Design and synthesis of Hsp90 inhibitors: Exploring the SAR of Sansalvamide A derivatives

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 18, 2010, Pages 6822-6856

  Sellers, Robert P ^a   Alexander, Leslie D ^a   Johnson, Victoria A ^a   Lin, Chun Chieh ^a   Savage, Jeremiah ^a   Corral, Ricardo ^a   Moss, Jason ^a   Slugocki, Tim S ^a   Singh, Erinprit K ^a   Davis, Melinda R ^a   Ravula, Suchitra ^a   Spicer, Jamie E ^a   Oelrich, Jenna L ^a   Thornquist, Andrea ^a   Pan, Chung Mao ^a   McAlpine, Shelli R ^a  

^a SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

Cytotoxicity; Docking; Growth inhibition; Hsp90; Macrocycles; Macrocyclic peptides; Pancreatic cancer; Sansalvamide A

Indexed keywords

HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; SANSALVAMIDE A DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL STRAIN CACO 2; DRUG DESIGN; DRUG HALF LIFE; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSPORT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; DEPSIPEPTIDES; DRUG DESIGN; HSP90 HEAT-SHOCK PROTEINS; HUMANS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956339835     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.07.042     Document Type: Article

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