3,4-Dihydroxytoluene, a metabolite of rutin, inhibits inflammatory responses in lipopolysaccharide-activated macrophages by reducing the activation of NF-κB signaling

BMC Complementary and Alternative Medicine

Volumn 14, Issue , 2014, Pages

  Su, Kang Yi ^b,c   Yu, Chao Y ^a   Chen, Ya Ping ^a   Hua, Kuo Feng ^a   Chen, Yi Lin S ^a  

^a NATIONAL ILAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Anti inflammation; Cyclooxygenase 2 (COX 2); Flavonoid; Inducible nitric oxide synthase; Saussurea involucrata

Indexed keywords

3,4 DIHYDROXYTOLUENE; ANTIINFECTIVE AGENT; CYCLOOXYGENASE 2; DRUG METABOLITE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; RUTOSIDE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 4-METHYLCATECHOL; ANTIINFLAMMATORY AGENT; AUTACOID; CATECHOL DERIVATIVE; I KAPPA B; NF-KAPPAB INHIBITOR ALPHA; NOS2 PROTEIN, MOUSE; PTGS2 PROTEIN, MOUSE; RUTOSIDE;

ADJUVANT THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CYTOPLASM; CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; INFLAMMATION; MACROPHAGE; MEDICINAL PLANT; MURINAE; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; BIOSYNTHESIS; CELL LINE; DRUG EFFECTS; METABOLISM; MOUSE; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CATECHOLS; CELL LINE; CYCLOOXYGENASE 2; ENZYME ACTIVATION; I-KAPPA B PROTEINS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; RUTIN; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84892418977     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-21     Document Type: Article

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