Elevation of whole-blood glutathione in peritoneal dialysis patients by L-2-oxothiazolidine-4-carboxylate, a cysteine prodrug (procysteine®)

Journal of the American Society of Nephrology

Volumn 9, Issue 6, 1998, Pages 1093-1099

  Moberly, James B ^a   Logan, Jan ^a   Borum, Peggy R ^b   Story, Kenneth O ^a   Webb, Lawrence E ^a   Jassal, Sarbjit V ^c   Mupas, Lou ^c   Rodela, Helen ^c   Alghamdi, Ghormullah A ^c   Moran, John E ^a   Wolfson, Marsha ^a   Martis, Leo ^a   Oreopoulos, Dimitrios G ^c  

^a BAXTER HEALTHCARE CORPORATION   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXO 4 THIAZOLIDINECARBOXYLIC ACID; CYSTEINE; GLUTATHIONE; HEMOGLOBIN; OXYGEN RADICAL; THIOL;

ADULT; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS AMBULATORY PERITONEAL DIALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG SAFETY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; KIDNEY FAILURE; MALE; ORAL DRUG ADMINISTRATION; PERITONEAL DIALYSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPECTROPHOTOMETRY;

EID: 0031749131     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Beutler E: Nutritional and metabolic aspects of glutathione. Annu Rev Nutr 9: 287-302, 1989
2. Meister A: Glutathione metabolism and its selective modification. J Biol Chem 263: 17205-17208, 1988
3. Meister A: Glutathione-ascorbic acid antioxidant system in animals. J Biol Chem 269: 9397-9400, 1994
4. Shi MM, Kugelman A, Iwamoto T, Tian L, Forman HJ: Quinone-induced oxidative stress elevates glutathione and induces gamma-glutamylcysteine synthetase activity in rat lung epithelial L2 cells. J Biol Chem 269: 26512-26517, 1994
5. Murakami K, Kondo T, Ohtsuka Y, Fujiwara Y, Shimada M, Kawakami Y: Impairment of glutathione metabolism in erythrocytes from patients with diabetes mellitus. Metabolism 38: 753-758, 1989
6. Staal J, Ela S, Roederer M, Anderson M, Herzenberg M, Herzenberg L: Glutathione deficiency and human immunodeficiency virus infection. Lancet 339: 909-912, 1992
7. Roum JH, Buhl R, McElvaney NG, Borok Z, Crystal RG: Systemic deficiency of glutathione in cystic fibrosis. J Appl Physiol 75: 2419-2424, 1993
8. Morris PE, Bernard GR: Significance of glutathione in lung disease and implications for therapy. Am J Med Sci 307: 119-127, 1994
9. Castagliola C, Romano L, Sorice P, di Benedetto A: Anemia and chronic renal failure: The possible role of the oxidative state of glutathione. Nephron 52: 11-14, 1989
10. Ross EA, Koo LC, Moberly JB: Low whole blood and erythrocyte levels of glutathione in hemodialysis and peritoneal dialysis patients. Am J Kidney Dis 30: 489-494, 1997
11. Durak I, Akyol O, Basesme E, Canbolat O, Kavutcu M: Reduced erythrocyte defense mechanisms against free radical toxicity in patients with chronic renal failure. Nephron 66: 76-80, 1994
12. Dass PD, Bermes EW, Holmes EW: Renal and hepatic output of glutathione in plasma and whole blood. Biochim Biophys Acta 1156: 99-102, 1992
13. Breborowicz A: Free radicals in peritoneal dialysis: Agents of damage? Perit Dial Int 12: 194-198, 1992
14. Costagliola C, Romano L, Scibelli G, de Vincentis A, Sorice P, di Benedetto A: Anemia and chronic renal failure: A therapeutical approach by reduced glutathione parenteral administration. Nephron 61: 404-408, 1992
15. Zachee P, Ferrant A, Daelemans R, Goossens W, Boogaerts MA, Lins RL: Reduced glutathione for the treatment of anemia during hemodialysis: A preliminary communication. Nephron 71: 343-349, 1995
16. Witschi A, Reddy S, Stofei B, Lauterburg BH: The systemic availability of oral glutathione. Eur J Clin Pharmacol 43: 667-669, 1992
17. Williamson JM, Meister A: Stimulation of hepatic glutathione formation by administration of L-2-oxothiazolidine-4-carboxylate, a 5-oxoprolinase substrate. Proc Natl Acad Sci USA 78: 936-939, 1981
18. Meister A, Anderson ME, Hwang O: Intracellular cysteine and glutathione delivery systems. J Am Coll Nutr 5: 137-151, 1986
19. Weitberg AB: The effect of L-2-oxothiazolidine on glutathione levels in cultured mammalian cells. Mutat Res 191: 189-191, 1987
20. Moslen MT, Harper BL, Roy D: Effects of a cysteine precursor, L-2-oxothiazolidine-carboxylate, nutritional status and sex on tissue glutathione and hepatic GSH-utilizing enzymes of CD-1 mice. Res Commun Chem Pathol Pharmacol 61: 49-63, 1988
21. Williamson JM, Boettcher B, Meister A: Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis. Proc Natl Acad Sci USA 79: 6246-6249, 1982
22. Chung TK, Funk MA, Baker DH: L-2-oxothiazolidine-4-carboxylate as a cysteine precursor: Efficacy for growth and hepatic glutathione synthesis in chicks and rats. J Nutr 120: 158-165, 1990
23. Rowe B, Borum P: Safety and efficacy of Procysteine supplemented TPN of neonatal piglets [Abstract]. FASEB J 6: A1941, 1992
24. Kalayjian RC, Skowron G, Emgushov RT, Chance M, Spell SA, Borum PR, Webb LE, Mayer KH, Jackson JB, Yen-Lieberman B, Story KO, Rowe WB, Thompson K, Goldberg D, Trimbo S, Lederman MM: A phase I/II trial of intravenous L-2-oxothiazolidine-4-carboxylic acid (Procysteine) in asymptomatic HIV-infected subjects. J Acquired Immune Defic Syndr 7: 369-374, 1994
25. Jassal V, Moberly JB, Mupas L, Rodela H, Logan J, Webb L, Borum P, Story K, Moran J, Martis L, Oreopoulos DG: Safety and pharmacokinetics of oral L-2-oxothiazolidine-4-carboxylic acid (OTZ) in CAPD patients [Abstract]. Perit Dial Int 16[Suppl 2]: S8, 1996
26. Webb LE, Gechman M, Story K: Determination of L-2-oxothiazolidine-4-carboxylic acid (Procysteine®) in human plasma by high-performance liquid chromatography. J Chromatogr 654: 257-262, 1994
27. Newton GL, Dorian R, Fahey RC: Analysis of biological thiols: Derivation with monobromobimane and separation by reversephase high-performance liquid chromatography. Anal Biochem 114: 383-387, 1981
28. Michelet F, Gueguen R, Leroy P, Wellman M, Nicolas A, Siest G: Blood and plasma glutathione measured in healthy subjects by HPLC: Relation to sex, aging, biological variables and life habits. Clin Chem 41: 1509-1517, 1995
29. Girelli D, Lupo A, Trevisan MT, Olivieri O, Bernich P, Zorzan P, Bassi A, Stanzial AM, Ferrari S, Corrocher R: Red blood cell susceptibility to lipid peroxidation, membrane lipid composition, and antioxidant enzymes in continuous ambulatory peritoneal dialysis patients. Perit Dial Int 12: 205-210, 1992
30. Richard MJ, Arnaud J, Jurkovitz C, Hachache T, Meftahi H, Laporte F, Foret M, Favier A: Trace elements and lipid peroxidation abnormalities in patients with chronic renal failure. Nephron 57: 10-15, 1991
31. Richie JP, Skowronski L, Abraham P, Leutzinger Y: Blood glutathione concentrations in a large-scale human study. Clin Chem 42: 64-70, 1996
32. Droge W, Pottmeyer-Gerber C, Schmidt H, Nick S: Glutathione augments the activation of cytotoxic T lymphocytes in vivo. Immunobiology 172: 151-156, 1986
33. Gotoh N, Graham A, Niki E, Darley-Usmar VM: Inhibition of glutathione synthesis increases the toxicity of oxidized low-density lipoprotein to human monocytes and macrophages. Biochem J 296: 151-154, 1993
34. Dobbie JW: New concepts in molecular biology and ultrastructural pathology of the peritoneum: Their significance for peritoneal dialysis. Am J Kidney Dis 15: 97-109, 1990
35. Breborowicz A, Witowski J, Wieczorowska K, Martis L, Serkes KD, Oreopoulos DG: Toxicity of free radicals to mesothelial cells and peritoneal membrane. Nephron 65: 62-66, 1993
36. Andreoli SP, Mallett C, Williams K, McAteer JA, Roghlein R, Doerschuk CM: Mechanisms of polymorphonuclear leukocytemediated peritoneal mesothelial cell injury. Kidney Int 46: 1100-1109, 1994
37. Breborowicz A, Patrikarea A, Martis L, Oreopoulos DG: L-2-oxothiazolidine-4-carboxylate and N-acetylcysteine as precursors of intracellular glutathione in human peritoneal mesothelial cells. Blood Purif 14: 1-7, 1996
38. Breborowicz A, Witowski J, Martis L, Oreopoulos DG: Enhancement of viability of human peritoneal mesothelial cells with glutathione precursor: L-2-oxothiazolidine-4-carboxylate. Adv Perit Dial 9: 21-24, 1993
39. Alverstrand A, Fürst P, Bergström J: Plasma and muscle free amino acids in uremia: Influence of nutrition with amino acids. Clin Nephrol 18: 297-305, 1982
40. Wilcken DEL, Gupta VJ: Accumulation of sulphur-containing amino acids including cysteine-homocysteine mixed disulfide in patients on hemodialysis. Clin Sci 58: 427-430, 1980