A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats

Biochemical Pharmacology

Volumn 83, Issue 3, 2012, Pages 406-418

  Scott, Victoria E ^a   Vortherms, Timothy A ^a   Niforatos, Wende ^a   Swensen, Andrew M ^a   Neelands, Torben ^a   Milicic, Ivan ^a   Banfor, Patricia N ^a   King, Andrew ^a   Zhong, Chengmin ^a   Simler, Gricelda ^a   Zhan, Cenchen ^a   Bratcher, Natalie ^a   Boyce Rustay, Janel M ^a   Zhu, Chang Z ^a   Bhatia, Pramila ^a   Doherty, George ^a   MacK, Helmut ^a   Stewart, Andrew O ^a   Jarvis, Michael F ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

A 1048400; Dorsal root ganglion; N type Ca 2+ channels; Neuropathic pain; Nociceptive pain; T type Ca 2+ channels

Indexed keywords

(1 (2 (4 BENZHYDRYL PIPERAZIN 1 YL) 2 OXO ETHYL) 3,3 DIPHENYL PIPERIDIN 2 ONE); 1 (2 (4 (3,5 DIMETHOXYBENZL)PIPERAZIN 1 YL)ETHYL) 3,3 BIS(4 FLUOROPHENYL)PYRROLIDIN 2 ONE; A 1048400; A 686085; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL T TYPE; CAPSAICIN; PIPERIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; ASSAY; HEMODYNAMIC PARAMETERS; HYPERSENSITIVITY; INFLAMMATION; ION CURRENT; MEAN ARTERIAL PRESSURE; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; RAT; SPINAL GANGLION; TACTILE STIMULATION;

ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; CALCIUM CHANNEL BLOCKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HEMODYNAMICS; HUMANS; MALE; NEURONS; PAIN MEASUREMENT; PIPERIDONES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84455208087     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.10.019     Document Type: Article

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