Rapid and quantitative measurement of metabolic stability without chromatography or mass spectrometry

Journal of the American Chemical Society

Volumn 133, Issue 37, 2011, Pages 14476-14479

  Traylor, Matthew J ^b   Ryan, Jessica D ^b   Arnon, Eric S ^b   Dordick, Jonathan S ^a   Clark, Douglas S ^b  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COFACTORS; CRITICAL COMPONENT; CYTOCHROME P450; DRUG DEVELOPMENT; FLUORESCENCE INTENSITY MEASUREMENT; GENERAL METHOD; LABOR INTENSIVE; MEASUREMENT STRATEGIES; METABOLIC STABILITY; OVERALL RATE; OXYGEN DEPLETION; QUANTITATIVE DETERMINATIONS; QUANTITATIVE MEASUREMENT; REACTION ENGINEERING APPROACH; SIMULTANEOUS MEASUREMENT; SUBSTRATE CONVERSION; SUBSTRATE DEPLETION;

CHROMATOGRAPHY; FLUORESCENCE; MASS SPECTROMETRY; STABILITY;

METABOLISM;

CYTOCHROME P450; OXYGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ACCURACY; ARTICLE; ENGINEERING; ENZYME SUBSTRATE; FLUORESCENCE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; QUANTITATIVE ANALYSIS;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG EVALUATION, PRECLINICAL; FLUORESCENCE; NADP; OXYGEN; PHARMACEUTICAL PREPARATIONS; TIME FACTORS;

EID: 80052792641     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja203172c     Document Type: Article

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