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Volumn 68, Issue 5, 2005, Pages 1281-1290

A prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid, regulates vascular permeability by reducing vascular endothelial growth factor expression in asthma

Author keywords

[No Author keywords available]

Indexed keywords

2 OXO 4 THIAZOLIDINECARBOXYLIC ACID; ALLERGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NUCLEAR PROTEIN; OVALBUMIN; REACTIVE OXYGEN METABOLITE; VASCULOTROPIN;

EID: 27544492881     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.016055     Document Type: Article
Times cited : (28)

References (50)
  • 2
    • 0029051789 scopus 로고
    • Effectiveness of carbocysteine lysine salt monohydrate on models of airway inflammation and hyperresponsiveness
    • Asti C, Melillo G, Caselli GF, Daffonchio L, Hernandez A, Clavenna G, and Omini C (1995) Effectiveness of carbocysteine lysine salt monohydrate on models of airway inflammation and hyperresponsiveness. Pharmacol Res 31:387-392.
    • (1995) Pharmacol Res , vol.31 , pp. 387-392
    • Asti, C.1    Melillo, G.2    Caselli, G.F.3    Daffonchio, L.4    Hernandez, A.5    Clavenna, G.6    Omini, C.7
  • 5
    • 0029151483 scopus 로고
    • The free radical scavenger, alpha-lipoic acid, protects against cerebral ischemia-reperfusion injury in gerbils
    • Cao X and Phillis JW (1995) The free radical scavenger, alpha-lipoic acid, protects against cerebral ischemia-reperfusion injury in gerbils. Free Radic Res 23:365-370.
    • (1995) Free Radic Res , vol.23 , pp. 365-370
    • Cao, X.1    Phillis, J.W.2
  • 7
    • 4344696207 scopus 로고    scopus 로고
    • alpha-Lipoic acid inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma
    • Cho YS, Lee J, Lee TH, Lee EY, Lee KU, Park JY, and Moon HB (2004) alpha-Lipoic acid inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. J Allergy Clin Immunol 114:429-435.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 429-435
    • Cho, Y.S.1    Lee, J.2    Lee, T.H.3    Lee, E.Y.4    Lee, K.U.5    Park, J.Y.6    Moon, H.B.7
  • 8
    • 0028229422 scopus 로고
    • Piecemeal degranulation of mast cells in the inflammatory eyelid lesions of interleukin-4 transgenic mice. Evidence of mast cell histamine release in vivo by diamine oxidase-gold enzyme-affinity ultrastructural cytochemistry
    • Dvorak AM, Tepper RI, Weller PF, Morgan ES, Estrella P, Monahan-Earley RA, and Galli SJ (1994) Piecemeal degranulation of mast cells in the inflammatory eyelid lesions of interleukin-4 transgenic mice. Evidence of mast cell histamine release in vivo by diamine oxidase-gold enzyme-affinity ultrastructural cytochemistry. Blood 83:3600-3612.
    • (1994) Blood , vol.83 , pp. 3600-3612
    • Dvorak, A.M.1    Tepper, R.I.2    Weller, P.F.3    Morgan, E.S.4    Estrella, P.5    Monahan-Earley, R.A.6    Galli, S.J.7
  • 9
    • 0029004025 scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability and angiogenesis
    • Dvorak HF, Brown LF, Detmar M, and Dvorak AM (1995) Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability and angiogenesis. Am J Pathol 146:1029-1039.
    • (1995) Am J Pathol , vol.146 , pp. 1029-1039
    • Dvorak, H.F.1    Brown, L.F.2    Detmar, M.3    Dvorak, A.M.4
  • 10
    • 0033797637 scopus 로고    scopus 로고
    • Oxidant stress in asthma
    • Dworski R (2000) Oxidant stress in asthma. Thorax 55:S51-S53.
    • (2000) Thorax , vol.55
    • Dworski, R.1
  • 12
    • 0037214475 scopus 로고    scopus 로고
    • Involvement of the cysteinyl-leukotrienes in allergen-induced airway eosinophilia and hyperresponsiveness in the mouse
    • Eum SY, Maghni K, Hamid Q, Campbell H, Eidelman DH, and Martin JG (2003) Involvement of the cysteinyl-leukotrienes in allergen-induced airway eosinophilia and hyperresponsiveness in the mouse. Am J Respir Cell Mol Biol 28:25-32.
    • (2003) Am J Respir Cell Mol Biol , vol.28 , pp. 25-32
    • Eum, S.Y.1    Maghni, K.2    Hamid, Q.3    Campbell, H.4    Eidelman, D.H.5    Martin, J.G.6
  • 13
    • 0020402676 scopus 로고
    • Lung mucociliary function in man: Interdependence of bronchial and tracheal mucus transport velocities with lung clearance in bronchial asthma and healthy subjects
    • Foster WM, Langenback EG, and Bergofsky EH (1982) Lung mucociliary function in man: interdependence of bronchial and tracheal mucus transport velocities with lung clearance in bronchial asthma and healthy subjects. Ann Occup Hyg 26:227-244.
    • (1982) Ann Occup Hyg , vol.26 , pp. 227-244
    • Foster, W.M.1    Langenback, E.G.2    Bergofsky, E.H.3
  • 14
    • 0035860375 scopus 로고    scopus 로고
    • A non-hypoxia, ROS-sensitive pathway mediates TNF-alpha-dependent regulation of HIF-1alpha
    • Haddad JJ and Land SC (2001) A non-hypoxia, ROS-sensitive pathway mediates TNF-alpha-dependent regulation of HIF-1alpha. FEBS Lett 505:269-274.
    • (2001) FEBS Lett , vol.505 , pp. 269-274
    • Haddad, J.J.1    Land, S.C.2
  • 15
    • 0037085465 scopus 로고    scopus 로고
    • Antidiabetic effect of a prodrug of cysteine, L-2-oxothiazolidine-4- carboxylic acid, through CD38 dimerization and internalization
    • Han MK, Kim SJ, Park YR, Shin YM, Park HJ, Park KJ, Park KH, Kim HK, Jang SI, An NH, et al. (2002) Antidiabetic effect of a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid, through CD38 dimerization and internalization. J Biol Chem 277:5315-5321.
    • (2002) J Biol Chem , vol.277 , pp. 5315-5321
    • Han, M.K.1    Kim, S.J.2    Park, Y.R.3    Shin, Y.M.4    Park, H.J.5    Park, K.J.6    Park, K.H.7    Kim, H.K.8    Jang, S.I.9    An, N.H.10
  • 16
    • 0035686459 scopus 로고    scopus 로고
    • Reactive oxygen species as mediators in asthma
    • Henricks PA and Nijkamp FP (2001) Reactive oxygen species as mediators in asthma. Pulm Pharmacol Ther 14:409-420.
    • (2001) Pulm Pharmacol Ther , vol.14 , pp. 409-420
    • Henricks, P.A.1    Nijkamp, F.P.2
  • 17
    • 0034995813 scopus 로고    scopus 로고
    • Gene expression of vascular endothelial growth factor and its receptors and angiogenesis in bronchial asthma
    • Hoshino M, Nakamura Y, and Hamid QA (2001) Gene expression of vascular endothelial growth factor and its receptors and angiogenesis in bronchial asthma. J Allergy Clin Immunol 107:1034-1038.
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 1034-1038
    • Hoshino, M.1    Nakamura, Y.2    Hamid, Q.A.3
  • 20
    • 0347334750 scopus 로고    scopus 로고
    • IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis
    • Jung YJ, Isaacs JS, Lee S, Trepel J, and Neckers L (2003) IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J 17:2115-2117.
    • (2003) FASEB J , vol.17 , pp. 2115-2117
    • Jung, Y.J.1    Isaacs, J.S.2    Lee, S.3    Trepel, J.4    Neckers, L.5
  • 21
    • 0037098081 scopus 로고    scopus 로고
    • How oxygen makes its presence felt
    • Kaelin WG Jr (2002) How oxygen makes its presence felt. Genes Dev 16:1441-1445.
    • (2002) Genes Dev , vol.16 , pp. 1441-1445
    • Kaelin Jr., W.G.1
  • 23
    • 0037382808 scopus 로고    scopus 로고
    • Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma
    • Kwak YG, Song CH, Yi HK, Hwang PH, Kim JS, Lee KS, and Lee YC (2003) Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma. J Clin Invest 111:1083-1092.
    • (2003) J Clin Invest , vol.111 , pp. 1083-1092
    • Kwak, Y.G.1    Song, C.H.2    Yi, H.K.3    Hwang, P.H.4    Kim, J.S.5    Lee, K.S.6    Lee, Y.C.7
  • 24
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • Laughner E, Taghavi P, Chiles K, Mahon PC, and Semenza GL (2001) HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 21:3995-4004.
    • (2001) Mol Cell Biol , vol.21 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3    Mahon, P.C.4    Semenza, G.L.5
  • 25
    • 7044260315 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung
    • Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, Kang MJ, Cohn L, Kim YK, McDonald DM, et al. (2004a) Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med 10:1095-1103.
    • (2004) Nat Med , vol.10 , pp. 1095-1103
    • Lee, C.G.1    Link, H.2    Baluk, P.3    Homer, R.J.4    Chapoval, S.5    Bhandari, V.6    Kang, M.J.7    Cohn, L.8    Kim, Y.K.9    McDonald, D.M.10
  • 26
    • 0037106353 scopus 로고    scopus 로고
    • Implication of the small GTPase Racl in the generation of reactive oxygen species in response to β-amyloid in C6 astrolgioma cells
    • Lee M, You HJ, Cho SH, Woo CH, Yoo MH, Joe EH, and Kim JH (2002a) Implication of the small GTPase Racl in the generation of reactive oxygen species in response to β-amyloid in C6 astrolgioma cells. Biochem J 366:937-943.
    • (2002) Biochem J , vol.366 , pp. 937-943
    • Lee, M.1    You, H.J.2    Cho, S.H.3    Woo, C.H.4    Yoo, M.H.5    Joe, E.H.6    Kim, J.H.7
  • 27
    • 0036533666 scopus 로고    scopus 로고
    • Contribution of vascular endothelial growth factor to airway hyper-responsiveness and inflammation in a murine model of toluene diisocyanate-induced asthma
    • Lee YC, Kwak YG, and Song CH (2002b) Contribution of vascular endothelial growth factor to airway hyper-responsiveness and inflammation in a murine model of toluene diisocyanate-induced asthma. J Immunol 168:3595-3600.
    • (2002) J Immunol , vol.168 , pp. 3595-3600
    • Lee, Y.C.1    Kwak, Y.G.2    Song, C.H.3
  • 28
    • 0035006275 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in patients with acute asthma
    • Lee YC and Lee HK (2001) Vascular endothelial growth factor in patients with acute asthma. J Allergy Clin Immunol 107:1106.
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 1106
    • Lee, Y.C.1    Lee, H.K.2
  • 29
    • 10044224510 scopus 로고    scopus 로고
    • Blockade of airway hyperresponsiveness and inflammation in a murine model of asthma by a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid
    • Lee YC, Lee KS, Park SJ, Park HS, Lim JS, Park KH, Im MJ, Choi IW, Lee HK, and Kim UH (2004b) Blockade of airway hyperresponsiveness and inflammation in a murine model of asthma by a prodrug of cysteine, L-2-oxothiazolidine-4- carboxylic acid. FASEB J 18:1917-1919.
    • (2004) FASEB J , vol.18 , pp. 1917-1919
    • Lee, Y.C.1    Lee, K.S.2    Park, S.J.3    Park, H.S.4    Lim, J.S.5    Park, K.H.6    Im, M.J.7    Choi, I.W.8    Lee, H.K.9    Kim, U.H.10
  • 30
    • 17144372970 scopus 로고    scopus 로고
    • A hypoxia independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells
    • Li YM, Zhou BP, Deng J, Pan Y, Hay N, and Hung M (2005) A hypoxia independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells. Cancer Res 65:3257-3263.
    • (2005) Cancer Res , vol.65 , pp. 3257-3263
    • Li, Y.M.1    Zhou, B.P.2    Deng, J.3    Pan, Y.4    Hay, N.5    Hung, M.6
  • 31
    • 0035966119 scopus 로고    scopus 로고
    • Differential regulation of two alternatively spliced isoforms of hypoxia-inducible factor-1 alpha in activated T lymphocytes
    • Lukashev D, Caldwell C, Ohta A, Chen P, and Sitkovsky M (2001) Differential regulation of two alternatively spliced isoforms of hypoxia-inducible factor-1 alpha in activated T lymphocytes. J Biol Chem 276:48754-48763.
    • (2001) J Biol Chem , vol.276 , pp. 48754-48763
    • Lukashev, D.1    Caldwell, C.2    Ohta, A.3    Chen, P.4    Sitkovsky, M.5
  • 32
    • 0035840849 scopus 로고    scopus 로고
    • Oxidative stress and lung inflammation in airways disease
    • MacNee W (2001) Oxidative stress and lung inflammation in airways disease. Eur J Pharmacol 429:195-207.
    • (2001) Eur J Pharmacol , vol.429 , pp. 195-207
    • MacNee, W.1
  • 34
    • 0024555808 scopus 로고
    • Administration of L-2-oxothiazolidine-4-carboxylate increases glutathione levels in rat brain
    • Mesina JE, Page RH, Hetzel FW, and Chopp M (1989) Administration of L-2-oxothiazolidine-4-carboxylate increases glutathione levels in rat brain. Brain Res 478:181-183.
    • (1989) Brain Res , vol.478 , pp. 181-183
    • Mesina, J.E.1    Page, R.H.2    Hetzel, F.W.3    Chopp, M.4
  • 35
    • 0043234256 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor-1α protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3β pathway in HepG2 cells
    • Mottet D, Dumont V, Deccache Y, Demazy C, Ninane N, Raes M, and Michiels C (2003) Regulation of hypoxia-inducible factor-1α protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3β pathway in HepG2 cells. J Biol Chem 278:31277-31285.
    • (2003) J Biol Chem , vol.278 , pp. 31277-31285
    • Mottet, D.1    Dumont, V.2    Deccache, Y.3    Demazy, C.4    Ninane, N.5    Raes, M.6    Michiels, C.7
  • 36
  • 37
    • 0029942269 scopus 로고    scopus 로고
    • Epithelial cells: Barrier functions and shedding restitution mechanisms
    • Persson CG (1996) Epithelial cells: barrier functions and shedding restitution mechanisms. Am J Respir Crit Care Med 153:S9-S10.
    • (1996) Am J Respir Crit Care Med , vol.153
    • Persson, C.G.1
  • 38
    • 0026075333 scopus 로고
    • L-2-Oxothiazolidine-4-carboxylic acid, a cysteine prodrug: Pharmacokinetics and effects on thiols in plasma and lymphocytes in human
    • Porta P, Aebi S, Summer K, and Lauterburg BH (1991) L-2-Oxothiazolidine- 4-carboxylic acid, a cysteine prodrug: pharmacokinetics and effects on thiols in plasma and lymphocytes in human. J Pharmacol Exp Ther 257:331-334.
    • (1991) J Pharmacol Exp Ther , vol.257 , pp. 331-334
    • Porta, P.1    Aebi, S.2    Summer, K.3    Lauterburg, B.H.4
  • 40
    • 0033233243 scopus 로고    scopus 로고
    • 2 homeostasis by hypoxia-inducible factor 1
    • 2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 15:551-578.
    • (1999) Annu Rev Cell Dev Biol , vol.15 , pp. 551-578
    • Semenza, G.L.1
  • 41
    • 0035029319 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: Control of oxygen homeostasis in health and disease
    • Semenza GL (2001) Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease. Pediatr Res 49:614-617.
    • (2001) Pediatr Res , vol.49 , pp. 614-617
    • Semenza, G.L.1
  • 43
    • 0030810734 scopus 로고    scopus 로고
    • Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice
    • Takeda K, Hamelmann E, Joetham A, Shultz LD, Larsen GL, Irvin CG, and Gelfand EW (1997) Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice. J Exp Med 186:449-454.
    • (1997) J Exp Med , vol.186 , pp. 449-454
    • Takeda, K.1    Hamelmann, E.2    Joetham, A.3    Shultz, L.D.4    Larsen, G.L.5    Irvin, C.G.6    Gelfand, E.W.7
  • 44
    • 0033961855 scopus 로고    scopus 로고
    • Airway eosinophilia is not a requirement for allergen-induced airway hyperresponsiveness
    • Tournoy KG, Kips JC, Schou C, and Pauwels RA (2000) Airway eosinophilia is not a requirement for allergen-induced airway hyperresponsiveness. Clin Exp Allergy 30:79-85.
    • (2000) Clin Exp Allergy , vol.30 , pp. 79-85
    • Tournoy, K.G.1    Kips, J.C.2    Schou, C.3    Pauwels, R.A.4
  • 45
    • 0037008770 scopus 로고    scopus 로고
    • Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
    • Treins C, Giogetti-Peraldi S, Murdaca J, Semenza GL, and Van Obberghen E (2002) Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. J Biol Chem 277:27975-27981.
    • (2002) J Biol Chem , vol.277 , pp. 27975-27981
    • Treins, C.1    Giogetti-Peraldi, S.2    Murdaca, J.3    Semenza, G.L.4    Van Obberghen, E.5
  • 46
    • 0026026861 scopus 로고
    • Respiratory membrane permeability and bronchial hyperreactivity in patients with stable asthma. Effects of therapy with inhaled steroids
    • Van de Graaf EA, Out TA, Roos CM, and Jansen HM (1991) Respiratory membrane permeability and bronchial hyperreactivity in patients with stable asthma. Effects of therapy with inhaled steroids. Am Rev Respir Dis 143:362-368.
    • (1991) Am Rev Respir Dis , vol.143 , pp. 362-368
    • Van De Graaf, E.A.1    Out, T.A.2    Roos, C.M.3    Jansen, H.M.4
  • 47
    • 0032521146 scopus 로고    scopus 로고
    • L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease
    • Vita JA, Frei B, Holbrook M, Gokce N, Leaf C, and Keaney JF Jr (1998) L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease. J Clin Investig 101:1408-1414.
    • (1998) J Clin Investig , vol.101 , pp. 1408-1414
    • Vita, J.A.1    Frei, B.2    Holbrook, M.3    Gokce, N.4    Leaf, C.5    Keaney Jr., J.F.6
  • 48
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxiainducible factor 1
    • Wang GL and Semenza GL (1995) Purification and characterization of hypoxiainducible factor 1. J Biol Chem 270:1230-1237.
    • (1995) J Biol Chem , vol.270 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 49
    • 2842598462 scopus 로고
    • Stimulation of hepatic glutathione formation by administration of L-2-oxothiazolidine-4-carboxylate, a 5-oxo-L-prolinase substrate
    • Williamson JM and Meister A (1981) Stimulation of hepatic glutathione formation by administration of L-2-oxothiazolidine-4-carboxylate, a 5-oxo-L-prolinase substrate. Proc Natl Acad Sci USA 78:936-939.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 936-939
    • Williamson, J.M.1    Meister, A.2
  • 50
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/ AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, and Semenza GL (2000) Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/ AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60:1541-1545.
    • (2000) Cancer Res , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6    Simons, J.W.7    Semenza, G.L.8


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