메뉴 건너뛰기




Volumn , Issue , 2013, Pages 35-61

Analytical tools and chemometrics in drug development process: A review

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84892345613     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter
Times cited : (2)

References (77)
  • 1
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as Sources of New Drugs over the last 25 Years
    • Newman D.J., Cragg G.M. Natural products as Sources of New Drugs over the last 25 Years. Journal of Natural Products, 2007, 70, 461-477.
    • (2007) Journal of Natural Products , vol.70 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 2
    • 27844474247 scopus 로고    scopus 로고
    • Drug discovery from medical plants
    • Balunas M.J.; Kinghorn A.D. Drug discovery from medical plants. Life Science, 2005, 78, 431-441.
    • (2005) Life Science , vol.78 , pp. 431-441
    • Balunas, M.J.1    Kinghorn, A.D.2
  • 3
    • 1942453222 scopus 로고    scopus 로고
    • Unconventional natural sources for future drug discovery
    • Tulp M.; Bohlin L. Unconventional natural sources for future drug discovery. Drug Discovery Today, 2004, 9, 450-458.
    • (2004) Drug Discovery Today , vol.9 , pp. 450-458
    • Tulp, M.1    Bohlin, L.2
  • 4
    • 27144529964 scopus 로고    scopus 로고
    • Principles and applications of LC-MS in new drug discovery
    • Korfmacher W.A. Principles and applications of LC-MS in new drug discovery. Drug Discovery Today, 2005, 10, 1357-1367.
    • (2005) Drug Discovery Today , vol.10 , pp. 1357-1367
    • Korfmacher, W.A.1
  • 5
    • 0037373590 scopus 로고    scopus 로고
    • New estimates of drug development costs
    • Frank R.G. New estimates of drug development costs. Journal of Health Economics, 2003, 22, 325-330.
    • (2003) Journal of Health Economics , vol.22 , pp. 325-330
    • Frank, R.G.1
  • 6
    • 56749125725 scopus 로고    scopus 로고
    • Dose optimization in drug development: role of phase 4 trials
    • Joubert P.H. Dose optimization in drug development: role of phase 4 trials. International Congress Series, 2001, 1220, 51-65.
    • (2001) International Congress Series , vol.1220 , pp. 51-65
    • Joubert, P.H.1
  • 7
    • 84862095769 scopus 로고    scopus 로고
    • Recent HPLC strategies to improve sensitivity and selectivity for the analysis of complex matrices
    • Locatelli M.; Melucci D.; Carlucci G.; Locatelli C. Recent HPLC strategies to improve sensitivity and selectivity for the analysis of complex matrices. Instrumentation Science & Technology, 2012, 40, 112-137.
    • (2012) Instrumentation Science & Technology , vol.40 , pp. 112-137
    • Locatelli, M.1    Melucci, D.2    Carlucci, G.3    Locatelli, C.4
  • 8
    • 79551627446 scopus 로고    scopus 로고
    • Anthraquinones: Analytical Techniques as a Novel Tool to Investigate on the Triggering of Biological Targets
    • Locatelli M. Anthraquinones: Analytical Techniques as a Novel Tool to Investigate on the Triggering of Biological Targets. Current Drug Targets, 2011, 12, 366-380.
    • (2011) Current Drug Targets , vol.12 , pp. 366-380
    • Locatelli, M.1
  • 9
    • 0034746706 scopus 로고    scopus 로고
    • Ultrafast liquid chromatography/ultraviolet and liquid chromatography/tandem mass spectrometric analysis
    • Cheng Y.F.; Lu Z.; Neuc U. Ultrafast liquid chromatography/ultraviolet and liquid chromatography/tandem mass spectrometric analysis. Rapid Communications in Mass Spectrometry, 2001, 15, 141-151.
    • (2001) Rapid Communications in Mass Spectrometry , vol.15 , pp. 141-151
    • Cheng, Y.F.1    Lu, Z.2    Neuc, U.3
  • 10
    • 0033787424 scopus 로고    scopus 로고
    • Parallel ultra-high flow rate liquid chromatography with mass spectrometric detection using a multiplex electrospray source for direct, sensitive determination of pharmaceuticals in plasma at extremely high-throughput
    • Bayliss M.; Little D.; Mallett D.; Plumb R. Parallel ultra-high flow rate liquid chromatography with mass spectrometric detection using a multiplex electrospray source for direct, sensitive determination of pharmaceuticals in plasma at extremely high-throughput. Rapid Communications in Mass Spectrometry, 2000, 14, 2039-2045.
    • (2000) Rapid Communications in Mass Spectrometry , vol.14 , pp. 2039-2045
    • Bayliss, M.1    Little, D.2    Mallett, D.3    Plumb, R.4
  • 11
    • 0033168524 scopus 로고    scopus 로고
    • High Throughput LC/MS/MS Determination of Benzodiazepines in Human Urine-1000 sample per 12 Hours
    • Zweigenbaum J.; Heinig K.; Steinborner S.; Wachs T.; Henion J. High Throughput LC/MS/MS Determination of Benzodiazepines in Human Urine-1000 sample per 12 Hours. Analytical Chemistry, 1999, 71, 2294-2300.
    • (1999) Analytical Chemistry , vol.71 , pp. 2294-2300
    • Zweigenbaum, J.1    Heinig, K.2    Steinborner, S.3    Wachs, T.4    Henion, J.5
  • 12
    • 0035979756 scopus 로고    scopus 로고
    • Ultra-short columns and ballistic gradients: considerations for ultra-fast chromatographic liquid chromatographic-tandem mass spectrometric analysis
    • Romanyshyn L.; Tiller P. Ultra-short columns and ballistic gradients: considerations for ultra-fast chromatographic liquid chromatographic-tandem mass spectrometric analysis. Journal of Chromatography A, 2001, 928, 41-51.
    • (2001) Journal of Chromatography A , vol.928 , pp. 41-51
    • Romanyshyn, L.1    Tiller, P.2
  • 13
    • 0031453346 scopus 로고    scopus 로고
    • The use of turbulent flow chromatography/mass spectrometry for the rapid, direct analysis of a novel pharmaceutical compound in plasma
    • Ayrton J.; Dear G.J.; Leavens W.J.; Mallet D.N.; Plumb R.S. The use of turbulent flow chromatography/mass spectrometry for the rapid, direct analysis of a novel pharmaceutical compound in plasma. Rapid Communications in Mass Spectrometry, 1997, 11, 1953-1958.
    • (1997) Rapid Communications in Mass Spectrometry , vol.11 , pp. 1953-1958
    • Ayrton, J.1    Dear, G.J.2    Leavens, W.J.3    Mallet, D.N.4    Plumb, R.S.5
  • 14
    • 1542719132 scopus 로고    scopus 로고
    • High-throughput chromatographic approaches to liquid chromatographic/tandem mass spectrometric bioanalysis to support drug discovery and development
    • Berna M.J.; Ackermann B.L.; Murphy A.T. High-throughput chromatographic approaches to liquid chromatographic/tandem mass spectrometric bioanalysis to support drug discovery and development. Analytica Chimica Acta, 2004, 509, 1-9.
    • (2004) Analytica Chimica Acta , vol.509 , pp. 1-9
    • Berna, M.J.1    Ackermann, B.L.2    Murphy, A.T.3
  • 16
    • 33847061996 scopus 로고    scopus 로고
    • Investigation of lipophilicity of anticancer-active thioquinoline derivatives
    • Bajda M.; Boryczka S.; Malawska B. Investigation of lipophilicity of anticancer-active thioquinoline derivatives. Biomedical Chroma-tography, 2007, 21, 123-131.
    • (2007) Biomedical Chroma-tography , vol.21 , pp. 123-131
    • Bajda, M.1    Boryczka, S.2    Malawska, B.3
  • 17
    • 2342627370 scopus 로고    scopus 로고
    • Determination of liquid-liquid partition coefficients by separation methods
    • Berthod A.; Carda-Broch S. Determination of liquid-liquid partition coefficients by separation methods. Journal of Chromatography A 2004, 1037, 3-14.
    • (2004) Journal of Chromatography A , vol.1037 , pp. 3-14
    • Berthod, A.1    Carda-Broch, S.2
  • 19
    • 34247230154 scopus 로고    scopus 로고
    • Recent develop-ments in Liquid Chromatography: Impact on qualitative and quantitative performance
    • Guillaume D.; Nguyen D.T.T.; Rudaz S.; Veuthey J.L. Recent develop-ments in Liquid Chromatography: Impact on qualitative and quantitative performance. Journal of Chromatography A, 2007, 1149, 20-29.
    • (2007) Journal of Chromatography A , vol.1149 , pp. 20-29
    • Guillaume, D.1    Nguyen, D.T.T.2    Rudaz, S.3    Veuthey, J.L.4
  • 25
    • 28544450370 scopus 로고    scopus 로고
    • A new separation technique takes advantage of sub-2 μm porous particles
    • Mazzeo J.R.; Neue U.D.; Kele M.; Plumb R.S. A new separation technique takes advantage of sub-2 μm porous particles. Analytical Chemistry, 2005, 77, 460A-465A.
    • (2005) Analytical Chemistry , vol.77
    • Mazzeo, J.R.1    Neue, U.D.2    Kele, M.3    Plumb, R.S.4
  • 26
    • 34748882992 scopus 로고    scopus 로고
    • Monolithic Columns in High Performance Liquid Chromatography
    • Guiochon G. Monolithic Columns in High Performance Liquid Chromatography. Journal of Chromatography A, 2007, 1168, 101-168.
    • (2007) Journal of Chromatography A , vol.1168 , pp. 101-168
    • Guiochon, G.1
  • 27
    • 39749109563 scopus 로고    scopus 로고
    • Particle Packed Columns and Monolithic Columns in High Performance Liquid Chromatography-Comparison and Critical Appraisal
    • Unger K.K.; Skudas R.; Schulte M.M. Particle Packed Columns and Monolithic Columns in High Performance Liquid Chromatography-Comparison and Critical Appraisal. Journal of Chromatography A, 2008, 1184, 393-415.
    • (2008) Journal of Chromatography A , vol.1184 , pp. 393-415
    • Unger, K.K.1    Skudas, R.2    Schulte, M.M.3
  • 29
    • 0035155866 scopus 로고    scopus 로고
    • Use of monolithic silica columns to increase analytical throughput for metabolite identification by liquid chromatography/tandem mass spectrometry
    • Dear G.; Plumb R.; Mallet D. Use of monolithic silica columns to increase analytical throughput for metabolite identification by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 2001, 15, 152-158.
    • (2001) Rapid Communications in Mass Spectrometry , vol.15 , pp. 152-158
    • Dear, G.1    Plumb, R.2    Mallet, D.3
  • 30
    • 0034955957 scopus 로고    scopus 로고
    • Direct analysis of pharmaceutical compounds in human plasma with chromatographic resolution using an alkyl-bonded silica rod column
    • Plumb R.; Dear G.; Mallet D.; Ayrton J. Direct analysis of pharmaceutical compounds in human plasma with chromatographic resolution using an alkyl-bonded silica rod column. Rapid Communi-cations in Mass Spectrometry, 2001, 15, 986-993.
    • (2001) Rapid Communi-cations in Mass Spectrometry , vol.15 , pp. 986-993
    • Plumb, R.1    Dear, G.2    Mallet, D.3    Ayrton, J.4
  • 32
    • 0005905707 scopus 로고    scopus 로고
    • Bioanalytical Method Validation
    • CDER and CVM Guidance for Industry, Food and Drug Administration, May
    • CDER and CVM Guidance for Industry, Bioanalytical Method Validation. Food and Drug Administration, May 2001. http://www.fda.gov\cder\guidance\4252fnl.pdf.
    • (2001)
  • 33
    • 84892249959 scopus 로고    scopus 로고
    • http://www.camag.com/tlc-ms
  • 36
    • 0033277328 scopus 로고    scopus 로고
    • A review of high-throughput screening approaches for drug discovery
    • Armstrong J.W. A review of high-throughput screening approaches for drug discovery. American Biotechnology Laboratory, 1999, 17, 26-28.
    • (1999) American Biotechnology Laboratory , vol.17 , pp. 26-28
    • Armstrong, J.W.1
  • 37
    • 65549112285 scopus 로고    scopus 로고
    • High-throughput cellular microarray platforms: Applications in drug discovery, toxicology and stem cell research
    • Fernandes T.G.; Diogo M.M.; Clark D.S.; Dordick J.S.; Cabral J. High-throughput cellular microarray platforms: Applications in drug discovery, toxicology and stem cell research. Trends in Biotechnology, 2009, 27, 342-349.
    • (2009) Trends in Biotechnology , vol.27 , pp. 342-349
    • Fernandes, T.G.1    Diogo, M.M.2    Clark, D.S.3    Dordick, J.S.4    Cabral, J.5
  • 39
    • 2942564021 scopus 로고    scopus 로고
    • Pursuing the leadlikeness concept in pharma-ceutical research
    • Hann M.; Opera T.I. Pursuing the leadlikeness concept in pharma-ceutical research. Current Opinion in Chemical Biology, 2004, 8, 255-263.
    • (2004) Current Opinion in Chemical Biology , vol.8 , pp. 255-263
    • Hann, M.1    Opera, T.I.2
  • 42
    • 49849099622 scopus 로고    scopus 로고
    • Development and validation of a HPLC-ESI-MS/MS method for the determination of 5-aminosalicylic acid and its major metabolite N-acetyl-5-aminosalicylic acid in human plasma
    • Pastorini E.; Locatelli M.; Simoni P.; Roda G.; Roda E.; Roda A. Development and validation of a HPLC-ESI-MS/MS method for the determination of 5-aminosalicylic acid and its major metabolite N-acetyl-5-aminosalicylic acid in human plasma. Journal of Chromatography B, 2008, 872, 99-106.
    • (2008) Journal of Chromatography B , vol.872 , pp. 99-106
    • Pastorini, E.1    Locatelli, M.2    Simoni, P.3    Roda, G.4    Roda, E.5    Roda, A.6
  • 44
    • 79959420942 scopus 로고    scopus 로고
    • Strategies for in vivo imaging of enzyme activity: An overview and recent advances
    • Razgulin A.; Ma N.; Rao J. Strategies for in vivo imaging of enzyme activity: An overview and recent advances. Chemical Society Reviews, 2011, 40, 4186-4216.
    • (2011) Chemical Society Reviews , vol.40 , pp. 4186-4216
    • Razgulin, A.1    Ma, N.2    Rao, J.3
  • 47
    • 16644386336 scopus 로고    scopus 로고
    • Comparison of the usefulness of MTT, ATP and calcein assays to predict the potency of cytotoxic agents in various human cancer cell lines
    • Mueller H.; Kassack M.; Wiese M. Comparison of the usefulness of MTT, ATP and calcein assays to predict the potency of cytotoxic agents in various human cancer cell lines. Journal of Biomolecular Screening, 2004, 9, 506-515.
    • (2004) Journal of Biomolecular Screening , vol.9 , pp. 506-515
    • Mueller, H.1    Kassack, M.2    Wiese, M.3
  • 48
    • 0141503523 scopus 로고    scopus 로고
    • Current trends in modern pharmaceutical analysis for drug discovery
    • Koh H.L.; Yau W.P.; Ong P.S.; Hegde A. Current trends in modern pharmaceutical analysis for drug discovery. Drug Discovery Today, 2003, 8, 889-897.
    • (2003) Drug Discovery Today , vol.8 , pp. 889-897
    • Koh, H.L.1    Yau, W.P.2    Ong, P.S.3    Hegde, A.4
  • 49
    • 34948906395 scopus 로고    scopus 로고
    • Highthroughput screening of packed-bed chromatography coupled with SELDI-TOFMS analysis: monoclonal antibodies versus host cell protein
    • Wierling P.S.; Bogumil R.; Knieps-Grünhagen E.; Hubbuch J. Highthroughput screening of packed-bed chromatography coupled with SELDI-TOFMS analysis: monoclonal antibodies versus host cell protein. Biotechnology and Bioengineering, 2007, 98, 440-450.
    • (2007) Biotechnology and Bioengineering , vol.98 , pp. 440-450
    • Wierling, P.S.1    Bogumil, R.2    Knieps-Grünhagen, E.3    Hubbuch, J.4
  • 50
    • 44349133384 scopus 로고    scopus 로고
    • Effects of ionic strength and mobile phase pH on the binding orientation of lysozyme on different ion-exchange adsorbents
    • Dismer F.; Petzold M.; Hubbuch J. Effects of ionic strength and mobile phase pH on the binding orientation of lysozyme on different ion-exchange adsorbents. Journal of Chromatography A, 2008, 1194, 11-21.
    • (2008) Journal of Chromatography A , vol.1194 , pp. 11-21
    • Dismer, F.1    Petzold, M.2    Hubbuch, J.3
  • 52
    • 77949407794 scopus 로고    scopus 로고
    • Multivariate evaluation of pharmacological responses in early clinical trials - A study of rIL-21 in the treatment of patients with metastatic melanoma
    • Rasmussen M.A.; Colding-Jørgensen, M.; Hansen, L.T.; Bro, R. Multivariate evaluation of pharmacological responses in early clinical trials - A study of rIL-21 in the treatment of patients with metastatic melanoma. British Journal of Clinical Pharmacology, 2010, 69 (4), 379-390.
    • (2010) British Journal of Clinical Pharmacology , vol.69 , Issue.4 , pp. 379-390
    • Rasmussen, M.A.1    Colding-Jørgensen, M.2    Hansen, L.T.3    Bro, R.4
  • 54
    • 84859441435 scopus 로고    scopus 로고
    • Metabolome classification of commercial hypericum perforatum (StJohn's Wort) preparations via UPLC-qTOF-MS and chemometrics
    • Farag M.A.; Wessjohann L.A. Metabolome classification of commercial hypericum perforatum (StJohn's Wort) preparations via UPLC-qTOF-MS and chemometrics. Planta Medica, 2012, 78 (5), 488-496.
    • (2012) Planta Medica , vol.78 , Issue.5 , pp. 488-496
    • Farag, M.A.1    Wessjohann, L.A.2
  • 55
    • 79951725936 scopus 로고    scopus 로고
    • Interpretation of analysis of variance models using principal component analysis to assess the effect of a maternal anticancer treatment on the mineralization of rat bones
    • Stanimirova I.; Michalik K.; Drzazga Z.; Trzeciak H.; Wentzell P.D.; Walczak B. Interpretation of analysis of variance models using principal component analysis to assess the effect of a maternal anticancer treatment on the mineralization of rat bones. Analytica Chimica Acta, 2011, 689 (1), 1-7.
    • (2011) Analytica Chimica Acta , vol.689 , Issue.1 , pp. 1-7
    • Stanimirova, I.1    Michalik, K.2    Drzazga, Z.3    Trzeciak, H.4    Wentzell, P.D.5    Walczak, B.6
  • 57
    • 84862751775 scopus 로고    scopus 로고
    • Development of a rapid resolution liquid chromatographic method combined with chemometrics for quality control of Angelicae dahuricae radix
    • Fan G.; Deng R.; Zhou L.; Meng X.; Kuang T.; Lai X.; Zhang J.; Zhang Y. Development of a rapid resolution liquid chromatographic method combined with chemometrics for quality control of Angelicae dahuricae radix. Phytochemical Analysis, 2012, 23 (4), 299-307.
    • (2012) Phytochemical Analysis , vol.23 , Issue.4 , pp. 299-307
    • Fan, G.1    Deng, R.2    Zhou, L.3    Meng, X.4    Kuang, T.5    Lai, X.6    Zhang, J.7    Zhang, Y.8
  • 58
    • 80052270878 scopus 로고    scopus 로고
    • Multivariate data analysis in pharmaceutics: A tutorial review
    • Rajalahti T.; Kvalheim O.M. Multivariate data analysis in pharmaceutics: A tutorial review. International Journal of Pharmaceutics. 2011, 417 (1-2), 280-290.
    • (2011) International Journal of Pharmaceutics , vol.417 , Issue.1-2 , pp. 280-290
    • Rajalahti, T.1    Kvalheim, O.M.2
  • 60
    • 78751551593 scopus 로고    scopus 로고
    • Two-dimensional fingerprinting approach for comparison of complex substances analysed by HPLC-UV and fluorescence detection
    • Ni Y.; Liu Y.; Kokot S. Two-dimensional fingerprinting approach for comparison of complex substances analysed by HPLC-UV and fluorescence detection. Analyst, 2011, 136 (3), 550-559.
    • (2011) Analyst , vol.136 , Issue.3 , pp. 550-559
    • Ni, Y.1    Liu, Y.2    Kokot, S.3
  • 61
    • 80255141790 scopus 로고    scopus 로고
    • FT-NIR spectroscopy for rapid and simple determination of nimesulide in rabbit plasma for pharmacokinetic analysis
    • Ajayakumar P.V.; Chanda D.; Pal A.; Singh M.P.; Samad A. FT-NIR spectroscopy for rapid and simple determination of nimesulide in rabbit plasma for pharmacokinetic analysis. Journal of Pharmaceutical and Biomedical Analysis, 2012, 58 (1), 157-162.
    • (2012) Journal of Pharmaceutical and Biomedical Analysis , vol.58 , Issue.1 , pp. 157-162
    • Ajayakumar, P.V.1    Chanda, D.2    Pal, A.3    Singh, M.P.4    Samad, A.5
  • 62
    • 84855351820 scopus 로고    scopus 로고
    • Rapid in-situ repeatable analysis of drugs in powder form using reflectance Near-Infrared Spectroscopy and multivariate calibration
    • Melucci D.; Monti D.; D'Elia M.; Luciano G. Rapid in-situ repeatable analysis of drugs in powder form using reflectance Near-Infrared Spectroscopy and multivariate calibration. Journal of Forensic Sciences, 2012, 57, 86-92.
    • (2012) Journal of Forensic Sciences , vol.57 , pp. 86-92
    • Melucci, D.1    Monti D.2    D'Elia, M.3    Luciano, G.4
  • 63
    • 83455208035 scopus 로고    scopus 로고
    • Ultra-performance liquid chromatography coupled to mass spectrometry as a sensitive and powerful technology for metabolomic studies
    • Wang X.; Sun H.; Zhang A.; Wang P.; Han Y. Ultra-performance liquid chromatography coupled to mass spectrometry as a sensitive and powerful technology for metabolomic studies. Journal of Separation Science, 2011, 34 (24), 3451-3459.
    • (2011) Journal of Separation Science , vol.34 , Issue.24 , pp. 3451-3459
    • Wang, X.1    Sun, H.2    Zhang, A.3    Wang, P.4    Han, Y.5
  • 64
    • 34247592064 scopus 로고    scopus 로고
    • Multivariate methods in tablet formulation suitable for early drug development: Predictive models from a screening design of several linked responses
    • Andersson M.; Ringberg A.; Gustafsson C. Multivariate methods in tablet formulation suitable for early drug development: Predictive models from a screening design of several linked responses. Chemometrics and Intelligent Laboratory Systems, 2007, 87 (1), 151-156.
    • (2007) Chemometrics and Intelligent Laboratory Systems , vol.87 , Issue.1 , pp. 151-156
    • Andersson, M.1    Ringberg, A.2    Gustafsson, C.3
  • 65
    • 67249138178 scopus 로고    scopus 로고
    • Pattern recognition analysis for the prediction of adverse effects by nonsteroidal anti-inflammatory drugs using 1H NMR-based metabolomics in rats
    • So Y.U.; Myeon W.C.; Kim K.-B.; Seon H.K.; Ji,S.O.; Hye Y.O.; Hwa J.L.; Ki H.C. Pattern recognition analysis for the prediction of adverse effects by nonsteroidal anti-inflammatory drugs using 1H NMR-based metabolomics in rats. Analytical Chemistry, 2009, 81 (12), 4734-4741.
    • (2009) Analytical Chemistry , vol.81 , Issue.12 , pp. 4734-4741
    • So, Y.U.1    Myeon, W.C.2    Kim, K.-B.3    Seon, H.K.4    Ji, S.O.5    Hye, Y.O.6    Hwa, J.L.7    Ki, H.C.8
  • 66
    • 79952259201 scopus 로고    scopus 로고
    • A classification study of respiratory syncytial virus (RSV) inhibitors by variable selection with random forest
    • Hao M.; Li Y.; Wang Y.; Zhang S. A classification study of respiratory syncytial virus (RSV) inhibitors by variable selection with random forest. International Journal of Molecular Sciences, 2011, 12 (2), 1259-1280.
    • (2011) International Journal of Molecular Sciences , vol.12 , Issue.2 , pp. 1259-1280
    • Hao, M.1    Li, Y.2    Wang, Y.3    Zhang, S.4
  • 67
    • 0037364162 scopus 로고    scopus 로고
    • ADMET in silico modelling: Towards prediction paradise?
    • Van de Waterbeemd H.; Gifford E. ADMET in silico modelling: Towards prediction paradise? Nature Reviews Drug Discovery, 2003, 2 (3), 192-204.
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.3 , pp. 192-204
    • Van de Waterbeemd, H.1    Gifford, E.2
  • 68
    • 0043198439 scopus 로고    scopus 로고
    • Predicting drug pharmacokinetic properties using molecular interaction fields and SIMCA
    • Wolohan P.R.N.; Clark R.D. Predicting drug pharmacokinetic properties using molecular interaction fields and SIMCA. Journal of Computer-Aided Molecular Design, 2003, 17 (1), 65-76.
    • (2003) Journal of Computer-Aided Molecular Design , vol.17 , Issue.1 , pp. 65-76
    • Wolohan, P.R.N.1    Clark, R.D.2
  • 69
    • 80052260608 scopus 로고    scopus 로고
    • Quality by design approach of a pharmaceutical gel manufacturing process, part 1: Determination of the design space
    • Rosas J.G.; Blanco M.; González J.M.; Alcalá M. Quality by design approach of a pharmaceutical gel manufacturing process, part 1: Determination of the design space. Journal of Pharmaceutical Sciences, 2011, 100 (10), 4432-4441.
    • (2011) Journal of Pharmaceutical Sciences , vol.100 , Issue.10 , pp. 4432-4441
    • Rosas, J.G.1    Blanco, M.2    González, J.M.3    Alcalá, M.4
  • 70
    • 79959885083 scopus 로고    scopus 로고
    • Statistical thinking and knowledge management for quality-driven design and manufacturing in pharmaceuticals
    • Korakianiti E.; Rekkas D. Statistical thinking and knowledge management for quality-driven design and manufacturing in pharmaceuticals. Pharmaceutical Research, 2011), 28 (7), 1465-1479.
    • (2011) Pharmaceutical Research , vol.28 , Issue.7 , pp. 1465-1479
    • Korakianiti, E.1    Rekkas, D.2
  • 76
    • 78951489458 scopus 로고    scopus 로고
    • Systematic generation of chemical structures for rational drug design based on QSAR models
    • Funatsu K.; Miyao T.; Arakawa M. Systematic generation of chemical structures for rational drug design based on QSAR models. Current Computer-Aided Drug Design, 2011, 7 (1), 1-9.
    • (2011) Current Computer-Aided Drug Design , vol.7 , Issue.1 , pp. 1-9
    • Funatsu, K.1    Miyao, T.2    Arakawa, M.3
  • 77
    • 77953499086 scopus 로고    scopus 로고
    • Statistical molecular design of balanced compound libraries for QSAR modeling
    • Linusson A.; Elofsson M.; Andersson I.E.; Dahlgren M.K. Statistical molecular design of balanced compound libraries for QSAR modeling. Current Medicinal Chemistry, 2010, 17 (19), 2001-2016.
    • (2010) Current Medicinal Chemistry , vol.17 , Issue.19 , pp. 2001-2016
    • Linusson, A.1    Elofsson, M.2    Andersson, I.E.3    Dahlgren, M.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.