Mechanisms involved in the antiplatelet activity of rutin, a glycoside of the flavonol quercetin, in human platelets

Journal of Agricultural and Food Chemistry

Volumn 52, Issue 14, 2004, Pages 4414-4418

  Sheu, Joen Rong ^a   Hsiao, George ^a   Chou, Po Hsiu ^a   Shen, Ming Yi ^a   Chou, Duen Suey ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Phospholipase C; Platelet aggregation; Protein kinase C; Rutin; Thromboxane A2

Indexed keywords

CALCIUM; CELL PROTEIN; COLLAGEN; CYCLIC AMP; CYCLIC GMP; FIBRINOGEN RECEPTOR; FLAVONOID; FLAVONOL; FLUORESCEIN ISOTHIOCYANATE; GLYCOSIDE; NITRIC OXIDE; PHOSPHOLIPASE C; PROTEIN KINASE C; PROTEIN P47; QUERCETIN; RUTOSIDE; THROMBOCYTE PROTEIN; THROMBOXANE A2; TRIFLAVIN; UNCLASSIFIED DRUG;

ANTIPLATELET ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; ICOSANOID METABOLISM; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; THROMBOCYTE AGGREGATION INHIBITION;

BLOOD PLATELETS; BLOOD PROTEINS; CALCIUM; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; PHOSPHOLIPASE C; PHOSPHOPROTEINS; PHOSPHORYLATION; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROTEIN KINASE C; RUTIN; THROMBOXANE A2;

EID: 3142583067     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf040059f     Document Type: Article

References (25)

1. Visioli, F.; Galli, C. Olive oil polyphenols and their potential effects on human health. J. Agric. Food Chem. 1998, 46, 4292-4296.
2. Kushi, L. H.; Lenart, E. B.; Willet, W. C.; Sacks, S.; Trichopoulou, A.; Drescher, G.; FerroLuzzi, A.; Helsin, E.; Trichopoulos, D. Mediterranean diet pyramida cultural model for healthy eating. Am. J. Clin. Nutr. 1995, 61, 1402S-1406S.
3. Hertog, M. G. L.; Hollman, P. C. H.; Venema, D. P. Optimization of a quantitative HPLC determination of potentially anticarcinogenic flavonoids in vegetables and fruit. J. Agric. Food Chem. 1992, 40, 1591-1598.
4. Deschner, E. E.; Ruperto, J.; Wong, G.; Newmark, H. L. Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis 1991, 12, 1193-1196.
5. Aleksandrov, P. N.; Speranskaia, T. V.; Bobkov, I. G.; Zagorevskii, V. A.; Zykov, D. A. Effect of rutin and esculamine on models of aseptic inflammation. Farmakol. Toksikol. 1986, 49, 84-86.
6. Swies, J.; Robak, J.; Dabrowski, L.; Duniec, Z.; Michalska, Z.; Gryglewski, R. J. Antiaggregatory effects of flavonoids in vivo and their influence on lipoxygenase and cyclooxygenase in vitro. Pol. J. Pharmacol. Pharm. 1984, 36, 455-463.
7. Chung, M. I.; Gan, K. H.; Lin, C. N.; Ko, F. N.; Teng, C. M. Antiplatelet effects and vasorelaxing action of some constitutes of Formosan plants. J. Nat. Prod. 1993, 56, 929-934.
8. Sheu, J. R.; Chao, S. H.; Yen, M. H.; Huang, T. F. In vivo antithrombotic effect of triflavin, an Arg-Gly-Asp containing peptide on platelet plug formation in mesenteric microvessels of mice. Thromb. Haemost. 1994, 72, 617-621.
9. Hass, W. K.; Easton, J. D.; Adams, H. P.; Pryse-Philips, W.; Molony, B. A.; Anderson, S.; Kamm, B. A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. New Engl. J. Med. 1989, 321, 501-507.
10. Gryglewski, R. J.; Korbut, R.; Robak, J.; Swies, J. On the mechanism of antithrombotic action of flavonoids. Biochem. Pharmacol. 1987, 36, 317-322.
11. Sheu, J. R.; Lee, C. R.; Lin, C. C.; Kan, Y. C.; Lin, C. H.; Hung, W. C.; Lee, Y. M.; Yen, M. H. The antiplatelet activity of PMC, a potent α-tocopherol analogue, is mediated through inhibition of cyclo-oxygenase. Br. J. Pharmacol. 1999, 127, 1206-1212.
12. Sheu, J. R.; Teng, C. M.; Huang, T. F. Triflavin, an RGD-containing antiplatelet peptide, binds to GP IIIa of ADP-stimulated platelets. Biochem. Biophys. Res. Commun. 1992, 189, 1236-1242.
13. Sheu, J. R.; Lin, C. H.; Peng, C. H.; Huang, T. F. Triflavin, an Arg-Gly-Asp-containing peptide, inhibits the adhesion of tumor cells to matrix protein via binding to multiple integrin receptors expressed on human hepatoma cells. Proc. Soc. Exp. Biol. Med. 1996, 213, 71-79.
14. 2+ indicator with greatly improved fluorescence properties. J. Biol. Chem. 1985, 260, 3440-3450.
15. Karniguian, A.; Legrand, Y. J.; Caen, J. P. Prostaglandins: specific inhibition of platelet adhesion to collagen and relationship with cyclic AMP level. Prostaglandins 1982, 23, 437-457.
16. Sheu, J. R.; Hung, W. C.; Su, C. H.; Lin, C. H.; Lee, L. W.; Lee, Y. M.; Yen, M. H. The antiplatelet activity of Escherichia coli lipopolysaccharide is mediated through a nitric oxide/cyclic GMP pathway. Eur. J. Haematol. 1999, 62, 317-326.
17. Grabarek, J.; Raychowdhury, M.; Ravid, K.; Kent, K. C.; Newman, P. J.; Ware, J. A. Identification and functional characterization of protein kinase C isozymes in platelets and HEL cells. J. Biol. Chem. 1992, 267, 10011-10017.
18. Siess, W.; Lapetina, E. G. Platelet aggregation induced by alpha 2-adrenoceptor and protein kinase C activation. A novel synergism. Biochem. J. 1989, 263, 377-385.
19. Charo, I. F.; Feinman, R. D.; Detwiler, T. C. Inhibition of platelet secretion by an antagonist of intracellular calcium. Biochem. Biophys. Res. Commun. 1976, 72, 1462-1467.
20. Kirk, C. J.; Creba, J. A.; Downes, C. P.; Michell, R. H. Hormone-stimulated metabolism of inositol lipids and its relationship to hepatic receptor function. Biochem. Soc. Trans. 1981, 9, 377-379.
21. Berridge, M. J. Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. Biochem. J. 1983, 212, 249-258.
22. 2 production. Biochem. Pharmacol. 1982, 31, 1158-1160.
23. McKean, M. L.; Smith, J. B.; Silver, W. J. Formation of lysophosphatidylcholine in human platelets in response to thrombin. J. Biol. Chem. 1981, 256, 1522-1524.
24. Walter, U.; Eigenthaler, M.; Geiger, J.; Reinhard, M. Role of cyclic nucleotide-dependent protein kinases and their common substrate VASP in the regulation of human platelets. Adv. Exp. Med. Biol. 1993, 344, 237-249.
25. McDonald, L. J.; Murad, F. Nitric oxide and cyclic GMP signaling. Proc. Soc. Exp. Biol. Med. 1996, 211, 1-6.