Osthole reverses beta-amyloid peptide cytotoxicity on neural cells by enhancing cyclic amp response element-binding protein phosphorylation

Biological and Pharmaceutical Bulletin

Volumn 36, Issue 12, 2013, Pages 1950-1958

  Hu, Yu ^a   Wen, Qingping ^b   Liang, Wenbo ^c   Kang, Tingguo ^a   Ren, Lu ^a   Zhang, Nan ^a   Zhao, Dan ^a   Sun, Dong ^a   Yang, Jingxian ^a  

^a LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b DALIAN MEDICAL UNIVERSITY   (China)

^c DALIAN UNIVERSITY   (China)

Author keywords

amyloid peptide25 35; Alzheimer's disease; Cyclic AMP response element binding protein; Osthole

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[25-35]; BETA SECRETASE 1; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; OSTHOLE; SYNAPSIN I;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CELL; CELL LINE; CELL PROTECTION; CELL STRAIN SH SY5Y; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MOUSE; NERVE CELL; NEWBORN; NONHUMAN; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; CELLS, CULTURED; COUMARINS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; HUMANS; MICE; MICE, INBRED C57BL; NEURONS; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; SYNAPSINS;

EID: 84892563180     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b13-00561     Document Type: Article

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