Anti-amyloidogenic effect of thiacremonone through anti-inflamation in vitro and in vivo models

Journal of Alzheimer's Disease

Volumn 29, Issue 3, 2012, Pages 659-676

  Lin, Gui Hua ^a   Lee, Young Jung ^a   Choi, Dong Young ^a   Han, Sang Bae ^a   Jung, Jae Kyung ^a   Hwang, Bang Yeon ^a   Moon, Dong Cheul ^a   Kim, Youngsoo ^a   Lee, Myung Koo ^a   Oh, Ki Wan ^a   Jeong, Heon Sang ^a   Leem, Jae Yoon ^b   Shin, Hwa Kyoung ^c   Leef, Jung Hwa ^d   Hong, Jin Tae ^a  

^a Chungbuk National University   (South Korea)

^b Woosuk University   (South Korea)

^c Pusan National University   (South Korea)

^d Konkuk University School of Medicine   (South Korea)

Author keywords

Amyloidogenesis; neuroinflammation; NF b; thiacremonone

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; ANTIINFLAMMATORY AGENT; BETA ACTIN; BETA SECRETASE; CYCLOOXYGENASE 2; GARLIC EXTRACT; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HISTONE H1; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; PROTEIN P50; SULFUR DERIVATIVE; SYNAPTOTAGMIN I; THIACREMONONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYLOIDOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; BRAIN CORTEX; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG EFFECT; GLIA; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MALE; MEMORY DISORDER; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 84859418805     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-111709     Document Type: Article

References (67)

1. Blennow K, de Leon MJ, Zetterberg H (2006) Alzheimer's disease. Lancet 368, 387-403. (Pubitemid 44108123)
2. Querfurth HW, LaFerla FM (2010) Alzheimer's disease. N Engl J Med 362, 329-344.
3. LaFerla FM (2010) Pathways linking Abeta and tau pathologies. Biochem Soc Trans 38, 993-995.
4. Heneka MT, O'Banion MK, Terwel D, Kummer MP (2010) Neuroinflammatory processes in Alzheimer's disease. J Neural Transm 117, 919-947.
5. Rossner S, Sastre M, Bourne K, Lichtenthaler SF (2006) Transcriptional and translational regulation of BACE1 expression-implications for Alzheimer's disease. Prog Neurobiol 79, 95-111. (Pubitemid 44247281)
6. Verkhratsky A, Olabarria M, Noristani HN, Yeh CY, Rodriguez JJ (2010) Astrocytes in Alzheimer's disease. Neurotherapeutics 7, 399-412.
7. Bettegazzi B, Mihailovich M, Di Cesare A, Consonni A, Macco R, Pelizzoni I, Codazzi F, Grohovaz F, Zacchetti D (2011) beta-Secretase activity in rat astrocytes: translational block of BACE1 and modulation of BACE2 expression. Eur J Neurosci 33, 236-243.
8. Cai Y, Zhang XM, Macklin LN, Cai H, Luo XG, Oddo S, Laferla FM, Struble RG, Rose GM, Patrylo PR, Yan XX (2011) BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of Alzheimer's disease: Differential Abeta antibody labeling of early-onset axon terminal pathology. Neurotox Res 21, 160-174.
9. Leuba G, Wernli G, Vernay A, Kraftsik R, Mohajeri MH, Saini KD (2005) Neuronal and nonneuronal quantitative BACE immunocytochemical expression in the entorhinohip-pocampal and frontal regions in Alzheimer's disease. Dement Geriatr Cogn Disord 19, 171-183. (Pubitemid 40522804)
10. Garwood CJ, Pooler AM, Atherton J, Hanger DP, Noble W (2011) Astrocytes are important mediators of Abeta-induced neurotoxicity and tau phosphorylationinprimary culture. Cell Death Dis 2, e167
11. Benzing WC, Wujek JR, Ward EK, Shaffer D, Ashe KH, Younkin SG, Brunden KR (1999) Evidence for glial-mediated inflammation in aged APP (SW) transgenic mice. Neurobiol Aging 20, 581-589. (Pubitemid 30064403)
12. Fillit H, Ding WH, Buee L, Kalman J, Altstiel L, Lawlor B, Wolf-Klein G (1991) Elevated circulating tumor necrosis factor levels in Alzheimer's disease. Neurosci Lett 129, 318-320.
13. Blum-Degen D, Muller T, Kuhn W, Gerlach M, Przuntek H, Riederer P (1995) Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients. Neurosci Lett 202, 17-20.
14. Blasko I, Veerhuis R, Stampfer-Kountchev M, Saurwein-Teissl M, Eikelenboom P, Grubeck-Loebenstein B (2000) Costimulatory effects of interferon-[gamma] and interleukin-1[beta] or tumor necrosis factor [alpha] on the synthesis of A[beta]1-40 and A[beta]1-42byhuman astrocytes. Neurobiol Dis 7, 682-689. (Pubitemid 32044292)
15. Sheng JG, Bora SH, Xu G, Borchelt DR, Price DL, Koliatsos VE (2003) Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice. Neurobiol Dis 14, 133-145. (Pubitemid 37103187)
16. Gong QH, Wang Q, Pan LL, Liu XH, Xin H, Zhu YZ (2011) S-propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: Involvement of TNF signaling and NF-kappaB pathway in rats. Brain Behav Immun 25, 110-119.
17. Yu JT, Lee CH, Yoo KY, Choi JH, Li H, Park OK, Yan B, Hwang IK, Kwon YG, Kim YM, Won MH (2010) Maintenance of anti-inflammatory cytokines and reduction of glial activation in the ischemic hippocampal CA1 region preconditioned with lipopolysaccharide. J Neurol Sci 296, 69-78.
18. Lee JW, Lee MS, Kim TH, Lee HJ, Hong SS, Noh YH, Hwang BY, Ro JS, Hong JT (2007) Inhibitory effect of inflexinol on nitric oxide generation and iNOS expression via inhibition of NF-kappaB activation. Mediators Inflamm 2007, 93148.
19. Gasparini L, Ongini E, Wenk G (2004) Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: Old and new mechanisms of action. J Neurochem 91, 521-536. (Pubitemid 39431148)
20. Jin M, Suh SJ, Yang JH, Lu Y, Kim SJ, Kwon S, Jo TH, Kim JW, Park YI, Ahn GW, Lee CK, Kim CH, Son JK, Son KH, Chang HW (2010) Anti-inflammatory activity of bark of Dioscorea batatas DECNE through the inhibition of iNOS and COX-2 expressions in RAW264.7 cells via NF-kappaB and ERK1/2 inactivation. Food Chem Toxicol 48, 3073-3079.
21. Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C (1997) Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc Natl Acad Sci USA 94, 2642-2647. (Pubitemid 27136929)
22. Bales KR, Du Y, Holtzman D, Cordell B, Paul SM (2000) Neuroinflammation and Alzheimer's disease: Critical roles for cytokine/Abeta-induced glial activation, NF-kappaB, and apolipoprotein E. Neurobiol Aging 21, 427-432; discussion 451-423. (Pubitemid 30349109)
23. Chen CH, Zhou W, Liu S, Deng Y, Cai F, Tone M, Tone Y, Tong Y, Song W (2011) Increased NF-kappaB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. Int J Neuropsychopharmacol 15, 77-90.
24. Paris D, Patel N, Quadros A, Linan M, Bakshi P, Ait-Ghezala G, Mullan M (2007) Inhibition of Abeta production by NF-kappaB inhibitors. Neurosci Lett 415, 11-16. (Pubitemid 46356710)
25. Chauhan NB (2006) Effect of aged garlic extract on APP processing and tau phosphorylationin Alzheimer's transgenic model Tg2576. J Ethnopharmacol 108, 385-394. (Pubitemid 44693108)
26. Peng Q, Buz'Zard AR, Lau BH (2002) Neuroprotective effect of garlic compounds in amyloid-beta peptide-induced apop-tosis in vitro. Med Sci Monit 8, BR328-BR337. (Pubitemid 34951423)
27. Brunetti L, Menghini L, Orlando G, Recinella L, Leone S, Epifano F, Lazzarin F, Chiavaroli A, Ferrante C, Vacca M (2009) Antioxidant effects of garlic in young and aged rat brain in vitro. J Med Food 12, 1166-1169.
28. Helen A, Krishnakumar K, Vijayammal PL, Augusti KT (2003) A comparative study of antioxidants S-allyl cysteine sulfoxide and vitamin E on the damages induced by nicotine in rats. Pharmacology 67, 113-117. (Pubitemid 36184454)
29. Chauhan NB (2006) Effect of aged garlic extract on APP processing and tau phosphorylationin Alzheimer's transgenic model Tg2576. J Ethnopharmacol 108, 385-394. (Pubitemid 44693108)
30. Ray B, Chauhan NB, Lahiri DK (2011) Oxidative insults to neurons and synapse are prevented by aged garlic extract and S-allyl-L-cysteine treatment in the neuronal culture and APP-Tg mouse model. J Neurochem 117, 388-402.
31. Ban JO, Oh JH, Kim TM, Kim DJ, Jeong HS, Han SB, Hong JT (2009) Anti-inflammatory and arthritic effects of thiacre-monone, a novel sulfur compound isolated from garlic via inhibition of NF-kappaB. Arthritis Res Ther 11, R145
32. Ban JO, Yuk DY, Woo KS, Kim TM, Lee US, Jeong HS, Kim DJ, Chung YB, Hwang BY, Oh KW, Hong JT (2007) Inhibition of cell growth and induction of apoptosis via inactivation of NF-kappaB by a sulfurcompound isolated from garlic in human colon cancer cells. J Pharmacol Sci 104, 374-383.
33. Lee JW, Lee YK, Yuk DY, Choi DY, Ban SB, Oh KW, Hong JT (2008) Neuro-inflammation induced by lipopolysaccha-ride causes cognitive impairment through enhancement of beta-amyloid generation. J Neuroinflammation 5, 37.
34. Sparkman NL, Martin LA, Calvert WS, Boehm GW (2005) Effects of intraperitoneal lipopolysaccharide on Morris maze performance in year-old and 2-month-old female C57BL/6J mice. Behav Brain Res 159, 145-151. (Pubitemid 40410596)
35. Park MH, Lee SM, Lee JW, Son DJ, Moon DC, Yoon DY, Hong JT (2006) ERK-mediated production of neurotrophic factors by astrocytes promotes neuronal stem cell differentiation by erythropoietin. Biochem Biophys Res Commun 339, 1021-1028. (Pubitemid 41790566)
36. Lee SY, Hwang DY, Kim YK, Lee JW, Shin IC, Oh KW, Lee MK, Lim JS, Yoon DY, Hwang SJ, Hong JT (2006) PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release. FASEB J 20, 151-153. (Pubitemid 43100497)
37. Lee JW, Lee YK, Ban JO, Ha TY, Yun YP, Han SB, Oh KW, Hong JT (2009) Green tea (-)-epigallocatechin-3-gallate inhibits beta-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-kappaB pathways in mice. J Nutr 139, 1987-1993.
38. Ray S, Howells C, Eaton ED, Butler CW, Shabala L, Adlard PA, West AK, Bennett WR, Guillemin GJ, Chung RS (2011) Tg2576 cortical neurons that express human Ab are susceptible to extracellular Abeta-induced, K+ efflux dependent neurodegeneration. PLoS One 6, e19026.
39. Selkoe DJ (2006) The ups and downs of Abeta. Nat Med 12, 758-759; discussion 759.
40. Cui M, Ono M, Kimura H, Kawashima H, Liu BL, Saji H (2011) Radioiodinated benzimidazole derivatives as single photon emission computed tomography probes for imaging of beta-amyloid plaques in Alzheimer's disease. Nucl Med Biol 38, 313-320.
41. Jaeger LB, Dohgu S, Sultana R, Lynch JL, Owen JB, Erickson MA, Shah GN, Price TO, Fleegal-Demotta MA, Butterfiled DA, Banks WA (2009) Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: A mechanism for inflammation in the progression of Alzheimer's disease. Brain Behav Immun 23, 507-517.
42. Kitazawa M, Oddo S, Yamasaki TR, Green KN, LaFerla FM (2005) Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J Neurosci 25, 8843-8853. (Pubitemid 41384452)
43. Rogers JT, Leiter LM, McPhee J, Cahill CM, Zhan SS, Potter H, Nilsson LN (1999) Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences. J Biol Chem 274, 6421-6431. (Pubitemid 29111057)
44. McAlpine FE, Lee JK, Harms AS, Ruhn KA, Blurton-Jones M, Hong J, Das P, Golde TE, LaFerla FM, Oddo S, Blesch A, Tansey MG (2009) Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiol Dis 34, 163-177.
45. Yamamoto M, Kiyota T, Horiba M, Buescher JL, Walsh SM, Gendelman HE, Ikezu T (2007) Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. Am J Pathol 170, 680-692. (Pubitemid 47339404)
46. Liao YF, Wang BJ, Cheng HT, Kuo LH, Wolfe MS (2004) Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway. J Biol Chem 279, 49523-49532. (Pubitemid 39625840)
47. Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM (2005) Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 45, 675-688. (Pubitemid 40320703)
48. Lee YJ, Han SB, Nam SY, Oh KW, Hong JT (2010) Inflammation and Alzheimer's disease. Arch Pharm Res 33, 1539-1556.
49. Heneka MT, Kummer MP, Weggen S, Bulic B, Multhaup G, Munter L, Hull M, Pflanzner T, Pietrzik CU (2011) Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimer's disease. Curr Alzheimer Res8, 115-131.
50. Veerhuis R (2011) Histological and direct evidence for the role of complement in the neuroinflammation of AD. Curr Alzheimer Res 8, 34-58.
51. Pasinetti GM, Aisen PS (1998) Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain. Neuroscience 87, 319-324. (Pubitemid 28370892)
52. Andreasson KI, Savonenko A, Vidensky S, Goellner JJ, Zhang Y, Shaffer A, Kaufmann WE, Worley PF, Isakson P, Markowska AL (2001) Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice. J Neurosci 21, 8198-8209. (Pubitemid 32952775)
53. Cakala M, Malik AR, Strosznajder JB (2007) Inhibitor of cyclooxygenase-2 protects against amyloid beta peptide-evoked memory impairment in mice. Pharmacol Rep 59, 164-172. (Pubitemid 46957315)
54. Sato H, Takahashi T, Sumitani K, Takatsu H, Urano S (2010) Glucocorticoid generates ROS to induce oxidative injury in the hippocampus, leading to impairment of cognitive function of rats. J Clin Biochem Nutr 47, 224-232.
55. Hosseini M, Dastghaib SS, Rafatpanah H, Hadjzadeh MA, Nahrevanian H, Farrokhi I (2010) Nitric oxide contributes to learning and memory deficits observed in hypothyroid rats during neonatal and juvenile growth. Clinics (Sao Paulo) 65, 1175-1181.
56. Ko SY, Lin YP, Lin YS, Chang SS (2010) Advanced glycation end products enhance amyloid precursor protein expression by inducing reactive oxygen species. Free Radic Biol Med 49, 474-480.
57. Kwak YD, Wang R, Li JJ, Zhang YW, Xu H, Liao FF (2011) Differential regulation of BACE1 expression by oxidative and nitrosative signals. Mol Neurodegener 6, 17.
58. Kern A, Behl C (2009) The unsolved relationship of brain aging and late-onset Alzheimer disease. Biochim Biophys Acta 1790, 1124-1132.
59. Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O'Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B, Wenk G, Wyss-Coray T (2000) Inflammation and Alzheimer's disease. Neurobiol Aging 21, 383-421. (Pubitemid 30349107)
60. Cole GM, Morihara T, Lim GP, Yang F, Begum A, Frautschy SA (2004) NSAID and antioxidant prevention of Alzheimer's disease: Lessons from in vitro and animal models. Ann NY Acad Sci 1035, 68-84. (Pubitemid 40362327)
61. Sastre M, Walter J, Gentleman SM (2008) Interactions between APP secretases and inflammatory mediators. J Neuroinflammation 5, 25.
62. Simmonds RE, Foxwell BM (2008) Signalling, inflammation and arthritis: NF-kappaB and its relevance to arthritis and inflammation. Rheumatology (Oxford) 47, 584-590. (Pubitemid 351619194)
63. Grilli M, Ribola M, Alberici A, Valerio A, Memo M, Spano P (1995) Identification and characterization of a kappa B/Rel binding site in the regulatory region of the amyloid precursor protein gene. J Biol Chem 270, 26774-26777. (Pubitemid 3007234)
64. Bourne KZ, Ferrari DC, Lange-Dohna C, Rossner S, Wood TG, Perez-Polo JR (2007) Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides. J Neurosci Res 85, 1194-1204. (Pubitemid 46724363)
65. Sung S, Yang H, Uryu K, Lee EB, Zhao L, Shineman D, Trojanowski JQ, Lee VM, Pratico D (2004) Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. Am J Pathol 165, 2197-2206. (Pubitemid 39578396)
66. Geng Z, Rong Y, Lau BH (1997) S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells. Free Radic Biol Med 23, 345-350. (Pubitemid 27276616)
67. Gupta VB, Rao KS (2007) Anti-amyloidogenic activity of S-allyl-L-cysteine and its activity to destabilize Alzheimer's beta-amyloid fibrils in vitro. Neurosci Lett 429, 75-80. (Pubitemid 350161110)