Synthesis and evaluation of biotinylated sansalvamide A analogs and their modulation of Hsp90

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 16, 2011, Pages 4716-4719

  Kunicki, Joseph B ^b   Petersen, Mark N ^b   Alexander, Leslie D ^b   Ardi, Veronica C ^b   McConnell, Jeanette R ^b   McAlpine, Shelli R ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

Hsp90; N Middle domain; Sansalvamide A

Indexed keywords

AMIDE; CHAPERONE; HEAT SHOCK PROTEIN 90; MACROCYCLIC COMPOUND; SANSALVAMIDE A; UNCLASSIFIED DRUG;

ARTICLE; BIOTINYLATION; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; IMMUNOMODULATION; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

BINDING SITES; BIOTIN; DEPSIPEPTIDES; HSP90 HEAT-SHOCK PROTEINS; MOLECULAR CONFORMATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960918066     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.083     Document Type: Article

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