YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit

Biochemistry

Volumn 53, Issue 1, 2014, Pages 101-114

  Purohit, Rahul ^a   Fritz, Bradley G ^a   The, Juliana ^a   Issaian, Aaron ^a   Weichsel, Andrzej ^a   David, Cynthia L ^b   Campbell, Eric ^d   Hausrath, Andrew C ^a   Rassouli Taylor, Leida ^c   Garcin, Elsa D ^c   Gage, Matthew J ^d   Montfort, William R ^a  

^a University of Arizona   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^d NORTHERN ARIZONA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC INHIBITION; CYCLASE ACTIVITY; DRUG DISCOVERY; EQUILIBRIUM BINDING; FULL-LENGTH PROTEINS; GUANYLYL CYCLASE; RELATED COMPOUNDS; SOLUBLE GUANYLATE CYCLASE (SGC);

NITRIC OXIDE; PORPHYRINS; PROTEINS;

CONFORMATIONS;

4 AMINO 5 CYCLOPROPYL 2 [1 (2 FLUOROBENZYL) 1H PYRAZOLO[3,4 B]PYRIDIN 3 YL]PYRIMIDINE; GUANYLATE CYCLASE; HEME; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; YC 1 PROTEIN;

ARTICLE; BINDING AFFINITY; CATALYSIS; MANDUCA SEXTA; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; SURFACE PLASMON RESONANCE;

ALLOSTERIC REGULATION; ANIMALS; CARBON MONOXIDE; CATTLE; GUANYLATE CYCLASE; HEME; INDAZOLES; MANDUCA; MODELS, MOLECULAR; NITRIC OXIDE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SURFACE PLASMON RESONANCE;

EID: 84892580366     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi4015133     Document Type: Article

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