Physiological role for the cochaperone FKBP52 in androgen receptor signaling

Molecular Endocrinology

Volumn 19, Issue 6, 2005, Pages 1654-1666

  Cheung Flynn, Joyce ^a   Prapapanich, Viravan ^a   Cox, Marc B ^a   Riggs, Daniel L ^a   Suarez Quian, Carlos ^b   Smith, David F ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; CHAPERONE; CYCLOPHILIN; FK 506 BINDING PROTEIN; HEAT SHOCK PROTEIN 90; IMMUNOPHILIN; STEROID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE TARGETING; GENITAL SYSTEM; HORMONE RESISTANCE; KNOCKOUT MOUSE; MALE; MOLECULAR WEIGHT; MORPHOLOGY; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROSTATE EPITHELIUM; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FOLDING; RECEPTOR BINDING; REPRODUCTION; SIGNAL TRANSDUCTION; SPERMATOGENESIS; TESTIS; WILD TYPE; YEAST;

ANIMALS; BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE DELETION; GENETIC VECTORS; GENOTYPE; HSP90 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, KNOCKOUT; MODELS, GENETIC; MODELS, MOLECULAR; MOLECULAR CHAPERONES; PLASMIDS; POINT MUTATION; PROLINE; PROSTATE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANDROGEN; SIGNAL TRANSDUCTION; TACROLIMUS BINDING PROTEINS; TESTIS; TISSUE DISTRIBUTION; TRANS-ACTIVATION (GENETICS);

EID: 22344451728     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2005-0071     Document Type: Article

References (45)

1. Pratt WB, Toft DO 2003 Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. Exp Biol Med (Maywood) 228:111-133
2. Felts SJ, Toft DO 2003 p23, A simple protein with complex activities. Cell Stress Chaperones 8:108-113
3. Ratajczak T, Ward BK, Minchin RF 2003 Immunophilin chaperones in steroid receptor signalling. Curr Top Med Chem 3:1348-1357
4. Smith DF 2004 Tetratricopeptide repeat cochaperones in steroid receptor complexes. Cell Stress Chap 9:109-121
5. Galat A 2003 Peptidylprolyl cis/trans isomerases (immunophilins): biological diversity-targets-functions. Curr Top Med Chem 3:1315-1347
6. Tai PK, Maeda Y, Nakao K, Wakim NG, Duhring JL, Faber LE 1986 A 59-kilodalton protein associated with progestin, estrogen, androgen, and glucocorticoid receptors. Biochemistry 25:5269-5275
7. Davies TH, Sanchez ER 2005 Fkbp52. Int J Biochem Cell Biol 37:42-47
8. Pratt WB, Galigniana MD, Harrell JM, DeFranco DB 2004 Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement. Cell Signal 16:857-872
9. Davies TH, Ning YM, Sanchez ER 2002 A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins. J Biol Chem 277:4597-4600
10. Wochnik GM, Ruegg J, Abel GA, Schmidt U, Holsboer F, Rein T 2005 FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells. J Biol Chem 280:4609-4616
11. Zhong L, Li W, Yang Z, Chen L, Li Y, Qing K, Weigel-Kelley KA, Yoder MC, Shou W, Srivastava A 2004 Improved transduction of primary murine hepatocytes by recombinant adeno-associated virus 2 vectors in vivo. Gene Ther 11:1165-1169
12. Peattie DA, Harding MW, Fleming MA, DeCenzo MT, Lippke JA, Livingston DJ, Benasutti M 1992 Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes. Proc Natl Acad Sci USA 89:10974-10978
13. Nair SC, Rimerman RA, Toran EJ, Chen S, Prapapanich V, Butts RN, Smith DF 1997 Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor. Mol Cell Biol 17: 594-603
14. Quigley CA, De Bellis A, Marschke KB, el-Awady MK, Wilson EM, French FS 1995 Androgen receptor defects: historical, clinical, and molecular perspectives. Endocr Rev 16:271-321
15. McPhaul MJ 2002 Molecular defects of the androgen receptor. Recent Prog Horm Res 57:181-194
16. Miller WL 2002 Disorders of androgen biosynthesis. Semin Reprod Med 20:205-216
17. Mahendroo MS, Cala KM, Hess DL, Russell DW 2001 Unexpected virilization in male mice lacking steroid 5 α-reductase enzymes. Endocrinology 142:4652-4662
18. Vornberger W, Prins G, Musto NA, Suarez-Quian CA 1994 Androgen receptor distribution in rat testis: new implications for androgen regulation of spermatogenesis. Endocrinology 134:2307-2316
19. Picard D, Khursheed B, Garabedian MJ, Fortin MG, Lindquist S, Yamamoto KR 1990 Reduced levels of hsp90 compromise steroid receptor action in vivo. Nature 348:166-168
20. Riggs DL, Roberts PJ, Chirillo SC, Cheung-Flynn J, Prapapanich V, Ratajczak T, Gaber R, Picard D, Smith DF 2003 The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo. EMBO J 22:1158-1167
21. Ramsey AJ, Russell LC, Whitt SR, Chinkers M 2000 Overlapping sites of tetratricopeptide repeat protein binding and chaperone activity in heat shock protein 90. J Biol Chem 275:17857-17862
22. Huang W, Shostak Y, Tarr P, Sawyers C, Carey M 1999 Cooperative assembly of androgen receptor into a nucleoprotein complex that regulates the prostate-specific antigen enhancer. J Biol Chem 274:25756-25768
23. Ahmed SF, Cheng A, Dovey L, Hawkins JR, Martin H, Rowland J, Shimura N, Tait AD, Hughes IA 2000 Phenotypic features, androgen receptor binding, and mutational analysis in 278 clinical cases reported as androgen insensitivity syndrome. J Clin Endocrinol Metab 85:658-665
24. Nelson GM, Prapapanich V, Carrigan PE, Roberts PJ, Riggs DL, Smith DF 2004 The heat shock protein 70 cochaperone hip enhances functional maturation of glucocorticoid receptor. Mol Endocrinol 18:1620-1630
25. Scherrer LC, Dalman FC, Massa E, Meshinchi S, Pratt WB 1990 Structural and functional reconstitution of the glucocorticoid receptor-hsp90 complex. J Biol Chem 265:21397-21400
26. Smith DF 1993 Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes. Mol Endocrinol 7:1418-1429
27. Nemoto T, Ohara-Nemoto Y, Sato N, OtaM1993 Dual roles of 90-kDa heat shock protein in the function of the mineralocorticoid receptor. J Biochem (Tokyo) 113:769-775
28. Fang Y, Fliss AE, Robins DM, Caplan AJ 1996 Hsp90 regulates androgen receptor hormone binding affinity in vivo. J Biol Chem 271:28697-28702
29. Pirkl F, Buchner J 2001 Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40. J Mol Biol 308:795-806
30. Alberti S, Esser C, Hohfeld J 2003 BAG-1-a nucleotide exchange factor of Hsc70 with multiple cellular functions. Cell Stress Chaperones 8:225-231
31. McDonough H, Patterson C 2003 CHIP: a link between the chaperone and proteasome systems. Cell Stress Chaperones 8:303-308
32. McNew JA, Sykes K, Goodman JM 1993 Specific crosslinking of the proline isomerase cyclophilin to a nonproline-containing peptide. Mol Biol Cell 4:223-232
33. He B, Gampe J, Robert T, Kole AJ, Hnat AT, Stanley TB, An G, Stewart EL, Kalman RI, Minges JT, Wilson EM 2004 Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance. Mol Cell 16:425-438
34. Langley E, Zhou Z-x, Wilson EM 1995 Evidence for an anti-parallel orientation of the ligand-activated human androgen receptor dimer. J Biol Chem 270:29983-29990
35. Doesburg P, Kuil CW, Berrevoets CA, Steketee K, Faber PW, Mulder E, Brinkmann AO, Trapman J 1997 Functional in vivo interaction between the amino-terminal, transactivation domain and the ligand binding domain of the androgen receptor. Biochemistry 36:1052-1064
36. Langley E, Kemppainen JA, Wilson EM 1998 Intermolecular NH2-/carboxyl-terminal interactions in androgen receptor dimerization revealed by mutations that cause androgen insensitivity. J Biol Chem 273:92-101
37. Berrevoets CA, Doesburg P, Steketee K, Trapman J, Brinkmann AO 1998 Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor 2). Mol Endocrinol 12:1172-1183
38. Quigley CA, Tan J-a, He B, Zhou Z-x, Mebarki F, Morel Y, Forest MG, Chatelain P, Ritzen EM, French FS, Wilson EM 2004 Partial androgen insensitivity with phenotypic variation caused by androgen receptor mutations that disrupt activation function 2 and the NH2- and carboxylterminal interaction. Mech Ageing Dev 125:683-695
39. Wilson JD 2001 The role of 5-reduction in steroid hormone physiology. Reprod Fertil Dev 13:673-678
40. McPhaul MJ 2002 Androgen receptor mutations and androgen insensitivity. Mol Cell Endocrinol 198:61-67
41. Paulozzi LJ 1999 International trends in rates of hypospadias and cryptorchidism. Environ Health Perspect 107: 297-302
42. Choi KC, Jeung EB 2003 The biomarker and endocrine disruptors in mammals. J Reprod Dev 49:337-345
43. Hoyer PB 2001 Reproductive toxicology: current and future directions. Biochem Pharmacol 62:1557-1564
44. Mumberg D, Muller R, Funk M 1995 Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. Gene 156:119-122
45. Freeman BC, Felts SJ, Toft DO, Yamamoto KR 2000 The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies. Genes Dev 14:422-434