Gαs-biased β2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart

Science Translational Medicine

Volumn 3, Issue 100, 2011, Pages

  Chakir, Khalid ^a   Depry, Charlene ^a   Dimaano, Veronica L ^a   Zhu, Wei Zhong ^b   Vanderheyden, Marc ^c   Bartunek, Jozef ^c   Abraham, Theodore P ^a   Tomaselli, Gordon F ^a   Liu, Shu Bai ^d   Xiang, Yang K ^d   Zhang, Manling ^a   Takimoto, Eiki ^a   Dulin, Nickolai ^e   Xiao, Rui Ping ^b   Zhang, Jin ^a   Kass, David A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c CARDIOVASCULAR CENTER   (Belgium)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^e UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CALCIUM; CYCLIC AMP; FENOTEROL; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; PERTUSSIS TOXIN; PROTEIN KINASE; PROTEIN RGS3; RGS PROTEIN; RGS2 PROTEIN; SARCOPLASMIC RETICULUM LOCALIZED PROTEIN KINASE A; UNCLASSIFIED DRUG; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; RGS2 PROTEIN, HUMAN; RGS3 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIAC RESYNCHRONIZATION THERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HEART CONTRACTION; HEART FAILURE; HEART MUSCLE CELL; HEART PACING; HUMAN; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; SARCOMERE; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL CULTURE; DOG; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEART MUSCLE; IN VITRO STUDY; METABOLISM; MUSCLE CELL; PHYSIOLOGY;

ANIMALS; CARDIAC RESYNCHRONIZATION THERAPY; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOGS; FLUORESCENCE RESONANCE ENERGY TRANSFER; GTP-BINDING PROTEINS; GTPASE-ACTIVATING PROTEINS; HEART FAILURE; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; MUSCLE CELLS; MYOCARDIUM; RECEPTORS, ADRENERGIC, BETA-2; RGS PROTEINS; SIGNAL TRANSDUCTION;

EID: 80052929596     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3001909     Document Type: Article

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