Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating G i/o signaling

Journal of Biological Chemistry

Volumn 287, Issue 15, 2012, Pages 12541-12549

  Osei Owusu, Patrick ^a   Sabharwal, Rasna ^b   Kaltenbronn, Kevin M ^a   Rhee, Man Hee ^a,d   Chapleau, Mark W ^b,c   Dietrich, Hans H ^a   Blumer, Kendall J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d Kyungpook National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIO-VASCULAR DISEASE; DOWN-REGULATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL FUNCTION; G PROTEIN; GTPASE-ACTIVATING PROTEIN; MICROVASCULAR; PERTUSSIS TOXIN; PHENYLEPHRINE; SODIUM NITROPRUSSIDE; SYNTHASES; VASCULAR SMOOTH MUSCLES;

BLOOD PRESSURE; BLOOD VESSELS; MUSCLE; NITRIC OXIDE; SODIUM;

SIGNALING;

ACETYLCHOLINE; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; PERTUSSIS TOXIN; PHENYLEPHRINE; POTASSIUM CHANNEL; RGS2 PROTEIN;

ALPHA CHAIN; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY; ARTERY CONSTRICTION; ARTERY DILATATION; ARTICLE; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM; GENE DELETION; HYPERTENSION; MESENTERIC RESISTANCE ARTERY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; RGS2 PROTEIN DEFICIENCY; SIGNAL TRANSDUCTION; VASCULAR RESISTANCE; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ACETYLCHOLINE; ANIMALS; BIOLOGICAL FACTORS; CYCLOOXYGENASE INHIBITORS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GENE KNOCKOUT TECHNIQUES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HEMODYNAMICS; HYPERTENSION; MESENTERIC ARTERIES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE TYPE III; PERTUSSIS TOXIN; RECEPTORS, ENDOTHELIN; RGS PROTEINS; SIGNAL TRANSDUCTION; VASODILATION; VASODILATOR AGENTS;

MUS;

EID: 84859515203     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.332130     Document Type: Article

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