Blocking NF-kB: An inflammatory issue

Proceedings of the American Thoracic Society

Volumn 8, Issue 6, 2011, Pages 497-503

  Rahman, Arshad ^a   Fazal, Fabeha ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Endothelium; Injury; Lung inflammation; Signal transduction; Transcription factors

Indexed keywords

ACTIN; GUANOSINE TRIPHOSPHATASE; I KAPPA B ALPHA; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RELA;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; IMMUNE RESPONSE; INFLAMMATION; LUNG DISEASE; LUNG INJURY; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; ANIMAL; DISEASE MODEL; METABOLISM; PATHOPHYSIOLOGY; REVIEW;

ACUTE LUNG INJURY; ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; INFLAMMATION; MICE; NF-KAPPA B; RESPIRATORY DISTRESS SYNDROME, ADULT;

EID: 80655125179     PISSN: 15463222     EISSN: 19435665     Source Type: Journal    
DOI: 10.1513/pats.201101-009MW     Document Type: Conference Paper

References (55)

1. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000;342:1334-1349. (Pubitemid 30408719)
2. Maniatis NA, Orfanos SE. The endothelium in acute lung injury/acute respiratory distress syndrome. Curr Opin Crit Care 2008;14:22-30.
3. Goodman RB, Strieter RM, Martin DP, Steinberg KP, Milberg JA, Maunder RJ, Kunkel SL, Walz A, Hudson LD, Martin TR. Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome. Am J Respir Crit Care Med 1996;154:602-611. (Pubitemid 26327279)
4. Fan J, Ye RD, Malik AB. Transcriptional mechanisms of acute lung injury. Lung Cell Mol Physiol 2001;281:L1037-L1050.
5. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994;76:301-314. (Pubitemid 24046692)
6. Rahman A, Fazal F. Hug tightly and say goodbye: role of endothelial ICAM-1 in leukocyte transmigration. Antioxid Redox Signal 2009;11:823-829.
7. Bijli KM, Rahman A. NF-κB signaling in endothelium. In: Aird WC, editor. Endothelial biomedicine. Cambridge University Press; Cambridge, UK: 2007. pp. 784-795.
8. Ghosh S, Hayden MS. New regulators of NF-κB in inflammation. Nat Rev Immunol 2008;8:837-848.
9. Hayden MS, Ghosh S. Signaling to NF-κB. Genes Dev 2004;18:2195-2224.
10. Karin M, Greten FR. NF-κB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005;5:749-759. (Pubitemid 41400849)
11. Kumar A, Takada Y, Boriek AM, Aggarwal BB. Nuclear factor-kappaB: its role in health and disease. J Mol Med 2004;82:434-448. (Pubitemid 39044283)
12. Ye X, Ding J, Zhou X, Chen G, Liu SF. Divergent roles of endothelial NF-kappaB in multiple organ injury and bacterial clearance in mouse models of sepsis. J Exp Med 2008;205:1303-1315. (Pubitemid 351831488)
13. Janssen-Heininger YM, Poynter ME, Aesif SW, Pantano C, Ather JL, Reynaert NL, Ckless K, Anathy V, van der Velden J, Irvin CG, et al. Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control. Proc Am Thorac Soc 2009;6:249-255.
14. Castranova V. Signaling pathways controlling the production of inflammatory mediators in response to crystalline silica exposure: role of reactive oxygen/nitrogen species. Free Radic Biol Med 2004;37:916-925. (Pubitemid 39172129)
15. Rieger-Fackeldey E, Hentschel R. Bronchopulmonary dysplasia and early prophylactic inhaled nitric oxide in preterm infants: current concepts and future research strategies in animal models. J Perinat Med 2008;36:442-447.
16. MacNee W, Tuder RM. New paradigms in the pathogenesis of chronic obstructive pulmonary disease I. Proc Am Thorac Soc 2009;6:527-531.
17. Yoshida T, Mett I, Bhunia AK, Bowman J, Perez M, Zhang L, Gandjeva A, Zhen L, Chukwueke U, Mao T, et al. Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema. Nat Med 2010;16:767-773.
18. Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986;46:705-716. (Pubitemid 16020062)
19. Bonizzi G, Karin M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 2004;25:280-288. (Pubitemid 38610351)
20. Imbert V, Rupec RA, Livolsi A, Pahl HL, Traenckner EB, Mueller-Dieckmann C, Farahifar D, Rossi B, Auberger P, Baeuerle PA, et al. Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha. Cell 1996;86:787-798. (Pubitemid 26303447)
21. Chen LF, Greene WC. Shaping the nuclear action of NF-kappaB. Nat Rev Mol Cell Biol 2004;5:392-401.
22. Zhong H, May MJ, Jimi E, Ghosh S. The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell 2002;9:625-636. (Pubitemid 34273792)
23. Rahman A, Anwar KN, True AL, Malik AB. Thrombin-induced p65 homodimer binding to downstream NF-kappa B site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion. J Immunol 1999;162:5466-5476. (Pubitemid 29307157)
24. Rahman A, Anwar KN, Uddin S, Xu N, Ye RD, Platanias LC, Malik AB. Protein kinase C-delta regulates thrombin-induced ICAM-1 gene expression in endothelial cells via activation of p38 mitogen-activated protein kinase. Mol Cell Biol 2001;21:5554-5565. (Pubitemid 32702459)
25. Minami T, Abid MR, Zhang J, King G, Kodama T, Aird WC. Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by PKCδ-NF-κB and PKCζ-GATA signaling pathways. J Biol Chem 2003;278:6976-6984. (Pubitemid 36800692)
26. Tiruppathi C, Shimizu J, Miyawaki-Shimizu K, Vogel SM, Bair AM, Minshall RD, Predescu D, Malik AB. Role of NF-kappaB-dependent caveolin-1 expression in the mechanism of increased endothelial permeability induced by lipopolysaccharide. J Biol Chem 2008;283:4210-4218.
27. Song D, Ye X, Xu H, Liu SF. Activation of endothelial intrinsic NF-κB pathway impairs protein C anticoagulation mechanism and promotes coagulation in endotoxemic mice. Blood 2009;114:2521-2529.
28. Levi M, van der Poll T. Two-way interactions between inflammation and coagulation. Trends Cardiovasc Med 2005;15:254-259. (Pubitemid 41437908)
29. Bair AM, Thippegowda PB, Freichel M, Cheng N, Ye RD, Vogel SM, Yu Y, Flockerzi V, Malik AB, Tiruppathi C. Ca2+ entry via TRPC channels is necessary for thrombin-induced NF-kappaB activation in endothelial cells through AMP-activated protein kinase and protein kinase Cdelta. J Biol Chem 2009;284:563-574.
30. Paria BC, Bair AM, Xue J, Yu Y, Malik AB, Tiruppathi C. Ca2+ influx induced by protease-activated receptor-1 activates a feed-forward mechanism of TRPC1 expression via nuclear factor-kappaB activation in endothelial cells. J Biol Chem 2006;281:20715-20727. (Pubitemid 44115413)
31. Rahman A, Anwar KN, Malik AB. Protein kinase Cζ mediates TNFα-induced ICAM-1 gene transcription in endothelial cells. Am J Physiol Cell Physiol 2000;279:C906-C914.
32. Anrather J, Csizmadia V, Soares MP, Winkler H. Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21 (ras) and protein kinase Czeta in primary endothelial cells. J Biol Chem 1999;274:13594-13603.
33. Rahman A, True AL, Anwar KN, Ye RD, Voyno-Yasenetskaya TA, Malik ABG. αq and Gβγ regulate PAR-1-induced NF-κB activation and ICAM-1 transcription in endothelial cells. Circ Res 2002;91:398-405. (Pubitemid 35034207)
34. Frey RS, Gao XP, Javaid K, Siddiqui SS, Rahman A, Malik AB. Phosphatidylinositol 3-kinase γ signaling via PKCζ induces NADPH oxidase-induced oxidant generation and NF-κB activation in endothelial cells. J Biol Chem 2006;281:16128-16138. (Pubitemid 43848508)
35. Frey RS, Rahman A, Kefer J, Minshall RD, Malik AB. PKC-ζ regulates TNFα-induced activation of NADPH oxidase in endothelial cells. Circ Res 2002;90:1012-1019. (Pubitemid 34633868)
36. Hawkins BJ, Solt LA, Chowdhury I, Kazi AS, Abid MR, Aird WC, May MJ, Foskett JK, Madesh M. G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence. Mol Cell Biol 2007;27:7582-7593. (Pubitemid 350033663)
37. Zhou Z, Connel MC, MacEwan DJ. TNFR1-induced NF-kappaB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells. Cell Signal 2007;19:1238-1248. (Pubitemid 46561561)
38. Anwar KN, Fazal F, Malik AB, Rahman A. RhoA/ROCK pathway selectively regulatesthrombin-induced ICAM-1 expression in endothelial cells via activation of IKKβ and phosphorylation of RelA/p65. J Immunol 2004;173:6965-6972. (Pubitemid 39541085)
39. Cernuda-Morollon E, Ridley AJ. Rho GTPases and leukocyte adhesion receptor expression and function in endothelial cells. Circ Res 2006;98:757-767.
40. Chen XL, Zhang Q, Zhao R, Ding X, Tummala PE, Medford RM. Rac1 and superoxide are required for the expression of cell adhesion molecules induced by tumor necrosis factor-alpha in endothelial cells. J Pharmacol Exp Ther 2003;305:573-580. (Pubitemid 36459172)
41. Fazal F, Minhajuddin M, Bijli KM, McGrath JL, Rahman A. Evidence for actin cytoskeleton-dependent and -independent pathways for RelA/p65 nuclear translocation in endothelial cells. J Biol Chem 2007;282:3940-3950. (Pubitemid 47084484)
42. Fazal F, Bijli KM, Minhajuddin M, Rein T, Finkelstein JN, Rahman A. Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and ICAM-1 expression in endothelial cells. J Biol Chem 2009;284:21047-21056.
43. Weber C, Negrescu E, Erl W, Pietsch A, Frankenberger M, Ziegler-Heitbrock HW, Siess W, Weber PC. Inhibitors of protein tyrosine kinase suppress TNF-stimulated induction of endothelial cell adhesion molecules. J Immunol 1995;155:445-451.
44. Bijli KM, Minhajuddin M, Fazal F, O'Reilly MA, Platanias LC, Rahman A. c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cells. Am J Physiol Lung Cell Mol Physiol 2007;292:L396-L404.
45. Bijli KM, Fazal F, Minhajuddin M, Rahman A. Activation of Syk by PKCδ regulates thrombin-induced ICAM-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65. J Biol Chem 2008;283:14674-14684.
46. Minhajuddin M, Bijli KM, Fazal F, Sassano A, Nakayama KI, Hay N, Platanias LC, Rahman A. Protein kinase Cδg and gPI 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-κB activation and ICAM-1 expression in endothelial cells. J Biol Chem 2009;284:4052-4061.
47. Minhajuddin M, Fazal F, Bijli KM, Rahman A. Inhibition of mTOR potentiates thrombin-induced ICAM-1 expression by accelerating and stabilizing NF-κB activation in endothelial cells. J Immunol 2005;174:5823-5829. (Pubitemid 40593227)
48. Weichhart T, Costantino G, Poglitsch M, Rosner M, Zeyda M, Stuhlmeier KM, Kolbe T, Stulnig TM, Hörl WH, Hengstschläger M, et al. The TSC-mTOR singaling pathway regulates the innate inflammatory response. Immunity 2008;29:565-577.
49. Lorne E, Zhao X, Zmijewski JW, Liu G, Park YJ, Tsuruta Y, Abraham E. Participation of mammalian target of rapamycin complex 1 in Toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury. Am J Respir Cell Mol Biol 2009;41:237-245.
50. Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004;14:1296-1302. (Pubitemid 38991819)
51. Lawrence T, Gilroy DW, Colville-Nash PR, Willoughby DA. Possible new role for NF-κB in the resolution of inflammation. Nat Med 2001;7:1291-1297. (Pubitemid 34007932)
52. Chen LW, Egan L, Li ZW, Greten FR, Kagnoff MF, Karin M. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med 2003;9:575-581. (Pubitemid 36597104)
53. Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, Prestwich GD, Mascarenhas MM, Garg HG, Quinn DA, et al. Regulation of lung injury and repair by Toll-like receptors and hyaluranon. Nat Med 2003;11:1173-1179.
54. Pasparakis M. Regulation of tissue homeostasis NF-κB signaling: implications for inflammatory diseases. Nat Rev Immunol 2009;9:778-788.
55. Perkins ND. Integrating cell-signaling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 2007;8:49-62. (Pubitemid 46012014)