Inhibitory effect of a 2,4-bis(4-hydroxyphenyl)-2-butenal diacetate on neuro-inflammatory reactions via inhibition of STAT1 and STAT3 activation in cultured astrocytes and microglial BV-2 cells

Neuropharmacology

Volumn 79, Issue , 2014, Pages 476-487

  Kim, Jin A ^a   Yun, Hyung Mun ^a   Jin, Peng ^a   Lee, Hee Pom ^a   Han, Jin Yi ^a   Udumula, Venkatareddy ^b   Moon, Dong Cheul ^a   Han, Sang Bae ^a   Oh, Ki Wan ^a   Ham, Young Wan ^c   Jung, Heon Sang ^a   Song, Ho Sueb ^d   Hong, Jin Tae ^a  

^a Chungbuk National University   (South Korea)

^b Brigham Young University   (United States)

^c UTAH VALLEY UNIVERSITY   (United States)

^d Gachon University   (South Korea)

Author keywords

2 4 Bis(4 hydroxyphenyl)but 2 enal diacetate; Anti amyloidogenesis; Anti neuroinflammation; NF andkappa; B; STAT1; STAT3

Indexed keywords

2,4 BIS(4 HYDROXYPHENYL) 2 BUTENAL DIACETATE; ALDEHYDE DERIVATIVE; AMYLOID BETA PROTEIN[1-42]; ANTIINFLAMMATORY AGENT; BETA SECRETASE; BETA SECRETASE 1; CELL PROTEIN; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PROTEIN C99; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STAT1 PROTEIN; STAT3 PROTEIN; UNCLASSIFIED DRUG; 2,4-BIS(4-HYDROXYPHENYL)BUT-2-ENAL DIACETATE; ACETIC ACID DERIVATIVE; ALDEHYDE; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); I KAPPA B KINASE; NOS2 PROTEIN, RAT; PEPTIDE FRAGMENT; PTGS2 PROTEIN, RAT; STAT1 PROTEIN, RAT; STAT3 PROTEIN, RAT;

ANIMAL CELL; ANTI AMYLOIDOGENIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG TARGETING; ENZYME INHIBITION; MICROGLIA; MOLECULAR DOCKING; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN CORTEX; CELL CULTURE; CELL SURVIVAL; DRUG EFFECTS; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; RAT; TOXICITY;

ACETATES; ALDEHYDES; AMYLOID BETA-PEPTIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTROCYTES; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; CYCLOOXYGENASE 2; I-KAPPA B KINASE; LIPOPOLYSACCHARIDES; MICROGLIA; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PEPTIDE FRAGMENTS; RATS; REACTIVE OXYGEN SPECIES; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR;

EID: 84892562580     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.06.032     Document Type: Article

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