Abnormal trafficking of endogenously expressed BMPR2 mutant allelic products in patients with heritable pulmonary arterial hypertension

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Frump, Andrea L ^a   Lowery, Jonathan W ^b   Hamid, Rizwan ^c   Austin, Eric D ^c   De Caestecker, Mark ^a,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 PHENYLBUTYRIC ACID; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; INHIBITOR OF DIFFERENTIATION 1; MUTANT PROTEIN; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TAURODEOXYCHOLIC ACID;

ANIMAL CELL; ARTICLE; BMPR2 GENE; CELL MIGRATION; CELL SURFACE; CONTROLLED STUDY; DRUG EFFECT; ENDOPLASMIC RETICULUM; ENDOTHELIUM CELL; EXON; GENE DELETION; GENE EXPRESSION; GENE IDENTIFICATION; GENE LOCATION; GENE MUTATION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; IN FRAME GENE DELETION; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; NONSENSE MEDIATED MRNA DECAY; OPEN READING FRAME; PROTEIN FOLDING; PROTEIN TRANSPORT; PULMONARY ENDOTHELIUM CELL; PULMONARY HYPERTENSION; RECEPTOR GENE; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION;

ALLELES; ANIMALS; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; CELLS, CULTURED; FEMALE; HUMANS; HYPERTENSION, PULMONARY; MALE; MICE; MUTATION; NONSENSE MEDIATED MRNA DECAY; PROTEIN TRANSPORT;

EID: 84892422673     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0080319     Document Type: Article

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