A heat shock protein 90 inhibitor that modulates the immunophilins and regulates hormone receptors without inducing the heat shock response

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 2, 2014, Pages 661-666

  McConnell, Jeanette R ^a   Alexander, Leslie A ^b   McAlpine, Shelli R ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

FKBP51; FKBP52; Heat shock factor 1 (HSF1); Heat shock protein 90 (hsp90); Heat shock response; Tetratricopeptide repeat (TPR)

Indexed keywords

HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; HORMONE RECEPTOR; IMMUNOPHILIN; SM 145; UNCLASSIFIED DRUG;

ARTICLE; DRUG EFFECT; HEAT SHOCK; HUMAN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION;

DIMETHYL SULFOXIDE; DMSO; FKBP51; FKBP52; HEAT SHOCK FACTOR 1 (HSF1); HEAT SHOCK PROTEIN 90 (HSP90); HEAT SHOCK RESPONSE; IC(50); INHIBITORY CONCENTRATION (50%); TETRATRICOPEPTIDE-REPEAT (TPR);

ANIMALS; BENZOQUINONES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEAT-SHOCK RESPONSE; HSP90 HEAT-SHOCK PROTEINS; IMMUNOPHILINS; LACTAMS, MACROCYCLIC; PROTEIN BINDING; RABBITS; RECEPTORS, CELL SURFACE;

EID: 84891862344     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.11.059     Document Type: Article

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