A host-guest relationship in bone morphogenetic protein receptor-ii defines specificity in ligand-receptor recognition

Biochemistry

Volumn 51, Issue 35, 2012, Pages 6968-6980

  Lee, John C ^a   Yeh, Lee Chuan C ^a   Falcon, Wilfredo E ^b   Garces, Andrea ^b   Lee, J Ching ^b  

^a University of Texas Health Science Center   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOPHYSICAL STUDIES; BONE MORPHOGENETIC PROTEINS; COMPUTATIONAL ANALYSIS; EXTRACELLULAR DOMAINS; GENETIC DISEASE; HOST-GUESTS; INTRA-DOMAIN; INTRIGUING QUESTIONS; LIGAND BINDING; LIGAND RECOGNITION; LIGAND SPECIFICITY; LIGAND-RECEPTOR; LONG-RANGE CONNECTIVITIES; LOOP STRUCTURE; PROTEIN STRUCTURES; STRUCTURAL CHANGE; TYPE II;

BIOCHEMISTRY; CHEMISTRY;

LIGANDS;

ACTIVIN; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; CELL SURFACE RECEPTOR; GROWTH DIFFERENTIATION FACTOR 5; LYSINE; OSTEOCALCIN; OSTEOGENIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA3;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; EXTRACELLULAR MATRIX; GENE EXPRESSION; HYDROPHOBICITY; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR RECOGNITION; MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN INTERACTION; PROTEIN STRUCTURE;

ACTIVIN RECEPTORS, TYPE II; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STABILITY; SEQUENCE ALIGNMENT; SEQUENCE DELETION; SUBSTRATE SPECIFICITY;

EID: 84865749837     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi3003023     Document Type: Article

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