A mixed Ca2+ channel blocker, A-1264087, utilizes peripheral and spinal mechanisms to inhibit spinal nociceptive transmission in a rat model of neuropathic pain

Journal of Neurophysiology

Volumn 111, Issue 2, 2014, Pages 394-404

  Xu, Jun ^a   Chu, Katharine L ^a   Zhu, Chang Z ^a   Niforatos, Wende ^a   Swensen, Andrew ^a   Searle, Xenia ^a   Lee, Lance ^a   Jarvis, Michael F ^a   McGaraughty, Steve ^a  

^a ABBVIE INC   (United States)

Author keywords

N type Ca2+ channels; Neuropathic pain; P Q type Ca2+ channels; Spinal cord; T type Ca2+ channels

Indexed keywords

A 1264087; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL N TYPE; UNCLASSIFIED DRUG; N2-METHYL-N-((2-(4-(TRIFLUOROMETHYL)PHENYL)OCTAHYDROCYCLOPENTA(C)PYRROL-4-YL)LEUCINAMIDE; ANESTHETIC AGENT; AZABICYCLO DERIVATIVE; DRUG DERIVATIVE; LEUCINE; N2 METHYL N ((2 (4 (TRIFLUOROMETHYL)PHENYL)OCTAHYDROCYCLOPENTA(C)PYRROL 4 YL)LEUCINAMIDE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DELTA NERVE FIBER; DORSAL ROOT; ELECTROSTIMULATION; EVOKED RESPONSE; FIBER; IC 50; MALE; NERVE CELL; NERVE FIBER C; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTIVE FIELD; SPINAL NERVE LIGATION INJURY; ACTION POTENTIAL; ANIMAL; DOSE RESPONSE; DRUG EFFECT; HYPERALGESIA; INTRADERMAL DRUG ADMINISTRATION; INTRASPINAL DRUG ADMINISTRATION; N-TYPE CA2+ CHANNELS; NEURALGIA; NEUROPATHIC PAIN; NOCICEPTION; P/Q-TYPE CA2+ CHANNELS; PATHOPHYSIOLOGY; PERIPHERAL NERVE; PHYSIOLOGY; SPINAL CORD; SPINAL NERVE; SPRAGUE DAWLEY RAT; T-TYPE CA2+ CHANNELS;

N-TYPE CA2+ CHANNELS; NEUROPATHIC PAIN; P/Q-TYPE CA2+ CHANNELS; SPINAL CORD; T-TYPE CA2+ CHANNELS;

ACTION POTENTIALS; ADMINISTRATION, CUTANEOUS; ANESTHETICS; ANIMALS; AZABICYCLO COMPOUNDS; CALCIUM CHANNEL BLOCKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERALGESIA; INHIBITORY CONCENTRATION 50; INJECTIONS, SPINAL; LEUCINE; MALE; NEURALGIA; NEURONS; NOCICEPTION; PERIPHERAL NERVES; RATS; RATS, SPRAGUE-DAWLEY; SPINAL NERVES;

EID: 84892578737     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00463.2013     Document Type: Article

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