NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism

EMBO Journal

Volumn 26, Issue 2, 2007, Pages 578-588

  Ma, Xiaolei ^a   Sayed, Nazish ^b   Beuve, Annie ^b   Van Den Akker, Focco ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Carbon monoxide; Guanylyl cyclase; Heme sensors; Nitric oxide; Signal transduction

Indexed keywords

CARBON DIOXIDE; GUANYLATE CYCLASE; HEME; LIGAND; NITRIC OXIDE; OXYGEN;

AMINO TERMINAL SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; CYANOBACTERIUM; ENZYME ACTIVATION; MODULATION; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROKARYOTE; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SOLUBILITY;

AMINO ACID SEQUENCE; ANABAENA; ANIMALS; CARBON MONOXIDE; CERCOPITHECUS AETHIOPS; COS CELLS; ENZYME ACTIVATION; GUANYLATE CYCLASE; HEME; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NITRIC OXIDE; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

CYANOBACTERIA; PROKARYOTA;

EID: 33846491964     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601521     Document Type: Article

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