Pattern recognition analysis for the prediction of adverse effects by nonsteroidal anti-inflammatory drugs using 1H NMR-based metabolomics in rats

Analytical Chemistry

Volumn 81, Issue 12, 2009, Pages 4734-4741

  So, Young Um ^a,b   Myeon, Woo Chung ^a   Kim, Kyu Bong ^a   Seon, Hwa Kim ^a   Ji, Seon Oh ^a   Hye, Young Oh ^a   Hwa, Jeong Lee ^b   Ki, Hwan Choi ^a  

^a Korea Food and Drug Administration   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE PAIN; ADVERSE DRUG REACTIONS; ADVERSE EFFECT; CELECOXIB; CLUSTERINGS; COX-2 INHIBITORS; CYCLOOXYGENASE; DIFFERENT MECHANISMS; DIMETHYLAMINE; DISCRIMINATION ANALYSIS; DRUG DEVELOPMENT; H NMR SPECTRA; HIGH DOSE; INDOMETHACIN; METABOLOMICS; MULTIVARIATE DATA ANALYSIS; NONSTEROIDAL ANTI-INFLAMMATORY DRUGS; PARTIAL LEAST SQUARES; RHEUMATOID ARTHRITIS; SELECTIVE INHIBITORS; SIDE EFFECT; SPECTRAL PATTERNS; URINE SPECTRA;

BIOMOLECULES; BODY FLUIDS; DRUG INTERACTIONS; METABOLISM; METABOLITES; MULTIVARIANT ANALYSIS; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATTERN RECOGNITION; RATS;

DRUG PRODUCTS;

ALLANTOIN; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; DIMETHYLAMINE; IBUPROFEN; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR; TAURINE;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIGESTIVE SYSTEM INJURY; MALE; METABOLOMICS; NONHUMAN; PATTERN RECOGNITION ANALYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; URINALYSIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 2 INHIBITORS; IBUPROFEN; INDOMETHACIN; LEAST-SQUARES ANALYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOMICS; PATTERN RECOGNITION, AUTOMATED; PREDICTIVE VALUE OF TESTS; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; STOMACH; SULFONAMIDES;

EID: 67249138178     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac9000282     Document Type: Article

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