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Volumn 24, Issue 2, 2014, Pages 85-93

Functional role, mechanisms of regulation, and therapeutic potential of regulator of G protein signaling 2 in the heart

Author keywords

[No Author keywords available]

Indexed keywords

RGS2 PROTEIN;

EID: 84891937990     PISSN: 10501738     EISSN: 18732615     Source Type: Journal    
DOI: 10.1016/j.tcm.2013.07.002     Document Type: Review
Times cited : (20)

References (71)
  • 2
    • 36148945617 scopus 로고    scopus 로고
    • R4 RGS proteins: regulation of G-protein signaling and beyond
    • Bansal G., Druey K.M., Xie Z. R4 RGS proteins: regulation of G-protein signaling and beyond. Pharmacology and Therapeutics 2007, 116:473-495.
    • (2007) Pharmacology and Therapeutics , vol.116 , pp. 473-495
    • Bansal, G.1    Druey, K.M.2    Xie, Z.3
  • 5
    • 33947371974 scopus 로고    scopus 로고
    • N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells
    • Bodenstein J., Sunahara R.K., Neubig R.R. N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells. Molecular Pharmacology 2007, 71:1040-1050.
    • (2007) Molecular Pharmacology , vol.71 , pp. 1040-1050
    • Bodenstein, J.1    Sunahara, R.K.2    Neubig, R.R.3
  • 6
    • 63649126968 scopus 로고    scopus 로고
    • Mechanisms of enhanced β-adrenergic reserve from cardiac resynchronization therapy
    • Chakir K., Daya S.K., Aiba T., Tunin R.S., Dimaano V.L., Abraham T.P., et al. Mechanisms of enhanced β-adrenergic reserve from cardiac resynchronization therapy. Circulation 2009, 119:1231-1240.
    • (2009) Circulation , vol.119 , pp. 1231-1240
    • Chakir, K.1    Daya, S.K.2    Aiba, T.3    Tunin, R.S.4    Dimaano, V.L.5    Abraham, T.P.6
  • 11
    • 36348958940 scopus 로고    scopus 로고
    • Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members
    • Gu S., He J., Ho W.T., Ramineni S., Thal D.M., Natesh R., et al. Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members. Journal of Biological Chemistry 2007, 282:33064-33075.
    • (2007) Journal of Biological Chemistry , vol.282 , pp. 33064-33075
    • Gu, S.1    He, J.2    Ho, W.T.3    Ramineni, S.4    Thal, D.M.5    Natesh, R.6
  • 12
    • 37349018834 scopus 로고    scopus 로고
    • Alternative translation initiation of human regulators of G-protein signaling-2 yields a set of functionally distinct proteins
    • Gu S., Anton A., Salim S., Blumer K.J., Dessauer C.W., Heximer S.P. Alternative translation initiation of human regulators of G-protein signaling-2 yields a set of functionally distinct proteins. Molecular Pharmacology 2008, 73:1-11.
    • (2008) Molecular Pharmacology , vol.73 , pp. 1-11
    • Gu, S.1    Anton, A.2    Salim, S.3    Blumer, K.J.4    Dessauer, C.W.5    Heximer, S.P.6
  • 14
    • 63449118167 scopus 로고    scopus 로고
    • RGS proteins: identifying new GAPs in the understanding of blood pressure regulation and cardiovascular function
    • Gu S., Cifelli C., Wang S., Heximer S.P. RGS proteins: identifying new GAPs in the understanding of blood pressure regulation and cardiovascular function. Clinical Science (London, England: 1979) 2009, 116:391-399.
    • (2009) Clinical Science (London, England: 1979) , vol.116 , pp. 391-399
    • Gu, S.1    Cifelli, C.2    Wang, S.3    Heximer, S.P.4
  • 16
    • 33746843994 scopus 로고    scopus 로고
    • Regulation of cardiomyocyte signaling by RGS proteins: differential selectivity towards G proteins and susceptibility to regulation
    • Hao J., Michalek C., Zhang W., Zhu M., Xu X., Mende U. Regulation of cardiomyocyte signaling by RGS proteins: differential selectivity towards G proteins and susceptibility to regulation. Journal of Molecular and Cellular Cardiology 2006, 41:51-61.
    • (2006) Journal of Molecular and Cellular Cardiology , vol.41 , pp. 51-61
    • Hao, J.1    Michalek, C.2    Zhang, W.3    Zhu, M.4    Xu, X.5    Mende, U.6
  • 17
    • 43049122122 scopus 로고    scopus 로고
    • Regulation of G protein-coupled receptor signalling: focus on the cardiovascular system and regulator of G protein signalling proteins
    • Hendriks-Balk M.C., Peters S.L., Michel M.C., Alewijnse A.E. Regulation of G protein-coupled receptor signalling: focus on the cardiovascular system and regulator of G protein signalling proteins. European Journal of Pharmacology 2008, 585:278-291.
    • (2008) European Journal of Pharmacology , vol.585 , pp. 278-291
    • Hendriks-Balk, M.C.1    Peters, S.L.2    Michel, M.C.3    Alewijnse, A.E.4
  • 18
    • 33750312906 scopus 로고    scopus 로고
    • RGS2 promotes formation of neurites by stimulating microtubule polymerization
    • Heo K., Ha S.H., Chae Y.C., Lee S., Oh Y.S., Kim Y.H., et al. RGS2 promotes formation of neurites by stimulating microtubule polymerization. Cellular Signalling 2006, 18:2182-2192.
    • (2006) Cellular Signalling , vol.18 , pp. 2182-2192
    • Heo, K.1    Ha, S.H.2    Chae, Y.C.3    Lee, S.4    Oh, Y.S.5    Kim, Y.H.6
  • 24
    • 0036733358 scopus 로고    scopus 로고
    • Cellular regulation of RGS proteins: modulators and integrators of G protein signaling
    • Hollinger S., Hepler J.R. Cellular regulation of RGS proteins: modulators and integrators of G protein signaling. Pharmacological Reviews 2002, 54:527-559.
    • (2002) Pharmacological Reviews , vol.54 , pp. 527-559
    • Hollinger, S.1    Hepler, J.R.2
  • 25
    • 17344374133 scopus 로고    scopus 로고
    • Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity
    • Ingi T., Krumins A.M., Chidiac P., Brothers G.M., Chung S., Snow B.E., et al. Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity. The Journal of Neuroscience 1998, 18:7178-7188.
    • (1998) The Journal of Neuroscience , vol.18 , pp. 7178-7188
    • Ingi, T.1    Krumins, A.M.2    Chidiac, P.3    Brothers, G.M.4    Chung, S.5    Snow, B.E.6
  • 26
    • 79551470816 scopus 로고    scopus 로고
    • Human miR-1271 is a miR-96 paralog with distinct non-conserved brain expression pattern
    • Jensen K.P., Covault J. Human miR-1271 is a miR-96 paralog with distinct non-conserved brain expression pattern. Nucleic Acids Research 2011, 39:701-711.
    • (2011) Nucleic Acids Research , vol.39 , pp. 701-711
    • Jensen, K.P.1    Covault, J.2
  • 27
    • 84866391947 scopus 로고    scopus 로고
    • Role of cholinergic innervation and RGS2 in atrial arrhythmia
    • Jones D.L., Tuomi J.M., Chidiac P. Role of cholinergic innervation and RGS2 in atrial arrhythmia. Frontiers in Physiology 2012, 3:239.
    • (2012) Frontiers in Physiology , vol.3 , pp. 239
    • Jones, D.L.1    Tuomi, J.M.2    Chidiac, P.3
  • 29
    • 77956186884 scopus 로고    scopus 로고
    • Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2
    • Klaiber M., Kruse M., Volker K., Schroter J., Feil R., Freichel M., et al. Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2. Basic Research in Cardiology 2010, 105:583-595.
    • (2010) Basic Research in Cardiology , vol.105 , pp. 583-595
    • Klaiber, M.1    Kruse, M.2    Volker, K.3    Schroter, J.4    Feil, R.5    Freichel, M.6
  • 30
    • 84857643399 scopus 로고    scopus 로고
    • Reverse remodeling in heart failure - mechanisms and therapeutic opportunities
    • Koitabashi N., Kass D.A. Reverse remodeling in heart failure - mechanisms and therapeutic opportunities. Nature Reviews Cardiology 2012, 9:147-157.
    • (2012) Nature Reviews Cardiology , vol.9 , pp. 147-157
    • Koitabashi, N.1    Kass, D.A.2
  • 31
    • 84875607396 scopus 로고    scopus 로고
    • Cell biology: receptor signals come in waves
    • Lohse M.J., Calebiro D. Cell biology: receptor signals come in waves. Nature 2013, 495:457-458.
    • (2013) Nature , vol.495 , pp. 457-458
    • Lohse, M.J.1    Calebiro, D.2
  • 33
    • 79952017623 scopus 로고    scopus 로고
    • Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways
    • Muinos-Gimeno M., Espinosa-Parrilla Y., Guidi M., Kagerbauer B., Sipila T., Maron E., et al. Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways. Biological Psychiatry 2011, 69:526-533.
    • (2011) Biological Psychiatry , vol.69 , pp. 526-533
    • Muinos-Gimeno, M.1    Espinosa-Parrilla, Y.2    Guidi, M.3    Kagerbauer, B.4    Sipila, T.5    Maron, E.6
  • 35
    • 58049166421 scopus 로고    scopus 로고
    • G-protein signaling and arrhythmogenic atrial remodeling: relevance to novel therapeutic targets in atrial fibrillation
    • Nattel S. G-protein signaling and arrhythmogenic atrial remodeling: relevance to novel therapeutic targets in atrial fibrillation. Heart Rhythm 2009, 6:85-86.
    • (2009) Heart Rhythm , vol.6 , pp. 85-86
    • Nattel, S.1
  • 36
    • 33746013755 scopus 로고    scopus 로고
    • Cellular mechanisms that determine selective RGS protein regulation of G protein-coupled receptor signaling
    • Neitzel K.L., Hepler J.R. Cellular mechanisms that determine selective RGS protein regulation of G protein-coupled receptor signaling. Seminars in Cell and Developmental Biology 2006, 17:383-389.
    • (2006) Seminars in Cell and Developmental Biology , vol.17 , pp. 383-389
    • Neitzel, K.L.1    Hepler, J.R.2
  • 39
    • 35748984127 scopus 로고    scopus 로고
    • Regulation of RGS2 and second messenger signaling in vascular smooth muscle cells by cGMP-dependent protein kinase
    • Osei-Owusu P., Sun X., Drenan R.M., Steinberg T.H., Blumer K.J. Regulation of RGS2 and second messenger signaling in vascular smooth muscle cells by cGMP-dependent protein kinase. Journal of Biological Chemistry 2007, 282:31656-31665.
    • (2007) Journal of Biological Chemistry , vol.282 , pp. 31656-31665
    • Osei-Owusu, P.1    Sun, X.2    Drenan, R.M.3    Steinberg, T.H.4    Blumer, K.J.5
  • 41
    • 84863617015 scopus 로고    scopus 로고
    • q/11-mediated signaling and hypertrophy in mice with cardiac-specific transgenic expression of regulator of G-protein signaling 2
    • q/11-mediated signaling and hypertrophy in mice with cardiac-specific transgenic expression of regulator of G-protein signaling 2. PLoS One 2012, 7:e40048.
    • (2012) PLoS One , vol.7
    • Park-Windhol, C.1    Zhang, P.2    Zhu, M.3    Su, J.4    Chaves, L.5    Maldonado, A.E.6
  • 47
    • 80052359992 scopus 로고    scopus 로고
    • Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
    • Shukla A.K., Xiao K., Lefkowitz R.J. Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. Trends in Biochemical Sciences 2011, 36:457-469.
    • (2011) Trends in Biochemical Sciences , vol.36 , pp. 457-469
    • Shukla, A.K.1    Xiao, K.2    Lefkowitz, R.J.3
  • 48
    • 0035931884 scopus 로고    scopus 로고
    • RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III
    • Sinnarajah S., Dessauer C.W., Srikumar D., Chen J., Yuen J., Yilma S., et al. RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III. Nature 2001, 409:1051-1055.
    • (2001) Nature , vol.409 , pp. 1051-1055
    • Sinnarajah, S.1    Dessauer, C.W.2    Srikumar, D.3    Chen, J.4    Yuen, J.5    Yilma, S.6
  • 50
    • 77957235831 scopus 로고    scopus 로고
    • Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling
    • Sjögren B., Neubig R.R. Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling. Molecular Pharmacology 2010, 78:550-557.
    • (2010) Molecular Pharmacology , vol.78 , pp. 550-557
    • Sjögren, B.1    Neubig, R.R.2
  • 54
    • 14944383669 scopus 로고    scopus 로고
    • RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling
    • Sun X., Kaltenbronn K.M., Steinberg T.H., Blumer K.J. RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling. Molecular Pharmacology 2005, 67:631-639.
    • (2005) Molecular Pharmacology , vol.67 , pp. 631-639
    • Sun, X.1    Kaltenbronn, K.M.2    Steinberg, T.H.3    Blumer, K.J.4
  • 55
    • 84858228729 scopus 로고    scopus 로고
    • G protein-coupled receptor signalling in the cardiac nuclear membrane: evidence and possible roles in physiological and pathophysiological function
    • Tadevosyan A., Vaniotis G., Allen B.G., Hebert T.E., Nattel S. G protein-coupled receptor signalling in the cardiac nuclear membrane: evidence and possible roles in physiological and pathophysiological function. The Journal of Physiology 2012, 590:1313-1330.
    • (2012) The Journal of Physiology , vol.590 , pp. 1313-1330
    • Tadevosyan, A.1    Vaniotis, G.2    Allen, B.G.3    Hebert, T.E.4    Nattel, S.5
  • 56
    • 61749089404 scopus 로고    scopus 로고
    • Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice
    • Takimoto E., Koitabashi N., Hsu S., Ketner E.A., Zhang M., Nagayama T., et al. Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. Journal of Clinical Investigation 2009, 119:408-420.
    • (2009) Journal of Clinical Investigation , vol.119 , pp. 408-420
    • Takimoto, E.1    Koitabashi, N.2    Hsu, S.3    Ketner, E.A.4    Zhang, M.5    Nagayama, T.6
  • 57
    • 10744233990 scopus 로고    scopus 로고
    • Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure
    • Tang M., Wang G., Lu P., Karas R.H., Aronovitz M., Heximer S.P., et al. Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nature Medicine 2003, 9:1506-1512.
    • (2003) Nature Medicine , vol.9 , pp. 1506-1512
    • Tang, M.1    Wang, G.2    Lu, P.3    Karas, R.H.4    Aronovitz, M.5    Heximer, S.P.6
  • 58
    • 0036247381 scopus 로고    scopus 로고
    • Parathyroid hormone induces RGS-2 expression by a cyclic adenosine 3',5'-monophosphate-mediated pathway in primary neonatal murine osteoblasts
    • Tsingotjidou A., Nervina J.M., Pham L., Bezouglaia O., Tetradis S. Parathyroid hormone induces RGS-2 expression by a cyclic adenosine 3',5'-monophosphate-mediated pathway in primary neonatal murine osteoblasts. Bone 2002, 30:677-684.
    • (2002) Bone , vol.30 , pp. 677-684
    • Tsingotjidou, A.1    Nervina, J.M.2    Pham, L.3    Bezouglaia, O.4    Tetradis, S.5
  • 60
    • 55449100829 scopus 로고    scopus 로고
    • Toward microRNA-based therapeutics for heart disease: the sense in antisense
    • Van Rooij E., Marshall W.S., Olson E.N. Toward microRNA-based therapeutics for heart disease: the sense in antisense. Circulation Research 2008, 103:919-928.
    • (2008) Circulation Research , vol.103 , pp. 919-928
    • Van Rooij, E.1    Marshall, W.S.2    Olson, E.N.3
  • 62
    • 17344367802 scopus 로고    scopus 로고
    • 2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors
    • 2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nature Cell Biology 2005, 7:405-411.
    • (2005) Nature Cell Biology , vol.7 , pp. 405-411
    • Wang, X.1    Zeng, W.2    Soyombo, A.A.3    Tang, W.4    Ross, E.M.5    Barnes, A.P.6
  • 63
    • 25444482429 scopus 로고    scopus 로고
    • Mammalian G proteins and their cell type specific functions
    • Wettschureck N., Offermanns S. Mammalian G proteins and their cell type specific functions. Physiological Reviews 2005, 85:1159-1204.
    • (2005) Physiological Reviews , vol.85 , pp. 1159-1204
    • Wettschureck, N.1    Offermanns, S.2
  • 64
    • 84856319563 scopus 로고    scopus 로고
    • Epigenetic repression of regulator of G-protein signaling 2 promotes androgen-independent prostate cancer cell growth
    • Wolff D.W., Xie Y., Deng C., Gatalica Z., Yang M., Wang B., et al. Epigenetic repression of regulator of G-protein signaling 2 promotes androgen-independent prostate cancer cell growth. International Journal of Cancer 2012, 130:1521-1531.
    • (2012) International Journal of Cancer , vol.130 , pp. 1521-1531
    • Wolff, D.W.1    Xie, Y.2    Deng, C.3    Gatalica, Z.4    Yang, M.5    Wang, B.6
  • 65
    • 84455173156 scopus 로고    scopus 로고
    • Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2 transcriptional regulation by angiotensin II in cultured vascular smooth muscles
    • Xie Z., Liu D., Liu S., Calderon L., Zhao G., Turk J., et al. Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2 transcriptional regulation by angiotensin II in cultured vascular smooth muscles. Journal of Biological Chemistry 2011, 286:44646-44658.
    • (2011) Journal of Biological Chemistry , vol.286 , pp. 44646-44658
    • Xie, Z.1    Liu, D.2    Liu, S.3    Calderon, L.4    Zhao, G.5    Turk, J.6
  • 66
    • 23344435021 scopus 로고    scopus 로고
    • Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population
    • Yang J., Kamide K., Kokubo Y., Takiuchi S., Tanaka C., Banno M., et al. Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population. Journal of Hypertension 2005, 23:1497-1505.
    • (2005) Journal of Hypertension , vol.23 , pp. 1497-1505
    • Yang, J.1    Kamide, K.2    Kokubo, Y.3    Takiuchi, S.4    Tanaka, C.5    Banno, M.6
  • 67
    • 84891905742 scopus 로고    scopus 로고
    • q/11-mediated signaling and cell proliferation in adult rat ventricular fibroblasts
    • q/11-mediated signaling and cell proliferation in adult rat ventricular fibroblasts. The FASEB Journal 2008, 22(588):2.
    • (2008) The FASEB Journal , vol.22 , Issue.588 , pp. 2
    • Zhang, P.1    King, M.2    Ayrapetov, M.3    Mende, U.4
  • 68
    • 79961071456 scopus 로고    scopus 로고
    • Regulators of G-protein signaling in the heart and their potential as therapeutic targets
    • Zhang P., Mende U. Regulators of G-protein signaling in the heart and their potential as therapeutic targets. Circulation Research 2011, 109:320-333.
    • (2011) Circulation Research , vol.109 , pp. 320-333
    • Zhang, P.1    Mende, U.2


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