Rapid crystallization process development strategy from lab to industrial scale with PAT tools in skid configuration

Organic Process Research and Development

Volumn 16, Issue 5, 2012, Pages 769-780

  Kadam, Somnath S ^a   Vissers, Jochem A W ^b   Forgione, Marco ^c   Geertman, Rob M ^d   Daudey, Peter J ^e   Stankiewicz, Andrzej I ^a   Kramer, Herman J M ^a  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

^c DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^d NV ORGANON   (Netherlands)

^e Albemarle Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS; ANDROSTA-1 ,4-DIENE-3 ,17-DIONE; BATCH COOLING CRYSTALLIZATION; BATCH CRYSTALLIZER; CONCENTRATION SENSORS; CONTROL STRATEGIES; COST-INTENSIVE; CRYSTAL SIZE DISTRIBUTIONS; CRYSTALLIZATION PROCESS; DESIGN MODIFICATIONS; DISSOLUTION BEHAVIOUR; DOWNSTREAM PROCESS; FORMULATION PROCESS; IN-SITU; INDUSTRIAL SCALE; INFORMATION CONCERNING; MODEL SYSTEM; OPERATING WINDOWS; PHARMACEUTICAL INDUSTRY; PHARMACEUTICAL INTERMEDIATES; PROCESS ANALYTICAL TECHNOLOGY; PROCESS DEVELOPMENT; PRODUCT QUALITY; RAPID CRYSTALLIZATION; RAPID PROCESS DEVELOPMENT; SEPARATION AND PURIFICATION; THERMODYNAMICS AND KINETICS;

CRYSTALLIZERS; DRUG PRODUCTS PLANTS; OLEFINS; OPTIMIZATION; SENSORS; STRATEGIC PLANNING;

INDUSTRY;

EID: 84862096648     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op300055g     Document Type: Article

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