural and functional characteristics
29. A chondroitin sulfate proteoglycan on human neutrophils specifically binds platelet factor 4 and is involved in cell activation
30. Proteoglycans as modulators of growth factor activities
31. Elastase-mediated release of heparan sulfate proteoglycans from pulmonary fibroblast cultures: A mechanism for basic fibroblast growth factor (bFGF) release and attenuation of bFGF binding following elastase-induced injury
32. Basic fibroblast growth factor (bFGF) dissociates rapidly from heparan sulfates but slowly from receptors: Implications for mechanisms of bFGF release from pericellular matrix